Antagonists for group I mGluRs attenuate excitotoxic neuronal death in cortical cultures

European Journal of Neuroscience

Volumn 10, Issue 9, 1998, Pages 2848-2855

  Strasser, Uta ^a   Lobner, Doug ^a   Behrens, M Margarita ^a   Canzoniero, Lorella M T ^a   Choi, Dennis W ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Glutamate; In vitro; Metabotropic; Mouse; Protection

Indexed keywords

4 CARBOXYPHENYLGLYCINE; AMPA RECEPTOR; AZETIDINE 2 CARBOXYLIC ACID; GLUTAMATE RECEPTOR AGONIST; GLUTAMATE RECEPTOR ANTAGONIST; GLUTAMIC ACID; KAINIC ACID; METABOTROPIC RECEPTOR; N METHYL DEXTRO ASPARTIC ACID; POTASSIUM ION;

ANIMAL CELL; ARTICLE; BRAIN CORTEX; CONTROLLED STUDY; EMBRYO; MOUSE; NERVE CELL CULTURE; NERVE CELL NECROSIS; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BLOCKING;

ANIMALS; ASTROCYTES; BENZOATES; CELL DEATH; CELLS, CULTURED; CEREBRAL CORTEX; COCULTURE TECHNIQUES; EMBRYO; EXCITATORY AMINO ACID ANTAGONISTS; GLUTAMIC ACID; GLYCINE; INDANS; MICE; N-METHYLASPARTATE; NEURONS; NEUROTRANSMITTER AGENTS; PROTEIN BINDING; RECEPTORS, AMPA; RECEPTORS, METABOTROPIC GLUTAMATE; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 0032465939     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1460-9568.1998.00291.x     Document Type: Article

References (6)

1. Adamson, P., Hajimohammadreza, I., Brammer, M.J., Campbell, I.C. & Meldram, B.S. (1990) Presynaptic glutamate/quisqualate receptors: effects on synaptosomal free calcium concentrations. J. Neurochem., 55, 1850-1854.
2. Ambrosini, A., Bresciani, L., Fracchia, S., Brunello, N. & Racagni, G. (1995) Metabotropic glutamate receptors negatively coupled to adenylate cyclase inhibit N-methyl-D-aspartate receptor activity and prevent neurotoxicity in mesencephalic neurons in vitro. Mol. Pharmacol., 47, 1057-1064.
3. Aramori, I. & Nakanishi, S. (1992) Signal transduction and pharmacological characteristics of a metabotropic glutamate receptor, mGluRl, in transfected CHO cells. Neuron, 8, 757-765.
4. Barnes-Davies, M. & Forsythe, I.D. (1995) Pre- and postsynaptic glutamate receptors at a giant excitatory synapse in rat auditory brainstem slices. J. Physiol (Lond.), 488, 387-406.
5. Baskys, A. & Malenka, R.C. (1991) Agonists at metabotropic glutamate receptors presynaptically inhibit EPSCs in neonatal rat hippocampus. J. Physiol. (Lond.), 444, 687-701.
6. Brabet, I., Mary, S., Bockaert, J. & Pin, J.-P. (1995) Phenylglycine derivatives discriminate between mGluRl- and mGluRS-mediated responses. Neuropharmacology, 34, 895-903.