Moderate and advanced Alzheimer's patients exhibit platelet activation differences

Neurobiology of Aging

Volumn 18, Issue 2, 1997, Pages 155-162

  Davies, Theresa A ^a   Long, H J ^a   Tibbles, H E ^a   Sgro, K R ^a   Wells, J M ^b   Rathbun, W H ^c   Seetoo, K F ^a   McMenamin, M E ^d   Smith, S J ^b   Feldman, R G ^a   Levesque, C A ^e   Fine, R E ^a,b   Simons, E R ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Psychology Service   (United States)

^c UNIVERSITY OF NEW HAMPSHIRE   (United States)

^d Maine Medical Center Research Institute   (United States)

^e BOSTON MEDICAL CENTER   (United States)

Author keywords

Alzheimer's disease; Amyloid Precursor Protein (APP); Cytoplasmic pH; Familial Alzheimer's disease; Platelet activation; Platelet functions; Surface markers

Indexed keywords

AMYLOID PRECURSOR PROTEIN; APOLIPOPROTEIN E;

ADULT; AGED; AGING; ALZHEIMER DISEASE; ARTICLE; CELL PH; CONTROLLED STUDY; DISEASE SEVERITY; HUMAN; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; THROMBOCYTE ACTIVATION;

ADULT; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; BLOOD PLATELETS; BLOTTING, WESTERN; CALCIUM; CELL DEGRANULATION; CYTOSOL; DISEASE PROGRESSION; FLOW CYTOMETRY; HUMANS; HYDROGEN-ION CONCENTRATION; INDICATORS AND REAGENTS; MEMBRANE POTENTIALS; MIDDLE AGED; NEUTROPHILS; P-SELECTIN; PLATELET ACTIVATION; THROMBIN;

EID: 18544412894     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0197-4580(97)00016-X     Document Type: Article

References (48)

