Systemic inhibition of tumor growth and tumor metastases by intramuscular administration of the endostatin gene

Nature Biotechnology

Volumn 17, Issue 4, 1999, Pages 343-348

  Blezinger, Paul ^a   Wang, Jijun ^a   Gondo, Margaret ^a   Quezada, Abraham ^a   Mehrens, Dorothy ^a   French, Martha ^a   Singhal, Arun ^a   Sullivan, Sean ^a   Rolland, Alain ^a   Ralston, Rob ^a   Min, Wang ^a  

^a GeneMedicine Inc   (United States)

Author keywords

Angiogenesis; Cancer; Endostatin; Gene therapy; Intramuscular delivery

Indexed keywords

ANGIOGENESIS INHIBITOR; ENDOSTATIN;

ADOLESCENT; ANGIOGENESIS; ANIMAL TISSUE; ARTICLE; CANCER; CANCER INHIBITION; CONTROLLED STUDY; FEMALE; GENE DOSAGE; GENE EXPRESSION; GENE THERAPY; HUMAN; HUMAN CELL; LUNG METASTASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS;

ANIMALS; ANTINEOPLASTIC AGENTS; COLLAGEN; ENDOSTATINS; FEMALE; GENE THERAPY; LUNG NEOPLASMS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MUSCLE, SKELETAL; NEOPLASM METASTASIS; NEOPLASMS, EXPERIMENTAL; NEOVASCULARIZATION, PATHOLOGIC; NEOVASCULARIZATION, PHYSIOLOGIC; PEPTIDE FRAGMENTS;

EID: 0032892179     PISSN: 10870156     EISSN: None     Source Type: Journal    
DOI: 10.1038/7895     Document Type: Article

References (37)

