An association between viral genes and human oncogenic alterations: The adenovirus E1A induces the Ewing tumor fusion transcript EWS-FLI1

Nature Medicine

Volumn 5, Issue 9, 1999, Pages 1076-1079

  Sanchez Prieto, Ricardo ^a,e   De Alava, Enrique ^b   Palomino, Teresa ^a   Guinea, Juan ^a   Fernandez, Victor ^a   Cebrian, Silvia ^a   Lleonart, Matilde ^a   Cabello, Pablo ^c   Martin, Pilar ^a   San Roman, Carlos ^c   Bornstein, Rafael ^d   Pardo, Javier ^b   Martinez, Ana ^a   Diaz Espada, Fernando ^a   Barrios, Yve ^a   Y Cajal, Santiago Ramon ^a  

^a HOSPITAL UNIVERSITARIO PUERTA DE HIERRO   (Spain)

^b UNIVERSITY CLINIC OF NAVARRA   (Spain)

^c HOSPITAL RAMÓN Y CAJAL   (Spain)

^d HOSPITAL UNIVERSITARIO 12 DE OCTUBRE   (Spain)

^e NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS; ARTICLE; CHROMOSOME TRANSLOCATION; EWING SARCOMA; FUSION GENE; GENE ACTIVATION; GENE INDUCTION; GENETIC STABILITY; HUMAN; HUMAN CELL; MALIGNANT TRANSFORMATION; ONCOGENE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR SUPPRESSOR GENE; VIRUS GENE;

ADENOVIRUS E1A PROTEINS; ADENOVIRUSES, HUMAN; BASE SEQUENCE; CELL LINE; CHROMOSOMES, HUMAN, PAIR 11; CHROMOSOMES, HUMAN, PAIR 22; FIBROBLASTS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, VIRAL; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; KERATINOCYTES; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; MUTATION; ONCOGENE PROTEINS, FUSION; ONCOGENES; PROTO-ONCOGENE PROTEIN C-FLI-1; RNA, MESSENGER; SARCOMA, EWING'S; TRANSCRIPTION FACTORS; TRANSLOCATION, GENETIC;

EID: 0032820855     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/12516     Document Type: Article

References (20)

1. Barr, F.G. Translocations, cancer and the puzzle of specificity. Nature Genet. 19, 121-124 (1998).
2. Delattre, O. et al. Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumors. Nature 359, 162-165 (1992).
3. Bayley, S.T. & Mymryk, J.S. Adenovirus E1A proteins and transformation (review). Int. J. Oncol. 5, 425-444 (1994).
4. Mymryk, J.S. Tumor suppressive properties of the adenovirus 5 EIA oncogene. Oncogene 13, 1581-1589 (1996).
5. Somasundaram, K. & El-Deiry, W. S. Inhibition of p53-mediated transactivation and cell cycle arrest by E1A through its p300/CBP-interacting region. Oncogene 14, 1047-1057 (1997).
6. Mymryk, J.S. & Smith, M.M. Influence of the adenovirus 5 E1A oncogene on chromatin remodelling. Biochem. Cell Biol. 75, 95-102 (1997).
7. Sánchez-Prieto, R. et al. In vivo tumor suppressor effect of retrovirus gene transfer of the adenovirus E1a gene. Cancer Gene Ther. 5, 215-224 (1998).
8. Sánchez-Prieto, R. et al. Carcinoma cell lines become sensitive to DNA-damaging agents by the expression of the adenovirus E1A gene. Oncogene 13, 1083-1092 (1996).
9. Ramón y Cajal, S., Sánchez-Prieto, R. & Anaya, A. A genetic model for undifferentiated cell tumor formation: similar tumors formed by different cell lines transformed by the E1A oncogene. Histol. Histopathol. 10, 811-820 (1995).
10. Frisch, S.M. E1A induces the expression of epithelial characteristics. J. Cell Biol. 127, 1085-1096 (1994).
11. Fukamizu, A. et al. Neuroectodermal tumors expressing c-, L-, and N-myc in transgenic mice that carry the E1A/E1B gene of human adenovirus type 12*. J. Biol. Chem. 269, 31252-31258 (1994).
12. Delattre, O. et al. The Ewing family of tumors. A subgroup of small round cell tumors defined by specific chimeric transcripts. N. Engl. J. Med. 331, 294-299 (1994).
13. De Alava, E. et al. EWS-FLI1 fusion transcript structure is an independent determinant of prognosis in Ewing's sarcoma. J. Clin. Oncol. 16, 1248-1255 (1998).
14. May, W.A. et al. EWS/FLI1-induced manic fringe renders NIH 3T3 cells tumorigenic. Nature Genet. 17, 495-497 (1997).
15. Hiom, K., Melek, M. & Gellert, M. DNA transposition by the RAG1 and RAG2 proteins: A possible source of oncogene translocations. Cell 94, 463-470 (1998).
16. Bertrand, P. et al. Increase of spontaneous intrachromosomal homologous recombination in mammalian cells expressing a mutant p53 protein. Oncogene 14, 1117-1122 (1997).
17. Zucman-Rossi, J., Legoix, P., Victor, J.M., Lopez, B. & Thomas, G. Chromosome translocation based on illegitimate recombination in human tumors. Proc. Natl. Acad. Sci. USA 95, 11786-11791 (1998).
18. Caporossi, D. & Bacchetti, S. Definition of adenovirus type 5 functions involved in the induction of chromosomal aberrations in human cells. J. Gen. Virol. 71, 801-808 (1990).
19. Schramayr, S., Caporossi, D., Mak, Y., Jelinek, T. & Bacchett, S. Chromosomal damage induced by human adenovirus type 12 requires expression of the E1B 55-kilodalton viral protein. J. Virol. 64, 2090-2095 (1990).
20. Serrano, M., Lin, A. W., McCurrach, M., Beach, D. & Lowe, S. W. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88, 593-602 (1997).