The role of leukotrienes in the regulation of tone and responsiveness in isolated human airways

American Journal of Respiratory and Critical Care Medicine

Volumn 161, Issue 2 II, 2000, Pages

  Schmidt, Dunja ^a   Rabe, Klaus F ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

HISTAMINE; INDOMETACIN; LEUKOTRIENE C4; LEUKOTRIENE D4; LEUKOTRIENE E4; MEPYRAMINE; N [1 (4 BENZYLOXYPHENYL)ETHYL]ACETOHYDROXAMIC ACID; PEPTIDOLEUKOTRIENE; POBILUKAST; PROTEIN KINASE C; THROMBOCYTE ACTIVATING FACTOR; ZILEUTON;

ALLERGIC REACTION; BRONCHODILATATION; BRONCHOSPASM; BRONCHUS REACTIVITY; BRONCHUS TONE; CONTROLLED STUDY; ENZYME INHIBITION; EOSINOPHIL; HUMAN; HUMAN TISSUE; PRIORITY JOURNAL; REGULATORY MECHANISM; RESPIRATORY EPITHELIUM; REVIEW;

EID: 0034058488     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.161.supplement_1.ltta-13     Document Type: Review

References (61)

1. Hawkins, D. F., and H. O. Schild. 1951. The action of drugs on isolated human bronchial chains. Br. J. Pharmacol. 6:682-690.
2. Schild, H., D. F. Hawkins, J. L. Mongar, and H. Herxheimer. 1951. Reactions of isolated human asthmatic lung and bronchial tissue to a specific antigen. Lancet ii:376-382.
3. Goldie, R. G., J. W. Patterson, D. Spina, and J. L. Wale. 1984. Classification of β-adrenoceptors in human isolated bronchus. Br. J. Pharmacol. 81:611-615.
4. Rabe, K. F., H. Tenor, G. Dent, C. Schudt, S. Liebig, and H. Magnussen. 1993. Phosphodiesterase isozymes modulating inherent tone in human airways: identification and characterization. Am. J. Physiol. 264:L458-L464.
5. Ellis, J. L., and B. J. Undem. 1994. Role of cysteinyl-leukotrienes and histamine in mediating intrinsic tone in isolated human bronchi. Am. J. Respir. Crit. Care Med. 149:118-122.
6. Watson, N., H. Magnussen, and K. F. Rabe. 1997. Inherent tone of human bronchus: role of eicosanoids and the epithelium. Br. J. Pharmacol. 121:1099-1104.
7. Peters, S. P., D. W. MacGlashan, Jr., E. S. Schulman, R. P. Schleimer, E. Hayes, J. Rokach, N. F. Adkinson, Jr., and L. M. Lichtenstein. 1984. Arachidonic acid metabolism in purified human lung mast cells. J. Immunol. 132:1972-1979.
8. Schleimer, R. P., D. W. MacGlashan, Jr., S. P. Peters, R. N. Pinckard, N. F. Adkinson, Jr., and L. M. Lichtenstein. 1986. Characterisation of inflammatory mediator release from purified human lung mast cells. Am. Rev. Respir. Dis. 133:614-617.
9. Dahlén, S.-E., P. Hedqvist, S. Hammarström, and B. Samuelsson. 1980. Leukotrienes are potent constrictors of human bronchi. Nature (London) 288:484-486.
10. 4 on isolated human airway smooth muscle. Can. J. Physiol. Pharmacol. 60:638-643.
11. Gorenne, I., X. Norel, and C. Brink. 1996. Cysteinyl-leukotriene receptors in the human lung: what's new? Trends Pharmacol. Sci. 17:342-345.
12. 4 in normal and asthmatic subjects. Am. Rev. Respir. Dis. 135:333-337.
13. 4 in healthy volunteers. Rinsho Iyaku 9:209-216.
14. 4 induced bronchoconstriction in subjects with asthma: a concentration effect study of ICI 204,219. Clin. Pharmacol. Ther. 54:430-436.
15. Pounsford, J. C., M. J. Birch, and K. B. Saunders. 1985. Effect of bronchodilators on the cough response to inhaled citric acid in normal and asthmatic subjects. Thorax 40:662-667.
16. Santamaria, J., S. Guillemi, S. Osborne, C. Coppin, R. Dahlby, and P. D. Pare. 1987. Site of bronchodilation with inhaled ipratropium bromide and fenoterol in normal subjects. Chest 91:86-90.
17. 4 in asthmatics. Pulm. Pharmacol. 4:37-42.
18. 4 receptor antagonist ICI204,219. Am. Rev. Respir. Dis. 141:988-992.
19. 4) receptor antagonist (MK-571) in patients with asthma. Am. Rev. Respir. Dis. 146:358-363.
20. Hui, K. P., and N. C. Barnes. 1991. Lung function improvement in asthma with a cysteinyl-leukotriene receptor antagonist. Lancet 337: 1062-1063.