1. Sugarbaker, E.V., Thornthwaite J. & Ketcham, A.S. in Progress in Cancer Research and Therapy (eds Day, S.B., Myers, W.P.L., Stansly, P., Garattini, S. & Lewis, M.G.) 227-240 (Raven Press, New York, 1977).
2. Warren, B.A. Chauvin W.J. & Philips J. in Progress in Cancer Research and Therapy (eds Day, S.B., Myers, W.P.L., Stansly, P., Garattini, S. & Lewis, M.G.) 185-197 (Raven Press, New York, 1977).
3. Clark, W.H.J. Model predicting survival in stage I melanoma based on tumor progression. J. Natl. Cancer Inst. 81, 1893-1904 (1989).
4. Prehn, R.T. The inhibition of tumor growth by tumor mass. Cancer Res. 51, 2-4 (1991).
5. Prehn, R.T. Two competing influences that may explain concomitant tumor resistance. Cancer Res. 53, 3266-3269 (1993).
6. O'Reilly, M.S. et al. The suppression of tumor metastases by a primary tumor. Surg. Forum 44, 474-478 (1993).
7. O'Reilly, M.S. et al. Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma. Cell 79, 315-328 (1994).
8. O'Reilly, M.S. et al. Endostatin: an endogenous inhibitor of angiogenesis and tumor growth. Cell 88, 277-285 (1997).
9. Volpert, O.V., Lawler, J. & Bouck, N.P. A human fibrosarcoma inhibits systemic angiogenesis and the growth of experimental metastases via thrombospondin-1. Proc. Natl. Acad. Sci. USA 95, 6343-6348 (1998).
10. Holmgren, L., O'Reilly, M.S. & Folkman, J. Dormancy of micrometastases: balanced proliferation and apoptosis in the presence of angiogenesis suppression. Nat. Med. 1, 149-153 (1995).
11. O'Reilly, M.S., Holmgren, L., Chen, C., & Folkman, J. Angiostatin induces and sustains dormancy of human primary tumors in mice. Nat. Med. 2, 689-692 (1996).
12. Lannutti, B.J., Gately, S.T., Quevedo, M.E., Soff, G.A., & Paller, A.S. Human angiostatin inhibits murine hemangioendothelioma tumor growth in vivo. Cancer Res. 57, 5277-5280 (1997).
13. Sim, B.K. et al. A recombinant human angiostatin protein inhibits experimental primary and metastatic cancer. Cancer Res. 57, 1329-1334 (1997).
14. Boehm, T., Folkman, J., Browder, T. & O'Reilly, M.S. Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance. Nature 390, 404-407 (1997).
15. Folkman, J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat. Med. 1, 27-31 (1997).
16. Hanahan, D. & Folkman, J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 86, 353-364 (1996).
17. Wolff, J.A. et al. Direct gene transfer into mouse muscle in vivo. Science 247, 1465-1468 (1990).
18. Davis, H.L., Demeneix, B.A., Quantin, B., Coulombe, J. & Whalen, R.G. Plasmid DNA is superior to viral vectors for direct gene transfer into adult mouse skeletal muscle. Hum. Gene Ther. 4, 733-740 (1993).
19. Schofield, J.P. & Caskey, C.T. Non-viral approaches to gene therapy. Br. Med. Bull. 51, 56-71 (1995).
20. Aihara, H. & Miyazaki, J. Gene transfer into muscle by electroporation in. Nat. Biotechnol. 16, 867-870 (1998).
21. Alila, H. et al. A. Expression of biologically active human insulin-like growth factor-I following intramuscular injection of a formulated plasmid in rats. Hum. Gene Ther. 8, 1785-1795 (1997).
22. Anwer, K. et al. Systemic effect of human growth hormone after intramuscular injection of a single dose of a muscle-specific gene medicine. Hum. Gene Ther. 9, 659-670 (1998).
23. Mumper, R.J. et al. Polyvinyl derivatives as novel interactive polymers for controlled gene delivery to muscle. Pharm. Res. 13, 701-709 (1996).
24. Mumper, R.J. et al. Protective interactive noncondensing (PINC) polymers for enhanced plasmid distribution and expression in rat skeletal muscle. J Controlled Release 52, 191-203 (1998).
25. Weidner, N., Semple, J.P., Welch, W.R. & Folkman, J. Tumor angiogenesis and metastasis - correlation in invasive breast carcinoma. N. Engl. J. Med. 324, 1-8 (1991).
26. Kenyon, B.M. et al. A model of angiogenesis in the mouse cornea. Invest. Ophthalmol. Vis. Sci. 37, 1625-1632 (1996).
27. Kerbel, R.S.A cancer therapy resistant to resistance. Nature 390, 335-336 (1997).
28. Hanahan, D.A flanking attack on cancer. Nat. Med. 4, 13-14 (1998).
29. Folkman, J. Antiangiogenic gene therapy. Proc. Natl. Acad. Sci. USA 95, 9064-9066 (1998).
30. Tanaka, T., Cao, Y., Folkman, J. & Fine, H.A. Viral vector-targeted antiangiogenic gene therapy utilizing an angiostatin complementary DNA. Cancer Res. 58, 3362-3369 (1998).
31. Griscelli, F. et al. Angiostatin gene transfer: inhibition of tumor growth in vivo by blockage of endothelial cell proliferation associated with a mitosis arrest. Proc. Natl. Acad. Sci. USA 95, 6367-6372 (1998).
32. Kong, H.L. & Crystal, R.G. Gene therapy strategies for tumor antiangiogenesis. J. Natl. Cancer Inst. 90, 273-286 (1998).
33. Kong, H.L. et al. Regional suppression of tumor growth by in vivo transfer of a cDNA encoding a secreted form of the extracellular domain of the flt-1 vascular endothelial growth factor receptor. Hum. Gene Ther. 9, 823-833 (1998).
34. Lin, P. et al. Antiangiogenic gene therapy targeting the endothelium-specific receptor tyrosine kinase Tie2. Proc. Natl. Acad. Sci. USA 95, 8829-8834 (1998).
35. Li, H. et al. Adenovirus-mediated delivery of a uPA/uPAR antagonist suppresses angiogenesis-dependent tumor growth and dissemination in mice. Gene Ther. 5, 1105-1113 (1998).
36. Anderson, W.F. Human gene therapy. Nature 392, 25-30 (1998).
37. Rolland, A.P. From genes to gene medicines: recent advances in nonviral gene delivery. Crit. Rev. Ther. Drug Carrier Syst. 15, 143-198 (1998).