Effects of montelukast (MK-0476), a potent cysteinyl leukotriene receptor antagonist, on bronchodilation in asthmatic subjects treated with and without inhaled corticosteroids

Thorax

Volumn 52, Issue 1, 1997, Pages 45-48

  Reiss, Theodore F ^a   Sorkness, Christine A ^b   Stricker, William ^c   Botto, Albert ^a   Busse, William W ^b   Kundu, Sudeep ^a   Zhang, Ji ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^c Clinical Research of the Ozarks   (United States)

Author keywords

bronchodilation; cysteinyl leukotriene receptor antagonist; montelukast (MK 0476)

Indexed keywords

BECLOMETASONE DIPROPIONATE; CORTICOSTEROID; LEUKOTRIENE RECEPTOR; LEUKOTRIENE RECEPTOR BLOCKING AGENT; MONTELUKAST; PLACEBO; SALBUTAMOL; THEOPHYLLINE; TRIAMCINOLONE;

ADULT; AIRWAY OBSTRUCTION; ARTICLE; ASTHMA; BRONCHODILATATION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; FEMALE; FORCED EXPIRATORY VOLUME; HUMAN; INHALATIONAL DRUG ADMINISTRATION; MALE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

EID: 0031024694     PISSN: 00406376     EISSN: None     Source Type: Journal    
DOI: 10.1136/thx.52.1.45     Document Type: Article

References (10)

1. Manning PJ, Watson RM; Margolskee DJ, Williams V, Schwartz J, O'Byrne PM. Inhibition of exercise-induced bronchoconstriction by MK-571, a potent leukotriene D4-receptor antagonist. N Engl J Med 1990;323:1736-9.
2. 4-receptor antagonist improves pulmonary function in patients with mild, chronic asthma. Am Rev Respir Dis 1989;140:1336-9.
3. 4) receptor antagonist (MK-571) in patients with asthma. Am Rev Respir Dis 1992;146:358-63.
4. 4 antagonist, MK-679. Am Rev Respir Dis 1993;147:1442-6.
5. Hui KP, Barnes NC. Lung function improvement in asthmatics with a cysteinyl-leukotriene receptor antagonist. Lancet 1991;337:1062-3.
6. 1 receptor antagonist. Can J Phys Pharm 1995;73:191-201.
7. Shapiro S, Wilk W. An analysis of variance test for normality (complete samples). Biometrika 1965;52:591-611.
8. Levene H. Robust test for equality of variances contributions to probability and statistics standard. Palo Alto, California: Stanford University Press, 1960:278-92.
9. Hong SL, Levine L. Inhibition of arachidonic acid release from cells as the biochemical action of anti-inflammatory corticosteroids. Proc Natl Acad Sci USA 1976;73:1730-4.
10. Dworski R, Fitzgerald GA, Oayr JA, Sheller JL. Effect of oral prednisone on airways inflammatory mediators in atopic disease. Am J Respir Crit Care Med 1994;149:953-9.