The vascular endothelial-cadherin promoter directs endothelial-specific expression in transgenic mice

Blood

Volumn 93, Issue 1, 1999, Pages 184-192

  Gory, S ^b   Vernet, M ^b   Laurent, M ^b   Dejana, E ^b   Dalmon, J ^b   Huber, P ^a  

^a CEA GRENOBLE   (France)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CADHERIN;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CATTLE; CELL STRAIN 3T3; CONTROLLED STUDY; DNA SEQUENCE; EMBRYO; EMBRYO DEVELOPMENT; ENDOTHELIUM CELL; GENE EXPRESSION; GENE TARGETING; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; TRANSGENIC MOUSE; VASCULAR ENDOTHELIUM;

EID: 0032961884     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v93.1.184     Document Type: Article

References (37)

1. Risau W: Differentiation of endothelium. FASEB J 9:926, 1995
2. Piovella F, Nalli G, Malamani GD, Majolino I, Frassoni F, Sitar GM, Ruggeri A, Dell'Orbo C, Ascari E: The ultrastructural localization of factor VIII-antigen in human platelets, megakaryocytes and endothelial cells utilizing a ferritin-labelled antibody. Br J Haematol 39:209, 1987
3. Muller WA, Ratti CM, McDonnel SL, Cohn ZA: A human endothelial cell-restricted externally disposed plasmalemmal protein enriched in intercellular junctions. J Exp Med 170:399, 1989
4. McCumber MW, Ross CA, Glaser BM, Snyder SH: Endothelin: Visualization of mRNAs by in situ hybridization provides evidence for local action. Proc Natl Acad Sci USA 86:7285, 1989
5. Sato TN, Qin Y, Kozak CA, Audus KL: Tie-1 and Tie-2 define a new class of putative receptor tyrosine kinases expressed in early embryonic vascular system. Proc Natl Acad Sci USA 90:9355, 1993
6. McEver RP, Beckstead JH, Moore KL, Marshall-Carlson L, Bainton DF: GMP-140, a platelet α-granule membrane protein, is also synthesized by vascular endothelial cells and is localized in Weibel-Palade bodies. J Clin Invest 84:92, 1989
7. Bevilacqua MP, Stengelin S, Gimbrone JMA, Seed B: Endothelial leukocyte adhesion molecule 1: An inducible receptor for neutrophils related to complement regulatory proteins and lectins. Science 243: 1160, 1989
8. Kaipainen A, Korthonen J, Pajusola K, Aprelikova O, Persico MG, Terman BI, Alitalo K: The related flt-4, flt-1, and KDR receptor tyrosine kinases show distinct expression patterns in human fetal endothelial cells. J Exp Med 178:2077, 1993
9. Fong GH, Klingensmith J, Wood CR, Rossant J, Breitman ML: Regulation of fit-1 expression during mouse embryogenesis suggests a role in the establishment of vascular endothelium. Dev Dyn 207:1, 1996
10. Millauer B, Wizigmann-Voos S, Schnürch H, Martinez R, Møller NP, Risau W, Ullrich A: High affinity VEGF binding and developmental expression suggest flk-1 as a major regulator of vasculogenesis and angiogenesis. Cell 72:835, 1993
11. Takeichi M: Morphogenic roles of classic cadherins. Curr Opin Cell Biol 7:619, 1995
12. Vittet D, Buchou T, Schweitzer A, Dejana E, Huber P: Targeted null-mutation in the vascular endothelial-cadherin gene impairs the organization of vascular-like structures in embryoid bodies. Proc Natl Acad Sci USA 94:6273, 1997
13. Lampugnani MG, Resnati M, Raiteri M, Pigott R, Pisacane A, Houen G, Ruco LP, Dejana E: A novel endothelial-specific membrane protein is a marker of cell-cell contacts. J Cell Biol 118:1511, 1992
14. Breier G, Breviario F, Caveda L, Berthier R, Schnürch H, Gotsch U, Vestweber D, Risau W, Dejana E: Molecular cloning and expression of murine vascular endothelial-cadherin in early stage development of cardiovascular system. Blood 87:630, 1996
15. Huber P, Dalmon J, Engiles J, Breviario F, Gory S, Siracusa LD, Buchberg A, Dejana E: Genomic structure and chromosomal mapping of the mouse VE-cadherin gene (Cdh5). Genomics 32:21, 1996
16. Luckow B, Schütz G: CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements. Nucl Acids Res 15:5490, 1987
