Combined antagonism of leukotrienes and histamine produces predominant inhibition of allergen-induced early and late phase airway obstruction in asthmatics

American Journal of Respiratory and Critical Care Medicine

Volumn 155, Issue 6, 1997, Pages 1856-1863

  Roquet, Annika ^b   Dahlén, Barbro ^b   Kumlin, Maria ^b   Ihre, Elisabeth ^b   Anstrén, Gudrun ^b   Binks, Sue ^b   Dahlén, Sven Erik ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTIHISTAMINIC AGENT; HISTAMINE; LEUKOTRIENE; LEUKOTRIENE RECEPTOR BLOCKING AGENT; LORATADINE; ZAFIRLUKAST;

ADULT; AIRWAY OBSTRUCTION; ARTICLE; ASTHMA; BRONCHUS REACTIVITY; CLINICAL ARTICLE; DRUG EFFECT; FEMALE; HISTAMINE RELEASE; HUMAN; MALE; PRIORITY JOURNAL;

EID: 0030944646     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.155.6.9196086     Document Type: Article

References (35)

1. Barnes, P. J., K. F. Chung, and C. P. Page. 1988. Inflammatory mediators and asthma. Pharm. Rev. 40:49-84.
2. Holgate, S. T., and J. P. Finnerty. 1989. Antihistamines in asthma. J. Allergy Clin. Immunol. 83:537-547.
3. Bousquet, J., P. Godard, and F. B. Michel. 1992. Antihistamines in the treatment of asthma. Eur. Respir. J. 5:1137-1142.
4. 2- and allergen-induced bronchoconstriction. J. Appl. Physiol. 66:1685-1693.
5. Freitag, A., R. M. Watson, G. Matsos, C. Eastwood, and P. M. O'Byrne. 1993. Effect of a platelet activating factor antagonist, WEB 2086, on allergen induced asthmatic responses. Thorax 48:594-598.
6. Chung, K. F. 1995. Leukotriene receptor antagonists and biosynthesis inhibitors: potential breakthrough in asthma therapy. Eur. Respir. J. 8: 1203-1213.
7. Holgate, S. T., P. Bradding, and A. P. Sampson. 1996. Leukotriene antagonists and synthesis inhibitors: new directions in asthma therapy. J. Allergy Clin. Immunol. 98:1-13.
8. Samuelsson, B., S.-E. Dahlén, J. Å. Lindgren, C. A. Rouzer, and C. N. Serhan. 1987. Leukotrienes and lipoxins: structures, biosynthesis, and biological effects. Science 237:1171-1176.
9. Buckner, C. K., J. S. Fedyna, J. L. Robertson, J. A. Will, D. M. England, R. D. Krell, and R. Saban. 1990. An examination of the influence of the epithelium on contractile responses to peptidoleukotrienes and blockade by ICI 204,219 in isolated guinea pig trachea and human intralobar airways. J. Pharm. Exp. Ther. 252:77-85.
10. Taylor, I. K., K. M. O'Shaughnessy, R. W. Fuller, and C. T. Dollery. 1991. Effect of cysteinyl-leukotriene receptor antagonist ICI 204,219 on allergen-induced bronchoconstriction and airway hyperreactivity in atopic subjects. Lancet 337:690-694.
11. Friedman, B. S., E. H. Bel, A. Buntinx, W. Tanaka, Y. H. R. Han, S. Shingo, R. Spector, and P. Sterk. 1993. Oral leukotriene inhibitor (MK-886) blocks allergen-induced airway responses. Am. Rev. Respir. Dis. 147:839-844.
12. Hui, K. P., I. K. Taylor, G. W. Taylor, P. Rubin, J. Kesterson, N. C. Barnes, and P. J. Barnes. 1991. Effect of a 5-lipoxygenase inhibitor on leukotriene generation and airway responses after allergen challenge in asthmatic patients. Thorax 46:184-189.
13. 4 receptor antagonist ICI 204,219 given by inhaled route inhibits early but not the late phase of allergen-induced bronchoconstriction. Am. Rev. Respir. Dis. 147:1425-1430.
14. Krell, R. D., D. Aharony, C. K. Buckner, R. A. Keith, E. J. Kusner, and D. W. Snyder. 1990. The preclinical pharmacology of ICI-204,219, a peptide leukotriene antagonist. Am. Rev. Respir. Dis. 141:978-987.
