Nitric oxide synthase in atherosclerosis and vascular injury: Insights from experimental gene therapy

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 20, Issue 8, 2000, Pages 1873-1881

  Channon, Keith M ^a   Qian, HuSheng ^b   George, Samuel E ^b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Adenovirus; Atherosclerosis; Endothelium; Gene transfer; Nitric oxide

Indexed keywords

NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

ATHEROGENESIS; ATHEROSCLEROSIS; BLOOD VESSEL INJURY; BLOOD VESSEL WALL; GENE EXPRESSION; GENE FUNCTION; GENE TARGETING; GENE THERAPY; GENE TRANSFER; PRIORITY JOURNAL; REVIEW;

EID: 0033903230     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.20.8.1873     Document Type: Review

References (156)

1. Mammalian nitric oxide synthases
2. Nitric oxide synthases: Which, where, how, and why?
3. Nitric oxide synthases: Properties and catalytic mechanism
4. Inducible nitric oxide synthase and vascular injury
5. Receptor-regulated translocation of endothelial nitric-oxide synthase
6. 2+-calmodulin and caveolin
7. Regulation of endothelium-derived nitric oxide production by the protein kinase Akt
8. Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
9. Laminar shear stress: Mechanisms by which endothelial cells can transduce an atheroprotective force
10. Overexpression of inducible nitric oxide synthase by neointimal smooth muscle cells
11. Expression of multiple isoforms of nitric oxide synthase in normal and atherosclerotic vessels
12. Induction of nitric oxide synthase in the neointima induced by a periarterial collar in rabbits
13. Potential functional significance of brain-type and muscle-type nitric oxide synthase I expressed in adventitia and media of rat aorta
14. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
15. Redox signaling: Nitrosylation and related target interactions of nitric oxide
16. NO forms an adduct with serum albumin that has endothelium-derived relaxing factor-like properties
17. S-nitrosohaemoglobin: A dynamic activity of blood involved in vascular control
18. The oxyhemoglobin reaction of nitric oxide
19. Nitric oxide in the regulation of blood flow and arterial pressure
20. The vascular biology of nitric oxide and its role in atherogenesis
21. Alterations of vasomotor regulation in atherosclerosis
22. The role of nitric oxide and cGMP in platelet adhesion molecules to vascular endothelium
23. Nitric oxide-generating vasodilators and 8-bromo cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells
24. The effects of exogenous nitric oxide on smooth muscle cell proliferation following porcine carotid angioplasty
25. Nitric oxide reversibly inhibits the migration of cultured vascular smooth muscle cells
26. Nitric oxide-generating compounds inhibit total protein and collagen synthesis in cultured vascular smooth muscle cells
27. Monocyte adhesion molecules and transmigration in atherosclerosis
28. Induction and stabilization of IκBα by nitric oxide mediates inhibition of NF-κB
29. Nitric oxide decreases cytokine-induced endothelial activation: Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines
30. Nitric oxide protects against leukocyte-endothelium interactions in the early stages of hypercholesterolemia
31. Nitric oxide modulates the expression of monocyte chemoattractant protein 1 in cultured human endothelial cells
32. Nitric oxide regulates monocyte chemotactic protein-1
33. Mechanisms of oxidative damage of low density lipoprotein in human atherosclerosis
34. Inhibition of low-density lipoprotein oxidation by nitric oxide: Potential role in atherogenesis
35. Effect of hypercholesterolemia on vascular reactivity in the rabbit, I: Endothelium-dependent and endothelium-independent contractions and relaxations in isolated arteries of control and hypercholesterolemic rabbits
36. Antiatherogenic effects of L-arginine in the hypercholesterolemic rabbit
37. Impaired endothelium-dependent relaxation to aggregating platelets and related vasoactive substances in porcine coronary arteries in hypercholesterolemia and atherosclerosis
38. 2 does not contribute to impaired endothelium-dependent relaxation
39. Chronic inhibition of nitric oxide production accelerates neointima formation and impairs endothelial function in hypercholesterolemic rabbits
40. Regression or progression: Dependency on vascular nitric oxide
41. Beneficial effect of SPM-5185, a cysteine-containing nitric oxide donor, in rat carotid artery intimal injury
