The Drosophila gene Bearded encodes a novel small protein and shares 3' UTR sequence motifs with multiple Enhancer of split Complex genes

Development

Volumn 124, Issue 20, 1997, Pages 4039-4051

  Leviten, Michael W ^a,b   Lai, Eric C ^a   Posakony, James W ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Deltagen Inc   (United States)

Author keywords

3' untranslated region; Basic amphipathic helix; Enhancer of split Complex; Neurogenesis; Notch signalling; Post transcriptional regulation; Sensory organ development; Transposable element

Indexed keywords

HELIX LOOP HELIX PROTEIN; MESSENGER RNA; REPRESSOR PROTEIN;

ARTICLE; DNA FLANKING REGION; DNA RESPONSIVE ELEMENT; DROSOPHILA; GENE; GENE EXPRESSION; GENE FUNCTION; GENE INSERTION; GENE MUTATION; GENE STRUCTURE; MOLECULAR CLONING; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; TRANSCRIPTION REGULATION; TRANSPOSON;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CLONING, MOLECULAR; DNA-BINDING PROTEINS; DROSOPHILA; DROSOPHILA PROTEINS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, INSECT; INSECT PROTEINS; MOLECULAR SEQUENCE DATA; REPRESSOR PROTEINS; SEQUENCE ANALYSIS;

EID: 0030778837     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (55)

