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Volumn 6, Issue 10, 2000, Pages 816-824

Presenilin 2 Mutation Does Not Influence Expression and Concentration of APP Forms in Human Platelets

Author keywords

Amyloid Cascade; Platelet APP; Platelet Homogenates; Presenilin (PS2); Val30Met Mutation

Indexed keywords

AMYLOID PRECURSOR PROTEIN; MEMBRANE PROTEIN; MESSENGER RNA; PRESENILIN 2; PRIMER DNA; PSEN2 PROTEIN, HUMAN;

EID: 0034295199     PISSN: 10761551     EISSN: 15283658     Source Type: Journal    
DOI: 10.1007/BF03401820     Document Type: Article
Times cited : (6)

References (41)
  • 1
    • 0023132387 scopus 로고
    • Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer’s disease
    • 1:CAS:528:DyaL2sXhtlaru70%3D, 3810169
    • D. Goldgaber M.I. Lerman O.W. McBride U. Saffiotti D.C. Gajdusek Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer’s disease Science 1987 235 877 880 10.1126/science.3810169 1:CAS:528:DyaL2sXhtlaru70%3D 3810169
    • (1987) Science , vol.235 , pp. 877-880
    • Goldgaber, D.1    Lerman, M.I.2    McBride, O.W.3    Saffiotti, U.4    Gajdusek, D.C.5
  • 2
    • 0023109592 scopus 로고
    • Amyloid β protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus
    • 1:CAS:528:DyaL2sXhtlaru7o%3D, 2949367
    • R.E. Tanzi J.F. Gusella P.C. Watkins et al. Amyloid β protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus Science 1987 235 880 884 10.1126/science.2949367 1:CAS:528:DyaL2sXhtlaru7o%3D 2949367
    • (1987) Science , vol.235 , pp. 880-884
    • Tanzi, R.E.1    Gusella, J.F.2    Watkins, P.C.3
  • 3
    • 0033616716 scopus 로고    scopus 로고
    • Constitutive and regulated α-secretase cleavage of Alzheimer’s amyloid precursor protein by a disintegrin metalloprotease
    • 1:CAS:528:DyaK1MXjslChsLY%3D, 10097139, 22396
    • S. Lammich E. Kojro R. Postina et al. Constitutive and regulated α-secretase cleavage of Alzheimer’s amyloid precursor protein by a disintegrin metalloprotease Proc. Natl. Acad. Sci. U.S.A. 1999 96 3922 3927 10.1073/pnas.96.7.3922 1:CAS:528:DyaK1MXjslChsLY%3D 10097139 22396
    • (1999) Proc. Natl. Acad. Sci. U.S.A , vol.96 , pp. 3922-3927
    • Lammich, S.1    Kojro, E.2    Postina, R.3
  • 4
    • 14444272986 scopus 로고    scopus 로고
    • Evidence that tumor necrosis factor (α-converting enzyme is involved in regulated (α-secretase cleavage of the Alzheimer amyloid precursor protein
    • 1:CAS:528:DyaK1cXntVCmtr0%3D, 9774383
    • J.D. Buxbaum K.N. Liu X. Luo et al. Evidence that tumor necrosis factor (α-converting enzyme is involved in regulated (α-secretase cleavage of the Alzheimer amyloid precursor protein J. Biol. Chem. 1998 273 27765 27767 10.1074/jbc.273.43.27765 1:CAS:528:DyaK1cXntVCmtr0%3D 9774383
    • (1998) J. Biol. Chem , vol.273 , pp. 27765-27767
    • Buxbaum, J.D.1    Liu, K.N.2    Luo, X.3
  • 5
    • 0033595706 scopus 로고    scopus 로고
    • β-secretase cleavage of Alzheimer’s amyloid precursor protein by the transmembrane aspartic protease BACE
    • 1:CAS:528:DyaK1MXntFWit74%3D, 10531052
    • R. Vassar B.D. Bennett S. Babu-Khan et al. β-secretase cleavage of Alzheimer’s amyloid precursor protein by the transmembrane aspartic protease BACE Science 1999 286 735 741 10.1126/science.286.5440.735 1:CAS:528:DyaK1MXntFWit74%3D 10531052
