Laminin-rich extracellular matrix association with mammary epithelial cells suppresses Brca1 expression

Cell Death and Differentiation

Volumn 7, Issue 4, 2000, Pages 360-367

  O'Connell, F C ^a   Martin, F ^a  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

Author keywords

Brca1; Cell proliferation; Extracellular matrix (ECM); Gene expression; Mammary epithelial cells

Indexed keywords

BETA CASEIN; BRCA1 PROTEIN; LAMININ; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BREAST EPITHELIUM; CELL CULTURE; CELL DIFFERENTIATION; CELL SURVIVAL; CONTROLLED STUDY; EXTRACELLULAR MATRIX; FEMALE; GENE EXPRESSION; LACTATION; MOUSE; NONHUMAN; ONCOGENE; PREGNANCY; PRIORITY JOURNAL;

ANIMALS; APOPTOSIS; BRCA1 PROTEIN; CELL DIFFERENTIATION; CELL SURVIVAL; EPITHELIAL CELLS; EXTRACELLULAR MATRIX; FEMALE; GENE EXPRESSION REGULATION; GENES, BRCA1; LACTATION; LAMININ; MAMMARY GLANDS, ANIMAL; MICE; POLYMERASE CHAIN REACTION; PREGNANCY;

ANIMALIA;

EID: 0034075308     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4400647     Document Type: Article

References (79)