1. Berman, C.; Yeo, E.; Wenczel-Drake, J.; Furie, B.; Ginsberg, M.; Furie, B. A platelet alpha-granule membrane protein that is associated with the plasma membrane after activation. J. Clin. Invest. 78:130-137; 1986.
2. Blass, J. P.; Gibson, G. E. Nonneural markers in Alzheimer's disease. Alzheimer Dis. Assoc. Disord. 6:205-224; 1992.
3. Bush, A. I.; Martins, R. N.; Rumble, B.; Moir, R.; Fuller, S.; Milward, E.; Currie, J.; Ames, D.; Weidemann, A.; Fischer, P.; Multhaup, G.; Beyreuther, K.; Masters, C. L. The amyloid precursor protein of Alzheimer's disease is released by human platelets. J. Biol. Chem. 265:15977-15983; 1990.
4. Bush, A. I.; Whyte, S.; Thomas, L. D.; Williamson, T. G.; Van Tiggelen,-C. J.; Currie, J.; Small, D. H.; Moir, R. D.; Li, Q. X.; Rumble, B.; Monning, U.; Beyreuther, K.; Masters, C. L. An abnormality of plasma amyloid protein precursor in Alzheimer's disease. Ann. Neurol. 32:57-65; 1992.
5. Cole, G. M.; Galasko, D.; Shapiro, I. P.; Saitoh, T. Stimulated platelets release amyloid β-protein precursor. Biochem. Biophys. Res. Commun. 170:288-295; 1990.
6. Davies, T. A.; Simons, E. R. Flow cytometric analysis of pH changes during platelet activation. In: Scharf, R., Clemetson, K. J. C. ed. Flow cytometry of the megakaryocyte-platelet system. Amsterdam: Elsevier; 1994.
7. Davies, T. A.; Drotts, D.; Weil, G. J.; Simons, E. R. Flow cytometric measurement of cytoplasmic calcium changes in human platelets. Cytometry 9:138-142; 1988.
8. Davies, T. A.; Fine, R. E.; Johnson, R. J.; Levesque, C. A.; Rathbun, W. H.; Seetoo, K. F.; Smith, S. J.; Stromeier, G.; Volicer, L.; Delva, L.; Simons, E. R. Non-age related differences in thrombin responses by platelets from male patients with advanced Alzheimer's disease. Biochem. Biophys. Res. Commun. 194:537-543; 1993.
9. Davies, T.; Long, H.; Rathbun, W.; Sgro, K.; Tibbles, H.; Smith, S.; Seetoo, K.; McMenamin, M.; Johnson, R.; Wells, J.; Levesque, C.; Fine, R.; Simons, E. R. Platelets from patients with Alzheimer's disease or other dementias exhibit disease-specific and apolipoprotein E-correlatable defects. Amyloid Int. J. Exp. Clin. Invest. 3:13-16; 1996.
10. Davies, T. A.; Long, H. J.; Sgro, K.; McMenamin, M. E.; Rathbun, W. H.; Seetoo, K. F.; Tibbles, H.; Billingslea, A. M.; Fine, R. E.; Fishman, J. B.; Levesque, C. A.; Smith, S. J.; Wells, J. M.; Simons, E. R. Activated Alzheimer disease platelets retain more beta amyloid precursor protein. Neurobiol. Aging 18:147-153.
11. Farlow, M.; Ghetti, B.; Benson, M. D.; Farrow, J. S.; van Nostrand, W. E.; Wagner, S. L. Low cerebrospinal-fluid concentrations of soluble amyloid β-protein precursor in hereditary Alzheimer's disease. Lancet 340:453-454; 1992.
12. Gardella, J. E.; Ghiso, J.; Gorgone, G. A.; Marratta, D.; Kaplan, A. P.; Frangione, B.; Gorevic, P. D. Intact Alzheimer amyloid precursor protein (APP) is present in platelet membranes and is encoded by platelet mRNA. Biochem. Biophys. Res. Commun. 173:1292-1298; 1990.
13. Ghiso, J.; Gardella, J. E.; Liem, L.; Gorevic, P. D.; Frangione, B. Characterization of a novel processing pathway for Alzheimer's amyloid β precursor protein. Neurosci. Lett. 171:213-216; 1994.
14. Hajimohammadreza, I.; Brammer, M. J.; Eagge, S.; Burns, A.; Levy, R. Platelet and erythrocyte membrane changes in Alzheimer's disease. Biochim. Biophys. Acta 1025:208-214; 1990.
15. Holmsen, H.; Kaplan, K. L.; Dandlemaier, C. A. Differential energy requirements for platelet responses. Biochem. J. 208:9-18; 1982.
16. Igarashi, K.; Murai, H.; Asaka, J. I. Proteolytic processing of amyloid β protein precursor (APP) by thrombin. Biochem. Biophys. Res. Commun. 185:1000-1004; 1992.