21. Liu, M., and M. I. Simon. 1996. Regulation by cAMP-dependent protein kinease of a G-protein-mediated phospholipase C. Nature (London) 382:83-87.
22. Reiss, T. F., C. A. Sorkness, W. Stricker, A. Botto, W. W. Busse, S. Kundu, and J. Zhang. 1997. Effects of montelukast (MK-0476), a potent cysteinyl leukotriene receptor antagonist, on bronchodilation in asthmatic subjects treated with and without inhaled corticosteroids. Thorax 52:45-48.
23. Barnes, P. J., and I. M. Adcock. 1997. NF-KB: a pivotal role in asthma and a new target for therapy. Trends Pharmacol. Sci. 18:46-50.
24. McGill, K. A., and W. W. Busse. 1996. Zileuton. Lancet 348:519-524.
25. Coleman, R. A., A. T. Nials, K. E. Sheldrick, and R. L. G. Sheldrick. 1986. A novel and versatile superfusion system: a replacement for the organ bath? Br. J. Pharmacol. 88:408P.
26. Coleman, R. A., and A. T. Nials. 1989. Novel and versatile superfusion system: its use in the evaluation of some spasmogenic and spasmolytic agents using guinea-pig isolated tracheal smooth muscle. J. Pharmacol. Methods 21:71-86.
27. Watson, N., H. Magnussen, and K. F. Rabe. 1998. The relevance of resting tension to responsiveness and inherent tone of human bronchial smooth muscle. Br. J. Pharmacol. 123:694-700.
28. Rabe, K. F., N. M. Muñoz, A. J. Vita, B. E. Morton, H. Magnussen, and A. R. Leff. 1994. Contraction of human bronchial smooth muscle caused by activated human eosinophils. Am. J. Physiol. 267:L326-L334.
29. Galens, S., N. M. Muñoz, K. F. Rabe, A. Herrenreiter, D. Mayer, B. Morton, K. McAllister, and A.R. Leff. 1995. Assessment of agonist-and cell-mediated response in airway microsections by computerized video micrometry. Am. J. Physiol. 268:L519-L525.
30. Ruehlmann, E., N. Watson, N. M. Muñoz, G. Dent, A. R. Leff, H. Magnussen, and K. F. Rabe. 1997. Assessment of agonist responses in human bronchus by videomicrometry: role of epithelium (abstract). Am. J. Respir. Crit. Care Med. 155:A127.
31. Dunlop, L. S., and A. P. Smith. 1975. Reduction of antigen-induced contraction of sensitized human bronchus in vitro by indomethacin. Br. J. Pharmacol. 54:495-497.
32. Watson, N., K. Bodtke, R. A. Coleman, G. Dent, B. E. Morton, E. Rühlmann, H. Magnussen, and K. F. Rabe. 1997. Role of IgE in hyperresponsiveness induced by passive sensitization of human airways. Am. J. Respir. Crit. Care Med. 155:839-844.
33. Coleman, R. A., A. T. Nials, K. F. Rabe, C. J. Vardey, and N. Watson. 1996. Isolated, electrically-stimulated airway preparations: their use in determining β-adrenoceptor agonist activity. Pulm. Pharmacol. 9:107-111.
34. Farmer, B., D. G. Farrar, and J. Wilson. 1972. A new preparation of the isolated intact tracheal smooth muscle of the guinea-pig. Br. J. Pharmacol. 46:536-537.
35. Orehek, J., J. S. Douglas, and A. Bouhuys. 1975. Contractile responses of the guinea-pig trachea in vitro: modification by prostaglandin synthesis inhibiting drugs. J. Pharmacol. Exp. Ther. 194:554-564.
36. Nials, A. T., R. A. Coleman, M. Johnson, H. Magnussen, K. F. Rabe, and C. J. Vardey. 1993. Effects of β-adrenoceptor agonists in human bronchial smooth muscle. Br. J. Pharmacol. 110:1112-1116.
37. de Jongste, J. C., H. Mons, I. L. Bonta, and K. F. Kerebijn. 1989. Relaxation of human peripheral airway smooth muscle in vitro does not correlate with severity of chronic airflow limitation in vivo. Pulm. Pharmacol. 2:75-79.
38. Brink, C., C. Grimaud, C. Guillof, and J. Orehek. 1980. The interaction between indomethacin and contractile agents on human isolated airway muscle. Br. J. Pharmacol. 69:383-388.
39. 4) synthesis and chemotaxis of human eosinophils from normal and atopic subjects. Br. J. Pharmacol. 118:1727-1735.
