-
1
-
-
0023218399
-
Pyrazoloacridines: A new class of antitumor agents with selectivity against solid tumors in vitro
-
Sebolt, J., Scavone, S., and Pinter, C. Pyrazoloacridines: a new class of antitumor agents with selectivity against solid tumors in vitro. Cancer Res., 47: 4299-4304, 1987.
-
(1987)
Cancer Res.
, vol.47
, pp. 4299-4304
-
-
Sebolt, J.1
Scavone, S.2
Pinter, C.3
-
2
-
-
0342621400
-
Pyrazoloacridine inhibits DNA topoisomerases I and II
-
Adjei, A. A., Charron, M., Rowinsky, E. K., Donehower, R. C., Sebolt-Leopold, J., and Kaufmann, S. H. Pyrazoloacridine inhibits DNA topoisomerases I and II. Proc. Am. Assoc. Cancer Res., 36: 349, 1995.
-
(1995)
Proc. Am. Assoc. Cancer Res.
, vol.36
, pp. 349
-
-
Adjei, A.A.1
Charron, M.2
Rowinsky, E.K.3
Donehower, R.C.4
Sebolt-Leopold, J.5
Kaufmann, S.H.6
-
3
-
-
0025078217
-
Antitumor efficacy of PD115932 (NSC 366140) against solid tumors of mice
-
LoRusso, P., Wozniak, A. J., and Polin, L. Antitumor efficacy of PD115932 (NSC 366140) against solid tumors of mice. Cancer Res., 50: 4900-4905, 1990.
-
(1990)
Cancer Res.
, vol.50
, pp. 4900-4905
-
-
LoRusso, P.1
Wozniak, A.J.2
Polin, L.3
-
4
-
-
0024995727
-
The pyrazoloacridines: Approaches to the development of a carcinoma-selective cytotoxic agent
-
Jackson, R., Sebolt, J., and Shillis, J. The pyrazoloacridines: approaches to the development of a carcinoma-selective cytotoxic agent. Cancer Invest., 8: 39-47, 1990.
-
(1990)
Cancer Invest.
, vol.8
, pp. 39-47
-
-
Jackson, R.1
Sebolt, J.2
Shillis, J.3
-
5
-
-
0024381930
-
Activity of the pyrazoloacridines against multidrug-resistant Tumor cells
-
Sebolt, J., Havlick, M., and Hamelehle, K. Activity of the pyrazoloacridines against multidrug-resistant Tumor cells. Cancer Chemother. Pharmacol., 24: 219-224, 1989.
-
(1989)
Cancer Chemother. Pharmacol.
, vol.24
, pp. 219-224
-
-
Sebolt, J.1
Havlick, M.2
Hamelehle, K.3
-
6
-
-
0025331434
-
Patterns of cross-resistance in a multidrug-resistant small cell lung carcinoma line
-
Cole, S. P. C. Patterns of cross-resistance in a multidrug-resistant small cell lung carcinoma line. Cancer Chemother. Pharmacol., 26: 250-256, 1990.
-
(1990)
Cancer Chemother. Pharmacol.
, vol.26
, pp. 250-256
-
-
Cole, S.P.C.1
-
7
-
-
0029583393
-
Phase I clinical trial of pyrazoloacridine NSC366140 (PD115934)
-
LoRusso, P., Foster, B. J., Poplin, E., McCormick, J., Kraut, M., Flaherty, L., Heilbrun, L. K., Valdivieso, M., and Baker, L. Phase I clinical trial of pyrazoloacridine NSC366140 (PD115934). Clin. Cancer Res., 1: 1487-1493, 1995.
-
(1995)
Clin. Cancer Res.
, vol.1
, pp. 1487-1493
-
-
LoRusso, P.1
Foster, B.J.2
Poplin, E.3
McCormick, J.4
Kraut, M.5
Flaherty, L.6
Heilbrun, L.K.7
Valdivieso, M.8
Baker, L.9
-
8
-
-
0029045628
-
Phase I and pharmacologic studies of pyrazoloacridine, a novel DNA intercalating agent, on single and multiple dosing schedules
-
Rowinsky, E. K., Noe, D. A., Grochow, L. B., Sartorious, S. E., Bowling, M. K., Chen, T-L., Lubejko, B. G., Kaufmann, S. H., and Donehower, R. C. Phase I and pharmacologic studies of pyrazoloacridine, a novel DNA intercalating agent, on single and multiple dosing schedules. J. Clin. Oncol., 13: 1975-1984, 1995.
