RAC1/P38 MAPK signaling pathway controls β1 integrin-induced interleukin-8 production in human natural killer cells

Immunity

Volumn 12, Issue 1, 2000, Pages 7-16

  Mainiero, Fabrizio ^a   Soriani, Alessandra ^a   Strippoli, Raffaele ^a   Jacobelli, Jordan ^a   Gismondi, Angela ^a   Piccoli, Mario ^a   Frati, Luigi ^a,b   Santoni, Angela ^a,c  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b Mediterranean Institute of Neuroscience   (Italy)

^c REGINA ELENA NATIONAL CANCER INSTITUTE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BETA1 INTEGRIN; FIBRONECTIN RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; INTERLEUKIN 8; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOTRANSFERASE;

ARTICLE; CYTOKINE PRODUCTION; ENZYME ACTIVATION; HUMAN; HUMAN CELL; NATURAL KILLER CELL; PRIORITY JOURNAL; PROTEIN CROSS LINKING; SIGNAL TRANSDUCTION;

EID: 0033959736     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)80154-5     Document Type: Article

References (60)

1. Allavena, P., Paganin, I., Martin-Padura, I., Peri, G., Gaboli, M., Dejana, E., Marchisio, P.C., and Mantovani, A. (1991). Molecules and structures involved in the adhesion of natural killer cells to vascular endothelium. J. Exp. Med. 173, 439-448.
2. Baggiolini, M., Dewald, B., and Moser, B. (1994). Interleukin-8 and related chemotactic cytokines-CXC and CC chemokines. Adv. Immunol. 55, 97-179.
3. Baggiolini, M., Dewald, B., and Moser, B. (1997). Human chemokines: an update. Annu. Rev. Immunol. 15, 675-705.
4. Bagrodia, S., Dèrijard, B., Davis, R.J., and Cerione, R.A. (1995). Cdc42 and PAK-mediated signaling leads to Jun kinase and p38 mitogen-activated protein kinase activation. J. Biol. Chem. 270, 27995-27998.
5. Billadeau, D.D., Brumbaugh, K.M., Dick, C.J., Schoon, R.A., Bustelo, X.R., and Leibson, P.J. (1998). The Vav-Rac1 pathway in cytotoxic lymphocytes regulates the generation of cell-mediated killing. J. Exp. Med. 188, 549-559.
6. Biron, C.A. (1997). Activation and function of natural killer cell responses during viral infections. Curr. Opin. Immunol. 9, 24-34.
7. Chen, Q., Kinch, M.S., Lin, T.H., Burridge, K., and Juliano, R.L. (1994). Integrin-mediated cell adhesion activates mitogen-activated protein kinases. J. Biol. Chem. 269, 26602-26605.
8. vav, in platelets. J. Biol. Chem. 271, 7544-7550.
9. Coso, O.A., Chiariello, M., Yu, J.C., Teramoto, H., Crespo, P., and Xu, N. (1995). The small GTP-binding proteins Rac-1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway. Cell 81, 1137-1146.
10. Craxton, A., Shu, G., Graves, J.D., Saklatvala, J., Krebs, E.G., and Clark, E.A. (1998). p38 MAPK is required for CD40-induced gene expression and proliferation in B lymphocytes. J. Immunol. 161, 3225-3236.
11. Crespo, P., Schuebel, K.E., Ostrom, A.A., Gutkind, J.S., and Bustelo, X.R. (1997). Phosphotyrosine-dependent activation of Rac-1 GDP/ GTP exchange by the vav proto-oncogene product. Nature 385, 169-172.
12. Defilippi, P., Gismondi, A., Santoni, A., and Tarone, G. (1997). Signal transduction by integrins. Landes Bioscience (Austin, TX: Springer).
13. Dérijard, B., Raingeaud, J., Barret, T., Wu, I-H., Han, J., Ulevitch, R.J., and Davis, R.J. (1995). Independent human MAP kinase signal transduction pathways defined by MEK and MKK isoforms. Science 267, 682-685.
14. D'Souza-Schorey, C., Boetther, B., and Van Aelst, L. (1998). Rac regulates integrin-mediated spreading and increased adhesion of T lymphocytes. Mol. Cell. Biol. 18, 3936-3946.
15. Enslen, H., Raingeaud, J., and Davis, R.J. (1998). Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase-kinase MKK3 and MKK6. J. Biol. Chem. 273, 1741-1748.
16. Fogler, W.E., Volker, K., McCormick, K.L., Watanabe, M., Ortaldo, J.R., and Wiltrout, R.H. (1996). NK cell infiltration into lung, liver, and subcutaneous B16 melanoma is mediated by VCAM-1/VLA-4 interaction. J. Immunol. 156, 4707-4714.
17. Galandrini, R., Palmieri, G., Piccoli, M., Frati, L., and Santoni, A. (1999). Role for the Rac1 exchange factor Vav in the signaling pathways leading to NK cell cytotoxicity. J. Immunol. 162, 3148-3152.
