High-fat hypercaloric diet induces obesity, glucose intolerance and hyperlipidemia in normal adult male Wistar rat

Diabetes Research and Clinical Practice

Volumn 31, Issue 1-3, 1996, Pages 27-35

  Akiyama, Toshiharu ^a,b   Tachibana, Issei ^a,b   Shirohara, Hisashi ^a,b   Watanabe, Nobuaki ^a,b   Otsuki, Makoto ^a,b  

^a UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

^b UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

Author keywords

High fat diet; Hypercaloric diet; Insulin resistance; Obesity

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; FATTY ACID; INSULIN; PHOSPHOLIPID; TRIACYLGLYCEROL;

ANIMAL; ARTICLE; BLOOD; BODY WEIGHT; CALORIC INTAKE; FAT INTAKE; FATTY LIVER; GLUCOSE BLOOD LEVEL; GLUCOSE INTOLERANCE; HYPERLIPIDEMIA; MALE; METABOLISM; OBESITY; PANCREAS; PANCREAS ISLET; PATHOLOGY; PATHOPHYSIOLOGY; RAT; REFERENCE VALUE; SECRETION; WISTAR RAT; ANIMAL EXPERIMENT; ANIMAL MODEL; CONTROLLED STUDY; INSULIN RESISTANCE; LIPID DIET; NONHUMAN;

ALANINE TRANSAMINASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; BLOOD GLUCOSE; BODY WEIGHT; DIETARY FATS; ENERGY INTAKE; FATTY ACIDS, NONESTERIFIED; FATTY LIVER; GLUCOSE INTOLERANCE; HYPERLIPIDEMIAS; INSULIN; ISLETS OF LANGERHANS; MALE; OBESITY; PANCREAS; PHOSPHOLIPIDS; RATS; RATS, WISTAR; REFERENCE VALUES; TRIGLYCERIDES;

EID: 0029665527     PISSN: 01688227     EISSN: None     Source Type: Journal    
DOI: 10.1016/0168-8227(96)01205-3     Document Type: Article

References (41)

1. Genetic influence on adult weight gain and maximum body mass index in male twins
2. Study of obesity in dogs visiting veterinary practices in the UK
3. Fatty, a new mutation in the rat
4. A new genetically obese-hyperglycemic rat (Wistar fatty)
5. Spontaneous long-term hyperglycemic rat with diabetic complications. Otsuka Long-Evans Tokushima Fatty (OLETF) strain
6. Development of glucose intolerance and impaired plasma insulin response to glucose in obese hyperglycemic (ob/ob) mice
7. Effect of a high-fat diet on energy intake and expenditure in rats
8. Energy expenditure in rats with diet-induced obesity
9. Alteration of insulinreceptor kinase activity by high-fat feeding
10. Factors influencing energy intake of rats fed either a high-fat or a fat mimetic diet
11. Effects of feeding lipids of different fatty acid compositions upon rat lymphocyte proliferation
12. Effect of dexfenfluramine on fat mass distribution in a high-fat rat model
13. Effect of diet change on insulin action: difference between muscles and adipocytes
14. High fat feeding causes insulin resistance and a marked decrease in the expression of glucose transporters (Glut-4) in fat cells of rats
15. Dietary obesity in adult rats: Similarities to hypothalamic and human obesity syndromes
16. Comparative study of the effects of equal amounts of fat, protein, and starch on plasma cholecystokinin in man
17. The influence of different nutrients on plasma cholecystokinin levels in the rat
18. Cholecystokinin decreases food intake in rats
19. Food intake response to modulation of secretion of cholecystokinin in Zucker rats
20. Long-term cannulation model for blood sampling and intragastric infusion in the rat
21. Effects of ethanol ingestion and dietary fat levels on mitochondrial lipids in male and female rats
22. Protein measurement with Folin phenol reagent
23. A simple, rapid and sensitive DNA assay procedure
24. A new and rapid method for the clinical determination of α-amylase activities in human serum and urine
25. A rapid and specific method for the determination of pancreatic lipase in serum and urine
26. The preparation and properties of two new chromogenic substrates of trypsin
27. Laboratory animals exhibiting obesity and diabetes syndromes
28. Weight loss in obese-hyperglycemic and normal mice following transauricular hypophysectomy by a modified technique
29. Hypophysectomy and regulation of body weight in the genetically obese Zucker rat
30. Failure of pancreatic polypeptide release in congenitally obese mice
31. Loss of sensitivity to cholecystokinin stimulation of isolated pancreatic acini from genetically diabetic rats
32. Genetic obesity in rats.1. The effects of food restriction on body composition and hypothalamic function
33. Metabolic abnormalities linked to obesity: Effects of dexfenfluramine in the corpulent rat
34. Reduction of carbohydrate-induced hypertriglyceridemia in (fa,fa) ‘Zucker’ rats by the α-glucosidases inhibitor acarbose (BAY g 5421)
35. Hormonal control of pancreatic growth
36. Amylase secretion by isolated pancreatic acini after chronic cholecystokinin treatment in vivo
37. Carbohydrate intake determines pancreatic acinar amylase activity and release despite chronic alcoholemia in rats
38. Effect of diabetes mellitus on the regulation of enzyme secretion by isolated rat pancreatic acini
39. Specific inhibition of glucokinase by long chain acyl coenzymes A below the critical micelle concentration
40. Palmitate inhibits liver glycolysis
41. Free-fatty acid inhibition of insulin binding, degradation, and action in isolated rat hepatocytes