17. Kaplan, K. L. In vitro platelet responses: α-granule secretion. In: Holmsen, H., ed. Platelet responses and metabolism, vol. 1. Boca Raton, FL: CRC Press; 1987:145-162.
18. Kukull, W. A.; Hinds, T. R.; Schellenberg, G. D.; van Belle, G.; Larson, E. B. Increased platelet membrane fluidity as a diagnostic marker for Alzheimer's disease. Neurology 42:607-614; 1992.
19. Li, Q. X.; Berndt, M. C.; Bush, A. I.; Rumble, B.; Mackenzie, I.; Friedhuber, A.; Beyreuther, K.; Masters, C. L. Membrane-associated forms of the βA4 amyloiod protein precursor of Alzheimer's disease in human platelet and brain: Surface expression on the activated human platelet. Blood 8:133-142; 1994.
20. Li, Q.; Evin, G.; Small, D.; Multhaup, G.; Beyreuther, K.; Masters, C. Proteolytic processing of Alzheimer's disease βA4 amyloid precursor protein in human platelets. J. Biol. Chem. 270:14140-14147; 1995.
21. Martins, R.; Muir, J.; Brooks, W.; Creasey, H.; Montgomery, P.; Sellers, P.; Broe, G. Plasma amyloid precursor protein is decreased in Alzheimer's disease. Neuroreport 4:757-759; 1993.
22. Matsushima, H.; Shimhama, S.; Tanaka, S.; Taniiguchi, T.; Hagiwara, M.; Hidaka, H.; Kimura, J. Platelet protein kinase C levels in Alzheimer's disease. Neurobiol. Aging 15:671-674; 1994.
23. Matsushima, H.; Shimohama, S.; Fujimoto, S.; Takenawa, T.; Kimura, J. Reduction of platelet phospholipase C activity in patients with Alzheimer's disease. Alzheimer Dis. Assoc. Dis. 9:213-217; 1995.
24. Nieuwenhuis, A. K.; Van Oosterhout, J. J. G.; Rozenmuller, E.; Van Iwaarden, F.; Sixma, J. J. Studies with a monoclonal antibody against activated platelets: Evidence that a secreted 53,000-molecular weight lysosome-like granule protein is exposed on the surface of activated platelets in circulation. Blood 70:838-844; 1987.
25. Parker, W. D.; Filley, C. M.; Parks, J. K. Cytochrome oxidase deficiency in Alzheimer's disease. Neurology 40:1302-1303; 1990.
26. Piletz, J. E.; Sarasua, M.; Whitehouse, P.; Chotani, M. Intracellular membranes are more fluid in platelets of Alzheimer's disease patients. Neurobiol. Aging 12:401-406; 1991.
27. Podlisny, M. B.; Mammen, A. L.; Schlossmacher, M. G.; Palmert, M. R.; Younkin, S. G.; Selkoe, D. J. Detection of soluble forms of the β-amyloid precursor protein in human plasma. Biochem. Biophys. Res. Commun. 167:1094-1101; 1990.
28. Prior, R.; Monning, U.; Schreiter-Gasser, U.; Weidemann, A.; Blennow, K.; Gottfries, C. G.; Masters, C. L.; Beyreuther, K. Quantitative changes in the amyloid βA4 precursor protein in Alzheimer cerebrospinal fluid. Neurosci. Lett. 124:69-73; 1991.
29. Roses, A. Apolipoprotein E affects the rate of Alzheimer disease expression: β-Amyloid burden is a secondary consequence dependent on APOE genotype and duration of disease. J. Neuropathol. Exp. Neurol. 53:429-437; 1994.
30. Sage, S. O.; Rink, T. J. The kinetics of changes in intracellular calcium concentration in Fura-2-loaded human platelets. J. Biol. Chem. 262: 16364-16369; 1987.
31. Saunders, A.; Schmader, K.; Breitner, J.; Benson, M.; Brown, W.; Goldfarb, L.; Goldgaber, D.; Manwaring, M.; Szymanski, M.; McCown, N.; Dole, K. C.; Schnechel, D. E.; Strittmatter, W. J.; Pericak-Vance, M. A.; Roses, A. D. Apolipoprotein E &egr;4 distribution in late-onset Alzheimer's disease and in other amyloid-forming diseases. Lancet 342:710-711; 1993.
32. Schlossmacher, M. G.; Ostaszewski, B. L.; Hecker, L. I.; Celi, A.; Haass, C.; Chin, D.; Lieberburg, I.; Furie, B. C.; Furie, B.; Selkoe, D. J. Detection of distinct isoform patterns of the β-amyloid precursor protein in human platelets and lymphocytes. Neurobiol. Aging 13: 421-434; 1992.
