Effects of gold thioglucose on neuropeptide Y messenger RNA levels in the mouse hypothalamus

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 270, Issue 6 39-6, 1996, Pages

  Marks, Jonathan L ^a   Waite, Kay ^b   Cameron Smith, David ^b   Blair, Stephen C ^b   Cooney, Gregory J ^b  

^a WESTMEAD HOSPITAL   (Australia)

^b NONE

Author keywords

arcuate nucleus; in situ hybridization; obesity

Indexed keywords

AUROTHIOGLUCOSE; MESSENGER RNA; NEUROPEPTIDE Y;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARCUATE NUCLEUS; ARTICLE; CONTROLLED STUDY; FOOD DEPRIVATION; GENE EXPRESSION; HISTOLOGY; HYPERGLYCEMIA; HYPERINSULINEMIA; HYPERPHAGIA; HYPOTHALAMUS; IN SITU HYBRIDIZATION; MALE; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA ANALYSIS; ZONA INCERTA;

EID: 0029827180     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.1996.270.6.r1208     Document Type: Article

References (33)

1. Abe, M., M. Saito, and T. Shimazu. Neuropeptide Y in the specific hypothalamic nuclei of rats treated neonatally with monosodium glutamate. Brain Res. Bull. 24: 289-291, 1990.
2. Abe, M., S. Saito, and T. Shimazu. Neuropeptide Y and norepinephrine injected into the paraventricular nucleus of the hypothalamus activate endocrine pancreas. Biomed. Res. 10: 431-436, 1989.
3. Alien, Y. S., T. E. Adrian, J. M. Alien, K. Tatemoto, T. J. Crow, S. R. Bloom, and J. M. Polak. Neuropeptide Y distribution in the rat brain. Science Wash. DC 221: 877-879, 1983.
4. Beck, B., A. Burlet, J.-P. Nicolas, and C. Burlet. Hyperphagia in obesity is associated with a central peptidergic dysregulation in rats. J. Nutr. 120: 806-811, 1990.
5. Billington, C. J., J. E. Briggs, M. Grace, and A. S. Levine. Effects of intracerebroventricular injection of neuropeptide Y on energy metabolism. Am. J. Physiol. 260 (Regulatory Integrative Comp. Physiol. 29). R321-R327, 1991.
6. Blair, S. C., I. D. Caterson, and G. J. Cooney. Effect of adrenalectomy on glucose tolerance and lipid metabolism in gold thioglucose obese mice. Am. J. Physiol. 266 (Endocrinol. Metab. 29): E993-E1000, 1994.
7. Bouchard, C., J.-P. Despres, and P. Mauriege. Genetic and non-genetic determinants of regional fat distribution. Endocr. Reu. 14: 72-93, 1993.
8. Chua, S. C., A. W. Brown, J. Kim, K. L. Hennessey, R. L. Leibel, and J. Hirsch. Food deprivation and hypothalamic neuropeptide gene expression: effects of strain background and the diabetes mutation. Mol. Brain Res. 11: 291-299, 1991.
9. Clark, J. T., P. S. Kalra, W. R. Crowley, and S. P. Kalra. Neuropeptide Y and human pancreatic polypeptide stimulate feeding behaviour in rats. Endocrinology 115: 427-429, 1984.
10. Davies, L., and J. L. Marks. Role of hypothalamic neuropeptide Y gene expression in body weight regulation. Am. J. Physiol. 266 (Regulatory Integrative Comp. Physiol. 35): R1687-R1691, 1994.
11. Debons, A. F., I. Krimsky, and A. From. A direct action of insulin on the hypothalamic satiety center. Am. J. Physiol. 219: 938-943, 1970.
12. Debons, A. F., I. Krimsky, A. From, and R. J. Clouthier. Site of action of gold thioglucose in the hypothalamic satiety center. Am. J. Physiol. 219: 1397-1402, 1970.
13. Debons, A. F., I. Krimsky, A. From, and H. Pattitian. Diabetes-induced resistance of ventromedial hypothalamus to damage by gold thioglucose: reversal by adrenalectomy. Endocrinology 95: 1636-1641, 1974.
14. Giraudo, S. Q., C. M. Kotz, M. K. Grace, A. S. Levine, and C. J. Billington. Rat hypothalamic NPY mRNA and brown fat uncoupling protein mRNA after high-carbohydrate or high-fat diets. Am. J. Physiol. 266 (Regulatory Integrative Comp. Physiol. 35): R1578-R1583, 1994.