18. Giancotti, F.G., and Mainiero, F. (1994). Integrin-mediated adhesion and signaling in tumorigenesis. Biochem. Biophys. Acta 1198, 47-64.
19. Gismondi, A., Morrone, S., Humphries, M.J., Piccoli, M., Frati, L., and Santoni, A. (1991). Human natural killer cells express VLA-4 and VLA-5, which mediate their adhesion to fibronectin. J. Immunol. 146, 384-392.
20. Gismondi, A., Milella, M., Palmieri, G., Piccoli, M., Frati, L., and Santoni, A. (1995). Stimulation of protein tyrosine phosphorylation by interaction of NK cells with fibronectin via α4β1 and α5β1. J. Immunol. 154, 3128-3137.
21. Gismondi, A., Bisogno, L., Mainiero, F., Palmieri, G., Piccoli, M., Frati, L., and Santoni, A. (1997). PYK-2 tyrosine phosphorylation by β1 integrin fibronectin receptor cross-linking and association with paxillin in human NK cells. J. Immunol. 159, 4729-4736.
22. Gotoh, A., Takahira, H., Geahlen, R.L., and Broxmeyer, H.E. (1997). Cross-linking of integrins induces tyrosine phosphorylation of the proto-oncogene product Vav and the protein tyrosine kinase Syk in human factor-dependent myeloid cells. Cell Growth Differ. 8, 721-729.
23. Hynes, R.O. (1992). Integrins: versatility, modulation, and signaling in cell adhesion. Cell 69, 11-25.
24. Lee, J.C., Laydon, J.T., McDonnel, P.C., Gallagher, T.F., Kumar, S., Green, D., McNulty, D., Blumenthal, M.J., Heys, J.R., Landvatter, S.W., et al. (1994). A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature 372, 739-746.
25. Lu, H.T., Yang, D.D., Wysk, M., Gatti, E., Mellman, I., Davis, R.J., and Flavell, R.A. (1999). Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient mice. EMBO J. 18, 1845-1857.
26. Mackay, D.J., and Hall, A. (1998). Rho GTPases. J. Biol. Chem. 273, 20685-20688.
27. Mainiero, F., Gismondi, A., Milella, M., Morrone, S., Palmieri, G., Piccoli, M., Frati, L., and Santoni, A. (1994). Long-term activation of NK cells results in modulation of β1-integrin expression and function. J. Immunol. 152, 446-454.
28. Mainiero, F., Pepe, A., Wary, K.K., Spinardi, L., Mohammadi, M., Schlessinger, J., and Giancotti, F.G. (1995). Signal transduction by the a6b4 integrin: distinct β4 subunit sites mediate recruitment of Shc/Grb2 and association with the cytoskeleton of hemidesmosomes. EMBO J. 14, 4470-4481.
29. Mainiero, F., Murgia, C., Wary, K.K., Pepe, A., Blumemberg, M., Westwick, J.K., Der, C.J., and Giancotti, F.G. (1997). The coupling of α6β4 integrin to Ras-MAP kinase pathways mediated by Shc controls keratinocyte proliferation. EMBO J. 16, 2365-2375.
30. Mainiero, F., Gismondi, A., Soriani, A., Cippitelli, M., Palmieri, G., Jacobelli, J., Piccoli, M., Frati, L., and Santoni, A. (1998). Integrin-mediated ras-extracellular regulated kinase (ERK) signaling regulates interferon γ production in human natural killer cells. J. Exp. Med. 188, 1267-1275.
31. Martin, G.A., Bollag, G., McCormick, F., and Abo, A. (1995). A novel serine kinase activated by Rac1/Cdc42Hs-dependent autophosphorylation is related to PAK65 and STE20. EMBO J. 14, 1970-1978.
32. Minden, A., Lin, A., Claret, F.X., Abo, A., and Karin, M. (1995). Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPase Rac and Cdc42Hs. Cell 81, 1147-1157.
33. Miranti, C.K., Leng, L., Maschberger, P., Brugge, J.S., and Shattil, S.J. (1998). Identification of a novel integrin signaling pathway involving the kinase Syk and the guanine nucleotide exchange factor Vav1. Curr. Biol. 8, 1289-1299.
34. Nagata, Y., Takahashi, N., Davis, R.J., and Todokoro, K. (1998). Activation of p38 MAP kinase and JNK but not ERK is required for erythropoietin-induced erythroid differentiation. Blood 92, 1859-1869.
35. Palmieri, G., Serra, A., De Maria, R., Gismondi, A., Milella, M., Piccoli, M., Frati, L., and Santoni, A. (1995). Cross-linking of α4β1 and α5β1 fibronectin receptors enhances natural killer cell cytotoxic activity. J. Immunol. 155, 5314-5322.
36. Pandey, P., Avraham, S., Kumar, S., Nakazawa, A., Place, A., Ghanem, L., Rana, A., Kumar, V., Majumder, P.K., Avraham, H., et al. (1999). Activation of p38 mitogen-activated protein kinase by PYK2/ related adhesion focal tyrosine kinase-dependent mechanism. J. Biol. Chem. 274, 10140-10144.