    • (1999) Science , vol.286 , pp. 735-741
    • Vassar, R.1    Bennett, B.D.2    Babu-Khan, S.3
  • 6
    • 0033382226 scopus 로고    scopus 로고
    • Identification of a novel aspartic protease (Asp2) as β-secreatase
    • 1:CAS:528:DyaK1MXnt1Chsrs%3D, 10656250
    • I. Hussain D. Powell D.R. Howlett et al. Identification of a novel aspartic protease (Asp2) as β-secreatase Mol. Cell. Neurosci. 1999 14 419 427 10.1006/mcne.1999.0811 1:CAS:528:DyaK1MXnt1Chsrs%3D 10656250
    • (1999) Mol. Cell. Neurosci , vol.14 , pp. 419-427
    • Hussain, I.1    Powell, D.2    Howlett, D.R.3
  • 7
    • 0033518264 scopus 로고    scopus 로고
    • Membrane-anchored aspartyl protease with Alzheimer’s disease β-secretase activity
    • 1:CAS:528:DyaK1MXotFKmu7k%3D, 10591213
    • R. Yan J.B. Bienkowski M.E. Shuck et al. Membrane-anchored aspartyl protease with Alzheimer’s disease β-secretase activity Nature 1999 402 533 536 10.1038/990107 1:CAS:528:DyaK1MXotFKmu7k%3D 10591213
    • (1999) Nature , vol.402 , pp. 533-536
    • Yan, R.1    Bienkowski, J.B.2    Shuck, M.E.3
  • 8
    • 0033518251 scopus 로고    scopus 로고
    • Purification and cloning of amyloid precursor protein β-secretase from human brain
    • 1:CAS:528:DyaK1MXotFKlsrc%3D, 10591214
    • S. Sinha J.P. Anderson R. Barbour et al. Purification and cloning of amyloid precursor protein β-secretase from human brain Nature 1999 402 537 540 10.1038/990114 1:CAS:528:DyaK1MXotFKlsrc%3D 10591214
    • (1999) Nature , vol.402 , pp. 537-540
    • Sinha, S.1    Anderson, J.P.2    Barbour, R.3
  • 9
    • 0030769091 scopus 로고    scopus 로고
    • Distinct sites of intracellular production for Alzheimer’s disease Aβ40/42 amyloid peptides
    • 1:CAS:528:DyaK2sXlvVykt74%3D, 9288729
    • T. Hartmann S.C. Bieger B. Bruhl et al. Distinct sites of intracellular production for Alzheimer’s disease Aβ40/42 amyloid peptides Nat. Med. 1997 3 1016 1020 10.1038/nm0997-1016 1:CAS:528:DyaK2sXlvVykt74%3D 9288729
    • (1997) Nat. Med , vol.3 , pp. 1016-1020
    • Hartmann, T.1    Bieger, S.C.2    Bruhl, B.3
  • 10
    • 0030952217 scopus 로고    scopus 로고
    • Intracellular generation and accumulation of amyloid β-peptide terminating at amino acid 42
    • 1:CAS:528:DyaK2sXkt1Wls7s%3D, 9195901
    • C. Wild-Bode T. Yamazaki A. Capell et al. Intracellular generation and accumulation of amyloid β-peptide terminating at amino acid 42 J. Biol. Chem. 1997 272 16085 16088 10.1074/jbc.272.26.16085 1:CAS:528:DyaK2sXkt1Wls7s%3D 9195901
    • (1997) J. Biol. Chem , vol.272 , pp. 16085-16088
    • Wild-Bode, C.1    Yamazaki, T.2    Capell, A.3
  • 11
    • 0025563206 scopus 로고
    • Intact Alzheimer amyloid precursor protein (APP) is present in platelet membranes and is encoded by platelet mRNA
    • 1:CAS:528:DyaK3MXnvFGruw%3D%3D, 1702629
    • J.E. Gardella J. Ghiso G.A. Gorgone et al. Intact Alzheimer amyloid precursor protein (APP) is present in platelet membranes and is encoded by platelet mRNA Biochem. Biophys. Res. Comm. 1990 173 1292 1298 10.1016/S0006-291X(05)80927-1 1:CAS:528:DyaK3MXnvFGruw%3D%3D 1702629
