Is brain uptake of leptin in vivo saturable and reduced by fasting?

European Journal of Nuclear Medicine

Volumn 25, Issue 6, 1998, Pages 607-612

  Karonen, Sirkka Liisa ^a   Koistinen, Heikki A ^a   Nikkinen, Päivi ^a   Koivisto, Veikko A ^a  

^a HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

Author keywords

Gamma imaging; In vivo autoradiography; Leptin; Ob protein; Rabbit

Indexed keywords

BRAIN RECEPTOR; LEPTIN; LEPTIN RECEPTOR; PEPTIDE HORMONE;

ADIPOCYTE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY FAT; BRAIN; CHOROID PLEXUS; CONTROLLED STUDY; DIET RESTRICTION; DOWN REGULATION; FOOD INTAKE; HORMONE RECEPTOR INTERACTION; HYPOTHALAMUS; IMAGING SYSTEM; KIDNEY; KINETICS; LIPID METABOLISM; LIVER; LUNG; NEGATIVE FEEDBACK; NONHUMAN; RABBIT; RADIOIODINATION; STEADY STATE; WEIGHT REDUCTION;

ANIMALS; BRAIN; CARRIER PROTEINS; CHOROID PLEXUS; FASTING; IODINE RADIOISOTOPES; LEPTIN; MICE; OBESITY; PROTEINS; RABBITS; RADIOPHARMACEUTICALS; RECEPTORS, CELL SURFACE; TISSUE DISTRIBUTION;

EID: 0031861201     PISSN: 03406997     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002590050262     Document Type: Article

References (36)

1. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature 1994; 372: 425-432.
2. Kennedy GC. The role of depot fat in the hypothalamic control of food intake in the rat. Proc R Soc Lond B Biol Sci 1953; 140; 578-592.
3. Pelleymounter MA, Cullen MJ, Baker MB, Hecht R, Winters D, Boone T, Collins F. Effects of the obese gene product on body weight regulation in ob/ob mice. Science 1995; 269: 540-543.
4. Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D, Lallone RL, Burley SK, Friedman JM. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 1995; 269: 543-546.
5. Campfield LA, Smith FJ, Guisez Y, Devos R, Burn PR. Recombinant mouse ob protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 1995; 269: 546-548.
6. Tartaglia LA, Dembski M, Weng X, Deng N, Culpepper J, Devos R, Richards GJ, Campfield LA, Clark FT, Deeds J, Muir G, Sanker S, Moriarty A, Moore KJ, Smutko JS, Mays GG, Woolf EA, Monroe CA, Tepper RI. Identification and expression cloning of a leptin receptor, OB-R. Cell 1995; 83: 1263-1271.
7. Lee GH, Proenca R, Montez JM, Carroll KM, Darvishzadeh JG, Lee JI, Friedman JM. Abnormal splicing of the leptin receptor in diabetic mice. Nature 1996; 379: 632-635.
8. Chen H, Charlat O, Tartaglia LA, Woolf EA, Weng X, Ellis SJ, Lakey ND, Culpepper J, Moore KJ, Breitbart RE, Duyk GM, Tepper RI, Morgenstern JP. Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell 1996; 84: 491-495.
9. Chua SC Jr., Chung WK, Wu-Peng XS, Zhang Y, Liu S-M, Tartaglia L, Leibel RL. Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor. Science 1996; 271: 994-996.
10. Mercer JG, Hoggard N, Williams LM, Lawrence CB, Hannah LT, Trayhurn P. Localization of leptin receptor mRNA and the long form splice variant (Ob-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization. FEBS Lett 1996; 387: 113-116.
11. Banks WA, Kastin AJ, Huang W, Jaspan JB, Maness LM. Leptin enters the brain by a saturable system independent of insulin. Peptides 1996; 17: 305-311.
12. Schwartz MW, Peskind E, Raskind M, Boyko EJ, Porte D Jr. Cerebrospinal fluid leptin levels: relationship to plasma levels and to adiposity in humans. Nature Med 1996; 2: 589-593.
13. Caro JF, Kolaczynski JW, Nyce MR, Ohannesian JP, Opentanova I, Goldman WH, Lynn RB, Zhang P-L, Sinha MK, Considine RV. Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance. Lancet 1996; 348: 159-161.
14. Considine RV, Considine EL, Williams CJ, Hyde TM, Caro JF. The hypothalamic leptin receptor in humans. Identification of incidental sequence polymorphisms and absence of the db/db mouse and fa/fa rat mutations. Diabetes 1996; 19: 992-994.
15. 125iodine. Anal Biochem 1975; 67: 1-10.
16. Guardabasso V, Munson PJ, Rodbard D. EXPFIT: a program for simultaneous analysis of families of exponential decay curves. Comp Methods Programs Biomed 1988; 27: 55-63.
17. Bennett HPJ, McMartin C. Peptide hormones and their analogues: distribution, clearance from the circulation, and inactivation in vivo. Pharmacol Rev 1979; 30: 247-292.
18. Chehab FF, Lim ME, Lu R. Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nature Genet 1996; 12: 318-320.
19. Cioffi JA, Shaker AW, Zupanic TJ, Smith-Gbur J, Mikhail A, Platika D, Snodgrass HR. Novel B219/OB receptor isoforms: possible role of leptin in hematopoiesis and reproduction. Nature Med 1996; 2: 585-588.
20. Jackson EK, Ping L. Human leptin has natriuretic activity in the rat. Am J Physiol 1997; 41: F333-F338.
21. 125I-leptin administration to ob/ob and db/db mice. Horm Metab Res 1996; 28: 653-658.
22. Cumin F, Baum H-P, Levens N. Leptin is cleared from the circulation primarily by the kidney. Int J Obes 1996; 20: 1120-1126.
23. Klein S, Coppack SW, Mohamed-Ali V, Landt M. Adipose tissue leptin production and plasma leptin kinetics in humans. Diabetes 1996; 45: 984-987.
24. Vaisse C, Halaas JF, Horvath CM, Darnell JE Jr., Stoffel M, Friedman JM. Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice. Nature Genet 1996; 14: 95-97.
25. Schwartz MW, Seeley RJ, Campfield LA, Burn P, Baskin DG. Identification of targets of leptin action in rat hypothalamus. J Clin Invest 1996; 98: 1101-1106.
26. Stephens TW, Basinski M, Bristow PK, Bue-Valleskey JM, Burgett SG, Craft L, Hale J, Hoffmann J, Hsiung HM, Kriauciunas A, MacKellar W, Rosteck PR, Schoner B, Smith D, Tinsley FC, Zhang X-Y, Heiman M. The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature 1995; 377: 530-532.
27. Schwartz MW, Baskin DG, Bukowski TR, Kuijper JL, Foster D, Lasser G, Prunkard DE, Porte D, Woods SC, Seeley RJ, Weigle D. Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice. Diabetes 1996; 45: 531-535.
28. Erickson JC, Clegg KE, Palmiter RD. Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y. Nature 1996; 381: 415-418.
29. Lynn RB, Cao G-Y, Considine RV, Hyde TM, Caro JF. Autoradiographic localization of leptin binding in the choroid plexus of ob/ob and db/db mice. Biochem Biophys Res Commun 1996; 219: 884-889.
30. Golden PL, Maccagnan TJ, Pardridge WM. Human blood-brain barrier leptin receptor. Binding and endocytosis in isolated human brain microvessels. J Clin Invest 1997; 99: 14-18.
31. Kolaczynski JW, Considine RV, Ohannesian J, Marco C, Opentanova I, Nyce MR, Myint M, Caro JF. Responses of leptin to short-term fasting and refeeding in humans. A link with ketogenesis but not ketones themselves. Diabetes 1996; 45: 1511-1515.
32. Ahima RS, Prabakaran D, Mantzoros C, Qu D, Lowell B, Maratos-Flier E, Flier JS. Role of leptin in the neuroendocrine response to fasting. Nature 1996; 382: 250-252.
33. Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, Ohannesian JP, Marco CC, McKee LJ, Bauer TL, Caro JF. Serum immunoreactive-leptin concentrations in normal-weight and obese subjects. N Engl J Med 1996; 334: 292-295.
34. Lahlou N, Landais P, De Boissieu D, Bougneres P-F. Circulating leptin in normal children and during the dynamic phase of juvenile obesity. Relation to body fatness, energy metabolism, caloric intake, and sexual dimorphism. Diabetes 1997; 46: 989-993.
35. Montague CT, Farooqi IS, Whitehead JP, Soos MA, Rau H, Wareham NJ, Sewter CP, Digby JE, Mohammed SN, Hurst JA, Cheetham CH, Earley AR, Barnett AH, Prins JB, O'Rahilly S. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 1997; 387: 903-908.
36. Van Heek M, Compton DS, France CF, Tedesco RP, Fawzi AB, Graziano MP, Sybertz EJ, Strader CD, Davis HR. Diet-induced obese mice develop peripheral, but not central resistance to leptin. J Clin Invest 1997; 99: 385-390.