-
(1995)
J. Clin. Oncol.
, vol.13
, pp. 1975-1984
-
-
Rowinsky, E.K.1
Noe, D.A.2
Grochow, L.B.3
Sartorious, S.E.4
Bowling, M.K.5
Chen, T.-L.6
Lubejko, B.G.7
Kaufmann, S.H.8
Donehower, R.C.9
-
9
-
-
0028723650
-
Carboplatin and Taxol (paclitaxel) in advanced ovarian carcinoma
-
Ozols, R. F. Carboplatin and Taxol (paclitaxel) in advanced ovarian carcinoma. Ann. Oncol., 5 (Suppl. 6): S39-S43, 1994.
-
(1994)
Ann. Oncol.
, vol.5
, Issue.6 SUPPL.
-
-
Ozols, R.F.1
-
10
-
-
0030054309
-
Cyclophosphamide and cisplatin compared with paclitaxel and cisplatin in patients with stage III and stage IV ovarian cancer
-
McGuire, W. P., Joskins, W. J., Brady, M. F., Kucera, P. R., Partridge, E. E., Look, K. Y., Clarke-Pearson, D. L., and Davidson, M. Cyclophosphamide and cisplatin compared with paclitaxel and cisplatin in patients with stage III and stage IV ovarian cancer. N. Engl. J. Med., 334: 1-6, 1996.
-
(1996)
N. Engl. J. Med.
, vol.334
, pp. 1-6
-
-
McGuire, W.P.1
Joskins, W.J.2
Brady, M.F.3
Kucera, P.R.4
Partridge, E.E.5
Look, K.Y.6
Clarke-Pearson, D.L.7
Davidson, M.8
-
11
-
-
0028908015
-
USA: Update on paclitaxel in ovarian cancer
-
Ozols, R. F. USA: update on paclitaxel in ovarian cancer. Ann. Med., 27: 127-130, 1995.
-
(1995)
Ann. Med.
, vol.27
, pp. 127-130
-
-
Ozols, R.F.1
-
12
-
-
0029067255
-
Paclitaxel, cisplatin, and cyclophosphamide in human ovarian cancer. Molecular rationale and early clinical results
-
Reed, E., Kohn, E. C., Sarosy, G., Dabholkar, M., Davis, P., Jacob, J., and Maher, M. Paclitaxel, cisplatin, and cyclophosphamide in human ovarian cancer. Molecular rationale and early clinical results Semin Oncol., 22 (3 Suppl. 6): 90-96, 1995.
-
(1995)
Semin Oncol.
, vol.22
, Issue.3-6 SUPPL.
, pp. 90-96
-
-
Reed, E.1
Kohn, E.C.2
Sarosy, G.3
Dabholkar, M.4
Davis, P.5
Jacob, J.6
Maher, M.7
-
13
-
-
0026772298
-
Effect of P-glycoprotein expression on the accumulation and cytotoxicity of topotecan (SK&F 104864), a new camptothecin analogue
-
Hendricks, C. B., Rowinsky, E. K., Grochow, L. B., Donehower, R. C., and Kaufmann, S. H. Effect of P-glycoprotein expression on the accumulation and cytotoxicity of topotecan (SK&F 104864), a new camptothecin analogue. Cancer Res., 52: 2268-2278, 1992.
-
(1992)
Cancer Res.
, vol.52
, pp. 2268-2278
-
-
Hendricks, C.B.1
Rowinsky, E.K.2
Grochow, L.B.3
Donehower, R.C.4
Kaufmann, S.H.5
-
14
-
-
0021118703
-
Quantitative analysis of dose-effect relationships: The combined effects of multiple drugs or enzyme inhibitors
-
Chou, T.-C., and Talalay, P. Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. Adv. Enzyme Regul., 22: 27-55, 1984.
-
(1984)
Adv. Enzyme Regul.
, vol.22
, pp. 27-55
-
-
Chou, T.-C.1
Talalay, P.2
-
15
-
-
0028326742
-
Role of platinum-DNA adduct formation and removal of cisplatin resistance in human ovarian cancer cell lines
-
Johnson, S. W., Perez, R. P., Godwin, A. K., Yeung, A. T., Handel, L. M., Ozols, R. F., and Hamilton, T. C. Role of platinum-DNA adduct formation and removal of cisplatin resistance in human ovarian cancer cell lines. Biochem. Pharmacol., 47: 689-697, 1994.
-
(1994)
Biochem. Pharmacol.