    • (1990) Biochem. Biophys. Res. Comm , vol.173 , pp. 1292-1298
    • Gardella, J.E.1    Ghiso, J.2    Gorgone, G.A.3
  • 12
    • 0026594114 scopus 로고
    • Characterization of Alzheimer amyloid precursor protein transcripts in platelets and mega-karyocytes
    • 1:CAS:528:DyaK38XktVGnsb4%3D, 1608533
    • J.E. Gardella G.A. Gorgone P. Newman B. Frangione P.D. Gorevic Characterization of Alzheimer amyloid precursor protein transcripts in platelets and mega-karyocytes Neurosci. Lett. 1992 138 229 232 10.1016/0304-3940(92)90921-S 1:CAS:528:DyaK38XktVGnsb4%3D 1608533
    • (1992) Neurosci. Lett , vol.138 , pp. 229-232
    • Gardella, J.E.1    Gorgone, G.A.2    Newman, P.3    Frangione, B.4    Gorevic, P.D.5
  • 13
    • 0025365401 scopus 로고
    • Platelet coagulation factor XIa—inhibitor, a form of Alzheimer amyloid precursor protein
    • 1:CAS:528:DyaK3cXktlKqtLk%3D, 2111585
    • R.P. Smith D.A. Higuchi G.J. Broze Platelet coagulation factor XIa—inhibitor, a form of Alzheimer amyloid precursor protein Science 1990 248 1126 1128 10.1126/science.2111585 1:CAS:528:DyaK3cXktlKqtLk%3D 2111585
    • (1990) Science , vol.248 , pp. 1126-1128
    • Smith, R.P.1    Higuchi, D.A.2    Broze, G.J.3
  • 14
    • 0031959497 scopus 로고    scopus 로고
    • Secretion of Alzheimer disease Aβ amyloid peptide by activation of human platelets
    • 9564890, 1:CAS:528:DyaK1cXivVSqtrg%3D
    • Q.X. Li S. Whyte J. Tanner G. Evin K. Beyreuther C.L. Masters Secretion of Alzheimer disease Aβ amyloid peptide by activation of human platelets Lab. Invest. 1998 78 461 469 9564890 1:CAS:528:DyaK1cXivVSqtrg%3D
    • (1998) Lab. Invest , vol.78 , pp. 461-469
    • Li, Q.X.1    Whyte, S.2    Tanner, J.3    Evin, G.4    Beyreuther, K.5    Masters, C.L.6
  • 15
    • 0027170518 scopus 로고
    • Nonage related differences in thrombin responses by platelets from male patients with advanced Alzheimer’s disease
    • 1:CAS:528:DyaK3sXkvFaqtbw%3D, 8333868
    • T.A. Davies R.E. Fine R.J. Johnson et al. Nonage related differences in thrombin responses by platelets from male patients with advanced Alzheimer’s disease Biochem. Biophys. Res. Commun. 1993 194 537 543 10.1006/bbrc.1993.1853 1:CAS:528:DyaK3sXkvFaqtbw%3D 8333868
    • (1993) Biochem. Biophys. Res. Commun , vol.194 , pp. 537-543
    • Davies, T.A.1    Fine, R.E.2    Johnson, R.J.3
  • 16
    • 0030788580 scopus 로고    scopus 로고
    • Activated Alzheimer disease platelets retain more β amyloid precursor protein
    • 1:CAS:528:DyaK2sXls1Sqs7c%3D, 9258891
    • T.A. Davies H.J. Long K. Sgro et al. Activated Alzheimer disease platelets retain more β amyloid precursor protein Neurobiol. Aging. 1997 18 147 153 10.1016/S0197-4580(97)00013-4 1:CAS:528:DyaK2sXls1Sqs7c%3D 9258891
    • (1997) Neurobiol. Aging , vol.18 , pp. 147-153
    • Davies, T.A.1    Long, H.J.2    Sgro, K.3
  • 17
    • 18544412894 scopus 로고    scopus 로고
    • Moderate and advanced Alzheimer’s patients exhibit platelet activation differences
    • 1:STN:280:DyaK2svgtlGgtA%3D%3D, 9258892
    • T.A. Davies H.J. Long H.E. Tibbles et al. Moderate and advanced Alzheimer’s patients exhibit platelet activation differences Neurobiol. Aging 1997 18 155 162 10.1016/S0197-4580(97)00016-X 1:STN:280:DyaK2svgtlGgtA%3D%3D 9258892
