1-Aminoindan-1,5-dicarboxylic acid and (S)-(+)-2-(3′-carboxybicyclo[1.1.1] pentyl)-glycine, two mGlu1 receptor-preferring antagonists, reduce neuronal death in in vitro and in vivo models of cerebral ischaemia

European Journal of Neuroscience

Volumn 11, Issue 10, 1999, Pages 3637-3647

  Pellegrini Giampietro, Domenico E ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

Author keywords

AIDA; CBPG; Metabotropic glutamate receptors; Neuroprotection; Rodents

Indexed keywords

1 AMINO 1,5 INDANDICARBOXYLIC ACID; 2 (3 CARBOXYBICYCLO[1.1.1]PENTYL)GLYCINE; 3,5 DIHYDROXYPHENYLGLYCINE; ALPHA METHYL 4 CARBOXYPHENYLGLYCINE; CYCLOLEUCINE; DIZOCILPINE; GLUTAMATE RECEPTOR ANTAGONIST; GLYCINE DERIVATIVE; METABOTROPIC RECEPTOR; N METHYL DEXTRO ASPARTIC ACID; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BRAIN ISCHEMIA; CONTROLLED STUDY; GERBIL; HIPPOCAMPUS; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; MOUSE; NERVE CELL CULTURE; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL;

ANIMALS; ANIMALS, NEWBORN; ASTROCYTES; BENZOATES; BICYCLO COMPOUNDS; CELL DEATH; CELLS, CULTURED; CEREBRAL CORTEX; DIZOCILPINE MALEATE; EXCITATORY AMINO ACID ANTAGONISTS; GERBILLINAE; GLYCINE; INDANS; ISCHEMIC ATTACK, TRANSIENT; MICE; NEUROPROTECTIVE AGENTS; NEUROTOXINS; ORGAN CULTURE TECHNIQUES; PYRAMIDAL CELLS; QUINOXALINES; RECEPTORS, METABOTROPIC GLUTAMATE; RESORCINOLS;

EID: 0032824540     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9568.1999.00786.x     Document Type: Article

References (3)

1. Abdel-Hamid, K.M. & Tymianski, M. (1997) Mechanisms and effects of intracellular calcium buffering on neuronal survival in organotypic hippocampal cultures exposed to anoxia/aglycemia or to excitotoxins. J. Neurosci., 17, 3538-3553.
2. Aniksztejn, L., Otani, S. & Ben-Ari, Y. (1992) Quisqualate metabotropic receptors modulate NMDA currents and facilitate the induction of long-term potentiation through protein kinase C. Eur. J. Neurosci., 4, 500-505.
3. Aramori, I. & Nakanishi, S. (1992) Signal transduction and pharmacological characteristics of a metabotropic glutamate receptor, mGIuR1, in transfected CHO cells. Neuron, 8, 757-765.