Regression of metastatic breast cancer in a patient treated with the anti-angiogenic drug TNP-470

Tumori

Volumn 85, Issue 1, 1999, Pages 51-53

  Offodile, Regina ^a   Walton, Terrence ^a   Lee, Maggie ^a   Stiles, Ann ^a   Nguyen, Mai ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Angiogenesis; Breast cancer; TNP 470

Indexed keywords

ANGIOGENESIS INHIBITOR; CYCLOPHOSPHAMIDE; DOXORUBICIN; FLUOROURACIL; FUMAGILLOL CHLOROACETYLCARBAMATE; MEGESTROL ACETATE; TAMOXIFEN;

ADULT; ARTICLE; BONE METASTASIS; BREAST CANCER; CANCER COMBINATION CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER REGRESSION; CANCER STAGING; CASE REPORT; FEMALE; FOLLOW UP; HUMAN; HUMAN TISSUE; LIVER METASTASIS; LUNG METASTASIS; QUALITY OF LIFE; TUMOR VASCULARIZATION;

EID: 0033043239     PISSN: 03008916     EISSN: None     Source Type: Journal    
DOI: 10.1177/030089169908500111     Document Type: Article

References (27)

1. Belman N., Bonnem E.M., Harvey H.A., Lipton A.: Phase I trial of recombinant platelet factor 4 (rPF4) in patients with advanced colorectal carcinoma. Invest. New Drugs, 14: 387-389, 1996.
2. DeVita V.T. Jr, Hellman S., Rosenberg S.A.: Cancer: principles and practice of oncology. Philadelphia, Lippincott-Raven, 1997.
3. DeVore R.F., Hellerqvist C.G., Wakefield G.B., Wamill B.D., Thurman G.B., Minton P.A., Sundell H.W., Yan H.P., Carter C.E., Wang Y. F., Zhang M.H., Johnson D.H.: Phase I study of the antineovascularization drug CM101. Clin. Cancer Res., 3: 365-372, 1997.
4. Dezube B.J., Von Roenn J.H., Holden-Wiltse J., Remick S., Colley T.P., Cheung T.W., Sommadossi F.P., Moore J., Shriver S., Suckow C., Gill P.: Fumagillin analog (TNP-470) in the treatment of Karposi's sarcoma: a phase I AIDS clinical trial group study. Natl. AIDS Malign. Conf., A35, 1996.
5. Eckhardt S.G., Burriss H.A., Eckardt J.R., Weiss G., Rinaldi D., Barrington R., Smith L., Field S., Kuhn J., Smith S., Smetzer L., Marcus S., Masuo K., Sobel R., Von Hoff D.D.: Initial phase I assessment of the novel angiogenesis inhibitor DS 4152 (Tecogalan sodium). Proc ASCO, 13: 55, 1994.
6. Ezekowitz R.A.B., Mulliken J.B., Folkman J.: Interferon alfa-2a therapy for life-threatening hemangiomas of infancy. N. Engl. J. Med., 326: 1456-1463, 1992.
7. Folkman J., Angiogenesis in cancer, vascular, rheumatoid and other disease. Nature Med., 1: 27-31, 1995.
8. Gradishar W.J.: An overview of clinical trials involving inhibitors of angiogenesis and their mechanism of action. Invest. New Drugs, 15: 49-59, 1997.
9. Hori A., Ikeyama S., Sudo K.: Suppression of cyclin D1 mRNA expression by the angiogenesis inhibitor TNP-470 (AGM-1470) in vascular endothelial cells. Biochem. Biophys. Res. Comm., 204: 1067-1073, 1994.
10. Ingber D., Fujita T., Kishimoto S., Sudo K., Kanamaru T., Brem H., Folkman J.: Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth. Nature, 348: 555-557, 1990.
11. Kohn E.C., Reed E., Sarosy G., Christiann M., Link C.J., Cole K., Figg W.D., Davis PA., Jacob J., Goldspiel B., Liotta L.A.: Clinical investigation of a cytostatic calcium influx inhibitor in patients with refractory cancers. Cancer Res., 56: 569-573, 1996.
12. Kudelka A.P., Levy T., Verschraegen C.F.: A phase I study of TNP-470 administered to patients with advanced squamous cell cancer of the cervix. Clin. Cancer Res., 3: 1501-1505, 1997.
