Telomeres and HIV disease

Microbes and Infection

Volumn 2, Issue 1, 2000, Pages 69-76

  Effros, Rita B ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

HIV disease; Replicative senescence; T cells; Telomeres

Indexed keywords

ANTIVIRAL ACTIVITY; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; PATHOGENESIS; PRIORITY JOURNAL; REVIEW; SENESCENCE; T LYMPHOCYTE; TELOMERE;

HUMAN IMMUNODEFICIENCY VIRUS; RNA VIRUSES;

EID: 0033973680     PISSN: 12864579     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1286-4579(00)00283-5     Document Type: Review

References (78)

1. McClintock B. The behavior of successive nuclear divisions of a chromosome broken at meiosis. Proc. Natl. Acad. Sci. USA. 25:1939;405-416.
2. Watson J.D. Origin of concatemeric T7 DNA. Nature New Biol. 239:1972;197-199.
3. Olovnikov A.M. A theory of marginotomythe incomplete copying of template margin in enzymatic synthesis of polynucleotides and biological significance of the phenomenon. J. Theoret. Biol. 41:1973;181-190.
4. Cohen J. Selling the immune system short. Science. 273:1996;30-31.
5. Blackburn E. Structure and function of telomeres. Nature. 350:1991;569-573.
6. Greider C., Blackburn E. A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis. Nature. 337:1989;331-334.
7. Lundblad V., Szostak J.W. A mutant with a defect in telomere elongation leads to senescence in yeast. Cell. 57:1989;633-643.
8. Vaziri H., Schachter F., Uchida I., et al. Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes. Am. J. Hum. Genet. 52:1993;661-667.
9. Bryant J.E., Hutchings K.G., Moyzis R.K., Griffith J.K. Measurement of telomeric DNA content in human tissues. BioTechniques. 23:1997;276-284.
10. Martens U.M., Zijlmans J.M., Poon S.S., et al. Short telomeres on human chromosome 17p. Nat. Genet. 18:1998;76-80.
11. Murnane J.P., Sabatier L., Marder B.A., Morgan W.F. Telomere dynamics in an immortal human cell line. EMBO J. 13:1994;4953-4962.
12. Lansdorp P.M., Verwoerd N.P., Van DeRijke F.M., et al. Heterogeneity in telomere length of human chromosomes. Hum. Mol. Genet. 5:1996;685-691.
13. Hultdin M., Greonlund E., Norrback K., Eriksson-Lindstreom E., Just T., Roos G. Telomere analysis by fluorescence in situ hybridization and flow cytometry. Nucleic Acids Res. 26:1998;3651-3656.
14. Kim N.W., Piatyszek M.A., Prowse K.R., et al. Specific association of human telomerase activity with immortal cells and cancer. Science. 266:1994;2011-2015.
15. Campisi J., Dimri G., Hara E. Control of replicative senescence. Schneider J.R. Handbook of the Biology of Aging. 1996.
16. Pawelec G., Effros R.B., Caruso C., Remarque E., Barnett Y., Solana R. T cells and aging (update February 1999). Front Biosci. 4:1999;D216-D269.
17. Hayflick L. The limited in vitro lifetime of human diploid cell strains. Exp. Cell. Res. 37:1965;614-636.
18. Smith J.R. Pereira-Smith OM Replicative senescence implications for in vivo aging and tumor suppression. Science. 273:1996;63-66.
19. Bodnar A., Quellette M., Frolkis M., et al. Extension of life-span by introduction of telomerase into normal human cells. Science. 1998;349-352.
20. Jiang X.R., Jimenez G., Chang E., et al. Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype. Nat. Genet. 21:1999;111-114.
21. Allsopp R.C., Vaziri H., Patterson C., Goldstein S., Yougli E.V., Futcher A.B. Telomere length predicts replicative capacity of human fibroblasts. Proc. Natl. Acad. Sci. USA. 89:1992;10114-10118.
22. Harley C., Futcher A.B., Greider C. Telomeres shorten during ageing of human fibroblasts. Nature. 345:1990;458-460.
23. Counter C.M., Hirte H.W., Bacchetti S., Harley C.B. Telomerase activity in human ovarian carcinoma. Proc. Natl. Acad. Sci. USA. 91:1994;2900-2904.
24. Shay J., Wright W. Telomerase activity in human cancer. Curr. Opin. Oncol. 8:1996;66-71.
25. Weng N.P., Levine B.L., June C.H., Hodes R.J. Regulated expression of telomerase activity in human T lymphocyte development and activation. J. Exp. M. 183:1996;2471-2479.
26. Bodnar A.G., Kim N.W., Effros R.B., Chiu C.P. Mechanism of telomerase induction during T cell activation. Exp. Cell. Res. 228:1996;58-64.
