In vivo expression of a new hepatitis B virus protein encoded by a spliced RNA

Journal of Clinical Investigation

Volumn 105, Issue 1, 2000, Pages 55-60

  Soussan, Patrick ^a,b   Garreau, Florianne ^a   Zylberberg, Hervé ^a   Ferray, Cyrille ^c   Brechot, Christian ^a   Kremsdorf, Dina ^a  

^a HÔPITAL NECKER ENFANTS MALADES   (France)

^b UNIVERSITÉ PARIS 13   (France)

^c HÔPITAL PAUL BROUSSE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

SPLICED LEADER RNA; VIRUS PROTEIN;

APOPTOSIS; ARTICLE; DNA REPLICATION; HEPATITIS B VIRUS; NONHUMAN; OPEN READING FRAME; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA SPLICING; VIRUS CELL INTERACTION; VIRUS CHARACTERIZATION;

EID: 0033987575     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI8098     Document Type: Article

References (24)

1. Ganem, D., and Varmus, H.E. 1987. The molecular biology of the hepatitis B viruses. Annu. Rev. Biochem. 56:651-693.
2. Wu, H.-L., et al. 1991. Characterization and genetic analysis of alternatively spliced transcripts of hepatitis B virus in infected human liver tissues and transfected Hep G2 cells. J. Virol. 65:1680-1686.
3. Chen, P.-J., Chen, C.-R., Sung, J.-L., and Chen, D.-S. 1989. Identification of a doubly spliced viral transcript joining the separated domains for putative protease and reverse transcriptase of hepatitis B virus. J. Virol. 63:4165-4171.
4. Terré, S., Petit, MA., and Bréchet, C. 1991. Defective hepatitis B virus particles are generated by packaging and reverse transcription of spliced viral RNAs in vivo. J. Virol. 65:5539-5543.
5. Wu, H.-L., Chen, P.-J., Lin, M.-H., and Chen, D.-S. 1991. Temporal aspects of major viral transcript expression in Hep G2 cells transfected with cloned hepatitis B virus DNA: with emphasis on the X transcript. Virology 185:644-651.
6. Suzuki, T., Kajino, K., Masui, N., Saito, I., and Miyamura, T. 1990. Alternative splicing of hepatitis B virus RNAs in HepG2 cells transfected with the viral DNA. Virology. 79:881-885.
7. Susuki, T., Masui, N., Kajino, K., Saito, I., and Miyamura, T. 1989. Detection and mapping of spliced RNA from a human hepatoma cell line transfected with the hepatitis B virus genome. Proc. Nat. Acad. Sci. USA. 86:8422-8426.
8. Su, T.S., et al. 1989. Hepatitis B virus transcript produced by RNA splicing. J. Virol. 63:4011-4018.
9. Ogston, C.W., and Razman, D.G. 1992. Spliced RNA of woodchuck hepatitis virus. Virology. 189:245-252.
10. Hantz, O., Baginski, I., Fourel, I., Chemin, I., and Trepo, C. 1992. Viral spliced RNA are produced, encapsidated and reverse transcribed during in vivo woodchuck hepatitis virus infection. Virology. 190:193-200.
11. Obert, S., et al. 1996. A spliced hepadnavirus RNA that is essential for virus replication. EMBO J. 15:2565-2574.
12. Rosmorduc, O., et al. 1995. In vivo and in vitro expression of defective hepatitis B virus particles generated by spliced hepatitis B virus RNA. Hepatology. 22:10-19.
13. Günther, S., Sommer, G., Iwanska, A., and Will, H. 1997. Heterogeneity and common features of defective hepatitis B virus genomes derived from spliced pregenomic RNA. Virology. 238:363-371.
14. Guidotti, L.G., Matzke, B., Schaller, H., and Chisari, F.V. 1995. High-level hepatitis B virus replication in transgenic mice. J. Virol. 69:6158-6169.
15. Zhang, P., Raney, A.K., and McLachlan, A. 1992. Characterization of the hepatitis B virus X-and nucleocapsid gene transcriptional regulatory elements. Virology. 191:31-41.
16. Gerlich, W.H., and Heerman, K.H. 1991. Hepatitis B virus proteins and virus assembly. In Viral hepatitis and liver disease. F.B. Hollinger, S.M. Lemon, and H.S. Margolies, editors. Lippincott Williams & Wilkins. Baltimore, MD. 121-134.
17. Yen, T. 1996. Hepadnaviral X protein: review of recent progress. J. Biomed. Sci. 3:20-30.
18. O'Brien, V. 1998. Viruses and apoptosis. J. Gen. Virol. 79:1833-1845.
19. Chisari, F.V. 1996. Hepatitis B virus transgenic mice: models of viral immunobiology and pathogenesis. Curr. Top. Microbiol. Immunol. 206:149-173.
20. Teodoro, J.G., and Branton, P.E. 1997. Regulation of apoptosis by viral gene products. J. Virol. 71:1739-1746.
21. Rothnie, H.M., Chapdelaine, Y., and Hohn, T. 1994. Pararetroviruses and retroviruses: a comparative review of viral structure and gene expression strategies. Adv. Virus Res. 44:1-67.
22. Kiss-Laszlo, Z., Blanc, S., and Hohn, T. 1995. Splicing of cauliflower mosaic virus 35S RNA is essential for viral infectivity. EMBO J. 14:3552-3562.
23. Giron, M.L., de The, H., and Saib, A. 1998. An evolutionarily conserved splice generates a secreted env-Bet fusion protein during human foamy virus infection. J. Virol. 72:4906-4910.
24. Kiss-Laszlo, Z., and Hohn, T. 1996. Pararetro-and retrovirus RNA: splicing and the control of nuclear export. Trends Microbiol. 4:480-485.