The relevance of resting tension to responsiveness and inherent tone of human bronchial smooth muscle

British Journal of Pharmacology

Volumn 123, Issue 4, 1998, Pages 694-700

  Watson, N ^a,b   Magnussen, H ^a   Rabe, K F ^a  

^a KRANKENHAUS GROSSHANSDORF   (Germany)

^b ROCHE BIOSCIENCE   (United States)

Author keywords

5 lipoxygenase inhibition; Carbachol; Electrical field stimulation; Human bronchial smooth muscle; Isoprenaline

Indexed keywords

BRONCHODILATING AGENT; CARBACHOL; DRUG DERIVATIVE; HYDROXYUREA; ISOPRENALINE; LIPOXYGENASE INHIBITOR; ZILEUTON;

ADULT; AGED; ARTICLE; BRONCHUS; DRUG EFFECT; ELECTROSTIMULATION; HUMAN; IN VITRO STUDY; MIDDLE AGED; MUSCLE TONE; PHYSIOLOGY; SMOOTH MUSCLE;

ADULT; AGED; AGED, 80 AND OVER; BRONCHI; BRONCHODILATOR AGENTS; CARBACHOL; ELECTRIC STIMULATION; HUMANS; HYDROXYUREA; ISOPROTERENOL; LIPOXYGENASE INHIBITORS; MIDDLE AGED; MUSCLE TONUS; MUSCLE, SMOOTH;

EID: 0031988873     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701637     Document Type: Article

References (15)

1. BARNES, P.J. (1989). Neuronal control of airways in health and disease. Am. Rev. Respir. Dis., 134, 1289 - 1314.
2. BARNES, P.J., BARANIUK, J.N. & BELVISI, M.G. (1991). Neuropeptides in the respiratory tract. Am. Rev. Respir. Dis., 144, 1187 - 1198.
3. CARTER, G.W., YOUNG, P.R., ALBERT, D.H., BOUSKA, J., DYER, R., BELL, R.L., SUMMERS, J.B. & BROOKS, D.W. (1991). 5-lipoxygenase inhibitory activity of zileuton. J. Pharmacol. Exp. Ther., 256, 929 - 237.
4. COLEMAN, R.A., NIALS, A.T., RABE, K.F., VARDEY, C.J. & WATSON, N. (1996). Isolated, electrically-stimulaled airway preparations their use in determining β-adrenoceptor agonist activity. Pulm. Pharmacol., 9, 107 - 117.
5. ELLIS, J.L. & UNDEM, B.J. (1994). Role of cysteinyl-leukotrienes and histamine in mediating intrinsic tone in isolated human bronchi. Am. J. Respir. Crit. Care Med., 149, 118 - 121.
6. FINNEY, M.J.B., KARLSSON, J.-A. & PERSSON, C.G.A. (1985). Effect of bronehoconstrictors and bronchodilators on a novel human small airway preparations. Br. J. Pharmacol., 85, 29 - 36.
7. HULSMANN, A.R., & DE JONGSTE, J.C. (1993). Studies of human airways in vitro: A review of the methodology. J. Pharmacol. Toxicol. Methods. 30, 117 - 132.
8. LAITINEN, A. (1985). Autonomic innervation of the human respiratory tract as revealed by histochemical and ultrastructural methods. Eur. J. Respir. Dis., 66 (Suppl. 140) 7 - 42.
9. MOLIMARD, M., MARTIN, C.A.E., NALINE, E., HIRSCH, A. & ADVENIER, C. (1994). Contractile effects of bradykinin on the isolated human small bronchus. Am. J. Respir. Crit. Care Med., 149, 123 - 127.
10. RABE, K.F., TENOR, H., DENT, G., SCHUDT, C., LIEBIG, S. & MAGNUSSEN, H. (1993). Functional and biochemical characterization of PDE isoenzymes effecting relaxation of inherent tone in human peripheral airways. Am. J. Physiol., 246, L458 - 462.
11. STEPHENS, N.L. & VAN NIEKERK, W. (1977). Isometric and isotonic contractions in airway smooth muscle. Can. J. Physiol. Pharmacol., 5 5, 833 - 838.
12. STRETTON, C.D., MAK, J.C.W., BELVISI, M.G., YACOUB, M.H. & BARNES, P.J. (1990). Cholinergic control of human airways in vitro following extrinsic denervation of human respiratory tract by heart-lung transplant. Am. Rev. Respir. Dis., 142, 1030 - 1033.
13. WARD, J., BELVISI, M.G., FOX, A.J., MIURA, M., TADJKARIMI, S., YACOUB, M.H. & BARNKS, P.J. (1993). Modulation of cholinergic neural bronchoconstriction by endogenous nitric oxide and vasoactive intestinal peplide in human airways in vitro. J. Clin. Invest., 92, 736 - 742.
14. WATSON, N., MAGNUSSEN, H. & RABE, K.F. (1995). Pharmacological characterization of the muscarinic receptor subtype mediating contraction of human peripheral airways. J. Pharmacol. Exp. Ther., 274, 1293 - 1297.
15. WATSON, N., MAGNUSSEN, H. & RABE, K.F. (1996). The influence of resting tension on inherent tone and responsiveness of human bronchial smooth muscle in vitro. Am. J Respir. Crit. Care Med. 153, A742.