Isolated, electrically-stimulated airway preparations: Their use in determining p-adrenoceptor agonist activity

Pulmonary Pharmacology

Volumn 9, Issue 2, 1996, Pages 107-117

  Coleman, R A ^a,c   Nials, A T ^a   Rabe, K F ^b   Vardey, C J ^a   Watson, N ^b  

^a GLAXOSMITHKLINE   (United Kingdom)

^b KRANKENHAUS GROSSHANSDORF   (Germany)

^c Pharmagene Laboratories Ltd   (United Kingdom)

Author keywords

Agonist; Cat trachea; Electrical stimulation; Guinea pig trachea; Human broncus; Inherent tone; adrenoceptor

Indexed keywords

ARACHIDONATE 5 LIPOXYGENASE; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; INDOMETACIN; ISOPRENALINE; PROSTAGLANDIN SYNTHASE; ZILEUTON;

ADULT; AGED; AIRWAY; AIRWAY CONSTRICTION; ANIMAL TISSUE; ARTICLE; BRONCHUS; CAT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENCY; ELECTROSTIMULATION; ENZYME INHIBITION; FEMALE; GUINEA PIG; HUMAN; HUMAN TISSUE; MALE; NONHUMAN; PRIORITY JOURNAL; SMOOTH MUSCLE RELAXATION; SMOOTH MUSCLE TONE; TRACHEA;

EID: 0030128737     PISSN: 09520600     EISSN: None     Source Type: Journal    
DOI: 10.1006/pulp.1996.0012     Document Type: Article

References (27)

1. 1. Castillo J C, DeBeer E J. The tracheal chain: a preparation for the study of antispasmodic drugs with particular reference to bronchodilator drugs. J Pharmac Exp Ther 1947; 90: 104-109.
2. 2. Akcasu A. The physiological and pharmacological characteristics of the tracheal muscle. Arch Int Pharmacodyn Ther 1959; 122: 201-207.
3. 3. Farmer J B, Farrar D G, Wilson J. A new preparation of the isolated intact tracheal smooth muscle of the guinea-pig. Br J Pharmacol 1972; 46: 536-537P.
4. 4. Goldie R G, Patterson J W, Spina D, Wale J L. Classification of β-adrenoceptors in human isolated bronchus. Br J Pharmacol 1984; 81: 611-615.
5. 5. Ito Y, Suzuki H, Aizawa H, Itakoda H, Hirose T. The spontaneous electrical and mechanical activity of human bronchial smooth muscle: its modulation by drugs. Br J Pharmacol 1989; 98: 1249-1260.
6. 6. O'Donnell S R. β-Adrenoceptor classification in the respiratory tract. In: Kalsner S, ed. Trends in Autonomic Pharmacology. London: Taylor & Francis Press, 1985: 1-13.
7. 7. Coleman R A, Niais A T. The characterization and use of the electrically-stimulated guinea-pig tracheal strip preparation. Br J Pharmacol 1986; 88: 409P.
8. 8. Coleman R A, Niais A T. Novel and versatile superfusion system: its use in the evaluation of some spasmogenic and spasmolytic agents using guinea-pig isolated tracheal smooth muscle. J Pharmacol Methods 1989; 21: 71-86.
9. 9. Coburn R F, Tomita T. Evidence for nonadrenergic inhibitory nerves in the guinea-pig trachealis muscle. Am J Physiol 1973; 222: 1072-1080.
10. 10. Coleman R A. Methods in prostanoid receptor classification. In: Kalsner S, ed. Trends in Autonomic Pharmacology. London: Taylor & Francis Press, 1985: 35-50.
11. 11. Coleman R A, Niais A T, Sheldrick K E, Sheldrick R L G. A novel and versatile superfusion system: a replacement for the organ bath? Br J Pharmacol 1986; 88: 408P.
12. 2-adrenoceptor agonist: characterisation of pharmacological activity in vitro and in vivo. Br J Pharmacol 1991; 104: 665-671.
13. 13. Orehek J, Douglas J S, Bouhuys A. Contractile responses of the guinea-pig trachea in vitro. Modification by prostaglandin synthesis inhibiting drugs. J Pharmacol Exp Ther 1975; 194: 554-564.
14. 14. Coleman R A, Levy G P. A non-adrenergic inhibitory nervous pathway in guinea-pig trachea. Br J Pharmacol 1974; 52: 167-174.
15. 3H]-acetylcholine release from isolated rat and guinea-pig trachea: role of the airway mucosa and prostaglandins. Br J Pharmacol 1994; 113: 1221-1230.
16. 3-adrenoceptors mediate prejunctional inhibition of non-adrenergic non-cholinergic contraction of guinea-pig main bronchi. Eur J Pharmacol 1995; 275: 199-206.
17. 17. Shore S, Collier B, Martin J G. Effect of endogenous prostaglandins on acetylcholine release from dog trachealis muscle. J Appl Physiol 1987; 62: 1837-1844.
18. 18. Chung K F, Evans T W, Graf P D, Nadel J A. Modulation of cholinergic neurotransmission in canine airways by thromboxane mimetic U46619. Eur J Pharmacol 1985; 117: 373-375.
19. 2 production. Br J Pharmacol 1988; 95: 300-308.
20. 2 and the epithelium. J Pharmacol Exp Ther 1987; 243: 356-363.
21. 21. Main I H M. The inhibitory actions of prostaglandins on respiratory smooth muscle. Br J Pharmacol 1964; 22: 511-519.
22. 22. Lulich K M, Mitchell H W, Sparrow M P. The cat lung strip as an in vitro preparation of peripheral airways: a comparison of β-adrenoceptor agonists, autacoids and anaphylactic challenge on the lung strip and trachea. Br J Pharmacol 1976; 58: 71-79.
23. 23. Apperley G H, Coleman R A, Kennedy I, Levy G P. The cat isolated trachea, a useful preparation for the study of the smooth muscle relaxant actions of prostaglandins. Br J Pharmacol 1979; 67: 412-413P.
24. 24. Chideckel E W, Frost J L, Pamela M, Fedan J S. The effect of ouabain on tension in isolated respiratory tract smooth muscle of humans and other species. Br J Pharmacol 1987; 92: 609-614.
25. 25. Davis C, Kannan M S, Jones T R, Daniel E E. Control of human airways smooth muscle: in vitro studies. J Appl Physiol 1982; 52: 1080-1087.
26. 26. Ellis J L, Undem B J. Role of cysteinyl leukotrienes and histamine in mediating intrinsic tone in isolated human bronchi. Am J Respir Crit Care Med 1994; 149: 118-122.
27. 27. Brink C, Grimaud C, Guillof C, Orehek J. The interaction between indomethacin and contractile agents on human isolated airway muscle. Br J Pharmacol 1980; 69: 383-388.