Age-induced decrease of glycoprotein Po and myelin basic protein gene expression in the rat sciatic nerve. Repair by steroid derivatives

Neuroscience

Volumn 85, Issue 2, 1998, Pages 569-578

  Melcangi, R C ^a   Magnaghi, V ^a   Cavarretta, I ^a   Martini, L ^a   Piva, F ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

Ageing; Glycoprotein Po; Metabolites; Myelin basic protein; Progesterone; Schwann cells; Sciatic nerve

Indexed keywords

20ALPHA DIHYDROPROGESTERONE; HYDROXYSTEROID DEHYDROGENASE; MYELIN BASIC PROTEIN; TETRAHYDROPROGESTERONE;

AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; ENZYME ACTIVITY; GENE EXPRESSION; HORMONE ACTION; MALE; NERVE REGENERATION; NONHUMAN; PRIORITY JOURNAL; RAT; SCHWANN CELL; SCIATIC NERVE;

20-ALPHA-DIHYDROPROGESTERONE; AGING; ANIMALS; ANIMALS, NEWBORN; BLOTTING, NORTHERN; CELLS, CULTURED; GENE EXPRESSION REGULATION; MALE; MYELIN BASIC PROTEINS; MYELIN P0 PROTEIN; OLIGODENDROGLIA; PREGNANOLONE; RATS; RATS, SPRAGUE-DAWLEY; SCHWANN CELLS; SCIATIC NERVE;

EID: 0032495839     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(97)00628-3     Document Type: Article

References (41)

