Adventitial expression of recombinant eNOS gene restores NO production in arteries without endothelium

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 18, Issue 8, 1998, Pages 1231-1241

  Tsutsui, Masato ^a   Chen, Alex F Y ^a   O'Brien, Timothy ^a   Crotty, Thomas B ^a   Katusic, Zvonimir S ^a  

^a MAYO CLINIC   (United States)

Author keywords

Adenoviral vector; Bradykinin; Fibroblasts; Gene therapy; Gene transfer

Indexed keywords

BRADYKININ; ENDOTHELIUM DERIVED RELAXING FACTOR; NITRIC OXIDE; VIRUS VECTOR;

ADENOVIRUS; ANIMAL TISSUE; ARTICLE; BASILAR ARTERY; CORONARY ARTERY; DOG; FEMORAL ARTERY; FIBROBLAST; GENE EXPRESSION REGULATION; GENE THERAPY; GENE TRANSFER; GENETIC RECOMBINATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; REPORTER GENE; SHEAR STRESS; SIGNAL TRANSDUCTION;

EID: 0031866890     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.18.8.1231     Document Type: Article

References (20)

1. Moncada S, Palmer RMJ, Higgs EA. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev. 1991;43:109-142.
2. Bredt DS, Snyder SH. Nitric oxide: a physiological messenger molecule. Annu Rev Biochem. 1994;63:175-195.
3. Huang PL, Huang Z, Mashimo H, Bloch KD, Moskowitz MA, Bevan JA, Fishman MC. Hypertension in mice lacking the gene for endothelial nitric oxide synthase. Nature. 1995;377:239-242.
4. Ignarro LJ. Biosynthesis and metabolism of endothelium-derived nitric oxide. Annu Rev Pharmacol Toxicol. 1990;30:535-560.
5. Nathan C. Nitric oxide synthases: roles, tolls, and controls. Cell. 1994; 78:915-918.
6. Dominiczak AF, Bohr DF. Nitric oxide and its putative role in hypertension. Hypertension. 1995;25:1202-1211.
7. Garg UC, Hassid A. Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells. J Clin Invest. 1989;83:1774-1777.
8. Radomski MW, Palmer RMJ, Moncada S. An L-arginine/nitric oxide pathway present in human platelets regulates aggregation. Proc Natl Acad Sci U S A. 1990;87:5193-5197.
9. Kubes P, Suzuki M, Granger DN. Nitric oxide: an endogenous modulator of leukocyte adhesion. Proc Natl Acad Sci U S A. 1991;88:4651-4655.
10. Cohen RA. The role of nitric oxide and other endothelium-derived vasoactive substances in vascular disease. Prog Cardiovasc Dis. 1995;38:105-128.
11. Moncada S, Higgs A. The L-arginine-nitric oxide pathway. N Engl J Med. 1993;329:2002-2012.
12. von der Leyen HE, Gibbons GH, Morishita R, Lewis NP, Zhang L, Nakajima M, Kaneda Y, Cooke JP, Dzau VJ. Gene therapy inhibiting neointimal vascular lesion: in vivo transfer of endothelial cell nitric oxide synthase gene. Proc Natl Acad Sci U S A. 1995;92:1137-1141.
13. Janssens SP, Bloch KD, Nong Z, Gerard RD, Zoldhelyi P, Collen D. Adenoviral-mediated transfer of the human endothelial nitric oxide synthase gene reduces acute hypoxic pulmonary vasoconstriction in rats. J Clin Invest. 1996;98:317-324.
14. Chen AFY, O'Brien T, Tsutsui M, Kinoshita H, Pompili VJ, Crotty TB, Spector DJ, Katusic ZS. Expression and function of recombinant endothelial nitric oxide synthase gene in canine basilar artery. Circ Res. 1997;80:327-335.
15. Spector DJ, Samaniego LA. Construction and isolation of recombinant adenovirus with gene replacements. Methods Mol Genet. 1995;7:31-44.
16. Graham FL, Smiley J, Russell WC, Naim R. Characteristics of a human cell line transformed by human adenovirus type 5. J Gen Virol. 1977;36:59-74.
17. Jones N, Shenk T. Isolation of adenovirus type 5 host range deletion mutants defective for transformation of rat embryo cells. Cell. 1979;17:683-689.
18. Volkert FC, Young CS. The genetic analysis of recombination using adenovirus overlapping terminal DNA fragments. Virology. 1983;125:175-193.
19. Kullo II, Pompili V, Tsutsui M, Fitzpatrick LA, Katusic ZS, O'Brien T. Transfer of the endothelial nitric oxide synthase gene to coronary smooth muscle cells inhibits cell proliferation. Circulation. 1996;94(suppl I):I-146. Abstract
20. Dawson TM, Bredt DS, Fotuhi M, Hwang PM, Snyder SH. Nitric oxide synthase and neuronal NADPH diaphorase are identical in brain and peripheral tissues. Proc Natl Acad Sci U S A. 1991;88:7797-7801.