Serologically silent hepatitis B virus coinfection in patients with hepatitis C virus-associated chronic liver disease: Clinical and virological significance

Journal of Medical Virology

Volumn 58, Issue 3, 1999, Pages 201-207

  Fukuda, Ryo ^a   Ishimura, Norihisa ^a   Niigaki, Misa ^a   Hamamoto, Sachiko ^a   Satoh, Shuichi ^a   Tanaka, Shino ^a   Kushiyama, Yoshinori ^a   Uchida, Yasushi ^a   Ihihara, Shunji ^a   Akagi, Shuji ^a   Watanabe, Makoto ^a   Kinoshita, Yoshikazu ^a  

^a SHIMANE UNIVERSITY   (Japan)

Author keywords

Hepatitis C virus associated chronic liver disease; Interferon therapy; Nested polymerase chain reaction; Serologically silent HBV

Indexed keywords

ALANINE AMINOTRANSFERASE; INTERFERON; RECOMBINANT ALPHA2B INTERFERON; VIRUS RNA;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; CHRONIC LIVER DISEASE; CONTROLLED STUDY; DELETION MUTANT; DISEASE ASSOCIATION; FEMALE; GENE DELETION; GENOTYPE; HEPATITIS B VIRUS; HEPATITIS C VIRUS; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PROMOTER REGION; SUPERINFECTION; VIRUS REPLICATION;

ADULT; ALANINE TRANSAMINASE; ANTIVIRAL AGENTS; DNA, VIRAL; FEMALE; GENOTYPE; HEPACIVIRUS; HEPATITIS B CORE ANTIGENS; HEPATITIS B SURFACE ANTIGENS; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HEPATITIS C, CHRONIC; HUMANS; INTERFERONS; LIVER; MALE; MIDDLE AGED; PROMOTER REGIONS (GENETICS); RNA, VIRAL;

EID: 0033037033     PISSN: 01466615     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9071(199907)58:3<201::AID-JMV3>3.0.CO;2-2     Document Type: Article

References (43)