, vol.47
, pp. 689-697
-
-
Johnson, S.W.1
Perez, R.P.2
Godwin, A.K.3
Yeung, A.T.4
Handel, L.M.5
Ozols, R.F.6
Hamilton, T.C.7
-
16
-
-
0029904810
-
Flavopiridol (NSC 649890, L86-8275): A cytotoxic flavone that induces cell death in human lung carcinoma cells
-
Bible, K. C., and Kaufmann, S. H. Flavopiridol (NSC 649890, L86-8275): a cytotoxic flavone that induces cell death in human lung carcinoma cells. Cancer Res., 56: 4856-4861, 1996.
-
(1996)
Cancer Res.
, vol.56
, pp. 4856-4861
-
-
Bible, K.C.1
Kaufmann, S.H.2
-
17
-
-
0027986676
-
Epidermal growth factor-mediated apoptosis of MDA-MB-468 human breast cancer cells
-
Armstrong, D. K., Kaufmann, S. H., Ottaviano, Y. L., Furuya, Y., Buckley, J. A., Isaacs, J. T., and Davidson, J. A. Epidermal growth factor-mediated apoptosis of MDA-MB-468 human breast cancer cells. Cancer Res., 54: 5280-5283, 1994.
-
(1994)
Cancer Res.
, vol.54
, pp. 5280-5283
-
-
Armstrong, D.K.1
Kaufmann, S.H.2
Ottaviano, Y.L.3
Furuya, Y.4
Buckley, J.A.5
Isaacs, J.T.6
Davidson, J.A.7
-
18
-
-
0002574670
-
Aphidicolin: A specific inhibitor of nuclear DNA replication in eukaryotes
-
Spadari, S., Sala, F., and Pedrali-Noy, G. Aphidicolin: a specific inhibitor of nuclear DNA replication in eukaryotes. Trends Biochem. Sci., 7: 29-32, 1982.
-
(1982)
Trends Biochem. Sci.
, vol.7
, pp. 29-32
-
-
Spadari, S.1
Sala, F.2
Pedrali-Noy, G.3
-
19
-
-
0029036955
-
The search for synergy: A critical review from a response surface perspective
-
Greco, W. R., Bravo, G., and Parsons, J. C. The search for synergy: a critical review from a response surface perspective. Pharmacol. Rev., 47: 331-385, 1995.
-
(1995)
Pharmacol. Rev.
, vol.47
, pp. 331-385
-
-
Greco, W.R.1
Bravo, G.2
Parsons, J.C.3
-
20
-
-
0019515510
-
Differential killing efficacy of twenty antitumor drugs on proliferating and nonproliferating human tumor cells
-
Drewinko, B., Patchen, M., Yang, L-Y., and Barlogie, B. Differential killing efficacy of twenty antitumor drugs on proliferating and nonproliferating human tumor cells. Cancer Res., 41: 2328-2333, 1981.
-
(1981)
Cancer Res.
, vol.41
, pp. 2328-2333
-
-
Drewinko, B.1
Patchen, M.2
Yang, L.-Y.3
Barlogie, B.4
-
21
-
-
0025133118
-
Involvement of nucleic acid synthesis in cell killing mechanisms of topoisomerase poisons
-
D'Arpa, P., Beardmore, C., and Liu, L. F. Involvement of nucleic acid synthesis in cell killing mechanisms of topoisomerase poisons. Cancer Res., 50: 6919-6924, 1990.
-
(1990)
Cancer Res.
, vol.50
, pp. 6919-6924
-
-
D'Arpa, P.1
Beardmore, C.2
Liu, L.F.3
-
23
-
-
0024234729
-
Influence of cis-diamminedichloroplatinum (II) on DNA synthesis and cell cycle progression in excision repair-proficient and -deficient Chinese hamster ovary cells
-
Sorenson, C. M., and Eastman, A. Influence of cis-diamminedichloroplatinum (II) on DNA synthesis and cell cycle progression in excision repair-proficient and -deficient Chinese hamster ovary cells. Cancer Res., 48: 6703-6707, 1988.
-
(1988)
Cancer Res.
, vol.48
, pp. 6703-6707
-
-
Sorenson, C.M.1
Eastman, A.2
-
24
-
-
0027029077
-
A fundamental role for cell cycle regulation in the chemosensitivity of cancer cells
-
O'Connor, P. M., and Kohn, K. W. A fundamental role for cell cycle regulation in the chemosensitivity of cancer cells. Semin. Cancer Biol., 3: 409-416, 1992.
-
(1992)
Semin. Cancer Biol.
, vol.3
, pp. 409-416
-
-
O'Connor, P.M.1
Kohn, K.W.2
-
25
-
-
0028901034
-
Disruption of p53 function sensitizes breast cancer MCF-7 cells to cisplatin and pentoxifylline
-
Fan, S., Smith, M. L., Rivet, D. J., Duba, D., Zhan, Q., Kohn, K. W., Fornace, A. J., and O'Connor, P. M. Disruption of p53 function sensitizes breast cancer MCF-7 cells to cisplatin and pentoxifylline. Cancer Res., 55: 1649-1654, 1995.