27. Effros R.B., Pawelec G. Replicative Senescence of T lymphocytes Does the Hayflick Limit lead to immune exhaustion? Immunol. Today. 18:1997;450-454.
28. Adibzadeh M., Pohla H., Rehbein A., Pawelec G. Long-term culture of monoclonal human T lymphocytes Models for immunosenescence? Mech. Ageing Dev. 83:1995;171-183.
29. Grubeck-Loebenstein B., Lechner H., Trieb K. Long term in vitro growth of human T cell clones can post-mitotic senescent cell populations be defined? Int. Arch. Allergy Immunol. 104:1994;232-239.
30. McCarron M., Osborne Y., Story C., Dempsey J.L., Turner R., Morley A. Effect of age on lymphocyte proliferation. Mech. Ageing Dev. 41:1987;211-218.
31. Weng N.P., Levine B.L., June C.H., Hodes R.J. Human naive and memory T lymphocytes differ in telomere length and replicative potential. Proc. Natl. Acad. Sci. USA. 92:1995;11091-11094.
32. Perillo N.L., Naeim F., Walford R.L., Effros R.B. The in vitro senescence of human lymphocytes failure to divide is not associated with a loss of cytolytic activity or memory T cell phenotype. Mech. Ageing Dev. 67:1993;173-185.
33. Pawelec G., Schneider E.M., Wernet P. Acquisition of suppressive activity and natural killer-like cytotoxicity by human alloproliferative «helper» T cell clones. J. Immunol. 136:1986;402-411.
34. + T cells in centenarians and in long-term T cell cultures a possible cause for both in vivo and in vitro immunosenescence. Exp. Gerontol. 29:1994;601-609.
35. Effros R.B., Zhu X., Walford R.L. Stress response of senescent T lymphocytes reduced hsp70 is independent of the proliferative block. J. Gerontol. 49:1994;B65-B70.
36. + T cells that reach replicative senescence after multiple rounds of antigen-specific proliferation. Exp. Gerontol. 1999.
37. Wang E., Lee M.J., Pandey S. Control of fibroblast senescence and activation of programmed cell death, J. Cell. Biochem. 54:1994;432-439.
38. + turnover. Science. 274:1996;1546-1547.
39. + subset in HIV disease implicate replicative senescence in HIV pathogenesis. AIDS/Fast Track10. 1996;F17-F22.
40. Pommier J.P., Gauthier L., Livartowski J., et al. Immunosenescence in HIV pathogenesis. Virology. 231:1997;148-154.
41. + T cells from HIV-discordant monozygotic twins. J. Exp. M. 185:1997;1381-1386.
42. Wei X., Ghosh S.K., Taylor M.E., et al. Viral dynamics in human immunodeficiency virus type 1 infection. Nature. 373:1995;117-122.
43. Ho D.D., Neumann A.U., Perelson A.S., Chen W., Leonard J.M., Markowitz M. Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature. 373:1995;123-126.
44. Paganin C., Monos D.S., Marshall J.D., Frank I., Trinchieri G. Frequency and cytokine profile of HPRT mutant T cells in HIV-infected and healthy donors implications for T cell proliferation in HIV disease. J. Clin. Invest. 99:1997;663-668.
45. + T lymphocyte turnover in simian immunodeficiency virus-infected macaques. Proc. Natl. Acad. Sci. USA. 95:1998;6388-6393.
46. Mohri H., Bonhoeffer S., Monard S., Perelson A.S., Ho D.D. Rapid turnover of T lymphocytes in SIV-infected rhesus macaques. Science. 279:1998;1223-1227.
47. Hellerstein M.K., McCune J.M. T cell turnover in HIV-1 disease. Immunity. 7:1997;583-589.
48. Douek D.D., McFarland R.D., Keiser P.H.E., et al. Changes in thymic function with age and during the treatment of HIV infection. Nature. 396:1998;690-695.
49. + T cell clonal expansion is associated with telomerase up-regulation and telomere length preservation a mechanism for rescue from replicative senescence. J. Immunol. 162:1999;4521-4526.
50. Brinchmann J.E., Dobloug J.H., Heger B.H., Haaheim L.L., Sannes M., Egeland T. Expression of costimulatory molecule CD28 on T cells in human immunodeficiency virus type 1 infection Functional and clinical correlations. J. Infect. Dis. 169:1994;730-738.
51. + lymphocyte subsets in infants using three-color flow cytometry. Clin. Immunol. Immunopath. 71:1994;8-13.
52. Borthwick N.J., Bofill M., Gombert W.M. Lymphocyte activation in HIV-1 infection II. Functional defects of CD28- T cells. AIDS. 8:1994;431-441.