15. Marks, J. L., M. Li, M. Schwartz, D. Porte, Jr., and D. G. Baskin. Effect of fasting on regional levels of neuropeptide Y mRNA and insulin receptors in the rat hypothalamus. An autoradiographic study. Mol. Cell. Neurosci. 3: 199-205, 1992.
16. Marks, J. L., D. Porte, Jr., W. L. Stahl, and D. G. Baskin. Localization of insulin receptor mRNA in rat brain by in situ hybridization. Endocrinology 127. 3234-3236, 1990.
17. Marshall, N. B. R., R. J. Barnett, and J. Mayer. Hypothalamic lesions in gold thioglucose injected mice. Proc. Soc. Exp. Biol. Med. 90: 240-244, 1955.
18. Matsuo, T., and A. Shino. Induction of diabetic alterations by gold thioglucose obesity in KK, ICR and C57BL mice. Diabetologia 8: 391-397, 1972.
19. Paxinos, G., and C. Watson. The Rat Brain in Stereotaxic Coordinates (2nd ed.). San Diego, CA: Academic, 1991.
20. Schwartz, M. W., D. P. Figlewicz, D. G. Baskin, S. C. Woods, and D. Porte, Jr. Insulin in the brain: a hormonal regulator of energy balance. Endocr. Rev. 13: 387-414, 1992.
21. Stanley, B. G., S. E. Kyrkouli, S. Lampert, and S. F. Leibowitz. Neuropeptide Y chronically injected into the hypothalamus, a powerful neurochemical inducer of hyperphagia and obesity. Peptides 7: 1189-1192, 1986.
22. Tse, C. S., and A. F. Debons. Anorexia after adrenalectomy in gold thioglucose-treated obese mice: role of adipose tissue mass. Physiol. Behav. 38: 105-110, 1986.
23. Wahlstedt, C., G. Skagerberg, R. Ekman, M. Heilig, F. Sundler, and R. Hakanson. Neuropeptide Y in the area of the hypothalamic paraventricular nucleus activates the pituitary-adrenocortical axis in the rat. Brain Res. 417: 33-38, 1987.
24. White, J. D. Neuropeptide Y: a central regulator of energy homeostasis. Regul. Pept. 49: 93-107, 1993.
25. Wilding, J. P. H., S. G. Gilbey, C. J. Bailey, R. A. L. Batt, G. Williams, M. A. Ghatei, and S. R. Bloom. Increased neuropeptide-YmRNAand decreased neurotensin mRNA in the hypothalamus of the obese (ob/ob) mouse. Endocrinology 132: 1939-1944, 1993.
26. Wilding, J. P. H., S. G. Gilbey, M. Mannan, N. Aslam, M. A. Ghatei, and S. R. Bloom. Increased neuropeptide Y content in individual hypothalamic nuclei but not neuropeptide Y mRNA in diet-induced obesity in rats. J. Endocrinol. 132: 299-304, 1992.
27. Williams, G., J. S. Gill, Y. C. Lee, H. M. Carduso, B. E. Okpere, and S. R. Bloom. Increased neuropeptide Y concentrations in specific hypothalamic regions of streptozotocin-induced diabetic rats. Diabetes 38: 321-327, 1989.
28. Williams, G., L. Shellard, D. E. Lewis, P. E. McKibben, H. D. McCarthy, D. G. Koeslag, and J. C. Russell. Hypothalamic neuropeptide Y disturbances in the obese (cp/cp) JCR: LA corpulent rat. Peptides 13: 537-540, 1992.
29. Young, J. K. Hypothalamic lesions increase neuronal immunore-activity for neuropeptide Y. Brain Res. Bull. 29: 375-380, 1992.
30. Young, J. K., J. C. McKenzie, L. S. Brady, and M. Herkenham. Hypothalamic lesions increase levels of neuropeptide Y mRNA in the arcuate nucleus of mice. Neurosci. Lett. 165: 13-17, 1994.
31. Zarjevski, N., I. Cusin, K. Vettor, F. Rohner-Jeanrenaud, and B. Jeanrenaud. Chronic intracerebroventricular neuropeptide-Y administration to normal rats mimics hormonal and metabolic changes of obesity. Endocrinology 133: 1753-1758, 1993.
32. Zarjevski, N., L Cusin, R. Vettor, F. Rohner Jeanrenaud, and B. Jeanrenaud. Intracerebroventricular administration of neuropeptide Y to normal rats has divergent effects on glucose utilization by adipose tissue and skeletal muscle. Diabetes 43: 764-769, 1994.
33. Zhang, Y., R. Proenca, M. Maffei, M. Barone, L. Leopold, and J. M. Friedman. Positional cloning of the mouse obese gene and its human homologue. Nature Land. 372: 425-431, 1994.