1. Alonso, M. C. and Cabrera, C. V. (1988). The achaete-scute gene complex of Drosophila melanogaster comprises four homologous genes. EMBO J. 7, 2585-2591.
2. Bailey, A. M. and Posakony, J. W. (1995). Suppressor of Hairless directly activates transcription of Enhancer of split Complex genes in response to Notch receptor activity. Genes Dev. 9, 2609-2622.
3. Baker, N. F., Mlodzik, M. and Rubin, G. M. (1990). Spacing differentiation in the developing Drosophila eye: a fibrinogen-related lateral inhibitor encoded by scabrous. Science 250, 1370-1377.
4. Bang, A. G., Bailey, A. M. and Posakony, J. W. (1995). Hairless promotes stable commitment to the sensory organ precursor cell fate by negatively regulating the activity of the Notch signaling pathway. Dev. Biol. 172, 479-494.
5. Bang, A. G. and Posakony, J. W. (1992). The Drosophila gene Hairless encodes a novel basic protein that controls alternative cell fates in adult sensory organ development. Genes Dev. 6, 1752-1769.
6. Bingham, P. and Chapman, C. (1986). Evidence that white-blood is a novel type of temperature-sensitive mutation resulting from temperature-dependent effects of a transposon insertion on formation of white transcripts. EMBO J. 5, 3343-3351.
7. Brou, C., Logeat, F., Lecourtois, M., Vandekerckhove, J., Kourilsky, P., Schweisguth, F. and Israel, A. (1994). Inhibition of the DNA-binding activity of Drosophila Suppressor of Hairless and of its human homolog. KBF2/RBP-JK, by direct protein-protein interaction with Drosophila Hairless. Genes Dev. 8, 2491-2503.
8. Brown, N. H. and Kafatos, F. C. (1988). Functional cDNA libraries from Drosophila embryos. J. Mol. Biol. 203, 425-437.
9. Cabrera, C. V. and Alonso, M. C. (1991). Transcriptional activation by heterodimers of the achaete-scute and daughterless gene products of Drosophila. EMBO J. 10, 2965-2973.
10. Cavener, D. R. (1987). Comparison of the consensus sequence flanking translational start sites in Drosophila and vertebrates. Nucleic Acids Res. 15, 1353-1361.
11. Cubas, P., de Celis, J.-F., Campuzano, S. and Modolell, J. (1991). Proneural clusters of achaete-scute expression and the generation of sensory organs in the Drosophila imaginal wing disc. Genes Dev. 5, 996-1008.
12. Delidakis, C. and Artavanis-Tsakonas, S. (1992). The Enhancer of split [E(spl)] locus of Drosophila encodes seven independent helix-loop-helix proteins. Proc. Nat. Acad. Sci. USA 89, 8731-8735.
13. Dietrich, U. and Campos-Ortega, J. A. (1984). The expression of neurogenic loci in the imaginai epidermal cells of Drosophila melanogaster. J. Neurogenetics 1, 315-332.
14. Ellis, H. M., Spann, D. R. and Posakony, J. W. (1990). extramacrochaetae, a negative regulator of sensory organ development in Drosophila. defines a new class of helix-loop-helix proteins. Cell 61, 27-38.
15. Fehon, R. G., Kooh, P. J., Rebay, I., Regan, C. L., Xu, T., Muskavitch, M. A. and Artavanis-Tsakonas, S. (1990). Molecular interactions between the protein products of the neurogenic loci Notch and Delta, two EGF-homologous genes in Drosophila. Cell 61, 523-534.
16. Fortini, M. E. and Artavanis-Tsakonas, S. (1994). The Suppressor of Hairless protein participates in Notch receptor signaling. Cell 79, 273-282.
17. Furukawa, T., Kobayakawa, Y., Tamura, K., kimura, K., Kawaichi, M., Tanimura, T. and Honjo, T. (1995). Suppressor of Hairless, the Drosophila homologue of RBP-JK. transactivates the neurogenic gene E(spl)m8. Jpn. J. Genet. 70, 505-524.
18. Ha, I., Wightman, B. and Ruvkun, G. (1996). A bulged lin-4/lin-14 RNA duplex is sufficient for Caenorhabditis elegans lin-14 temporal gradient formation. Genes Dev. 10, 3041-3050.
19. Hartenstein, V. and Posakony, J. W. (1989). Development of adult sensilla on the wing and notum of Drosophila melanogaster. Development 107, 389-405.
20. Hartenstein, V. and Posakony, J. W. (1990). A dual function of the Notch gene in Drosophila sensillum development. Dev. Biol. 142, 13-30.
21. Heitzler, P. and Simpson, P. (1991). The choice of cell fate in the epidermis of Drosophila. Cell 64, 1083-1092.
22. Hsieh, J. J., Henkel, T., Salmon, P., Robey, E., Peterson, M. G. and Hayward, S. D. (1996). Truncated mammalian Notch 1 activates CBF1/RBPJk-repressed genes by a mechanism resembling that of Epstein-Barr virus EBNA2. Mol. Cell. Biol. 16, 952-959.
23. Huang, F., Dambly-Chaudière, C. and Ghysen, A. (1991). The emergence of sense organs in the wing disc of Drosophila. Development 111, 1087-1095.
24. Jarriault, S., Brou, C., Logeat, F., Schroeter, E. H., Kopan, R. and Israel, A. (1995). Signalling downstream of activated mammalian Notch. Nature 377, 355-358.
25. Jiang, J., Kosman, D., Ip, Y. T. and Levine, M. (1991). The dorsal morphogen gradient regulates the mesoderm determinant twist in early Drosophila embryos. Genes Dev. S. 1881-1891.
26. Kemp, B. E. and Pearson, R. B. (1990). Protein kinase recognition sequence motifs. Trends Biochem. Sci. 15, 342-346.
27. Klämbt, C., Knust, E., Tietze, K. and Campos-Ortega, J. (1989). Closely related transcripts encoded by the neurogenic gene complex Enhancer of split of Drosophila melanogaster. EMBO J. 8, 203-210.
