Variable efficacy of radical scavengers and iron chelators to attenuate gentamicin ototoxicity in guinea pig in vivo

Hearing Research

Volumn 94, Issue 1-2, 1996, Pages 87-93

  Song, Ben Bo ^a   Schacht, Jochen ^a  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

Free radical; Gentamicin; Iron chelator; Ototoxicity; Protection; Scavenger

Indexed keywords

2,3 DIHYDROXYBENZOIC ACID; 21 [4 [2,6 BIS(1 PYRROLIDINYL) 4 PYRIMIDINYL] 1 PIPERAZINYL]PREGNA 1,4,9(11) TRIENE 3,20 DIONE; 4 (METHYLTHIO)BENZOIC ACID; ALLOPURINOL; AMIFOSTINE; BENZOIC ACID; CHELATING AGENT; DEFEROXAMINE; DIMETHYL SULFOXIDE; FREE RADICAL; GENTAMICIN; IRON; MANNITOL; SCAVENGER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; GUINEA PIG; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; OTOTOXICITY; PRIORITY JOURNAL; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0030068133     PISSN: 03785955     EISSN: None     Source Type: Journal    
DOI: 10.1016/0378-5955(96)00003-2     Document Type: Article

References (41)

1. Aust, S.D., Morehouse, L.A. and Thomas, C.E. (1985) Role of metals in oxygen radical reactions. Free Radic. Biol. Med. 1, 3-25.
2. Ben Ismail, T.H., Ali, B.H. and Bashir, A.A. (1994) Influence of iron, deferoxamine and ascorbic acid on gentamicin-induced nephrotoxicity in rats. Gen. Pharmacol. 25, 1249-1252.
3. Bock, G.R., Yates, G.K., Miller J.J. and Moorjani, P. (1983) Effects of N-acetylcysteine on kanamycin ototoxicity in the guinea pig. Hear. Res. 9, 255-262.
4. Boogaard, P.J., Lempers, E.L.M., Mulder, G.J. and Meerman, H.N. (1991) 4-methylthiobenzoate reduces cisplatin nephrotoxicity in rats without compromising anti-tumour activity. Biochem. Pharmacol. 41, 1997-2003.
5. Braughler, J.M., Duncan, L.A. and Chase, R.L. (1986) The involvement of iron in lipid peroxidation. J. Biol. Chem. 261, 10282-10289.
6. Byler, R.M., Sherman N.A., Wallner, J.S. and Horwitz, L.D. (1994) Hydrogen peroxide cytotoxicity in cultured cardiac myocytes is iron dependent. Am. J. Physiol. 266, H121-H127.
7. Crann, S.A., Huang, M.Y., McLaren, J.D. and Schacht, J. (1992) Formation of a toxic metabolite from gentamicin by a hepatic cytosolic traction. Biochem. Pharmacol. 43, 1835-1839.
8. Djaldetti, M., Fishman, P., Notti, I. and Bessler, H. (1981) The effect of tetracycline administration on iron absorption in mice. Biomedicine 35, 150-152.
9. Durak, J., Kavutcu, M., Canbolat, O., Ozturk, S., Ulutepe, S. and Gokhun, I.H. (1995) Effects of gentamicin on iron and copper contents of kidney tissue. Nephron 70, 380-381.
10. Evenson, L., Rybak, L.P., Whitworth, C., Kanno, H. and Morris C. (1995) MTBA as a protective agent for cisplatin ototoxicity. Abstr. Assoc. Res. Otolaryngol. 18, 81.
11. Garetz, S.L., Altschuler, R.A. and Schacht, J. (1994a) Attenuation of gentamicin ototoxicity by glutathione in the guinea pig in vivo. Hear. Res. 77, 81-87.
12. Garetz, S.L., Rhee, D.J. and Schacht, J. (1994b) Sulfhydryl compounds and antioxidants inhibit cytotoxicity to outer hair cells of a gentamicin metabolite in vitro. Hear. Res. 77, 75-80.
13. Geever, E.F., Crowley, L.V. and Levenson, S.M. (1970) The effect of neomycin on iron absorption in germfree rats. Br. J. Haematol. 18, 567-574.
14. Gutteridge, J.M.C. (1984) Reactivity of hydroxyl and hydroxyl-like radicals discriminated by release of thiobarbituric acid-reactive material from deoxy sugars, nucleosides and benzoate. Biochem. J. 224, 761-767.
15. Gutteridge, J.M.C. (1986) Iron promoters of the Fenton reaction and lipid peroxidation can be released from haemoglobin by peroxides. FEBS Lett. 201, 291-295.
16. Halliwell, B. and Gutteridge, J.M.C. (1986) Oxygen free radicals and iron in relation on biology and medicine: some problems and concepts. Arch. Biochem. Biophys. 246, 501-514.
17. Hershko, C. (1992) Iron chelators in medicine. Mol. Asp. Med. 13, 113-165.
18. Huang, M.Y. and Schacht, J. (1990) Formation of a cytotoxic metabolite from gentamicin by liver. Biochem. Pharmacol. 40, R11-R14.