37. Price, M.A., Cruzalegui, F.H., and Treisman, R. (1996). The p38 and ERK MAP kinase pathways cooperate to activate ternary complex factors and c-fos transcription in response to UV light. EMBO J. 15, 6552-6563.
38. Price, L.S., Leng, J., Schwartz, M.A., and Bokoch, G.M. (1998). Activation of Rac and Cdc42 by integrins mediates cell spreading. Mol. Biol. Cell 9, 1863-1871.
39. + human blood mononuclear cells. J. Clin. Invest. 101, 711-721.
40. Raingeaud, J., Whitmarsh, A.J., Barrett, T., Derijard, B., and Davis, R.J. (1996). MKK3-and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway. Mol. Cell. Biol. 16, 1247-1255.
41. Roberts, A.W., Chaekyun, K., Zhen, L., Lowe, J.B., Kapur, R., Petryniak, B., Spaetti, A., Pollock, J.D., Borneo, J.B., Bradford, G.B., et al. (1999). Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defence. Immunity 10, 183-196.
42. Robinson, M.J., and Cobb, M.H. (1997). Mitogen-activated protein kinase pathways. Curr. Opin. Cell Biol. 9, 180-186.
43. Rollins, B.J. (1997). Chemokines. Blood 90, 909-928.
44. Rudel, T., Zenke, F.T., Chuang, T.H., and Bokoch, G.M. (1998). p21-activated kinase (PAK) is required for Fas-induced JNK activation in Jurkat cells. J. Immunol. 160, 7-11.
45. bright natural killer cells in the human early pregnancy decidua. Biochem. Biophys. Res. Comm. 200, 378-383.
46. Salmon, R.A., Foltz, I.N., Young, P.R., and Schrader, J.W. (1997). The p38 mitogen-activated protein kinase is activated by ligation of the T or B lymphocyte antigen receptors, Fas or CD40, but suppression of kinase activity does not inhibit apoptosis induced by antigen receptors. J. Immunol. 159, 5309-5317.
47. Scott, P., and Trinchieri, G. (1995). The role of natural killer cells in host-parasite interactions. Curr. Opin. Immunol. 7, 34-40.
48. Seger, R., and Krebs, E.G. (1995). The MAPK signaling cascade. FASEB J. 9, 726-735.
49. Sells, M.A., and Chernoff, J. (1997). Emerging from the Pak: the p21-activated protein kinase family. Trends Cell Biol. 7, 162-167.
50. Somersalo, K., and Saksela, E. (1991). Fibronectin facilitates the migration of natural killer cells. Eur. J. Immunol. 21, 35-42.
51. Somersalo, K., Carpen, O., and Saksela, E. (1994). Stimulated natural killer cells secrete factors with chemotactic activity, including NAP-1/IL-8, which supports VLA-4-and VLA-5-mediated migration of T lymphocytes. Eur. J. Immunol. 24, 2957-2965.
52. Su, B., and Karin, M. (1996). Mitogen-activated protein kinase cascades and regulation of gene expression. Curr. Opin. Immunol. 8, 402-411.
53. Tan, Y., Rouse, J., Zhang, A., Cariati, S., Cohen, P., and Comb, M.J. (1996). FGF and stress regulate CREB and ATF-2 via a pathway involving p38 MAP kinase and MAPKAP kinase-2. EMBO J. 15, 4629-4642.
54. Tokiwa, G., Dikic, I., Lev, S., and Schlessinger, J. (1996). Activation of Pyk2 by stress signals and coupling with JNK signaling pathway. Science 273, 792-794.
55. Van Aelst, L., and D'Souza-Schorey, C. (1997). Rho GTPases and signaling networks. Genes Dev. 11, 2295-2322.
56. Wary, K.K., Mainiero, F., Isakoff, S.J., Marcantonio, E.E., and Giancotti, F.G. (1996). The adaptor protein Shc couples a class of integrins to the control of cell cycle progression. Cell 87, 1-11.
57. Wysk, M., Yang, D.D., Lu, H.T., Flavell, R.A., and Davis, R.J. (1999). Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for tumor necrosis factor-induced cytokine expression. Proc. Natl. Acad. Sci. USA 96, 3763-3768.
58. Zhang, S., Han, J., Sells, M.A., Chernoff, J., Knaus, U.G., Ulevitch, R.J., and Bokoch, G.M. (1995). Rho family GTPases regulate p38 mitogen-activated protein kinase through the downstream mediator Pak1. J. Biol. Chem 270, 23934-23936.
59. Zhang, J., Salojin, K.V., Gao, J.X., Cameron, M.J., Bergerot, I., and Delovitch, T.L. (1999). p38 mitogen-activated protein kinase mediates signal integration of TCR/CD28 costimulation in primary murine T cells. J. Immunol. 162, 3819-3828.
60. Zu, Y., Qi, J., Gilchrist, A., Fernandez, G., Vazquez-Abad, D., Kreutzer, D., Huang, C., and Sha'afi, R. (1998). p38 mitogen-activated protein kinase activation is required for human neutrophil function triggered by TNF-α or FMLP stimulation. J. Immunol. 160, 1982-1989.