28. Knust, E., Schrons, H., Grawe, F. and Campos-Ortega, J. A. (1992). Seven genes of the Enhancer of split complex of Drosophila melanogaster encode helix-loop-helix proteins. Genetics 132, 505-518.
29. Kramatschek, B. and Campos-Ortega, J. A. (1994). Neuroectodermal transcription of the Drosophila neurogenic genes E(spl) and HLH-m5 is regulated by proneural genes. Development 120, 815-826.
30. Lecourtois, M. and Schweisguth, F. (1995). The neurogenic Suppressor of Hairless DNA-binding protein mediates the transcriptional activation of the Enhancer of split Complex genes triggered by Notch signaling. Genes Dev. 9, 2598-2608.
31. Lee, R. C., Feinbaum, R. L. and Ambros, V. (1993). The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 75, 843-854.
32. Leviten, M. W. and Posakony, J. W. (1996). Gain-of-function alleles of Bearded interfere with alternative cell fate decisions in Drosophila adult sensory organ development. Dev. Biol. 176, 264-283.
33. Maniatis, T., Fritsch, E. F. and Sambrook, J. (1982). Molecular Cloning: A Laboratory Manual. New York: Cold Spring Harbor Laboratory.
34. Margolis, J. S., Borowsky, M., Shim, C. W. and Posakony, J. W. (1994). A small region surrounding the distal promoter of the hunchback gene directs maternal expression. Dev. Biol. 163, 381-388.
35. Mlodzik, M., Baker, N. E. and Rubin, G. M. (1990). Isolation and expression of scabrous, a gene regulating neurogenesis in Drosophila. Genes Dev. 4, 1848-1861.
36. Nakao, K. and Campos-Ortega, J. A. (1996). Persistent expression of genes of the Enhancer of split complex suppresses neural development in Drosophila. Neuron 16, 275-286.
37. Parks, A. L. and Muskavitch, M. A. (1993). Delta function is required for bristle organ determination and morphogenesis in Drosophila. Dev, Biol. 157, 484-496.
38. Posakony, J. W. (1994). Nature versus nurture: asymmetric cell divisions in Drosophila bristle development. Cell 76, 415-418.
39. Price, B. D., Chang, Z., Smith, R., Bockheim, S. and Laughon, A. (1993). The Drosophila neuralized gene encodes a C3HC4 zinc finger. EMBO J. 12, 2411-2418.
40. Robertson, H. M., Preston, G. R., Phillis, R. W., Johnson-Schlitz, D. M., Benz, W. K. and Engels, W. R. (1988). A stable source of P-element transposase in Drosophila melanogaster. Genetics 118, 461-470.
41. Romani, S., Campuzano, S., Macagno, E. R. and Modolell, J. (1989). Expression of achaete and scute genes in Drosophila imaginai discs and their function in sensory organ development. Genes Dev. 3, 997-1007.
42. Rooke, J., Pan, D., Xu, T. and Rubin, G. M. (1996). KUZ, a conserved metalloprotease-disintegrin protein with two roles in Drosophila neurogenesis. Science 273, 1227-1231.
43. Schweisguth, F. (1995). Suppressor of Hairless is required for signal reception during lateral inhibition in the Drosophila pupal notum. Development 121, 1875-1884.
44. Schweisguth, F. and Posakony, J. W. (1992). Suppressor of Hairless, the Drosophila homolog of the mouse recombination signal-binding protein gene, controls sensory organ cell fates. Cell 69, 1199-1212.
45. Schweisguth, F. and Posakony, J. W. (1994). Antagonistic activities of Suppressor of Hairless and Hairless control alternative cell fates in the Drosophila adult epidermis. Development 120, 1433-1441.
46. Segrest, J., De Loof, H., Dohlman, J., Brouillette, C. and Anantharamaiah, G. (1990). Amphipathic helix motif: Classes and properties. Proteins 8, 103-117.
47. Singson, A., Leviten, M. W., Bang, A. G., Hua, X. H. and Posakony, J. W. (1994). Direct downstream targets of proneural activators in the imaginai disc include genes involved in lateral inhibitory signaling. Genes Dev. 8, 2058-2071.
48. Skeath, J. B. and Carroll, S. B. (1991). Regulation of achaete-scute gene expression and sensory organ pattern formation in the Drosophila wing. Genes Dev. 5, 984-995.
49. Smoller, D., Friedel, C., Schmid, A., Bettler, D., Lam, L. and Yedvobnick, B. (1990). The Drosophila neurogenic locus mastermind encodes a nuclear protein unusually rich in amino acid homopolymers. Genes Dev. 4, 1688-1700.
50. Struhl, G., Fitzgerald, K. and Greenwald, I. (1993). Intrinsic activity of the Lin-12 and Notch intracellular domains in vivo. Cell 74, 331-345.
51. Tamura, K., Taniguchi, Y., Minoguchi, S., Sakai, T., Tun, T., Furukawa, T. and Honjo, T. (1995). Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-JK/Su(H). Curt: Biol. 5, 1416-1423.
52. Tata, F. and Hartley, D. A. (1995). Inhibition of cell fate in Drosophila by Enhancer of split genes. Mech. Dev. 51, 305-315.
53. Tautz, D. and Pfeifle, C. (1989). A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback. Chromosoma 98, 81-85.
54. Van Doren, M., Po well, P. A., Pasternak, D., Singson, A. and Posakony, J. W. (1992). Spatial regulation of proneural gene activity: auto- and cross-activation of achaete is antagonized by extramacrochaetae. Genes Dev. 6, 2592-2605.
55. Vässin, H., Vielmetter, J. and Campos-Ortega, J. A. (1985). Genetic interactions in early neurogenesis of Drosophila melanogaster. J. Neurogenetics 2, 291-308.