53. + T cells from HIV-infected persons. J. Immunol. 153:1994;412-420.
54. - T lymphocytes antigenic and functional properties. J. Immunol. 150:1993;1147-1159.
55. + cell levels. J. Infect. Dis. 170:1994;775-781.
56. + cytotoxic T cells express CD38 and HLA-DR antigens. J. Immunol. 150:1993;3070-3079.
57. Carmichael A., Jin X., Sissons P., Borysiewicz L. Quantitative analysis of the human immunodeficiency virus type 1 (HIV-1)-specific cytotoxic T lymphocyte (CTL) response at different stages of HIV-1 infection Differential CTL responses to HIV-1 and Epstein-Barr virus in late disease. J. Exp M. 177:1993;249-256.
58. + T cells in HIV disease following in vitro activation. Schlossman S.F, Boumsell L, Gilks Wea. Leukocyte Typing V White Cell Differentiation Antigens. 1995;446-461 Oxford University Press.
59. + cells that supressesw T cell proliferative responses. J. Immunol. 131:1983;2757-2761.
60. + T cells in respiratory virus infections. J. Immunol. 154:1995;6013-6021.
61. Tough D., Borrow P., Sprent J. Induction of bystander T cell proliferation by viruses and type I interferon in vivo. Science. 272:1996;1947-1950.
62. Altman J.D., Moss P.A.H., Goulder P.J.R., et al. Phenotypic analysis of antigen-specific T lymphocytes. Science. 274:1996;94-96.
63. Boucher N., Defeu-Duchesne T., Vicaut E., Farge D., Effros R.B., Schachter F. CD28 expression in T cell aging and human longevity. Exp. Geronol. 33:1998;267-282.
64. Maryanski J.L., Jongeneel C.V., Bucher P., Casanova J.L. Walker PR Single-cell PCR analysis of TCR repertoires selected by antigen in vivo a high magnitude CD8 response is comprised of very few clones. Immunity. 4:1996;47-55.
65. Kalams S.A., Johnson R.P., Tricha A.K., et al. Longitudinal analysis of T cell receptor (TCR) gene usage by human immunodeficiency virus 1 envelope-specific cytotoxic T lymphocyte clones reveals a limited TCR repertoire. J. Exp. M. 179:1994;1261-1271.
66. Wills M.R., Carmichael A.J., Mynard K., et al. The human cytotoxic T-lymphocyte (CTL) response to cytomegalovirus is dominated by structural protein pp65 frequency, specificity, and T-cell receptor usage of pp65-specific CTL. J. Virol. 70:1996;7569-7579.
67. + T cells during the primary immune response to Epstein-Barr virus In vivo. J. Exp. M. 187:1998;1395-1402.
68. + T cells contain greatly expanded functional virus-specific memory CTL clones. J. Immunol. 162:1999;7569-7577.
69. + cytotoxic T lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection. J. Virol. 68:1994;6103-6110.
70. Koup R.A., Safrit R.T., Cao Y., et al. Temporal association of cellular immue responses with the initial contol of viremia in primary human immunodeficency virus type 1 syndrome. J. Virol. 68:1994.
71. Brodie S.J., Lewinsohn D.A., Patterson B.K., et al. In vivo migration and function of transferred HIV-1-specific cytotoxic T cells [see comments]. Nat. M. 5:1999;34-41.
72. Cao Y., Qin L., Zhang L., Safrit J., Ho D. Virologic and immunologic characterization of long term survivors of human immunodeficeiency virus type 1 infection. N. Eng. J. M. 332:1995;201-208.
73. Goulder P.J., Phillips R.E., Colbert R.A., et al. Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS. Nat. M. 3:1997;212-217.
74. Harrer T., Harrer E., Kalams S.A., et al. Cytotoxic T lymphocytes in asymptomatic long-term nonprogressing HIV-1 infection. Breadth and specificity of the response and relation to in vivo viral quasispecies in a person with prolonged infection and low viral load. J. Immunol. 156:1996;2616-2623.
75. Shimizu Y., VanSeventer G., Ennis E., Newman W., Horgan K., Shaw S. Crosslinking of the T cell-specific accessory moleculesCD7 and CD28 modulates T cell adhesion. J. Exp. M. 175:1992;577-582.
76. + T cells. Eur. J. Immunol. 11:1996;2640-2649.
77. Rocha B., Dautigny N., Pereira P. Peripheral T lymphocytes Expansion potential and homeostatic regulation of pool sizes and CD4/CD8 ratios in vivo. Eur. J. Immunol. 19:1989;905-911.
78. Vignoli M., Stecca B., Furlini G., et al. Impaired telomerase activity in uninfected haematopoietic progenitors in HIV-1-infected patients. AIDS. 12:1998;999-1005.