Iron chelators protect from aminoglycoside-induced cochleo- and vestibulo-toxicity

Free Radical Biology and Medicine

Volumn 25, Issue 2, 1998, Pages 189-195

  Song, Ben Bo ^a   Sha, Su Hua ^a   Schacht, Jochen ^a  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

Free radicals; Gentamicin; Kanamycin; Ototoxicity; Protection; Scavengers; Streptomycin

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; DIHYDROXYBENZOIC ACID; GENTAMICIN; IRON CHELATE; KANAMYCIN; MANNITOL; STREPTOMYCIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ANTIBIOTIC THERAPY; ARTICLE; AUDITORY THRESHOLD; COCHLEA INJURY; CONTROLLED STUDY; DRUG BINDING; DRUG EFFICACY; DRUG SAFETY; GUINEA PIG; HEARING LOSS; IRON CHELATION; IRON METABOLISM; MALE; NONHUMAN; PRIORITY JOURNAL;

AMINOGLYCOSIDES; ANIMALS; ANTI-BACTERIAL AGENTS; BLOOD UREA NITROGEN; BODY WEIGHT; COCHLEA; CREATININE; DEFEROXAMINE; DRUG ADMINISTRATION SCHEDULE; EVOKED POTENTIALS, AUDITORY, BRAIN STEM; FREE RADICAL SCAVENGERS; GENTAMICINS; GUINEA PIGS; HYDROXYBENZOIC ACIDS; IRON CHELATING AGENTS; KANAMYCIN; MALE; MANNITOL; MICROBIAL SENSITIVITY TESTS; REFLEX, VESTIBULO-OCULAR; SERUM ALBUMIN; STREPTOMYCIN; VESTIBULE;

EID: 0032527629     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(98)00037-9     Document Type: Article

References (26)

1. Schacht J. The biochemical basis of ototoxicity. Rybak L. P. Otolaryngologic clinics of North America, vol. 26. 1993;845-856 W. B. Saunders, Philadelphia.
2. Garetz S. L., Schacht J. Ototoxicity Of mice and men . van De Water T. R., Popper A. N., Fay R. R. Handbook of auditory research vol. VII: Clinical aspects of hearing. 1996;116-154 Springer Verlag, New York.
3. Huang M. Y., Schacht J. Formation of a cytotoxic metabolite from gentamicin by liver. Biochem. Pharmacol. 40:1990;R11-R14.
4. Crann S. A., Huang M. Y., McLaren J. D., Schacht J. Formation of a toxic metabolite from gentamicin by a hepatic cytosolic fraction. Biochem. Pharmacol. 43:1992;1835-1839.
5. Garetz S. L., Rhee D. J., Schacht J. Sulfhydryl compounds and antioxidants inhibit cytotoxicity to outer hair cells of a gentamicin metabolite in vitro. Hear. Res. 77:1994;75-80.
6. Crann S. A., Schacht J. Activation of aminoglycoside antibiotics to cytotoxins. Audiol. Neuro-Otol. 1:1996;80-85.
7. Priuska E., Schacht J. Formation of free radicals by gentamicin and iron and evidence for an iron/gentamicin complex. Biochem. Pharmacol. 50:1995;1749-1752.
8. Wang H., Priuska E. M., Schacht J. The iron embrace Exposing the secret activities of gentamicin . Assoc. Res. Otolaryngol. 19:1996;29.
9. Sha S.-H., Schacht J. Amplification of free radicals by gentamicin in a biological system. Assoc. Res. Otolaryngol. 19:1996;30.
10. Song B.-B., Schacht J. Variable efficacy of radical scavengers and iron chelators to attenuate gentamicin ototoxicity in guinea pig in vivo. Hear. Res. 94:1996;87-93.
11. Song B.-B., Anderson D. J., Schacht J. Protection from gentamicin ototoxicity by iron chelators in guinea pig in vivo. J. Pharmacol. Exp. Ther. 282:1997;369-377.
12. Hawkins J. E. Drug ototoxicity. Keidel W. D., Neff W. D. Handbook of sensory physiology. V: Auditory system. 1976;707-748 Springer Verlag, Berlin.
13. Lautermann J., McLaren J., Schacht J. Glutathione protection against gentamicin ototoxicity depends on nutritional status. Hear. Res. 86:1995;15-24.
14. Priuska, E. M.; Clark, K.; Pecoraro, V.; Schacht, J. NMR spectra of iron-gentamicin complexes and the implications for aminoglycoside toxicity. Inorg. Chim. Acta in press.
15. Gordon S., Senson J., Facklam R., Pigott N., Hill B., Cooks R., Jarvis W., Thornsberry C. NNIS Enterococcal Study Group A multicenter study of the epidemiology of enterococcal infections . Antimicrobiol. Agents Chemother. 29:1989;233.
16. Chiew Y. F., Lim S. W., Kuah B. G., Liew H. Y. Prevalence in Singapore of enterococci with high-level resistance to aminoglycosides and comparison of three methods for their detection. J. Infect. 27:1993;125-131.
17. Edson R. S., Terrell C. L. The aminoglycosides. Proc. Mayo Clin. 66:1991;1158-1164.
18. Basile A. S., Huang J. M., Xie C., Webster D., Berlin C., Skolnik P. N-Methyl-D-aspartate antagonists limit aminoglycoside antibiotic-induced hearing loss. Nat. Med. 12:1996;1338-1343.
19. Williams S. E., Smith D. E., Schacht J. Characteristics of gentamicin uptake in the isolated crista ampullaris of the inner ear of the guinea pig. Biochem. Pharmacol. 36:1987;89-95.
20. Henley Ch. M., Gerhardt H. J., Schacht J. Inhibition of inner ear ornithine decarboxylase by neomycin in-vitro. Brain Res. Bull. 19:1987;695-698.
21. O'Sullivan W. J. Stability constants of metal complexes. Dawson R. M. C., Elliot D. C., Elliot W. H., Jones K. M. Data for biochemical research. 1969;423-434 Oxford University Press, New York.
22. Babbs C. F., Steiner M. G. Detection and quantitation of hydroxyl radical using dimethyl sulfoxide as molecular probe. Methods Enzymol. 186:1990;137-147.
23. Walker P. D., Shah S. V. Evidence suggesting a role for hydroxyl radical in gentamicin-induced acute renal failure in rats. J. Clin. Invest. 81:1988;334-341.
24. Kanno H., Yamanobe S., Rybak L. P. The ototoxicity of deferoxamine mesylate. Am. J. Otolaryngol. 16:1995;148-152.
25. Ryals B., Westbrook E., Schacht J. Morphological evidence of ototoxicity of the iron chelator deferoxamine. Hear. Res. 112:1997;44-48.
26. Peterson C. M., Graziano J. H., Grady R. W., Jones R. L., Markenson A., Lavi U., Canale V. C., Gray G. F., Cerami A., Miller D. R. Chelation therapy in β-thalassemia major A one-year double blind study of 2,3-dihydroxybenzoic acid . Exp. Hematol. 7:1979;74-80.