    • (1997) Neurobiol. Aging , vol.18 , pp. 155-162
    • Davies, T.A.1    Long, H.J.2    Tibbles, H.E.3
  • 18
    • 0031721665 scopus 로고    scopus 로고
    • Differential pattern of platelet APP isoforms: an early marker for Alzheimer Disease
    • 9740113
    • M. Di Luca L. Pastorino A. Bianchetti et al. Differential pattern of platelet APP isoforms: an early marker for Alzheimer Disease Arch. Neurol. 1998 55 1195 1200 10.1001/archneur.55.9.1195 9740113
    • (1998) Arch. Neurol , vol.55 , pp. 1195-1200
    • Di Luca, M.1    Pastorino, L.2    Bianchetti, A.3
  • 19
    • 0031047350 scopus 로고    scopus 로고
    • Altered amyloid protein processing in platelets of patients with Alzheimer disease
    • 1:STN:280:DyaK2s7psVCitA%3D%3D, 9041854
    • R.N. Rosenberg F. Baskin J.A. Fosmire et al. Altered amyloid protein processing in platelets of patients with Alzheimer disease Arch. Neurol. 1997 54 139 144 10.1001/archneur.1997.00550140019007 1:STN:280:DyaK2s7psVCitA%3D%3D 9041854
    • (1997) Arch. Neurol , vol.54 , pp. 139-144
    • Rosenberg, R.N.1    Baskin, F.2    Fosmire, J.A.3
  • 20
    • 0029819924 scopus 로고    scopus 로고
    • Abnormal pattern of platelet APP isoforms in Alzheimer disease and Down syndrome
    • 8912490
    • M. Di Luca L. Pastorino F. Cattabeni et al. Abnormal pattern of platelet APP isoforms in Alzheimer disease and Down syndrome Arch. Neurol. 1996 53 1162 1166 10.1001/archneur.1996.00550110114019 8912490
    • (1996) Arch. Neurol , vol.53 , pp. 1162-1166
    • Di Luca, M.1    Pastorino, L.2    Cattabeni, F.3
  • 21
    • 0031754145 scopus 로고    scopus 로고
    • Alzheimer disease-related abnormalities of amyloid β precursor protein isoforms in the platelets—the brain delegates in the periphery
    • 1:STN:280:DyaK1cvhtVyhtA%3D%3D, 9740110
    • A.I. Bush R.E. Tanzi Alzheimer disease-related abnormalities of amyloid β precursor protein isoforms in the platelets—the brain delegates in the periphery Arch. Neurol. 1998 55 1179 1180 10.1001/archneur.55.9.1179 1:STN:280:DyaK1cvhtVyhtA%3D%3D 9740110
    • (1998) Arch. Neurol , vol.55 , pp. 1179-1180
    • Bush, A.I.1    Tanzi, R.E.2
  • 22
    • 8944241774 scopus 로고    scopus 로고
    • Alzheimer disease associated with muatations in presenilin 2 is rare and variably penetrant
    • 1:CAS:528:DyaK28Xkt1Cnt7s%3D
    • R. Sherrington S. Froelich S. Sorbi et al. Alzheimer disease associated with muatations in presenilin 2 is rare and variably penetrant Human Mol. Gen. 1996 5 985 988 10.1093/hmg/5.7.985 1:CAS:528:DyaK28Xkt1Cnt7s%3D
    • (1996) Human Mol. Gen , vol.5 , pp. 985-988
    • Sherrington, R.1    Froelich, S.2    Sorbi, S.3
  • 23
    • 0029087026 scopus 로고
    • Candidate gene for the chromosome 1 familial Alzheimer’s disease locus
    • 1:CAS:528:DyaK2MXnsFOmtLk%3D, 7638622
    • E. Levy-Lahad W. Wasco P. Poorkaj et al. Candidate gene for the chromosome 1 familial Alzheimer’s disease locus Science 1995 269 973 977 10.1126/science.7638622 1:CAS:528:DyaK2MXnsFOmtLk%3D 7638622
    • (1995) Science , vol.269 , pp. 973-977