-
(1995)
Cancer Res.
, vol.55
, pp. 1649-1654
-
-
Fan, S.1
Smith, M.L.2
Rivet, D.J.3
Duba, D.4
Zhan, Q.5
Kohn, K.W.6
Fornace, A.J.7
O'Connor, P.M.8
-
26
-
-
0028990479
-
Apoptosis in 7-hydroxystaurosporine-treated T lymphoblasts correlates with activation of cyclin-dependent kinases 1 and 2
-
Wang, Q., Worland, P. J., Clark, J. L., Carlson, B. A., and Sausville, E. A. Apoptosis in 7-hydroxystaurosporine-treated T lymphoblasts correlates with activation of cyclin-dependent kinases 1 and 2. Cell Growth & Differ., 6: 927-936, 1995.
-
(1995)
Cell Growth & Differ.
, vol.6
, pp. 927-936
-
-
Wang, Q.1
Worland, P.J.2
Clark, J.L.3
Carlson, B.A.4
Sausville, E.A.5
-
27
-
-
0029895439
-
UCN-01: A potent abrogator of G2 checkpoint function in cancer cells with disrupted p53
-
Wang, Q., Fan, S., Eastman, A., Worland, P. J., Sausville, E. A., and O'Connor, P. M. UCN-01: a potent abrogator of G2 checkpoint function in cancer cells with disrupted p53. J. Natl. Cancer Inst., 88: 956-965, 1996.
-
(1996)
J. Natl. Cancer Inst.
, vol.88
, pp. 956-965
-
-
Wang, Q.1
Fan, S.2
Eastman, A.3
Worland, P.J.4
Sausville, E.A.5
O'Connor, P.M.6
-
28
-
-
0028788427
-
DNA topoisomerase IIα expression is associated with alkylating agent resistance
-
Eder, J. P., Chan, V. T-W., Ng, S-W., Rizvi, N. A., Zacharoulis, S., Teicher, B. A., and Schnipper, L. E. DNA topoisomerase IIα expression is associated with alkylating agent resistance. Cancer Res., 55: 6109-6116, 1995.
-
(1995)
Cancer Res.
, vol.55
, pp. 6109-6116
-
-
Eder, J.P.1
Chan, V.T.-W.2
Ng, S.-W.3
Rizvi, N.A.4
Zacharoulis, S.5
Teicher, B.A.6
Schnipper, L.E.7
-
29
-
-
0027492913
-
Topoisomerase II: Inhibition and altered kinetics of formation and repair of nitrosourea and cisplatin-induced DNA interstrand cross-links and cytotoxicity in human glioblastoma cells
-
Ali-Osman, F., Berger, M. S., Rajagopal, S., Spence, A., and Livingston, R. B. Topoisomerase II: inhibition and altered kinetics of formation and repair of nitrosourea and cisplatin-induced DNA interstrand cross-links and cytotoxicity in human glioblastoma cells. Cancer Res., 53: 5663-5668, 1993.
-
(1993)
Cancer Res.
, vol.53
, pp. 5663-5668
-
-
Ali-Osman, F.1
Berger, M.S.2
Rajagopal, S.3
Spence, A.4
Livingston, R.B.5
-
30
-
-
0029867026
-
Potentiation of cisplatin cytotoxicity by 9-aminocamptothecin
-
Goldwasser, F., Valenti, M., Torres, R., Kohn, K. W., and Pommier, Y. Potentiation of cisplatin cytotoxicity by 9-aminocamptothecin. Clin. Cancer Res., 2: 687-693, 1996.
-
(1996)
Clin. Cancer Res.
, vol.2
, pp. 687-693
-
-
Goldwasser, F.1
Valenti, M.2
Torres, R.3
Kohn, K.W.4
Pommier, Y.5
-
31
-
-
0028917765
-
An XPG DNA repair defect causing mutagen hypersensitivity in mouse leukemia L1210 cells
-
Vilpo, J. A., Vilpo, L. M., Szymkowski, D. E., O'Donovan, A., and Wood, R. D. An XPG DNA repair defect causing mutagen hypersensitivity in mouse leukemia L1210 cells. Mol. Cell. Biol., 15: 290-297, 1995.
-
(1995)
Mol. Cell. Biol.