42. Inhibition of neointimal proliferation in rabbits after vascular injury by a single treatment with a protein adduct of nitric oxide
43. Hypertension in mice lacking the gene for endothelial nitric oxide synthase
44. Direct evidence for the importance of endothelium-derived nitric oxide in vascular remodeling
45. Gene transfer of endothelial nitric oxide synthase (eNOS) in eNOS-deficient mice
46. Lessons from genetically engineered animal models, IV: Nitric oxide synthase gene knockout mice
47. Reduced endothelial nitric oxide synthase expression and production in human atherosclerosis
48. Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries
49. Endothelium-mediated coronary blood flow modulation in humans: Effects of age, atherosclerosis, hypercholesterolemia, and hypertension
50. Impaired vasodilation of forearm resistance vessels in hypereholesterolemic humans
51. Impaired nitric oxide-mediated vasodilation in patients with non-insulin-dependent diabetes mellitus
52. Effect of local intra-arterial N(G)-monomethyl-L-arginine in patients with hypertension: The nitric oxide dilator mechanism appears abnormal
53. Long-term cigarette smoking impairs endothelium-dependent coronary arterial vasodilator function
54. Oral L-arginine improves endothelium-dependent dilation in hypercholesterolemic young adults
55. Reduction in serum cholesterol with pravastatin improves endothelium-dependent coronary vasomotion in patients with hypercholesterolemia
56. Correction of endothelial dysfunction in coronary microcirculation of hypercholesterolaemic patients by L-arginine
57. L-arginine improves endothelium-dependent vasodilation in hypercholesterolemic humans
58. Ascorbic acid reverses endothelial vasomotor dysfunction in patients with coronary artery disease
59. Explanted vein grafts with an intact endothelium demonstrate reduced focal expression of endothelial nitric oxide synthase specific to atherosclerotic sites
60. Oxidized low-density lipoprotein decreases the expression of endothelial nitric oxide synthase
61. Endothelial dysfunction in chronic myocardial infarction despite increased vascular endothelial nitric oxide synthase and soluble guanylate cyclase expression: Role of enhanced vascular superoxlde production
62. Superoxide anion production is increased in a model of genetic hypertension: Role of the endothelium
63. Interactions between NO and reactive oxygen species: Pathophysiological importance in atherosclerosis, hypertension, diabetes and heart failure
64. Cellular and molecular mechanisms of endothelial dysfunction
65. Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor
66. Superoxide and peroxynitrite in atherosclerosis
67. Peroxynitrite inhibits leukocyte-endothelial cell interactions and protects against ischemia-reperfusion injury in rats
68. The simultaneous generation of superoxide and nitric oxide can initiate lipid peroxidation in human low density lipoprotein
69. Reactive oxygen spectes mediate the activation of Akt/ protein kinase B by angiotensin II in vascular smooth muscle cells
70. Cell transformation by the superoxidegenerating oxidase Mox1
71. Vascular release of superoxide radicals is enhanced in hypercholesterolemic rabbits
72. Hypercholesterolemia increases endothelial superoxide anion production
73. Increased NADH-oxidase-mediated superoxide production in the early stages of atherosclerosis: Evidence for involvement of the renin-angiotensin system
74. Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NAD/NADPH oxidase activation
75. p22phox mRNA expression and NADPH oxidase activity are increased in aortas from hypertensive rats
76. Dietary correction of hypercholesterolemia in the rabbit normalizes endothelial superoxide anion production
77. Atherosclerosis, oxidative stress, and antioxidant protection in endothelium-derived relaxing factor action
78. Chronic treatment with polyethylene-glycolated superoxide dismutase partially restores endothelium-dependent vascular relaxations in cholesterol-fed rabbits
79. Release of intact endothelium-derived relaxing factor depends on endothelial superoxide dismutase activity
80. Native low-density lipoprotein increases endothelial cell nitric oxide synthase generation of superoxide anion
81. High glucose increases nitric oxide synthase expression and superoxide anion generation in human aortic endothelial cells