17. Gorman CM, Merlino GT, Willingham MC, Pastan I, Howard BH: The Rous sarcoma virus long terminal repeal is a strong promoter when introduced into a variety of eukaryotic cells by DNA-mediated transfection. Proc Natl Acad Sci USA 79:6777, 1982
18. Balconi G, Dejana E: Cultivation of endothelial cells: Limitations and perspectives. Med Biol 64:231, 1986
19. Wigler M, Silverstein S, Lee LS, Pellicer A, Cheng Y, Axel R: Transfer of purified herpes virus thymidine kinase gene to cultured mouse cells. Cell 11:223, 1977
20. Huber P, Laurent M, Dalmon J: Human β-fibrinogen gene expression. Upstream sequences involved in its tissue-specific expression and its dexamethasone and interleukine-6 stimulation. J Biol Chem 265:5695, 1990
21. Hogan B, Beddington R, Costantini F, Lacy E: Manipulating the Mouse Embryo (ed 2). Cold Spring Harbor, NY, Cold Spring Harbor Laboratory, 1994
22. Sambrook J, Fritsch EF, Maniatis T: Molecular Cloning (ed 2). Cold Spring Harbor, NY, Cold Spring Harbor Laboratory, 1989
23. Arcari P, Martinelli R, Salvatore F: The complete sequence of a full length cDNA for human liver glyceraldehyde-3-phosphate dehydrogenase: Evidence for multiple mRNA species. Nucl Acids Res 12:9179-9189, 1984
24. Downs KM, Harmann C: Developmental potency of the murine allantois. Development 124:2769-2780, 1997
25. Risau W, Wolburg H: Development of the blood-brain barrier. Trends Neurosci 13:174, 1990
26. Qin Y, Sato TN: Mouse multidrug resistance 1a/3 gene is the earliest known endothelial cell differentiation marker during blood-brain barrier development. Dev Dyn 202:172, 1995
27. Aird WC, Jahroudi N, Weiler-Guettler H, Rayburn HB, Rosenberg RD: Human von Willebrand factor gene sequences target expression to a subpopulation of endothelial cells in transgenic mice. Proc Natl Acad Sci USA 92:4567, 1995
28. Aird WC, Edelberg JM, Weiler-Guettler H, Simmons WW, Smith TW, Rosenberg RD: Vascular bed-specific expression of an endothelial cell gene is programmed by the tissue microenvironment. J Cell Biol 138:1117, 1997
29. Asano H, Kobayashi M, Hoshino T: The hemopoietic microenvironment in the fetal liver of mice: Relationship between developing hepatocytes and erythroblasts. J Electron Microsc 36:15, 1987
30. Scoazec JY, Racine L, Couvelard A, Flejou JF, Feldmann G: Endothelial cell heterogeneity in the normal human liver acinus: In situ immunohistochemical demonstration. Liver 14:113, 1994
31. Pardanaud L, Luton D, Prigent M, Bourcheix LM, Catala M, Dieterlin-Lièvre F: Two distinct endothelial lineages in ontogeny, one of them related to hemopoiesis. Development 122:1363, 1996
32. Schlaeger TN, Qin Y, Fujiwara Y, Magram J, Sato TN: Vascular endothelial cell lineage-specific promoter in transgenic mice. Development 121:1089, 1995
33. Gory S, Dalmon J, Prandini M-H, Kortulewski T, de Launoit Y, Huner P: Requirement of a GT box (Sp1 site) and two Ets binding sites for vascular endothelial cadherin gene transcription. J Biol Chem 273:6750, 1998
34. Prandini MH, Martin F, Thevenon D, Uzan G: The tissue-specific transcriptional regulation of the megakaryocytic glycoprotein IIb is controlled by interactions between a represser and positive cis-acting elements. Blood 88:2062, 1996
35. Pierce JW, Gifford AM, Baltimore D: Silencing of the expression of the immunoglobulin kappa gene in non-B cells. Mol Cell Biol 11:1431, 1991
36. Kamachi Y, Kondoh H: Overlapping positive and negative regulatory elements determine lens-specific activity of the δ1-crystallin enhancer. Mol Cell Biol 13:5206, 1993
37. Schlaeger TM, Bartunkova S, Lawitts JA, Teichmann G, Risau W, Deutsch U, Sato TN: Uniform vascular-endothelial-cell-specific gene expression in both embryonic and adult transgenic mice. Proc Natl Acad Sci USA 94:3058, 1997