1. Adinolfi A. M., Yamury J., Morales F. R., Chase M. H. Segmental demyelination in peripheral nerves of old cats. Neurobiol. Aging. 12:1991;175-179.
2. 3H] palmitic acid into Po protein, the major intrinsic protein of rat sciatic nerve myelin. J. biol. Chem. 258:1983;6556-6560.
3. Bradford M. M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Ann. Biochem. 72:1976;248-254.
4. A receptors mediate 3α-hydroxy-5α-pregnan-20-one-induced gonadotropin secretion. Endocrinology. 126:1990;1854-1859.
5. Brockes J. P., Raff M. C., Nishiguchi D. J., Winter J. Studies on cultured rat Schwann cells: assay for peripheral myelin proteins. J. Neurocytol. 9:1980;67-77.
6. Campagnoni A. T., Macklin W. B. Cellular and molecular aspect of myelin protein gene expression. Molec. Neurobiol. 2:1988;41-89.
7. Celotti F., Melcangi R. C., Martini L. The 5α-reductase in the brain: molecular aspects and relation to brain function. Front. Neuroendocrinol. 13:1992;163-215.
8. Chase M. H., Engelhardt J. K., Adinolfi A. M., Chirwa S. S. Age-dependent changes in cat masseter nerve: an electrophysiological and morphological study. Brain Res. 586:1992;279-288.
9. Chomczynski P., Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Analyt. Biochem. 162:1987;156-159.
10. Downie A. W., Newell D. J. Sensory nerve conduction in patients with diabetes mellitus and controls. Neurology. 11:1961;876-882.
11. D'Urso D., Brophy P. J., Staugaitus S. M., Gillespie C. S., Frey A. B., Stempak J. G., Colman D. R. Protein zero of peripheral nerve myelin: biosynthesis, membrane insertion, and evidence for homotypic interaction. Neuron. 4:1990;449-460.
12. Everly J. L., Brady R. O., Quarles R. H. Evidence that the major protein in rat sciatic nerve myelin is a glycoprotein. J. Neurochem. 21:1973;329-334.
13. Feltri M. L., Scherer S. S., Wrabetz L., Kamholz J., Shy M. E. Mitogen-expanded Schwann cells retain the capacity to myelinate regenerating axons after transplantation into rat sciatic nerve. Proc. natn. Acad. Sci. U.S.A. 89:1992;8827-8831.
14. Grover-Johnson N., Spencer P. S. Peripheral nerve abnormalities in aging rats. J. Neuropath. exp. Neurol. 40:1981;155-165.
15. Johansson C. S., Stenstrom M., Hildebrand C. Target influence on aging of myelinated sensory nerve fibres. Neurobiol. Aging. 17:1996;61-66.
16. Jung-Testas I., Schumacher M., Robel P., Baulieu E.-E. Demonstration of progesterone receptors in rat Schwann cells. J. Steroid Biochem. molec. Biol. 58:1996;77-82.
17. Kitamura K., Suzuki M., Uyemura K. Purification and partial characterization of two glycoproteins in bovine peripheral nerve myelin membrane. Biochim. biophys. Acta. 455:1976;806-816.
18. Koenig H. L., Schumacher M., Ferzaz B., DoThi A. N., Ressouches A., Guennoun R., Jung-Testas I., Robel P., Akwa Y., Baulieu E.-E. Progesterone synthesis and myelin formation by Schwann cells. Science. 268:1995;1500-1503.
19. Ishaque A., Roomi M. W., Szymanska I., Kowalski S., Eylar E. H. The Po glycoprotein of peripheral nerve myelin. Can. J. Biochem. 58:1980;913-921.
20. Lemke G. Molecular biology of the major myelin genes. Trends Neurosci. 9:1986;266-270.
21. Mayer R. F. Nerve conduction studies in man. Neurology. 13:1963;1021-1030.
22. Martini L. The 5α-reduction of testosterone in the neuroendocrine structures. Biochemical and physiological implications. Endocr. Rev. 3:1982;1-25.
23. 35S] sulfate incorporation into myelin glycoproteins. II. Peripheral nervous system. Biochim. biophys. Acta. 392:1975;167-174.
24. Melcangi R. C., Celotti F., Ballabio M., Castano P., Massarelli R., Poletti A., Martini L. 5α-reductase activity in isolated and cultured neuronal and glial cells of the rat. Brain Res. 516:1990;229-236.
25. Melcangi R. C., Celotti F., Ballabio M., Poletti A., Martini L. Testosterone metabolism in peripheral nerves: presence of the 5α-reductase-3α-hydroxysteroid-dehydrogenase enzymatic system in the sciatic nerve of adult and aged rats. J. Steroid Biochem. 35:1990;145-148.
26. Melcangi R. C., Celotti F., Castano P., Martini L. Differential localization of the 5α-reductase and the 3α-hydroxysteroid dehydrogenase in neuronal and glial cultures. Endocrinology. 132:1993;1252-1259.
27. Melcangi R. C., Celotti F., Martini L. Progesterone 5α-reduction in neuronal and in different types of glial cell cultures: type 1 and 2 astrocytes and oligodendrocytes. Brain Res. 639:1994;202-206.
28. Morales J. F. R., Boxer P. A., Fung S. J., Chase M. H. Basic electrophysiological properties of spinal cord motoneurons during old age in the cat. J. Neurophysiol. 58:1987;180-194.
29. A receptor system. Biol. Reprod. 45:1991;266-272.
30. Rabuffetti M., Motta M., Celotti F., Martini L., Poletti A. Allopregnenolone must be converted into 5α-dihydroprogesterone to regulate the transcriptional activity of progesterone receptor expressed in yeasts saccharomyces cerevisiae. J. Endocrinol. 152(Suppl.):1997;OC4.
31. Roomi M. W., Ishaque A., Khann N. R., Eylar E. H. The Po protein. The major glycoprotein of peripheral nerve myelin. Biochim. biophys. Acta. 536:1978;112-121.
32. Rupprecht R., Reul J. M. H. M., Trapp T., van Steensel B., Wetzel C., Damm K., Zieglgansberger W., Holsboer F. Progesterone receptor-mediated effects of neuroactive steroids. Neuron. 11:1993;523-530.
33. Rupprecht R., Hauser C. A. E., Trapp T., Holsboer F. Neurosteroids: molecular mechanisms of action and psychopharmacological significance. J. Steroid Biochem. molec. Biol. 56:1996;163-168.
34. Sakamoto Y., Kitamura K., Yoshimura K., Nishijima T., Uyemura K. Fatty acid-linked peptides from bovine Po protein in peripheral nerve myelin. Biomed. Res. 7:1986;261-266.
35. Singh H., Spritz N. Protein kinase associated with peripheral nerve myelin. 1. Phosphorylation of endogenous myelin proteins and exogenous substrates. Biochim. biophys. Acta. 448:1976;325-337.
36. Snipes G. J., Suter U. Molecular anatomy and genetics of myelin proteins in the peripheral nervous system. J. Anat. 186:1995;483-494.
37. Spencer P. S., Thomas P. K. The examination of isolated nerve fibres by light and electron microscopy with observations on demyelination proximal to neuromas. Acta neuropath., Berlin. 16:1970;177-186.
38. Spencer P. S., Thomas P. K. Ultrastructural studies with the dying back process. II. The sequestration and removal by Schwann cells and oligodendrocytes of organelles from normal and diseased axons. J. Neurocytol. 3:1974;763-783.
39. Stahl N., Harry J., Popko B. Quantitative analysis of myelin protein gene expression during development in the rat sciatic nerve. Molec. Brain Res. 8:1990;209-212.
40. Thomas P. K., King R. H. M., Sharma A. K. Changes with age in the peripheral nerves of the rat. Acta neuropath., Berlin. 52:1980;417-428.
41. Wiggins R. C., Morell P. Phosphorylation and fucosylation of myelin protein in vitro by sciatic nerve from developing rats. J. Neurochem. 34:1980;627-634.