82. Nitric oxide synthase generates superoxide and nitric oxide in arginine-depleted cells leading to peroxynitrite-mediated cellular injury
83. Mechanism of superoxide generation by neuronal nitric oxide synthase
84. In situ flow activates endothelial nitric oxide synthase in luminal caveolae of endothelium with rapid caveolin dissociation and calmodulin association
85. Opposing effects of reactive oxygen species and cholesterol on endothelial nitric oxide synthase and endothelial cell caveolae
86. Hypercholesterolemia decreases nitric oxide production by promoting the interaction of caveolin and endothelial nitric oxide synthase
87. Oxidized low density lipoprotein displaces endothelial nitric-oxide synthase (eNOS) from plasmalemmal caveolac and impairs eNOS activation
88. Dynamic activation of endothelial nitric oxide synthase by Hsp90
89. Signal transduction of eNOS activation
90. Tetrahydrobiopterin-dependent formation of endothelium-derived relaxing factor (nitric oxide) in aortic endothelial cells
91. Tetrahydrobiopterin regulates superoxide and nitric oxide generation by recombinant endothelial nitric oxide synthase
92. Superoxide generation by endothelial nitric oxide synthase: The influence of cofactors
93. 2-imbalance in insulin-resistant rat aorta
94. Tetrahydrobiopterin alters superoxide and nitric oxide release in prehypertensive rats
95. Tetrahydrobiopterin restores endothelial function in hypercholesterolemia
96. Tetrahydrobiopterin improves endothelium-dependent vasodilation in chronic smokers: Evidence for a dysfunctional nitric oxide synthase
97. Inhibition of tetrahydrobiopterin biosynthesis impairs endothelium-dependent relaxations in canine basilar artery
98. Endogenous nitric oxide synthase inhibitor a novel marker of atherosclerosis
99. Asymmetric dimethylarginine (ADMA): A novel risk factor for endothelial dysfunction: Its role in hypercholesterolemia
100. Elevated L-arginine/dimethylarginine ratio contributes to enhanced systemic NO production by dietary L-arginine in hypercholesterolemic rabbits
101. Biological significance of endegenous methylarginines that inhibit nitric oxide synthases
102. Vascular gene transfer: From bench to bedside
103. Adenoviral gene transfer of nitric oxide synthase: High level expression in human vascular cells
104. Altered vascular function after adenovirus-mediated overexpression of endothelial nitric oxide synthase
105. Improvement of relaxation in an atherosclerotic artery by gene transfer of endothelial nitric oxide synthase
106. Ex vivo gene transfer of endothelial nitric oxide synthase to atherosclerotic rabbit aortic rings improves relaxations to acetylcholine
107. Expression and function of a recombinant endothelial nitric oxide synthase gene in porcine coronary arteries
108. Expression and function of recombinant endothelial nitric oxide synthase gene in canine basilar artery
109. New approaches to prevention and treatment of radial artery graft vasospasm
110. Recombinant endothelial nitric oxide synthase transduced human saphenous veins: Gene therapy to augment nitric oxide production in bypass conduits
111. Adventitial expression of recombinant eNOS gene restores NO production in arteries without endothelium
112. Human endothelial nitric oxide synthase gene transfer inhibits vascular smooth muscle cell proliferation and neointima formation after balloon injury in rats
113. Gene therapy inhibiting neointimal vascular lesion: In vivo transfer of endothelial cell nitric oxide synthase gene
114. Enhanced recovery of injury-caused downregulation of paxillin protein by eNOS gene expression in rat carotid artery: Mechanism of NO inhibition of intimal hyperplasia?
115. Efficient inhibition of intimal hyperplasia by adenovims-mediated inducible nitric oxide synthase gene transfer to rats and pigs in vivo
116. Local adenovirus-mediated transfer of human endothelial nitric oxide synthase reduces luminal narrowing after coronary angioplasty in pigs
117. In vivo gene transfer of nitric oxide synthase enhances vasomotor function in carotid arteries from normal and cholesterol-fed rabbits
118. Nitric oxide synthase gene therapy rapidly reduces adhesion molecule expression and inflammatory cell infiltration in carotid arteries of cholesterol-fed rabbits
119. Enhanced endothelium-dependent relaxations after gene transfer of recombinant endothelial nitric oxide synthase to rabbit carotid arteries