    • Levy-Lahad, E.1    Wasco, W.2    Poorkaj, P.3
  • 24
    • 85186851990 scopus 로고
    • Familial Alzheimer’s disease in kindreds with missense mutation in a gene on chromosome 1 related to the Alzheimer’s disease type 3 gene
    • E.I. Rogaev R. Sherrington E.A. Rogaeva et al. Familial Alzheimer’s disease in kindreds with missense mutation in a gene on chromosome 1 related to the Alzheimer’s disease type 3 gene Nature 1995 13 713 725
    • (1995) Nature , vol.13 , pp. 713-725
    • Rogaev, E.I.1    Sherrington, R.2    Rogaeva, E.A.3
  • 25
    • 0029073383 scopus 로고
    • Genetic dissection of Alzheimer disease, a heterogenous disorder
    • G.D. Shellenberg Genetic dissection of Alzheimer disease, a heterogenous disorder PNAS 1995 92 8552 8559 10.1073/pnas.92.19.8552
    • (1995) PNAS , vol.92 , pp. 8552-8559
    • Shellenberg, G.D.1
  • 26
    • 16044373524 scopus 로고    scopus 로고
    • The amyloid β precursor deposited in the senile plaque of Alzheimer’s disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer’s disease
    • D. Sheuner C. Eckman M. Jensen et al. The amyloid β precursor deposited in the senile plaque of Alzheimer’s disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer’s disease Nat. Med. 1996 2 864 870 10.1038/nm0896-864
    • (1996) Nat. Med , vol.2 , pp. 864-870
    • Sheuner, D.1    Eckman, C.2    Jensen, M.3
  • 27
    • 0029004341 scopus 로고
    • Cloning of a gene bearing missense mutation in early-onset familial Alzheimer’s disease
    • 1:CAS:528:DyaK2MXmvVymtbo%3D, 7596406
    • R. Sherrington E.I. Rogaev Y. Liang et al. Cloning of a gene bearing missense mutation in early-onset familial Alzheimer’s disease Nature 1995 375 754 760 10.1038/375754a0 1:CAS:528:DyaK2MXmvVymtbo%3D 7596406
    • (1995) Nature , vol.375 , pp. 754-760
    • Sherrington, R.1    Rogaev, E.I.2    Liang, Y.3
  • 28
    • 0031721511 scopus 로고    scopus 로고
    • Calsenilin—a calcium binding protein that interacts with the presenilins and regulates the level of a presenilin fragment
    • 1:CAS:528:DyaK1cXms1Ggt70%3D, 9771752
    • J.D. Buxbaum E.K. Choi Y.X. Luo et al. Calsenilin—a calcium binding protein that interacts with the presenilins and regulates the level of a presenilin fragment Nat. Med. 1998 4 1177 1181 10.1038/2673 1:CAS:528:DyaK1cXms1Ggt70%3D 9771752
    • (1998) Nat. Med , vol.4 , pp. 1177-1181
    • Buxbaum, J.D.1    Choi, E.K.2    Luo, Y.X.3
  • 29
    • 0032531793 scopus 로고    scopus 로고
    • Destabilization of β-catenin by mutations in presenilin 1 potentiates neuronal apoptosis
    • 1:CAS:528:DyaK1cXms1Ojsb4%3D, 9790190
    • Z. Zhang H. Hartmann V.M. Do et al. Destabilization of β-catenin by mutations in presenilin 1 potentiates neuronal apoptosis Nature 1998 395 698 702 10.1038/27208 1:CAS:528:DyaK1cXms1Ojsb4%3D 9790190
    • (1998) Nature , vol.395 , pp. 698-702
    • Zhang, Z.1    Hartmann, H.2    Do, V.M.3
  • 30
    • 0032905727 scopus 로고    scopus 로고
    • Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of β-catenin, a component of the presenilin protein complex
    • 1:CAS:528:DyaK1MXntlWguw%3D%3D, 9930863