15. 4-induced bronchoconstriction in subjects with asthma: a concentration-effect study of ICI 204,219. Clin. Pharmacol. Ther. 54:430-436.
16. Clissold, S. P., E. M. Sorkin, and K. L. Goa. 1989. Loratadine: a preliminary review of its pharmacodynamic properties and therapeutical efficacy. Drugs 37:42-57.
17. Town, G. I., and S. T. Holgate. 1990. Comparison of the effect of loratadine on the airway and skin responses to histamine, methacholine, and allergen in subjects with asthma. J. Allergy Clin. Immunol. 86:886-893.
18. Björck, T., and S.-E. Dahlén. 1993. Leukotrienes and histamine mediate IgE-dependent contractions of human bronchi: pharmacological evidence obtained with tissues from asthmatic and non-asthmatic subjects. Pulmonary Pharmacology 6:87-96.
19. Dahlén, B., T. Björck, O. Zetterström, and S.-E. Dahlén. 1994. The leukotriene-antagonist ICI-204,219 inhibits allergen-induced airway obstruction in asthmatics. Eur. Respir. J. 7:324-331.
20. 4 in human urine. Clin. Exp. Allergy 25:467-479.
21. Snedecor, G. W., and W. G. Cochran. 1967. Statistical Methods, 6th ed. Iowa State University Press, Ames.
22. Bland, J. M., and D. G. Altman. 1986. Statistical methods for assessing agreement between two methods of clinical measurements. Lancet ii:307-310.
23. 4 receptor antagonist. N. Engl. J. Med. 323:1736-1739.
24. Israel, E., R. Dermarkarian, M. Rosenberg, R. Sperling, G. Taylor, and J. M. Drazen. 1990. The effects of a 5-lipoxygenase inhibitor of asthma induced by cold, dry air. N. Engl. J. Med. 323:1740-1744.
25. Dahlén, B., M. Kumlin, D. J. Margolskee, C. Larsson, H. Blomqvist, V. C. Williams, O. Zetterström, and S.-E. Dahlén. 1993. The leukotriene-receptor antagonist MK-0679 blocks airway obstruction induced by inhaled lysine-aspirin in aspirin-sensitive asthmatics. Eur. Respir. J. 6:1018-1026.
26. Israel, E., A. R. Fischer, M. A. Rosenberg, C. M. Lilly, J. C. Callery, J. Shapiro, J. Cohn, P. Rubin, and J. M. Drazen. 1993. The pivotal role of 5-lipoxygenase products in the reaction of aspirin-sensitive asthmatics to aspirin. Am. Rev. Respir. Dis. 148:1447-1451.
27. 4 causes granulocyte infiltration into asthmatic airways. Lancet 341:989-990.
28. Roquet, A., J. Raud, G. Halldén, M. van Hage-Hamsten, J. Hed, L.-O. Hansson, O. Zetterström, and R. Grönneberg. 1995. Effects of loratadine on anti-IgE-induced inflammation, histamine release, and leukocyte recruitment in skin of atopies. Allergy 50:414-420.
29. 1-receptor antihistamines in the airways and skin of subjects with asthma. J. Allergy Clin. Immunol. 91:1005-1014.
30. 1-receptor antagonist, terfenadine, on antigen-induced asthma. Br. J. Dis. Chest. 80:375-384.
31. 1 antihistamine, on the early and late allergic reactions in a bronchial provocation test with allergen. J. Allergy Clin. Immunol. 91:1189-1197.
32. Godard, P., and J. Bousquet. 1993. Modulation of eicosanoid and histamine release from human dispersed lung cells by terfenadine. Allergy 48:125-129.
33. 4-induced bronchoconstriction in patients with atopic asthma. J. Allergy Clin. Immunol. 87:1010-1013.
34. Inman, M. D., R. Watson, D. W. Cockroft, B. J. Wong, F. E. Hargreave, and P. M. O'Byrne. 1995. Reproducibility of allergen-induced early and late asthmatic responses. J. Allergy Clin. Immunol. 95:1191-1195.
35. 4-receptor antagonist, ICI 204,219, relieves symptoms of acute seasonal allergic rhinitis. Am. J. Respir. Crit. Care Med. 151:1734-1737.