Novel mechanism of inhibition of elastase by β-lactams is defined by two inhibitor crystal complexes

Journal of Biological Chemistry

Volumn 274, Issue 35, 1999, Pages 24901-24905

  Taylor, Paul ^a   Anderson, Violet ^a   Dowden, James ^a   Flitsch, Sabine L ^a   Turner, Nicholas J ^a   Loughran, Karen ^b   Walkinshaw, Malcolm D ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b GENERAL ELECTRIC COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA LACTAM; ELASTASE; SERINE PROTEINASE INHIBITOR;

ARTICLE; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME INHIBITION; ENZYME REACTIVATION; ENZYME STRUCTURE; GEOMETRY; HYDROGEN BOND; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ANIMALS; BETA-LACTAMS; BINDING SITES; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; HYDROGEN BONDING; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PANCREATIC ELASTASE; PROTEIN BINDING; SERINE PROTEINASE INHIBITORS; SWINE;

SUIDAE;

EID: 0033609912     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.35.24901     Document Type: Article

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