    • M. Nishimura G. Yu G. Levesque et al. Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of β-catenin, a component of the presenilin protein complex Nat. Med. 1999 5 164 169 10.1038/5526 1:CAS:528:DyaK1MXntlWguw%3D%3D 9930863
    • (1999) Nat. Med , vol.5 , pp. 164-169
    • Nishimura, M.1    Yu, G.2    Levesque, G.3
  • 31
    • 0021271971 scopus 로고
    • Clinical diagnosis of Alzheimer’s disease: report of the NINCDS-ADRDA Work Group under the auspicies of the Department of Health and Human Services Task Force on Alzheimer’s disease
    • 1:STN:280:DyaL2c3ks1altQ%3D%3D
    • G. Mc Khann D. Drachman M. Folstein R. Katzman D. Price E.M. Stadlan Clinical diagnosis of Alzheimer’s disease: report of the NINCDS-ADRDA Work Group under the auspicies of the Department of Health and Human Services Task Force on Alzheimer’s disease Neurology 1984 34 939 944 10.1212/WNL.34.7.939 1:STN:280:DyaL2c3ks1altQ%3D%3D
    • (1984) Neurology , vol.34 , pp. 939-944
    • Mc Khann, G.1    Drachman, D.2    Folstein, M.3    Katzman, R.4    Price, D.5    Stadlan, E.M.6
  • 32
    • 0025373986 scopus 로고
    • Expression of β amyloid protein precursor mRNAs: recognition of a novel alternatively spliced form and quantitation in AD using PCR
    • 1:CAS:528:DyaK3cXkslGrtL8%3D, 2106330
    • T.E. Golde S. Estes M. Usiak L. Younkin S. Younkin Expression of β amyloid protein precursor mRNAs: recognition of a novel alternatively spliced form and quantitation in AD using PCR Neuron 1990 4 253 267 10.1016/0896-6273(90)90100-T 1:CAS:528:DyaK3cXkslGrtL8%3D 2106330
    • (1990) Neuron , vol.4 , pp. 253-267
    • Golde, T.E.1    Estes, S.2    Usiak, M.3    Younkin, L.4    Younkin, S.5
  • 33
    • 10544229795 scopus 로고    scopus 로고
    • Expression of presenilin 1 and 2 (PS1 and PS2) in human and murine tissues
    • M.K. Lee H.H. Slunt L.J. Martina et al. Expression of presenilin 1 and 2 (PS1 and PS2) in human and murine tissues J. Neurosci. 1996 23 7513 7525 10.1523/JNEUROSCI.16-23-07513.1996
    • (1996) J. Neurosci , vol.23 , pp. 7513-7525
    • Lee, M.K.1    Slunt, H.H.2    Martina, L.J.3
  • 34
    • 0030576937 scopus 로고    scopus 로고
    • Alzheimer’s presenilin 1 gene expression in platelets and megakaryocytes. Identification of a novel splice variant
    • 1:CAS:528:DyaK28XlsFWktb4%3D, 8804415
    • R. Vidal J. Ghiso T. Wiesniewski B. Frangione Alzheimer’s presenilin 1 gene expression in platelets and megakaryocytes. Identification of a novel splice variant FEBS Lett. 1996 393 19 23 10.1016/0014-5793(96)00845-9 1:CAS:528:DyaK28XlsFWktb4%3D 8804415
    • (1996) FEBS Lett , vol.393 , pp. 19-23
    • Vidal, R.1    Ghiso, J.2    Wiesniewski, T.3    Frangione, B.4
  • 35
    • 0030727230 scopus 로고    scopus 로고
    • Presenilins and Alzheimer’s disease
    • 1:CAS:528:DyaK2sXnsVOitrc%3D, 9384549
    • T.W. Kim R.E. Tanzi Presenilins and Alzheimer’s disease Curr. Opin. Neurobiol. 1997 7 683 688 10.1016/S0959-4388(97)80089-X 1:CAS:528:DyaK2sXnsVOitrc%3D 9384549
    • (1997) Curr. Opin. Neurobiol , vol.7 , pp. 683-688
    • Kim, T.W.1    Tanzi, R.E.2
  • 36
    • 0031982670 scopus 로고    scopus 로고
    • Presenilins, the endoplasmic reticulum and neuronal apoptosis in Alzheimer disease
