Targeted expression of Bcl-2 in mouse oocytes inhibits ovarian follicle atresia and prevents spontaneous and chemotherapy-induced oocyte apoptosis in vitro

Molecular Endocrinology

Volumn 13, Issue 6, 1999, Pages 841-850

  Morita, Yutaka ^a,b   Perez, Gloria I ^a   Maravei, Daniel V ^a   Tilly, Kim I ^a   Tilly, Jonathan L ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; DOXORUBICIN; PROTEIN BCL 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL GROWTH; CHEMOTHERAPY; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GERM CELL; IMMUNOHISTOCHEMISTRY; MORPHOMETRICS; NONHUMAN; OOCYTE; OVARY FOLLICLE ATRESIA; OVULATION; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; TRANSGENE;

EID: 0033305096     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/mend.13.6.0306     Document Type: Article

References (38)

1. BCL-2 family: Regulators of cell death
2. The Bcl-2 protein family: Arbiters of cell survival
3. The genes of cell death and cellular susceptibility to apoptosis in the ovary: A hypothesis
4. Expression of members of the bcl-2 gene family in the immature rat ovary: Equine chorionic gonadotropin-mediated inhibition of granulosa cell apoptosis is associated with decreased bax and constitutive bcl-2 and bcl-x(long) messenger RNA levels
5. Analysis of apoptosis and expression of bcl-2 gene family members in the human and baboon ovary
6. Increased bax and interleukin-1β-converting enzyme (Ice) messenger RNA levels coincide with apoptosis in the bovine corpus luteum during structural regression
7. Estradiol-mediated suppression of apoptosis in the rabbit corpus luteum is associated with a shift in expression of bcl-2 family members favoring cellular survival
8. Anti-oxidants mimic the ability of chorionic gonadotropin to suppress apoptosis in the rabbit corpus luteum in vitro: A novel role for superoxide dismutase in regulating bax expression
9. Bax-deficient mice with lymphoid hyperplasia and male germ cell death
10. Prolongation of ovarian lifespan into advanced chronological age by Bax-deficiency
11. Ablation of bcl-2 gene expression decreases the number of oocytes and primordial follicles established in the postnatal female mouse gonad
12. Expression and regulation of genes associated with cell death during murine preimplantation embryo development
13. Apoptosis-associated signaling pathways are required for chemotherapy-mediated female germ cell destruction
14. A mouse oocyte-specific protein that binds to a region of mZP3 promoter responsible for oocyte-specific mZP3 gene expression
15. Zona pellucida glycoproteins
16. Programmed cell death in invertebrates
17. Cell death and species propagation: Molecular and genetic aspects of apoptosis in the vertebrate female gonad
18. Apoptosis and its impact in clinical reproductive medicine
19. Chemotherapy and the adult gonad: A review
20. Breast cancer in young women: Effect of chemotherapy on ovarian function, fertility and birth defects
21. Coordinate expression of the three zona pellucida genes during mouse oogenesis
22. A quantitative and cytological study of germ cells in human ovaries
23. Regulation of ovarian follicular development in primates: Facts and hypotheses
24. Apoptosis in the degeneration process of unfertilized mouse ova
25. Cumulus cells are required for the increased apoptotic potential in oocytes of aged mice
26. DNA strand breaks and phosphatidylserine redistribution in newly ovulated and cultured mouse and human oocytes: Occurrence and relationship to apoptosis
27. Fragmentation and death (apoptosis) of ovulated oocytes
28. A day in the life of the Bcl-2 protein: Does the turnover rate of Bcl-2 serve as a biological clock for cellular lifespan regulation?
29. Apoptosis or retinoblastoma: Alternative fates of photoreceptors expressing the HPV-16 E7 gene in the presence or absence of p53
30. cis-Acting DNA elements involved in oocyte-specific expression of mouse sperm receptor gene mZP3 are located close to the gene's transcription start site
31. An upstream region of the mouse ZP 3 gene directs expression of firefly luciferase specifically to growing oocytes in transgenic mice
32. Isolation of high-molecular-weight DNA from mammalian cells
33. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity
34. Differential expression of members of the bcl-2 gene family in proliferative and secretory human endometrium: Glandular epithelial cell apoptosis is associated with increased expression of bax
35. Antigen retrieval in formalin-fixed, paraffin-embedded tissues: An enhancement method for immunohistochemical staining based on microwave oven heating of tissue sections
36. Immunohistochemical analysis of Mcl-1 and Bcl-2 proteins in normal and neoplastic lymph nodes
37. Defects in regulation of apoptosis in caspase-2-deficient mice