Growth factor and bcl-2 mediated survival during abortive proliferation of hybridoma cell line

Biotechnology and Bioengineering

Volumn 57, Issue 2, 1998, Pages 164-171

  Chung, John D ^a,b   Sinskey, Anthony J ^b   Stephanopoulos, Gregory ^a,b  

^a USA   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Abortive proliferation; Apoptosis; bcl 2; Cell culture; Cell death; Cell viability; Growth factors; Hybridomas; Survival factors

Indexed keywords

BATCH CELL CULTURE; FERMENTATION; INSULIN;

ABORTIVE PROLIFERATION; APOPTOSIS; HYBRIDOMAS;

ANIMAL CELL CULTURE;

GROWTH FACTOR; INSULIN; PROTEIN BCL 2;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL DEATH; CELL POPULATION; CELL PROLIFERATION; CELL SURVIVAL; CELL VIABILITY; CULTURE MEDIUM; FERMENTATION; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HYBRIDOMA; NONHUMAN; PROTO ONCOGENE;

ANIMALS; BIOTECHNOLOGY; CELL DIVISION; CELL LINE; CELL SURVIVAL; CULTURE MEDIA, SERUM-FREE; FERMENTATION; GENES, BCL-2; GROWTH SUBSTANCES; HUMANS; HYBRIDOMAS; INSULIN; MODELS, BIOLOGICAL; TRANSFECTION;

ANIMALIA;

EID: 0031973241     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0290(19980120)57:2<164::AID-BIT5>3.0.CO;2-L     Document Type: Article

References (21)

1. Clarke, A. R., Purdie, C. A., Harrison, D. J., Morris, R. G., Bird, C. C., Hooper, M. L., Wyllie, A. H. 1993. Thymocyte apoptosis induced by p53-dependent and independent pathways, Nature 262: 849-851.
2. Deng, G., Podack, E. R. 1993. Suppression of apoptosis in a cytotoxic T-cell line by interleukin 2-mediated gene transcription and deregulated expression of the proto-oncogene bcl-2. Proc. Natl. Acad. Sci. 90: 2189-2193.
3. Evans, G. I., Wyllie, A. H., Gilbert, C. S., Littlewood, T. D., Land, H., Brooks, M., Waters, C. M., Penn, L. Z., Hancock, D. C. 1992. Induction of apoptosis in fibroblasts by c-myc protein. Cell 69: 119-128.
4. Hall, P. A., McKee, P. H., Menage, H. P., Dover, R., Lane, D. P. 1993. High level of p53 protein in UV-irradiated normal human skin. Oncogene 8: 203-207.
5. Itoh, Y., Ueda, H., Suzuki, E. 1995. Overexpression of bcl-2, apoptosis suppressing gene: Prolonged viable culture period of hybridoma and enhanced antibody production, Biotechnol. Bioeng. 48: 118-122.
6. Kelly, K., Cochran, B. H., Stiles, C. D., Leder, P. 1983. Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor. Cell 35: 603-610.
7. Korsmeyer, S. J. 1992. Bcl-2: An antidote to programmed cell death. Cancer Surveys 15: 105-118.
8. Lowe, S. W., Schmitt, E. M, Smith, S. W., Osborne, B. A., Jacks, T. 1993. p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature 362: 847-849.
9. Miyashita, T., Reed, J. C. 1993. Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line. Blood 81: 151-157.
10. Miyashita, T., Krajewski, S., Krajewska, M., Wang, H. G., Lin, H. K., Liebermann, D. A., Hoffman, B., Reed, J. C. 1994. Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Oncogene 9: 1799-1805.
11. Murray, K., Ang, C., Gull, K., Hikman, J. A., Dickson, A. J. 1996. NSO myeloma cell death: Influence of bcl-2 overexpression. Biotechnol. Bioeng. 51: 298-304.
12. Nunez, G., London, L., Hockenbery, D., Alexander, M., McKearn, J. P., Korsmeyer, S. J. 1990. Deregulated bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines. J. Immunol. 144: 3602-3610.
13. Oltavi, Z. N., Milliman, C. L., Korsmeyer, S. J. 1993. Bcl-2 heterodimerizes in vivo with a conserve homolog, Bax, that accelerates programmed cell death. Cell 74: 609-619.
14. Otani, H., Erdos, M., Leonard, W. J. 1993. Tyrosine kinase(s) regulate apoptosis and bcl-2 expression in a growth factor-dependent cell line. J. Biol. Chem. 268: 22733-22736.
15. Pettersson, M., Jernberg-Wiklund, H., Sundstrom, C., Givol, I., Tsujimoto, Y., Nilsson, K. 1992. Expression of the bcl-2 gene human multiple myeloma cell lines and normal plasma cells. Blood 79: 495-502.
16. Renner, W. A., Lee, K. H., Hatzimanikatis, V., Bailey, J. E., Eppenberger, H. M. 1995. Recombinant cyclin E expression activates proliferation and obviates surface attachment of Chinese hamster ovary (CHO) cells in protein-free medium. Biotechnol. Bioeng. 47: 476-482.
17. Shepard, J. S., Pettengill, O. S., Wurster-Hill, D. H., Sorenson, G. D. 1978. A specific chromosome breakpoint associated with mouse plasmacytomas. J. Natl. Cancer Inst. 61: 225-257.
18. Vaux, D. L., Cory, S., Adams, J. M. 1988. Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature 335: 440-442.
19. Walton, M. L, Whysong, D., O'Connor, P. M., Hockenbery, D., Korsmeyer, S. J., Kohn, K. W. 1993. Constitutive expression of human bcl-2 modulates nitrogen mustard and camptothecin induced apoptosis. Cancer Res. 53: 1853-1861.
20. Waters, C. M., Littlewood, T. D., Hancock, D. C., Moore, J. P., Evans, G. I. 1991. c-Myc protein expression in untransformed fibroblasts. Oncogene 6: 797-805.
21. Xie, L., Wang, D. I. C. 1994. Applications of improved stoichiometric model in medium design and fed-batch cultivation of animal cells in bioreactors. Cytotechnology 15: 17-29.