, vol.15
, pp. 290-297
-
-
Vilpo, J.A.1
Vilpo, L.M.2
Szymkowski, D.E.3
O'Donovan, A.4
Wood, R.D.5
-
32
-
-
0027364921
-
Human xeroderma pigmentosum group D gene encodes a DNA helicase
-
Sung, P., Bailly, V., Weber, C., Thompson, L. H., Prakash, L., and Prakash, S. Human xeroderma pigmentosum group D gene encodes a DNA helicase. Nature (Lond.), 365: 852-855, 1993.
-
(1993)
Nature (Lond.)
, vol.365
, pp. 852-855
-
-
Sung, P.1
Bailly, V.2
Weber, C.3
Thompson, L.H.4
Prakash, L.5
Prakash, S.6
-
33
-
-
0028360068
-
Dual role of TFIIH in DNA excision repair and in transcription by RNA polymerase II
-
Drapkin, R., Reardon, J. T., Ansari, A., Huang, J. C., Zawel, L., Ahn, K., Sancar, A., and Reinberg, D. Dual role of TFIIH in DNA excision repair and in transcription by RNA polymerase II. Nature (Lond.), 368: 769-772, 1994.
-
(1994)
Nature (Lond.)
, vol.368
, pp. 769-772
-
-
Drapkin, R.1
Reardon, J.T.2
Ansari, A.3
Huang, J.C.4
Zawel, L.5
Ahn, K.6
Sancar, A.7
Reinberg, D.8
-
34
-
-
0343055805
-
Biochemistry of the interactions between DNA and the pyrazoloacridines: A series of biologically novel anticancer agents
-
Sebolt-Leopold, J. S., and Scavone, S. V. Biochemistry of the interactions between DNA and the pyrazoloacridines: a series of biologically novel anticancer agents. Proc. Am. Assoc. Cancer Res., 32: 334, 1991.
-
(1991)
Proc. Am. Assoc. Cancer Res.
, vol.32
, pp. 334
-
-
Sebolt-Leopold, J.S.1
Scavone, S.V.2
-
35
-
-
0027080829
-
Helicase inhibition of anthracycline anticancer agents
-
Bachur, N. J., Yu, F., Johnson, R., Hickey, R., Wu, Y., and Malkas, L. Helicase inhibition of anthracycline anticancer agents. Mol. Pharmacol., 41: 993-998, 1992.
-
(1992)
Mol. Pharmacol.
, vol.41
, pp. 993-998
-
-
Bachur, N.J.1
Yu, F.2
Johnson, R.3
Hickey, R.4
Wu, Y.5
Malkas, L.6
-
36
-
-
0028037663
-
Tumor-promoting phorbol ester transiently down-modulates the p53 level and blocks the cell cycle
-
Skouv, J., Jensen, P. O., Forchhammer, J., Larsen, J. K., and Lund, L. R. Tumor-promoting phorbol ester transiently down-modulates the p53 level and blocks the cell cycle. Cell Growth & Differ., 5: 329-340, 1994.
-
(1994)
Cell Growth & Differ.
, vol.5
, pp. 329-340
-
-
Skouv, J.1
Jensen, P.O.2
Forchhammer, J.3
Larsen, J.K.4
Lund, L.R.5
-
37
-
-
0028985932
-
1 checkpoint-competent cells
-
1 checkpoint-competent cells. Cancer Res., 55: 1639-1642, 1995.
-
(1995)
Cancer Res.
, vol.55
, pp. 1639-1642
-
-
Russell, K.J.1
Wiens, L.W.2
Demers, G.W.3
Galloway, D.A.4
Plon, S.E.5
Groudine, M.6
-
38
-
-
0022538776
-
Expression of p53 in human leukemia and lymphoma
-
Prokocimer, M., Shaklai, M., Ben Bassat, H., Wolf, D., Goldfinger, N., and Rotter, V. Expression of p53 in human leukemia and lymphoma Blood, 68: 113-118, 1986.
-
(1986)
Blood
, vol.68
, pp. 113-118
-
-
Prokocimer, M.1
Shaklai, M.2
Ben Bassat, H.3
Wolf, D.4
Goldfinger, N.5
Rotter, V.6
-
39
-
-
0018172657
-
Plasma levels and urinary excretion of filterable platinum species following bolus injection and IV infusion of cis-dichlorodiammineplatinum (II) in man
-
Patton, T. F., Himmelstein, K. H., and Belt, R. Plasma levels and urinary excretion of filterable platinum species following bolus injection and IV infusion of cis-dichlorodiammineplatinum (II) in man. Cancer Treat. Rep., 62: 1359-1362, 1978.
-
(1978)
Cancer Treat. Rep.
, vol.62
, pp. 1359-1362
-
-
Patton, T.F.1
Himmelstein, K.H.2
Belt, R.3
|