13. Lush R.M., Figg W.D., Pluda J.M., Bitton R., Headlee D., Kohler D., Reed E., Sartor O., Cooper M.R.: A phase I study of pentosan polysulfate sodium in patients with advanced malignancies. Ann. Oncol., 7: 936-944, 1996.
14. Masakazu T., Yamamoto Y., Imazawa T., Akutsu K., Tominaga T.: Antitumor effect of the angiogenesis inhibitor AGM-1470 and its combination effect with tamoxifen in DMBA induced mammary tumors in rats. Int. J. Oncol., 3: 525-528, 1993.
15. Northfelt D.W., Robles R., Lang W., Wagner B., Kahn J., Bonnem E.: Phase I/II study of intravenous (IV) recombinant platelet factor 4 (rPF4) in AIDS-related Kaposi's Sarcoma (KS). Proc. ASCO, 14: 288, 1995.
16. O'Reilly M.S., Holmgren L., Shing Y., Chen C., Rosenthal R.A., Moses M., Lane W.S., Cao Y., Sage E.H., Folkman J.: Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma. Cell, 79: 315-328, 1994.
17. O'Reilly M.S., Boehm T., Shing Y., Fukai N., Vasios G., Lane W.S., Flynn E., Birkhead J.R., Olsen B.R., Folkman J.: Endostatin: an endogenous inhibitor of angiogenesis and tumor growth. Cell, 88: 277-285, 1997.
18. Pluda J.M., Wyvill K.K., Lietzau J., Figg W.D., Whitcup S.M., Feigal E., Humphrey R., Welles L., Yarchoan R.: A phase I trial administering the angiogenesis inhibitor TNP-470 (AGM-1470) to patients with HIV-associated Kaposi's Sarcoma (KS). Natl. AIDS Malign. Conf., A19, 1996.
19. Sin N., Meng L., Wang M.Q.W.: The anti-angiogenic agent fumagillin covalently binds and inhibits the methionine aminopeptidase, MetAP-2. Proc. Natl. Acad. Sci., 94: 6099-6103, 1997.
20. Singh Y., Shikata N., Kiyozuka Y., Nambu H., Morimoto J., Kurebayashi J., Hioki K., Tsubura, A.: Inhibition of tumor growth and metastasis by angiogenesis inhibitor TNP-470 on breast cancer cell lines in vitro and in vivo. Breast Cancer Res. Treat., 45: 15-27, 1997.
21. Suto A., Kubota T., Matsuzaki S.W., Takeshita T., Sato S., Hoffman R.M., Kitajima M.: Effect of the antiangiogenesis agent AGM-1470 (TNP-470) on lung micrometastasis of rodent mammary tumors in nude mice. Breast Cancer Res. Treat., 32(Supp): 60, 1994.
22. Teicher B.A., Holden S.A., Dupuis N.P., Kakeji Y., Ikebe M., Emi Y., Goff D.: Potentiation of cytotoxic therapies by TNP-470 and minocycline in mice bearing EMT-6 mammary carcinoma. Breast Cancer Res. Treat., 36: 227-236, 1995.
23. Tulpule A., Snyder J.C., Espina B.M., Higashi L., Satomi M., Lombardy E.E., Gill P.S.: A phase I study of Tecogalan, a novel angiogenesis inhibitor in the treatment of AIDS-related Kaposi's Sarcoma and solid tumors. Retroviral Dis., A248, 1996.
24. TNP-470: information for clinical investigators. Deerfield: TAP Holdings Inc., 1997.
25. Wojtowicz-Praga S., Low J., Marshall J., Ness E., Dickson R., Barter J., Sale M., McCann P., Moore J., Cole A., Hawkins M.J.: Phase I trial of a novel matrix metalloproteinase inhibitor batimastat (BB-94) in patients with advanced cancer. Invest. New Drugs, 14: 193-202, 1996.
26. Yamaoka M., Yamamoto T., Ikeyama S., Sudo K., Fujita T.: Angiogenesis inhibitor TNP-470 (AMG-1470) potently inhibits the tumor growth of hormone-independent human breast and prostate carcinoma cell lines. Cancer Res., 53: 5233-5236, 1993.
27. Yamamoto Y., Toi M., Yamada R., Tominaga T.: Combination effect of an angiogenesis inhibitor AGM-1470 with 5'-deoxy-5-fluorouridine and with hormonal drugs in DMBA-induced rat mammary tumors. Oncol. Rep., 2: 793-796, 1995.