Salicylate attenuates gentamicin-induced ototoxicity

Laboratory Investigation

Volumn 79, Issue 7, 1999, Pages 807-813

  Sha, Su Hua ^a   Schacht, Jochen ^a  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENTAMICIN; SALICYLATE SODIUM;

ACOUSTIC NERVE FIBER; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG INDUCED DISEASE; DRUG SAFETY; GUINEA PIG; HEARING LOSS; MALE; NONHUMAN; OTOTOXICITY; PRIORITY JOURNAL;

ADMINISTRATION, ORAL; ANIMALS; ANTIOXIDANTS; AUDITORY THRESHOLD; COCHLEA; EVOKED POTENTIALS, AUDITORY, BRAIN STEM; GENTAMICINS; GUINEA PIGS; IRON CHELATING AGENTS; MALE; MICROBIAL SENSITIVITY TESTS; SALICYLIC ACID;

EID: 0032765253     PISSN: 00236837     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Basile AS, Huang JM, Xie C, Webster D, Berlin C, and Skolnick P (1996). N-methyl-D-aspartate antagonists limit aminoglycoside antibiotic-induced hearing loss. Nat Med 12:1338-1343.
2. Bergamo RR, Cominelli F, Kopple JD, and Zipser RD (1989). Comparative acute effects of aspirin, diflunisal, ibuprofen and indomethacin on renal function in healthy man. Am J Nephrol 9:460-463.
3. Bernstein JM and Weiss AD (1967). Further observations on salicylate ototoxicity. J Laryngol Otol 81:915-925.
4. Clerici WJ, Hensley K, DiMartino DL, and Butterfield DA (1996). Direct detection of ototoxicant-induced reactive oxygen species generation in cochlear explants. Hear Res 98:116-124.
5. Clive DM and Stoff JS (1984). Renal syndromes associated with nonsteroidal antiinflammatory drugs. N Engl J Med 310:563-372.
6. Conlon BJ and Smith DW (1998). Attenuation of neomycin ototoxicity by iron chelation. Laryngoscope 108:284-287.
7. Dinis TC, Maderia VM, and Almeida LM (1994). Action of phenolic derivatives (acetaminophen, salicylate, and 5-aminosalicylate) as inhibitors of membrane lipidperoxidation and as peroxyl radical scavengers. Arch Biochem Biophys 315:161-169.
8. Dulon D, Aurousseau C, Erre JP, and Aran JM (1988). Relationship between the nephrotoxicity and ototoxicity induced by gentamicin in the guinea pig. Acta Otolaryngol 106:219-225.
9. Farinelli SE and Greene LA (1996). Cell cycle blockers mimosine, ciclopirox, and deferoxamine prevent the death of PC12 cells and postmitotic sympathetic neurons after removal of trophic support. J Neurosci 16:1150-1162.
10. Fu DM (1985). Survey of 1583 deaf mutes. Qinghai Med J 1:22-23.
11. Garetz SL and Schacht J (1996). Ototoxicity: Of Mice and Men. In: Clinical aspects of hearing. Van De Water TR, Popper AN, Fay RR, editors. New York: Springer Verlag, 116-154.
12. Ghiselli A, Laurenti O, De Mattia G, Maiani G, and Ferro-Luzzi A (1992). Salicylate hydroxylation as an early marker of in vivo oxidative stress in diabetic patients. Free Radio Biol Med 13:621-626.
13. Hirose K, Hockenbery DM, and Rubel EW (1997). Reactive oxygen species in chick hair cells after gentamicin exposure in vitro. Hear Res 104:1-14.
14. Jastreboff PJ and Sasaki CT (1994). An animal model of tinnitus: a decade of development. Am J Otol 15:19-27.
15. Kanno H, Yamanobe S, and Rybak LP (1995). The ototoxicity of deferoxamine mesylate. Am J Otolaryngol 16:148-152.
16. Lautermann J, McLaren J, and Schacht J (1995). Glutathione protection against gentamicin ototoxicity depends on nutritional status. Hear Res 86:15-24.
17. Lu YF (1987). Cause of 611 deaf mutes in schools for deaf children in Shanghai. Shanghai Med J 10:159.
18. Moore RD, Smith CR, and Lietman PS (1994). Risk factors for the development of auditory toxicity in patients receiving aminoglycosides. J Infect Dis 149:23-30.
19. Neubert D (1998). Significance of pharmacokinetic variables in reproductive and developmental toxicity. Xenobiotica 18(Suppl. 1):45-58.
20. O'Connell MJ and Webster NR (1990). Hyperoxia and salicylate metabolism in rats. J Pharm Pharmacol 42:205-206.
21. Olin BR, Hebel SK, Dombek CE, and Kastrup EK (1994). Drug facts and comparisons. St. Louis: Wolters Kluwers, 1192-1195.
22. Perneger TV, Whelton PK, and Klag MJ (1994). Risk of kidney failure associated with the use of acetaminophen, aspirin, and nonsteroidal antiinflammatory drugs. N Engl J Med 331:1675-1679.
23. Peterson CM, Graziano JH, Grady RW, Jones RL, Markenson A, Lavi U, Canale V, Gray GF, Cerami A, and Miller DR (1979). Chelation therapy in beta-thalassemia major: a one-year double blind study of 2:3-dihydroxybenzoic acid. Exp Hematol 7:74-80.
24. Pierson MG and Møller AR (1981). Prophylaxis of kanamycin-induced ototoxicity by a radioprotectant. Hear Res 4:79-81.
25. Powell SR (1994). Salicylate trapping of OH as a tool for studying post-ischemic oxidative injury in the isolated rat heart. Free Rad Res 21:355-370.
26. Priuska EM and Schacht J (1995). Formation of free radicals by gentamicin and iron and evidence for an iron/gentamicin complex. Biochem Pharmacol 50:1749-1752.
27. Priuska EM, Clark K, Pecoraro V, and Schacht J (1998). NMR spectra of iron-gentamicin complexes and the implications for aminoglycoside toxicity. Inorg Chim Acta 273:85-91.
28. Raphael Y and Altschuler RA (1991). Scar formation after drug-induced cochlear insult. Hear Res 51:173-183.
29. Ryals B, Westbrook E, and Schacht J (1997). Morphological evidence of ototoxicity of the iron chelator deferoxamine. Hear Res 112:44-48.
30. Schnellmann RG (1998). Analgesic nephropathy in rodents. J Toxicol Env Health Part B 1:81-90.
31. Sha SH and Schacht J (1999a). Formation of reactive oxygen species following bioactivation of gentamicin. Free Rad Biol Med 26:341-347.
32. Sha SH and Schacht J (1999b). Stimulation of free radical formation by aminoglycoside antibiotics. Hear Res 128:112-118.
33. Song BB and Schacht J (1996). Variable efficacy of radical scavengers and iron chelators to attenuate gentamicin ototoxicity in guinea pig in vivo. Hear Res 94:87-93.
34. Song BB, Anderson DJ, and Schacht J (1997). Protection from gentamicin ototoxicity by iron chelators in guinea pig in vivo. J Pharmacol Exp Ther 282:369-377.
35. Song BB, Sha SH, and Schacht J (1998). Iron chelators protect from aminoglycoside-induced cochleo- and vestibulotoxicity in guinea pig. Free Rad Biol Med 25:189-195.
36. Walker PD and Shah SV (1987). Gentamicin enhanced production of hydrogen peroxide by renal cortical mitochondria. Am J Physiol 253:C495-C499.
37. Xu M (1993). Experimental study of prevention ototoxicity of gentamicin by Shajiyou (in Chinese). SanXi Med J 22:701.