33. Schmaier, A.; Dahl, L.; Hasan, A.; Cines, D.; Bauer, K.; Van Nostrand, W. Factor IXa inhibition by protease Nexin-2/amyloid β-protein precursor on phospholipid vesicles and cell membranes. Biochemistry 34:1171-1178; 1995.
34. Schmaier, A.; Dahl, L.; Rozemuller, A.; Roos, R.; Wagner, S.; Chung, R.; Van Nostrand, W. Protease Nexin-2/amyloid β protein precursor. J. Clin. Invest. 92:2540-2545; 1993.
35. Selkoe, D. J. Alzheimer's disease: A central role for amyloid. J. Neuropathol. Exp. Neurol. 53:438-447; 1994.
36. Simons, E. R.; Davies, T. A.; Greenberg, S. M.; Dunn, J. M.; Horne, W. C. Platelet membrane potentials and their significance in monitoring stimulus response. In: Gunn, R. B.; Parker, J. C., eds. Cell physiology of blood. New York: Rockefeller University Press; 1988: 265-280.
37. Simons, E. R.; Schwartz, D. B.; Norman, N. E. Stimulus response coupling in human platelets: Thrombin-induced changes in pH. In: Deamer, D.; Nuccitelli, R., eds. Intracellular pH: Its measurement, regulation, and utilization in cellular functions. New York: Alan R Liss, Inc.; 1982:463-482.
38. Smith, R.; Broze, G., Jr. Characterization of platelet-releasable forms of β-amyloid precursor protein: The effect of thrombin. Blood 9:2252-2260; 1992.
39. Stenberg, P.; McEver, R.; Shuman, M.; Jacques, Y.; Bainton, D. A platelet alpha-granule membrane protein (GMP-140) is expressed on the plasma membrane after activation; J. Cell Biol. 101:880-886; 1985.
40. Strittmatter, W. J.; Weisgraber, K. H.; Huang, D.; Dong, L.; Salvesen, G.; Pericak-Vance, M.; Schmechel, D.; Saunder, A.; Goldgaber, D.; Roses, A. Binding of human apolipoprotein E to synthetic amyloid β peptide: Isoform specific effects and implicaiton for late-onset Alzheimer disease. Proc. Natl. Acad. Sci USA 90:8098-8102; 1993.
41. Urakami, K.; Takahash, I. K.; Saito, H.; Okada, A.; Nakamura, S.; Tanaka, S.; Kitaguchi, N.; Tokushima, Y.; Yamamoto, S. Amyloid β protein precursors with Kunitz-type inhibitor domains and acetylcholinesterase in cerebrospinal fluid from patients with dementia of the Alzheimer type. Acta Neurol. Scand. 85:343-346; 1992.
42. Van Nostrand, W. E.; Wagner, S. L.; Shankle, W. R.; Farrow, J. S.; Dick, M.; Rozemuller, J. M.; Kuiper, M. A.; Wolters, E. C.; Zimmerman, J.; Cotman, C. W.; Cunningham, D. D. Decreased levels of soluble amyloid β-protein precursor in cerebrospinal fluid of Alzheimer disease patients. Proc. Natl. Acad. Sci. USA 89:2551-2555; 1992.
43. Van Nostrand, W.; Rozemuller, A.; Chung, R.; Cotman, C.; Saporito-Irwin, S. Amyloid β-protein precursor in cultured leptomeningeal smooth muscle cells. Amyloid Int. J. Exp. Clin. Invest. 1:1-7; 1994.
44. Van Nostrand, W.; Schmaier, A.; Farrow, J.; Cunningham, D. Protease Nexin II (amyloid precursor protein): A platelet alpha-granule protein. Science 248:745-748; 1990.
45. Wasco, W.; Gurrubhagavatula, S.; Paradis, M. D.; Romano, D. M.; Sisodia, S. S.; Hyman, B. T.; Neve, R. L.; Tanzi, R. E. Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid β protein precursor. Nat. Genet. 5:95-100; 1993.
46. Wisnewski, H.; Frackowiak, J.; Zoltowska, A.; Kim, K. Vascular β-amyloid in Alzheimer's disease angiopathy is produced by proliferating and regenerating smooth muscle cells. Amyloid Int. J. Exp. Clin. Invest. 1:8-16; 1994.
47. Zavoico, G. B.; Cragoe, J. E. J.; Feinstein, M. B. Regulation of intracellular pH in human platelets; J. Biol. Chem. 261:13160-13167; 1986.
48. Zubenko, G. S.; Cohen, B. M.; Boller, F.; Malinakova, I.; Keefe, N.; Chojnacki, B. Platelet membrane abnormality in Alzheimer's disease. Ann. Neurol. 22:237-244; 1987.