Inherent tone of human bronchus: Role of eicosanoids and the epithelium

British Journal of Pharmacology

Volumn 121, Issue 6, 1997, Pages 1099-1104

  Watson, N ^a,b   Magnussen, H ^a   Rabe, K F ^a  

^a KRANKENHAUS GROSSHANSDORF   (Germany)

^b ROCHE BIOSCIENCE   (United States)

Author keywords

5 Lipoxygenase inhibition; Bronchial epithelium; Cyclo oxygenase inhibition; Human bronchial smooth muscle

Indexed keywords

ARACHIDONATE 5 LIPOXYGENASE; ARACHIDONIC ACID; ICOSANOID; INDOMETACIN; PROSTAGLANDIN SYNTHASE; ZILEUTON;

ADULT; AGED; AIRWAY; ARTICLE; BRONCHUS MUCOSA; BRONCHUS MUSCLE; CLINICAL ARTICLE; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN TISSUE; MALE; METABOLITE; PRIORITY JOURNAL; SHUNTING; SMOOTH MUSCLE TONE; SPECIES DIFFERENCE;

ADULT; AGED; BRONCHI; CARBACHOL; CYCLOOXYGENASE INHIBITORS; EICOSANOIDS; EPITHELIUM; FEMALE; HUMANS; HYDROXYUREA; INDOMETHACIN; LIPOXYGENASE INHIBITORS; MALE; MIDDLE AGED; MUSCLE TONUS;

EID: 0030737890     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701244     Document Type: Article

References (22)

1. BRADDING, P., REDINGTON, A.E., DJUKANOVIC, R., CONRAD, D.C. & HOLGATE, S.T. (1995). 15-Lipoxygenase immunoreactivity in normal and in asthmatic airways. Am. J. Respir. Crit. Care Med., 151, 1201-1204.
2. BRINK, C., GRIMAUD, C., GUILLOT, C. & OREHEK, J. (1980). The interaction between indomethacin and contractile agents on human isolated airway muscle. Br. J. Pharmacol., 69, 383-388.
3. BUTLER, G.B., ADLER, B.K.B., EVANS, J.A., MORGAN, D.W. & SZAREK, J.L. (1987). Modulation of rabbit airway smooth muscle responsiveness by respiratory epithelium; Involvement of an inhibitory metabolite of arachidonic acid. Am. Rev. Respir. Dis., 135, 1099-1104.
4. CHURCHILL, L., CHILTON, F.H., RESAU, J.H., BASCOM, R., HUBBARD, W.C. & PROUD, D. (1989). Cyclooxygenase metabolism of endogenous arachidonic acid by cultured human tracheal epithelial cells. Am. Rev. Respir. Dis., 140, 449-459.
5. COLEMAN, R.A., NIALS, A.T., RABE, K.F., VARDEY, C.J. & WATSON, N. (1996). Isolated, electrically-stimulated airway preparations - their use in determining β-adrenoceptor agonist activity. Pulm. Pharmacol., 9, 107-117.
6. ELLIS, J.L. & UNDEM, B.J. (1994). Role of cysteinyl-leukotrienes and histamine in mediating intrinsic tone in isolated human bronchi. Am. J. Respir. Crit. Care Med., 149, 118-121.
7. FLAVAHAN, N.A., AARHUS, L.L., RIMELE, T.J. & VANHOUTTE, P.M. (1985). Respiratory epithelium inhibits bronchial smooth muscle tone. J. Appl. Physiol., 58, 834-838.
8. GAO, Y. & VANHOUTTE, P.M. (1994). Epithelium acts as a modulator and a diffusion barrier to responses of canine airway smooth muscle. J. Appl. Physiol., 76, 1843-1847.
9. HALEY, K., SUNDAY, M., REILLY, J., SUGARBAKER, D., METZNER, S., EVANS, J., VICKERS, P. & DRAZEN, J. (1995). Immunolocalization of five lipoxygenase activating protein and five lipoxygenase in normal and asthmatic lung. Am. J. Respir. Crit. Care Med., 151, A677.
10. HUNTER, J.A., FINKBEINER, W.E., NADEL, J.A., GOETZL, E.J. & HOLTZMAN, M.J. (1985). Predominant generation of 15-lipoxygenase metabolites of arachidonic acid by epithelial cells from human trachea. Proc. Natl. Acad. Sci. U.S.A., 82, 4633-4637.
11. HUTAS, I., HADHAZY, P., DEBRECZENI, L. & VIZI, E.S. (1981). Relaxation of human bronchial smooth muscle. Lung, 159, 153-161.
12. ITO, M., BABA, K., TAKAGI, K., SATAKE, T. & TOMITA, T. (1985). Some properties of calcium-induced contraction of the isolated human and guinea-pig tracheal smooth muscle. Respir. Physiol., 59, 143-153.
13. ITO, Y., SUZUKI, H., AIZAWA, H., HAKODA, H. & HIROSE, T. (1989). The spontaneous electrical and mechanical activity of human bronchial smooth muscle: its modulation by drugs. Br. J. Pharmacol., 98, 1249-1260.
14. KUEHL, F.A., DOUGHERTY, H.W. & HAM, E.H. (1984). Interactions between prostaglandins and leukotrienes. Biochem. Pharmacol., 33, 1-5.
15. KUMLIN, M., HAMBERG, M., GRANSTRÖM, E., BJÖRCK, T. DAHLÉN, B., MATSUDA, H., ZETTERSTRÖM, O. & DAHLÉN, S-E. (1990). 15(S)-hydroxyeicosatetraenoic acid is the major arachidonic acid metabolite in human bronchi: Association with airway epithelium. Arch. Biochem. Biophys., 282, 254-262.
16. RABE, K.F., TENOR, H., DENT, G., SCHUDT, C., LIEBIG, S. & MAGNUSSEN, H. (1993). Phosphodiesterase isozymes modulating inherent tone in human airways: identification and characterization. Am. J. Physiol., 246, L458-462.
17. RABE, K.F., DENT, G. & MAGNUSSEN, H. (1995). Hydrogen peroxide contracts human airways in vitro: role of epithelium. Am. J. Physiol., 269, L332-L338.
18. 2) by cultured human bronchial epithelial cells. Am. J. Cell Mol. Biol., 1, 245-250.
19. SALARI, H. & SHELLENBERG, R.R. (1991). Stimulation of human epithelial cells by platelet activating factor (PAF) and arachidonic acid produces 15-hydroxyeicosatetraenoic acid (15-HETE) capable of contracting bronchial smooth muscle. Pulm. Pharmacol., 4, 1-7.
20. STUART-SMITH, K. & VANHOUTTE, P.M. (1988). Arachidonic acid evokes epithelium-dependent relaxations in canine airways. J. Appl. Physiol., 65, 2170-2180.
21. SZCZEKLIK, A. (1990). The cyclooxygenase theory of asprin-induced asthma. Eur. Respir. J., 3, 588-593.
22. WATSON, N., MAGNUSSEN, H. & RABE, K.F. (1995). Nature of inherent tone in human bronchial smooth muscle and its effects on responses to carbachol. Eur. Respir. J., 8, 50s.