Protein kinase C inhibition enhances platelet-activating factor-induced eicosanoid production in human eosinophils

American Journal of Respiratory Cell and Molecular Biology

Volumn 18, Issue 1, 1998, Pages 136-144

  Dent, Gordon ^a   Muñoz, Nilda M ^b   Rühlmann, Elke ^b   Zhu, Xiangdong ^b   Leff, Alan R ^b   Magnussen, Helgo ^b   Rabe, Klaus F ^b  

^a KRANKENHAUS GROSSHANSDORF   (Germany)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONIC ACID; BISINDOLYLMALEIMIDE; CALCIUM; CALPHOSTIN C; CATALASE; ENZYME INHIBITOR; ICOSANOID; INDOLE DERIVATIVE; LEUKOTRIENE C4; MALEIMIDE DERIVATIVE; NAPHTHALENE DERIVATIVE; PHORBOL 13 ACETATE 12 MYRISTATE; PHORBOL DIBUTYRATE; PROTEIN KINASE C; SUPEROXIDE; THROMBOCYTE ACTIVATING FACTOR; THROMBOXANE B2;

ARTICLE; BIOSYNTHESIS; DRUG ANTAGONISM; DRUG EFFECT; EOSINOPHIL; FEMALE; HUMAN; MALE; METABOLISM; PHYSIOLOGY; RESPIRATORY BURST;

ARACHIDONIC ACID; CALCIUM; CATALASE; EICOSANOIDS; ENZYME INHIBITORS; EOSINOPHILS; FEMALE; HUMANS; INDOLES; LEUKOTRIENE C4; MALE; MALEIMIDES; NAPHTHALENES; PHORBOL 12,13-DIBUTYRATE; PLATELET ACTIVATING FACTOR; PROTEIN KINASE C; RESPIRATORY BURST; SUPEROXIDES; TETRADECANOYLPHORBOL ACETATE; THROMBOXANE B2;

EID: 0031600155     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/ajrcmb.18.1.2817     Document Type: Article

References (28)