1. Aufiero B, Schneider J. 1990. The hepatitis B virus X-gene product trans-activates both RNA polymerase II and III promoters. EMBO J 9:497-504.
2. Chen DS, Kuo GC, Sung JL, Lai MY, Sheu JC, Chen PJ, Yang PM, Hsu HM, Chang CJ, Hahn LC, Choo QL, Wang TH, Houghton M. 1990. Hepatitis C virus infection in an area hyperendemic for hepatitis B virus and chronic liver disease: the Taiwan experience. J Infect Dis 162:817-822.
3. Chen HS, Kaneko S, Gironews R, Anderson RW, Hornbucle WE, Tennant BC, Cote PJ, Berin JL, Purcell RH, Miller RH. 1993. The woodchuck hepatitis virus X gene is important for establishment of virus infection in woodchucks. J Virol 67:1218-1226.
4. Chung AC, Lai CL, Lok ASF. 1995. Pathogenic role of hepatitis B virus in hepatitis B surface antigen-negative decompensated cirrhosis. Hepatology 22:25-29.
5. Farci P, Mandas A, Coiana A, Lai ME, Desmet V, Van Eyken P, Gibo Y, Caruso L, Scaccabarozzi S, Criscuolo D, Ryff JC, Balestrieri A. 1994. Treatment of chronic hepatitis D with interferon alpha-2a. N Engl J Med 330:88-94.
6. Feitelson MA, Duan LX, Guo J, Woo J, Steensma K, Horiike N, Blumberg BS. 1995. X region deletion variants of hepatitis B virus in surface antigen-negative infections and non-A, non-B hepatitis. J Infect Dis 172:713-22.
7. Fong TL, Di Biscegli AM, Waggoner JG, Bank SM, Hoofnagle JH. 1991. The significance of antibody to hepatitis C virus in patients with chronic hepatitis B. Hepatology 14:64-67.
8. Fujiyama A, Miyanohara A, Nozaki C, Yoneyama T, Ohtomo M, Matsubara K. 1983. Cloning and structural analysis of hepatitis B virus DNAs, subtype adr. Nucleic Acids Res 11:4601-4610.
9. Fukuda R, Ishimura N, Kushiyama Y, Nguyen TX, Moriyama T, Ishihara S, Chowdhury A, Sakai S, Satoh S, Akagi S, Watanabe M, Fukumoto S. 1996. Hepatitis B virus with X gene mutation is responsible for the majority of serologically "silent" non-B, non-C chronic hepatitis. Microbiol Immunol 40:481-488.
10. Gonzalez S, Navas S, Madejon A, Bartoleme J, Castillo I, Moraleda G, Moartin J, Mariiott E, Herrero M, Carreno V. 1995. Hepatitis B virus and D virus genomes in hepatitis B surface antigen negative patients with chronic hepatitis C. J Med Virol 45:168-173.
11. Hagiwara H, Hayashi N, MiTa E, Takehara T, Kasahara A, Fusamoto H, Kamada T. 1993. Quantitative analysis of hepatitis C virus RNA in serum during interferon alpha therapy. Gastroenterology 104:877-883.
12. Knodell RG, Ishak KG, Black WC, Chen TS, Craig R, Kaplowitz N, Kiernan TW, Wollman J. 1981. Formulation and application of a numerical scoring system for assessing histological activity in asymptotic chronic active hepatitis. Hepatology 1:431-435.
13. Kobayashi M, Tanaka E, Sodeyama T, Urushihara A, Matsumoto A, Kiyosawas K. 1996. The natural course of chronic hepatitis C: a comparison between patients with genotype 1 and 2 hepatitis C viruses. Hepatology 23:695-699.
14. Kohara M, Tanaka T, Tsukiyama-Kohara K, Tanaka S, Mizokami M, Lau JYN, Hattori N. 1995. Hepatitis C virus genotype 1 and 2 respond to interferon-a with different virological kinetics. J Infect Dis 172:934-938.
15. Koike K, Yasuda K, Yotsuyanagi H, Moriya K, Hino K, Kurasawa K, Iino S. 1995. Dominant replication of either virus in dual infection with hepatitis viruses B and C. J Med Virol 45:236-239.
16. Koike K, Nakamura Y, Kobayashi M, Takada S, Urashima T, Saigo K, Kobayashi S, Isono K, Hayashi I, Fujii A. 1996. Hepatitis B virus DNA integration frequently observed in the hepatocellular carcinoma DNA of hepatitis C virus-infected patients. Int J Oncol 8: 781-784.
17. Koike K, Kobayashi M, Gondo M, Hayashi I, Osuga T, Takada S. 1998. Hepatitis B virus DNA is frequently found in liver biopsy samples from hepatitis C virus-infected chronic hepatitis patients. J Med Virol 54:249-255.
18. Liaw Yun-Fan. 1995. Role of hepatitis C virus in dual and triple hepatitis virus infection. Hepatology 22:1101-1108.
19. Lopez-Cabrera M, Letovsky J, Hu KQ, Siddiqui A. 1990. Multiple liver-specific factors bind to the hepatitis B virus core/pregenomic promoter:Trans-activation and repression by CCAT/enhancer binding protein. Proc Natl Acad Sci USA 87:5069-5073.
20. Lopez-Cabrera M, Letovsky J, Hu KQ, Siddiqui A. 1991. Transcriptional factor C/EBP binds to and transactivates the enhancer element II of the hepatitis B virus. Virology 183:825-829.
21. Maguire HF, Hoeffler JP, Siddiqui A. 1990. HBV X protein alters the DNA binding specificity of CREB and ATF-2 by protein-protein interactions. Science 252:842-844.