19. Jeffery, E.H. and Haschek, W.M. (1988) Protection by dimethylsulfoxide against acetammophen-induced hepatic but not respiratory toxicity in the mouse. Toxicol. Appl. Pharmacol. 93, 452-461.
20. Kays, S.E., Crowell, W.A. and Johnson, M.A. (1991) Iron supplementation increases gentamicin nephrotoxicity in rats. J. Nutr. 121, 1869-1875.
21. Kvietys, P.R., Inauen, W., Bacon, R.B. and Grisham, M.B. (1989) Xanthine oxidase-induced injury to endothelium: role of intracellular iron and hydroxyl radical. Am. J. Physiol. 257, H1640-H1646.
22. Lautermann, J., McLaren, J. and Schacht, J. (1995) Glutathione protection against gentamicin ototoxicity depends on nutritional status. Hear. Res. 86, 15-24.
23. Lee, P.H., Chung, Y.C., Hu, R.H., Huang, M.T., and Lee, C.S. (1992) Protective effect of superoxide dismutase and allopurinol on oxygen free radical-induced damage to the kidney. Transplant Proc. 24, 1353-1354.
24. Lotan, D., Kaplan, B.S., Fong, J.S.C., Goodyer, P.R. and de Chadarevian, J.-P. (1984) Reduction of protein excretion by dimethyl sulfoxide in rats with passive Heymann nephritis. Kidney Int. 25, 778-788.
25. Pierson, M.G. and Møller, A.R. (1981) Prophylaxis of kanamycin-induced ototoxicity by a radioprotectant. Hear. Res. 4, 79-87.
26. Priuska, E.M. and Schacht, J. (1995) Formation of tree radicals by gentamicin and iron and evidence for an iron/gentamicin complex. Biochem. Pharmacol. 50, 1749-1752.
27. Quirk, W.S., Shivapuja, B.C., Schwimmer, C.L. and Seidman, M.D. (1994) Lipid peroxidation inhibitor attenuates noise-induced temporary threshold shifts. Hear. Res. 74, 217-220.
28. Ramsammy, L.S., Josepovitz, C., Ling, K.-Y., Lane, B.P. and Kaloyanides, G.J. (1987) Failure of inhibition of lipid peroxidation by vitamin E to protect against gentamicin nephrotoxicity in the rat. Biochem. Pharmacol. 36, 2125-2132.
29. Ruutu, R. (1975) Determination of iron and unsaturated iron-binding capacity in serum with ferrozine. Clin. Chim. Acta 61, 229-232.
30. Schacht, J. (1993) Biochemical basis of aminoglycoside ototoxicity. Otolaryn. Clin. North Am. 26, 845-856.
31. Seidman, M.D., Quirk, W.S., Nuttall, A.L. and Schweitzer, V.G. (1991) The protective effects of allopurinol and superoxide dismutase-polyethylene glycol on ischemic and reperfusion-induced cochlear damage. Otolaryngol. Head Neck Surg. 105, 457-463.
32. Seidman, M.S., Shivapuja, B.G. and Quirk, W.S. (1993) The protective effects of allopurinol and superoxide dismutase on noise-induced cochlear damage. Otolaryngol. Head Neck Surg. 209, 1052-1056.
33. Smyth, B.J. and Davis, W.G. (1995) Allopurinol fails to protect against gentamicin-induced renal damage in normotensive and spontaneously hypertensive rats. Nephron 68, 468-472.
34. Stratta, P., Segoloni, G.P., Canavese, C., Muzio, G., Dogliani, M., Serra, A., Allemandi, P., Salomone, M., Caramellino, C. and Canuto, R. (1994) Oxygen free radicals are not the main factor in experimental gentamicin nephrotoxicity. Ren. Fail. 16, 445-455.
35. Taudy, M., Syka, J. Popelar, J. and Ulehlova, L. (1992) Carboplatin and cisplatin ototoxicity in guinea pigs. Audiology 31, 293-299.
36. Ueda, N., Guidet, B, and Shah, S.V. (1993) Gentamicin-induced mobilization of iron from renal cortical mitochondria. Am. J. Physiol. 265, F435-F439.
37. Walker, P.D. and Shah, S.V. (1987) Gentamicin enhanced production of hydrogen peroxide by renal cortical mitochondria. Am. J. Physiol. 253, C495-C499.
38. Walker, P.D. and Shah, S.V. (1988) Evidence suggesting a role for hydroxyl radical in gentamicin-induced acute renal failure in rats. J. Clin. Invest. 81, 334-341.
39. Walker, P.D. and Shah, S.V. (1991) Hydrogen peroxide cytotoxicity in LLC-PK1 cells: a role for iron. Kidney Int. 40, 891-898.
40. Yu, L., Seguro, A.C. and Rocha, A.S. (1992) Acute renal failure following hemorrhagic shock: protective and aggravating factors. Ren. Fail. 14, 49-55.
41. Wang, H., Priuska, E.M. and Schacht, J. (1996) The iron embrace: exposing the secret activities of gentamicin. Abst. Assoc. Res. Otolaryngol. 19, 29.