1. Miki Y, Swensen J, Shattuck-Evans D, Futreal AP, Harshman K, Tavtigian S, Liu Q. Cochran C, Bennett ML, Ding W, Bell R, Rosenthal J, Hussey C, Tran T, McClure M, Frye C, Hattier T, Phelps R, Haugen-Strano A, Katcher H, Yakumo K, Gholami Z, Shaffer D, Stone S, Bayer S, Wray C, Bogden R, Dayananth P, Ward J. Tonin P, Narod S, Bristow PK, Norris FH, Helvering L, Morrison P, Rosteck P, Lai M, Barrett C, Lewis C, Neuhausen S, Cannon-Albright L, Goldgar D, Wiseman R, Kamb A and Skolnick MH (1994) A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science 266: 66-71
2. Sharan SK, Wims M and Bradley A (1995) Murine Brca1: sequence and significance for human missense mutations. Hum. Mol. Genet. 4: 2275-2278
3. Abel KJ, Xy J, Yin GY, Lyons RH, Meisler, MH and Weber, BL (1995) Mouse Brca1: localization sequence analysis and identification of evolutionary conserved domains. Hum. Mol. Genet. 4: 2265-2273
4. Chen Y, Chen C-F, Riley, DJ, Allred DC, Chen P-L, von Hoff D, Osborne CK and Lee W-H (1995) Aberrant subcellular localisation of BRCA1 in breast cancer. Science 270: 789-791
5. Chen CF, Li S, Chen Y, Chen PL, Sharp DZ and Lee WH (1996) The nuclear localization sequences of the BRCA1 protein interact with the importin-α subunit of the nuclear transport signal. J. Biol. Chem. 271: 32863-32868
6. Chen Y, Chen P-L, Riley DJ, Lee W-H, Allred, DC and Osborne CK (1996) Response to Scully et al. (1996) Science 272: 125-126
7. Scully R, Ganesan S, Brown M, de Caprio JA, Cannistra SA, Feuteun J, Schnitt S and Livingston DM (1996) Location of BRCA1 in human breast and ovarian cancer cells. Science 272: 123-125
8. Thomas JE, Smith M, Rubinfeld B, Gutowski M, Beckmann RP and Polakis P (1996) Subcellular localisation and analysis of apparent 180-KDa and 220-kDa proteins of the breast cancer susceptibility gene, BRCA1. J. Biol. Chem. 271: 28630-28635
9. Coene E, van Oostveld P, Willems K, van Emmelo J and de Potter CR (1997) BRCA1 is localised in cytoplasmic tube-like invaginations in the nucleus. Nat Genet. 16: 122-124
10. Jensen RA, Thompson ME, Jetton TL, Szabo Cl, van der Meer R, Helou B, Tronick SR, Page DL, King M-C and Holt J. (1996) BRCA1 is secreted and exhibits properties of a granin. Nat. Genet. 12: 303-308
11. Bernard-Gallon DJ, Peffault de Latour M, de Olivera F, Rio P, Hizel C, Favy D, Bignon YJ (1998) BRCA1 is localized in ductal secretions of normal breast tissues: detection by antibodies raised against the amino terminus of BRCA1 (K-18). Int. J. Cancer 77: 803-806
12. Bernard-Gallon DJ, Dechelotte P, Rio PG and Bignon YJ (1999) BRCA1 and BRCA2 proteins are expressed in milk fat globules. Int. J. Cancer 81: 839-843
13. Bertwistle D and Ashworth A (1998) Functions of the BRCA1 and BRCA2 genes. Curr. Opin. Genet. Dev. 8: 14-20
14. De Potter CR, Coene ED and Schelfhout VRJ (1998) Localisation of BRCA 1 protein at the cellular level. J. Mammary Gland Biol. and Neoplasia 3: 423-430
15. Gudas JM, Li T, Nguyen H, Jensen D, Rauscher III FJ and Cowan KH (1996) Growth retardation and tumour inhibition by BRCA1. Nat. Genet. 12: 298-302
16. Lu M, Conzen SD, Cole CN and Arrick BA (1996) Characterisation of functional messenger RNA splice variants of BRCA1 expressed in nonmalignant and tumour-derived breast cells. Cancer Res. 56: 4578-4581
17. Thakur S, Zhang HB, Peng Y, Le H, Carroll B, Ward T, Yao J, Farid LM, Couch FJ, Wilson RB and Weber BL. (1997) Localization of BRCA1 and a splice variant identifies the nuclear localization signal. Mol. Cell. Biol. 17: 444-452
18. Wilson CA, Payton MN, Elliot GS, Buaas FW, Cajulis EE, Groshaans D, Ramos L, Reese DM, Slamon DJ and Calzone FJ (1997) Differential subcellular localisation, expression and biological toxicity of BRCA1 and the splice variant BRCA 1-Δ 11b. Oncogene 14: 1-16
19. Saurin AJ, Borden KL, Boddy MN and Freemont PS (1996) Does this have a familiar RING? Trends Biochem. Sci. 21: 208-214