40. Belvisi, M. G., M. A. Saunders, E.-B. Haddad, S. J. Hirst, M. H. Yacoub, P. J. Barnes, and J. A. Mitchell. 1997. Induction of cyclo-oxygenase-2 by cytokines in human cultured airway smooth muscle cells: novel inflammatory role of this cell type. Br. J. Pharmacol. 120:910-916.
41. Pang, L., A. J. Knox. 1997. PGE2 release by bradykinin in human airway smooth muscle cells: involvement of cyclooxygenase-2 induction. Am. J. Physiol. 273(6, Pt. 1):L1132-L1140.
42. Matsumoto, T., C. D. Funk, O. Rådmark, J. Hoog, H. Jornvall, and B. Samuelsson. 1989. Molecular cloning and amino acid sequence of human 5-lipoxygenase. Adv. Prostaglandin Thromboxane Leukotriene Res. 19:466-469.
43. 4 synthase and preparation of a polyclonal antibody. Am. J. Respir. Crit. Care Med. 152:283-289.
44. Davis, C., T. R. Jones, and E. E. Daniel. 1982. Studies of the mechanism of passive anaphylaxis in human airway smooth muscle. Can. J. Physiol. Pharmacol. 61:705-713.
45. 4. Eur. J. Pharmacol. 125:29-35.
46. 2-adrenoceptor agonists on anti-IgE-induced contraction and smooth muscle reactivity in human airways. Br. J. Pharmacol. 114:935-940.
47. 4. Eur. Respir. J. 14:315-319.
48. Muñoz, N. M., K. F. Rabe, S. P. Neeley, A. Herrenreiter, C. Zhu, K. McAllister, D. Mayer, H. Magnussen, S. Galens, and A. R. Leff. 1996. Eosinopohil VLA-4 binding to fibronectin augments bronchial narrowing through 5-lipoxygenase activation. Am. J. Physiol. 270:L587-L594.
49. Dent, G., N. M. Muñoz, E. Ruehlmann, X. Zhu, A. R. Leff, H. Magnussen, and K. F. Rabe. 1998. Protein kinase C inhibition enhances platelet-activating factor-induced eicosanoid production in human eosinophils. Am. J. Respir. Cell Mol. Biol. 18:136-144.
50. 2+, protein kinase C and phospholipases C and D. Biochem. J. 310:795-806.
51. 4 synthase in bronchial biopsies from patients with aspirin-intolerant asthma. J. Clin. Invest. 101:834-846.
52. 4. Proc Natl. Acad. Sci. U.S.A. 80:1712-1716.
53. Roquet, A., B. Dahlén, M. Kumlin, E. Ihre, G. Anstren, S. Binks, and S. E. Dahlen. 1997. Combined antagonism of leukotrienes and histamine produces predominant inhibition of allergen-induced early and late phase airway obstruction in asthmatics. Am. J. Respir. Crit. Care Med. 155:1856-1863.
54. Björck, T., and S.-E. Dahlén. 1993. Leukotrienes and histamine mediate IgE-dependent contractions of human bronchi: pharmacological evidence obtained with tissues from asthmatic and nonasthmatic subjects. Pulm. Pharmacol. 6:87-96.
55. Polosa, R., and S. T. Holgate. 1997. Adenosine bronchoprovocation: a promising marker of allergic inflammation in asthma? Thorax 52:919-923.
56. Björck, T., L. E. Gustafsson, and S. E. Dahlén. 1992. Isolated bronchi from asthmatics are hyperresponsive to adenosine, which apparently acts indirectly by liberation of leukotrienes and histamine. Am. Rev. Respir. Dis. 145:1087-1091.
57. Black, J. L., R. Marthan, C. L. Armour, and P. R. A. Johnson. 1989. Sensitization alters contractile responses and calcium influx in human airway smooth muscle. J. Allergy Clin. Immunol. 84:440-447.
58. Marthan, R., H. Crevel, H. Guenard, and J. P. Savineau. 1992. Responsiveness to histamine in human sensitized airway smooth muscle. Respir. Physiol. 90:239-250.
59. Ben-Jebria, A., R. Marthan, M. Rossetti, and J.-P. Savineau. 1993. Effect of passive sensitization on the mechanical activity of human isolated bronchial smooth muscle induced by substance P, neurokinin A and VIP. Br. J. Pharmacol. 109:131-136.
60. Rabe, K. F., N. Watson, G. Dent, B. E. Morton, K. Wagner, H. Magnussen, and C. H. Heusser. 1998. Inhibition of human airway sensitization by a novel monoclonal anti-IgE antibody, 17-9. Am. J. Respir. Crit. Care Med. 157:1429-1435.
61. 4. methacholine and histamine in normal and asthmatic subjects. Eur. Respir. J. 1:913-917.