22. Ohkawa K, Hayashi N, Yuki N, Kato H, Yamamoto K, Eguchi H, Fusamoto H, Masuzawa H, Kamada T. 1994. Hepatitis C virus antibody and hepatitis C virus replication in chronic hepatitis B patients. J Hepatol 21:509-514.
23. Ohkawa K, Hayashi N, Yuki N, Masuzawa M, Kato M, Yamamoto K, Hosotsubo H, Deguchi M, Katayama K, Kasahara A, Fusamoto H, Kamada T. 1995. Long-term follow-up of hepatitis B virus in chronic hepatitis C virus replication levels in chronic hepatitis patients coinfected with both viruses. J Med Virol 46:258-264.
24. Okamoto H, Yotsumoto S, Akahane Y, Yamanaka T, Miyazaki Y, Sugai Y, Tsuda F, Tanaka T, Miyakawa Y, Mayumi M. 1990. Hepatitis B virus with precore region defects prevail in persistently infected host along with seroconversion to antibody against e antigen. J Virol 64:1298-1303.
25. Repp R, Keller C, Borkhardt A, Cseckke A. 1992. Detection of a hepatitis B virus variant with a truncated X gene and enhancer II. Arch Virol 125:299-304.
26. Ritter SE, Whitten TM, Quets AT, Schloemer RH. 1990. An internal domain of the hepatitis B virus X antigen is necessary for transactivity. Virology 182:841-845.
27. Rossner MT. 1992. Review: hepatitis B virus X-gene product: a promiscuous transcriptional activator. J Med Virol 36:101-107.
28. Sambrook J, Fritsh FF, Maniatis T. 1989. Molecular cloning. 2nd Ed. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
29. Seeger C, Ganem D, Varmus HE. 1986. Biochemical and genetic evidences for the hepatitis B virus replication strategy. Science 232: 477-484.
30. Shih CM, Lo SJ, Miyamura T, Chen SY, Wu Lee YH. 1993. Suppression of hepatitis B virus expression and replication by hepatitis C virus core protein in Huh-7 cells. J Virol 67:5823-5832.
31. Simmonds P, McOmish F, Yap PL, Chan S-W, Lin CK, Dusheiko G, Saeed AA, Holmes EC. 1993. Sequence variability in the 5′ noncoding region of hepatitis C virus: identification of a new type and new strictions on sequence diversity. J Gen Virol 74:661-668.
32. Spandau DF, Lee CH. 1988. Trans-activation of viral enhancers by the hepatitis B virus X protein. J Virol 62:427-34.
33. Takada S, Koike K. 1990. X protein of hepatitis B virus resembles a serine protease inhibitor. Jpn J Cancer Res 81:1191-1194.
34. Tsukiyama K, Izuka N, Kohara M, Nomoto A. 1992. Internal ribosome entry site within hepatitis C virus RNA. J Virol 66:1476-1483.
35. Uchida T, Shimojima M, Gotoh K, Shikata T, Tanaka E, Kiyosawa K. 1994. "Silent" hepatitis virus mutants are responsible for non-A, non-B, non-C, non-D, non-E hepatitis. Microbiol Immunol 38:281-285.
36. Uchida T, Kaneita Y, Gotoh K, Kanagawa H, Kouyama H, Kawanishi T, Mima S. 1997. Hepatitis C virus is frequently coinfected with serum marker-negative Hepatitis B virus: Probable replication promotion of the former by the latter as demonstrated by in vitro cotransfection. J Med Virol 52:399-405.
37. Unger T, Shaul Y. 1990. The X protein of the hepatitis B virus acts as a transcrptional factor when targeted to its responsive elements. EMBO J 9:1889-1895.
38. Urashima T, Saigo K, Kobayashi S, Imaseki H, Matsubara H, Koide Y, Asano T, Kondo Y, Koike K, Isono K. 1997. Identification of hepatitis B virus integration in hepatitis C virus-infected hepatocellular carcinoma tissues. J Hepatol 26:771-778.
39. Villa E, Grottolia A, Buttafoco P, Trande P, Merighi A, Fratti N, Seium Y, Cioni G, Manenti F. 1995. Evidence for hepatitis B virus infection in patients with chronic hepatitis C with and without serological markers of hepatitis B. Digest Dis Sci 40:8-11.
40. Wang Y, Chen P, Wu S, Sun AL, Wabg H, Zhu YA, Li ZP. 1990. A new enhancer element, ENII, identified in the X gene of hepatitis B virus. J Virol 64:3977-3981.
41. Weltman WD, Brotodihardjo A, Crewe EB, Farrell GC, Bilous M, Grierson JM, Liddle C. 1995. Coinfection with hepatitis B and C or B, C and D viruses results in severe chronic liver disease and responds poorly to interferon-a treatment. J Viral Hepatitis 2:29-45.
42. Zignego AL, Fontana R, Pulti S, Barbagli S, Monti M, Careccia G, Giannelli F, Giannini C, Buzzelli G, Rossana M, Bonino F, Gentilini P. 1997. Relevance of inapparent coinfection by hepatitis B virus in alpha interferon-treated patients with hepatitis C virus chronic infection. J Medical Virol 51:313-318.
43. Zoulim F, Saputelli J, Seeger C. 1994. Woodchuck hepatitis virus X protein is required for viral infection in vivo. J Virol 68:2026-2030.