20. Wu LC, Wang ZW, Tsan JT, Spillman MA, Phung A, Xu XL, Yang M-CW, Hwang L-Y, Bowcock AM and Baer R (1996) Identification of a RING protein that can interact in vivo with the BRCA1 gene product. Nat. Genet. 14: 430-440
21. Chapman MS and Verma IM (1996) Transcriptional activation by BRCA1. Nature 382: 678-679
22. Monteiro A, August A and Hanafusa H (1996) Evidence for a transcriptional activation function of BRCA1 C-terminal region. Proc. Natl. Acad. Sci. USA 93: 13595-13599
23. Milner J, Ponder B, Hughes-Davies L, Seltmann M and Kouzarides T (1997) Transcriptional activation functions in BRCA2. Nature 386: 772-773
24. Holt JT, Thompson ME, Szabo C, Robinson-Benion C, Arteaga CL, King MC and Jensen RA (1997) Transcriptional activation functions in BRCA2. Nature 386: 772-773
25. Hu YF, Hao ZL and Li R (1999) Chromatin remodelling and activation of chromosomal DNA replication by an acidic transcriptional activation domain from BRCA1. Genes Dev. 13: 637-642
26. Yarden RI and Brody LC (1999) BRCA1 interacts with components of the histone deacetylase complex. Proc. Natl. Acad. Sci. USA 96: 4983-4988
27. Scully R, Anderson SF, Chao DM, Wei W, Ye L, Young RA, Livingston DM and Parvin JD (1997) BRCA1 is a component of the RNA polymerase II holoenzyme. Proc. Natl. Acad. Sci. USA 94: 5605-5610
28. Anderson SF, Schlegel BP, Nakajima T, Wolpin ES and Parvin JD (1998) BRCA1 protein is linked to the RNA polymerase II holoenzyme comples via RNA helicase A. Nat. Genet. 19: 254-256
29. Gowen LC, Avrutskaya AV, Latour AM, Koller BH and Leadon SA (1998) BRCA1 required for transcription-coupled repair of oxidative DNA damage. Science 281: 1009-1012
30. Abbott DW, Thompson ME, Robinson-Benion C, Tomlinson G, Jensen RA and Holt JT (1999) BRCA1 expression restores radiation resistance in BRCA1-defective cancer cells through enhancement of transcription-coupled DBA repair. J Biol. Chem. 274: 18808-18812
31. Scully R, Chen J, Plug A, Xiao Y, Weaver D, Feunteun J, Ashley T and Livingston D (1997) Association of BRCA1 with Rad51 in mitotic and meiotic cells. Cell 88: 265-275
32. Scully R, Chen J, Ochs RL, Keegan K, Hoekstra M, Feunteun J and Livingston DM (1997) Dynamic changes of BRCA1 subnuclear location and phophorylation state are initiated by DNA damage. Cell 90: 425-435
33. Zhong Q, Chen CF, Li S, Chen Y, Wang CC, Xiao J, Chen PL, Sharp ZD and Lee WH (1999) Association of BRCA1 with the hRad50-hMre11 -p95 complex and the DNA damage response. Science 285: 747-750
34. Chen JJ, Silver D, Cantor S, Livingston DM and Scully R (1999) BRCA1, BRCA2 and Rad51 operate in a common DNA damage response pathway. Cancer Res. 59 (Suppl.): 1752s-1756s
35. Edelmann W and Kucherlapati R (1996) Role of recombination enzymes in mammalian cell survival. Proc. Natl. Acad. Sci. USA 93: 6225-6227
36. Hsu LC and White RL (1998) BRCA1 is associated with the centrosome during mitosis. Proc. Natl. Acad. Sci. USA 95: 12983-12988
37. Marquis ST, Rajan JV, Wynshaw-Boris A, Xu J, Yin G-Y, Abel KJ, Weber BL and Chodosh LA (1995) The developmental pattern of Brcal expression implies a role in differentiation of the breast and other tissues. Nat. Genet. 11: 17-26
38. Ludwig T, Chapman DL, Papaioannou VE and Efstratiadis A (1997) Targeted mutation of breast cancer susceptibility gene homologues in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53 and Brca2/p53 nullizygous embryos. Genes Dev. 11: 1226-1241
39. Rajan JV, Marquis ST, Gardner HP and Chodosh LA (1997) Developmental expression of Brca2 colocalizes with Brca1 and is associated with proliferation and differentiation in multiple tissues. Dev. Biol. 184: 385-401
40. Gowen LC, Johnson BL, Latour AM, Sulik KK and Koller BH (1996) Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities. Nat. Genet. 12: 191-194
41. Hakem R, de la Pompa JL, Sirard C, Mo R, Woo M, Hakem A, Wakeham A, Potter J, Reitmar A, Billia F, Firpo E, Hui CC, Roberts J, Rossant J and Mak TW (1996) The tumour suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse. Cell 85: 1009-1023