120. Adventitial gene transfer of recombinant endothelial nitric oxide synthase to rabbit carotid arteries alters vascular reactivity
121. Effects of in vivo adventitial expression of recombinant endothelial nitric oxide synthase gene in cerebral arteries
122. Inducible nitric oxide synthase suppresses the development of allograft arteriosclerosis
123. Hemagglutinating virus of Japan-liposome-mediated gene transfer of endothelial cell nitric oxide synthase inhibits intimal hyperplasia of canine vein grafts under conditions of poor runoff
124. Adenoviral-mediated transfer of the human endothelial nitric oxide synthase gene reduces acute hypoxic pulmonary vasoconstriction in rats
125. Overexpression of endothelium nitric oxide synthase reverses the diminished vasorelaxation in the hindlimb vasculature in ischemic heart failure in vivo
126. Gene transfer of endothelial nitric oxide synthase improves nitric oxidedependent endothelial function in a hypertensive rat model
127. Gene transfer of endothelial nitric oxide synthase reduces angiotensin II-induced endothelial dysfunction
128. Gene transfer of endothelial nitric oxide synthase improves relaxation of carotid arteries from diabetic rabbits
129. Gene transfer of endothelial nitric oxide synthase to the lung of the mouse In vivo: Effect on agonist-induced and flow-mediated vascular responses
130. Vascular endothelial cell regulation of extracellular matrix collagen: Role of nitric oxide
131. L-Arginine improves endothelium-dependent vasorelaxation and reduces intimal hyperplasia after balloon angioplasty
132. Intraoperative adenoviral gene transfer of nitric oxide synthase reduces early inflammation and intimal hyperplasia in venous bypass grafts
133. Nitric oxide-induced downregulation of Cdk2 activity and cyclin A gene transcription in vascular smooth muscle cells
134. NOS gene transfer inhibits expression of cell cycle regulatory molecules in vascular smooth muscle cells
135. eNOS gene transfer inhibits smooth muscle cell migration and MMP-2 and MMP-9 activity
136. Vasoactive substances regulate vascular smooth muscle cell apoptosis: Countervailing influences of nitric oxide and angiotensin II
137. Potentiation of endogenous nitric oxide with superoxide dismutase inhibits platelet-mediated thrombosis in injured and stenotic arteries
138. Gene transfer of nitric oxide synthase: Effects on endothelial biology
139. Adventitia-dependent relaxations of canine basilar arteries transduced with recombinant eNOS gene
140. Adenovirus-mediated gene transfer in vivo to cerebral blood vessels and perivascular tissue
141. Adenovirus-mediated gene transfer in vivo to cerebral blood vessels and perivascular tissue in mice
142. Arterial smooth muscle cells express nitric oxide synthase in response to endothelial injury
143. Reciprocal changes m endothelial and inducible nitric oxide synthase expression following carotid angioplasty in the pig
144. Inducible nitric-oxide synthase generates superoxide from the reductase domain
145. Phosphorylation and subcellular translocation of endothelial nitric oxide synthase
146. Endothelial nitric oxide synthase targeting to caveolae: Specific interactions with caveolin isoforms in cardiac myocytes and endothelial cells
147. Electron transfer andcatalytic activity of nitric oxide synthases: Chimeric constructs of the neuronal, inducible, and endothelial isoforms
148. Tetrahydrobiopterin and endothelial function
149. Optimization of ex vivo inducible nitric oxide synthase gene transfer to vein grafts
150. Inhibition of coronary artery superoxide dismutase attenuates endothelium-dependent and -independent nitrovasodilator relaxation
151. 2 production via NADH-derived superoxide
152. Overexpression of human superoxide dismutase inhibits oxidation of low-density lipoprotein by endothelial cells
153. Superoxide production in vascular smooth muscle contributes to oxidative stress and impaired relaxation in atherosclerosis
154. Gene transfer of endothelial nitric oxide synthase and superoxide dismutase improves vascular reactivity of aortas from diabetic rabbits
155. Adenovirus-mediated transfer of soluble guanylate cyclase α1 and β1 subunits increases nitric oxide responsiveness and reduces neointima formation in balloon-injured rat carotid arteries
156. Adenovirus-mediated gene transfer of cGMP-dependent protein kinase increases the sensitivity of cultured vascular smooth muscle cells to the antiproliferative and pro-apoptotic effects of nitric oxide/cGMP