1. Hamann, K. J. 1996. Inflammatory cells in airways. In Pulmonary and Critical Care Pharmacology and Therapeutics. A. R. Leff, editor. McGraw-Hill, New York. 355-369.
2. Rabe, K. F., N. M. Muñoz, A. J. Vita, B. E. Morton, H. Magnussen, and A. R. Leff. 1994. Contraction of human bronchial smooth muscle caused by activated human eosinophils. Am. J. Physiol. 267:L326-L334.
3. Yukawa, T., R. C. Read, C. Kroegel, A. Rutman, K. F. Chung, R. Wilson, P. J. Cole, and P. J. Barnes. 1990. The effects of activated eosinophils and neutrophils on guinea pig airway epithelium in vitro. Am. J. Respir. Cell Mol. Biol. 2:341-353.
4. 2+, protein kinase C and phospholipases C and D. Biochem. J. 310:795-806.
5. Kroegel, C., M. A. Giembycz, H. Matthys, J. Westwick, and P. J. Barnes. 1994. Modulatory role of protein kinase C on the signal transduction pathway utilized by platelet-activating factor in eosinophil activation. Am. J. Respir. Cell Mol. Biol. 11:593-599.
6. Toullee, D., P. Pianetti, H. Coste, P. Bellevergue, T. Grand-Perret, M. Ajakane, V. Baudet, P. Boissin, E. Boursier, F. Loriolle, L. Duhamel, D. Charon, and J. Kirilovsky. 1991. The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. J. Biol. Chem. 266: 15771-15781.
7. Jacobson, P. B., S. L. Kuchera, A. Metz, C. Schächtele, K. Imre, and D. J. Schrier. 1995. Anti-inflammatory properties of Gö 6850: a selective inhibitor of protein kinase C. J. Pharmacol. Exp. Ther. 275:995-1002.
8. 2 and E-series prostaglandins. J. Immunol. 144:3489-3497.
9. Böyum, A. 1968. Isolation of mononuclear cells and granulocytes from human blood: isolation of mononuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g. Scand. J. Clin. Lab. Invest. Suppl. 97:77-89.
10. Hansel, T. T., I. J. M. de Vries, T. Iff, S. Rih, M. Wandzilak, S. Betz, K. Blaser, and C. Walker. 1991. An improved immunomagnetic procedure for the isolation of highly purified human blood eosinophils. J. Immunol. Methods 145:105-110.
11. 4. Proc. Natl. Acad. Sci. USA 80:7626-7630.
12. 2 and histamine activate human eosinophils. J. Immunol. 148:3536-3542.
13. Mahoney, C. W., and K.-P. Huang. 1994. Molecular and catalytic properties of protein kinase C. In Protein Kinase C. J. F. Kuo, editor. Oxford University Press, New York, 16-63.
14. Davis, P. D., C. H. Hill, G. Lawton, J. S. Nixon, S. E. Wilkinson, S. A. Hurst, E. Keech, and S. E. Turner. 1992. Inhibitors of protein kinase C, L 2,3-bisarylmaleimides. J. Med. Chem. 35:177-184.
15. Kobayashi, E., H. Nakano, M. Morimoto, and T. Tamaoki. 1989. Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C. Biochem. Biophys. Res. Commun. 159:548-553.
16. 4) synthesis and chemotaxis of human eosinophils from normal and atopic subjects. Br. J. Pharmacol. 118:1727-1735.
17. Evans, D. J., M. A. Lindsay, B. J. O'Connor, and P. J. Barnes. 1996. Increased expression and activity of PKCζ following LAR to allergen challenge. Am. J. Respir. Crit. Care Med. 153:A57. (Abstr.)
18. Shukla, S. D. 1992. Platelet-activating factor receptor and signal transduction mechanisms. FASEB J. 6:2296-2301.
19. 2 in mouse spleen and the macrophage cell line J774: purification, substrate interaction and phosphorylation by protein kinase C. Eur. J. Biochem. 202:873-880.
20. 2 by p42 microtubule-associated protein 2 kinase and protein kinase C. J. Biol. Chem. 268:1960-1964.
21. Lambeth, J. D. 1994. Receptor-regulated phospholipases and their generation of lipid mediators, which activate protein kinase C. In Protein Kinase C. J. F. Kuo, editor. Oxford University Press, New York, 121-170.
22. Chao, W., H. Liu, D. J. Hanahan, and M. S. Olson. 1990. Regulation of platelet-activating factor receptor and PAF receptor-mediated arachidonic acid release by protein kinase C activation in rat Kupffer cells. Arch. Biochem. Biophys. 282:188-197.
23. Avdonin, P. V., I. V. Svitina-Ulitina, and V.A. Tkachuk. 1989. Selective inactivation by endogenous protein kinase C of human platelet high-affinity GTPase coupled with PAF receptors. J. Mol. Cell. Cardiol. 21(Suppl. 1): 139-143.
24. 4 and platelet-activating factor and the responses they induce in neutrophils: site of action. Proc. Natl. Acad. Sci. USA 86: 5791-5794.
25. O'Flaherty, J. T., D. P. Jacobson, and J. F. Redman. 1989. Bidirectional effects of protein kinase C activators: studies with human neutrophils and platelet-activating factor. J. Biol. Chem. 264:6836-6843.
26. Muller, S., and S. Nigam. 1992. Arachidonic acid release and platelet-activating factor formation by staurosporine in human neutrophils challenged with N-formyl peptide. Eur. J. Pharmacol. 218:251-258.
27. 4 synthase activity and attenuates cysteinyl leukotriene production in an eosinophilic substrain of HL-60 cells. J. Immunol. 153:776-788.
28. van der Bruggen, T., P. T. Kok, M. Blom, A. J. Verhoeven, J. A. M. Raaijmakers, J.-W. J. Lammers, and L. Koenderman. 1993. Transient exposure of human eosinophils to the protein kinase C inhibitors CGP39-360, CGP41-251 and CGP44-800 leads to priming of the respiratory burst induced by opsonized particles. J. Leuk. Biol. 54:552-557.