    • 1:CAS:528:DyaK1cXmtFyg, 9422341
    • M.P. Mattson Q. Guo K. Furukawa W.A. Pedersen Presenilins, the endoplasmic reticulum and neuronal apoptosis in Alzheimer disease J. Neurochem. 1998 70 1 14 10.1046/j.1471-4159.1998.70010001.x 1:CAS:528:DyaK1cXmtFyg 9422341
    • (1998) J. Neurochem , vol.70 , pp. 1-14
    • Mattson, M.P.1    Guo, Q.2    Furukawa, K.3    Pedersen, W.A.4
  • 37
    • 0034652369 scopus 로고    scopus 로고
    • Presenilin-1 mutation increases neuronal vulnerability to focal ischemia in vivo and to hypoxia and glucose deprivation in cell culture: involvement of perturbated calcium homeostasis
    • 1:CAS:528:DC%2BD3cXitVOktbs%3D, 10662826
    • M.P. Mattson H. Zhu J. Yu M.S. Kindy Presenilin-1 mutation increases neuronal vulnerability to focal ischemia in vivo and to hypoxia and glucose deprivation in cell culture: involvement of perturbated calcium homeostasis J. Neurosci. 2000 20 1358 1364 10.1523/JNEUROSCI.20-04-01358.2000 1:CAS:528:DC%2BD3cXitVOktbs%3D 10662826
    • (2000) J. Neurosci , vol.20 , pp. 1358-1364
    • Mattson, M.P.1    Zhu, H.2    Yu, J.3    Kindy, M.S.4
  • 38
    • 0029671219 scopus 로고    scopus 로고
    • Interfering with apoptosis: Ca++-binding protein Alg2 and Alzheimer disease gene Alg3
    • 1:CAS:528:DyaK28XmvFyqsg%3D%3D, 8560270
    • P. Vito E. Lacana L. Dadamio Interfering with apoptosis: Ca++-binding protein Alg2 and Alzheimer disease gene Alg3 Science 1996 271 521 525 10.1126/science.271.5248.521 1:CAS:528:DyaK28XmvFyqsg%3D%3D 8560270
    • (1996) Science , vol.271 , pp. 521-525
    • Vito, P.1    Lacana, E.2    Dadamio, L.3
  • 39
    • 10544224542 scopus 로고    scopus 로고
    • Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation
    • B. Volozin K. Iwazaki P. Vito et al. Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation Science 1996 274 1710 1713 10.1126/science.274.5293.1710
    • (1996) Science , vol.274 , pp. 1710-1713
    • Volozin, B.1    Iwazaki, K.2    Vito, P.3
  • 40
    • 0031949628 scopus 로고    scopus 로고
    • A variant of Alzheimer disease with spastic paraparesis and an unusual plaques due to deletion of exon 9 of presenilin 1
    • 1:CAS:528:DyaK1cXisVeluro%3D, 9546792
    • R. Crook A. Verkkoniemi J. Perez-Tur et al. A variant of Alzheimer disease with spastic paraparesis and an unusual plaques due to deletion of exon 9 of presenilin 1 Nat. Med. 1998 4 452 455 10.1038/nm0498-452 1:CAS:528:DyaK1cXisVeluro%3D 9546792
    • (1998) Nat. Med , vol.4 , pp. 452-455
    • Crook, R.1    Verkkoniemi, A.2    Perez-Tur, J.3
  • 41
    • 0030761059 scopus 로고    scopus 로고
    • Alzheimer presenilins in the nuclear membrane, interphase kinetochores, and centrosome suggest a role in chromosome segregation
    • 1:CAS:528:DyaK2sXmtV2htrw%3D, 9298903
    • J.H. Li M. Xu H. Zhou J.Y. Ma H. Potter Alzheimer presenilins in the nuclear membrane, interphase kinetochores, and centrosome suggest a role in chromosome segregation Cell 1997 90 917 927 10.1016/S0092-8674(00)80356-6 1:CAS:528:DyaK2sXmtV2htrw%3D 9298903
    • (1997) Cell , vol.90 , pp. 917-927
    • Li, J.H.1    Xu, M.2    Zhou, H.3    Ma, J.Y.4    Potter, H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.