42. Liu C-Y, Flesken-Nikitin A, Li S, Zeng Y and Lee W-H (1996) Inactivation of the mouse Brca1 gene leads to failure in the morphogenesis of the egg cylinder in early postimplantation development. Genes Dev. 10: 1835-1843
43. Suzuki A, de la Pompa JL, Hakem R, Elia A, Yoshida R, Mo R, Nishina H, Chuang T, Wakeham A, Itie A, Koo W, Billia P, Ho A, Fukumoto M, Hui CC and Mak TW (1997) Brca2 is required for embryonic cellular proliferation in the mouse. Genes. Dev. 11: 1242-1252
44. Lane TF, Deng C, Elson A, Lyu M, Kozak CA and Leder P (1995) Expression of Brca1 is associated with terminal differentiation of ectodermally and mesodermally derived tissue in mice. Nat. Genet. 9: 2712-2722
45. Thompson ME, Jensen RA, Obermiller PS, Page DL and Holt JT (1996) Decreased expression of BRCA1 accelerates growth and is often present during sporadic breast cancer progression. Nat. Genet. 9: 444-450
46. Holt JT, Thompson ME, Szabo C, Robinson-Benion C, Arteaga CL, King MC and Jensen RA (1996) Growth retardation and tumour inhibition by BRCA1 Nat. Genet. 12: 298-302
47. Rajan JV, Wang M, Marquis ST and Chodosh LA (1996) Brca2 is coordinately regulated with Brca1 during proliferation and differentiation in mammary epithelial cells. Proc. Natl. Acad. Sci. USA 93: 13078-13083
48. Vaughn JP, Cirisano FD, Huper G, Berchuck A, Futreal AP, Marks JR and Iglehart JD (1996) Cell cycle control of BRCA2. Cancer Res. 56: 4590-4594
49. Vaughn JP, Davis PL, Jarboe MD, Huper G, Evans AC, Wiseman RW, Berchuck A, Iglehart JD, Futreal AP and Marks JR (1996) BRCA1 expression is induced before DNA synthesis in both normal and tumour-derived breast cells. Cell Growth Differ. 7: 711-715
50. Edwards PA, Hiby SE, Papkoff J and Bradbury JM (1992) Hyperplasia of mouse mammary epithelium induced by expression of the Wnt-1(int-1) oncogene in reconstituted mammary gland. Oncogene 7: 2041-2051
51. Knight CH and Peaker M (1982) Mammary cell proliferation in mice during pregnancy and lactation in relation to milk yield. Q. J. Exp. Physiol. 67: 165-177
52. Strange R, Li F, Saurer S, Burkhardt A and Friis RR (1992) Apoptotic cell death and tissue remodelling during mouse mammary gland involution. Development 115: 49-58
53. Talhouk RS. Bissell MJ and Werb Z (1992) Coordinated expression of extracellular matrix-degrading proteins and their inhibitors regulates mammary epithelial function during involution. J. Cell Biol. 118: 1271-1282
54. Robinson GW, McKnight RA, Smith GH and Henighausen L (1995) Mammary epithelial cells undergo secretory differentiation in cycling virgins but require pregnancy for the establishment of terminal differentiation. Development 121: 2079-2090
55. Streuli CH, Edwards GM, Delcomenne M, Whitelaw BA, Burdon TG, Schindler C and Watson CJ (1995) Stat5 as a target for regulation by extracellular matrix. J. Biol. Chem. 270: 21639-21644
56. Pullan S, Wilson J, Metcalfe A, Edwards GM, Goberdhan N, Tilly J, Hickman JA, Dive C, Streuli CH (1996) Requirement of basement membrane for the suppression of programmed cell death in mammary epithelium. J. Cell Sci. 109: 631-642
57. Furlong EEM, Keon NK, Thornton F, Rein T and Martin F (1996) Expression of a 74 kD NF-1 protein is induced in mouse mammary gland involution. Involution enhanced occupation of a twin NF-1 binding element in the TRPM-2/clusterin promoter. J. Biol. Chem. 271: 29688-29697
58. Finlay D, Healy V, Furlong F, O'Connell FC, Keon NK and Martin F (2000) MAP kinase pathway signalling is essential for extracellular matrix determined mammary epithelial cell survival. Cell Death Differ. in press
59. Streuli CH, Bailey N and Bissell MJ (1991) Control of mammary epithelial differentiation: basement membrane induces tissue-specific gene expression in the absence of cell-cell interaction and morphological polarity. J. Cell Biol. 115: 1383-1395
60. Streuli CH, Schmidhauser C, Bailey N, Yurchenco P, Skubitz AP, Roskelley C and Bissell MJ (1995b) Laminin mediates tissue-specific gene expression in mammary epithelia. J. Cell Biol. 129: 591-603
61. Farrelly N, Lee YJ, Oliver J, Dive C and Streuli CH (1999) Extracellular matrix regulates Apoptosis in mammary epithelium through a control on insulin signaling. J. Cell Biol. 144: 1337-1348
62. Williams JM and Daniel CW (1983) Mammary ductal elongation: differentiation of myoepithelium and basal lamina during branching morphogenesis. Dev. Biol. 97: 274-290
63. Humphreys RC, Krajewska M, Krnacik S, Jaeger R, Weiher H, Krajewski S, Reed, JC and Rosen JM (1996) Apoptosis in the terminal endbud of the murine mammary gland: a mechanism of ductal morphogenesis. Development 122: 4013-4022
64. Xu X, Wagner K-U, Larson D, Weaver Z, Li C, Ried T, Hennighausen L, Wynshaw-Boris A and Deng C-X (1999) Conditional mutat on of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation. Nat. Genet. 22: 37-43
65. Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y and Greenberg ME (1997) Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91: 231-241
66. Gajewski TF and Thompson CB (1996) Apoptosis meets signal transduct on: elimination of a BAD influence. Cell 87: 589-592
67. Khwaja A, Rodriguez-Viciana P, Wennstrom S, Warne PH and Downward J (1997) Matrix adhesion and Ras transformation both activate a pnosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway. EMBO J. 16: 2783-2793
68. Roskelley CD, Desprez PY and Bissell MJ (1994) Extracellular matrix-dependent tissue-specific gene expression in mammary epithel al cells requires both physical and biochemical signal transduction. Proc. Natl. Acad. Sci. USA 91: 12378-12382
69. Schmidhauser C, Casperson GF, Myers CA, Sanzo KT, Bollen S and Bissell MJ (1992) A novel transcriptional enhancer is involved in the prolactin- and extracellular matrix-dependent regulation of beta-casein gene expression. Mol. Biol. Cell 3: 699-709
70. Myers CA, Schmidhauser C, Mellentin-Michelotti J, Fragoso G, Roskelley CD, Casperson G, Mossi R, Pujuguet P, Hager G and Bissel MJ (1998) Characterization of BCE-1, a transcriptional enhancer regulaled by prolactin and extracellular matrix and modulated by the state of histone acetylation. Mol. Cell. Biol. 18: 2184-2195
71. Streuli CH, Schmidhauser C, Kobrin M, Bissell MJ and Derynck R (1993) Extracellular matrix regulates expression of the TGF-beta 1 gene. J. Cell Biol. 120: 253-260
72. Marti A, Jehn B, Costello E, Keon N, Ke G, Martin F and Jagg R (1994) AP-1 (cFos/JunD) is induced during apoptosis of mouse mammary epithelial cells. Oncogene 9: 1213-1223
73. Marti A, Feng Z, Jehn B, Djonov V, Chicaiza G, Altermatt H and Jaggi R (1995) Expression and activity of cell cycle regulators during proliferation and programmed death in the mammary gland. Cell Death Differ. 2: 277-283
74. Barcellos-Hoff MH, Aggeler J, Ram, TG and Bissell MJ (1989) Functional differentiation and alveolar morphogenesis of primary mammary cultures on reconstituted basement membrane. Development 105: 223-235
75. Streuli CH and Bissell MJ (1990) Expression of extracellular matrix components is regulated by substratum. J. Cell Biol. 110: 1405-1415
76. Gavrieli Y, Sherman Y and Ben-Sasson SA (1992) Identification of programmed cell death in situ via specific labelling of nuclear DNA fragmentation. J. Cell Biol. 119: 493-501
77. Chomczynski P and Sacchi N (1987) Single-step method of RNA solation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162: 156-159
78. Hathaway HJ and Shur BD (1996) Mammary gland morphogenesis is inhibited in transgenic mice that overexpress cell surface β 1,4-galactosyltransferase. Development 122: 2859-2872
79. Siegel PM, Dankort DL, Hardy WR and Muller WJ (1994) Novel activating mutations in the neu proto-oncogene involved in induction of mammary tumors. Mol. Cell. Biol. 14: 7068-7077