Hepatic expression of the woodchuck hepatitis virus X-antigen during acute and chronic infection and detection of a woodchuck hepatitis virus X- antigen antibody response

Hepatology

Volumn 26, Issue 6, 1997, Pages 1607-1615

  Jacob, James R ^a   Ascenzi, Mary A ^a   Roneker, Carol A ^a   Toshkov, Illia A ^a   Cote, Paul J ^b   Gerin, John L ^b   Tennant, Bud C ^a  

^a Department of Population Medicine and Diagnostic Sciences   (United States)

^b GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

UNCLASSIFIED DRUG; VIRUS ANTIGEN; WOODCHUCK HEPATITIS VIRUS X ANTIGEN;

ACUTE HEPATITIS; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY RESPONSE; ANTIGEN EXPRESSION; ARTICLE; CHRONIC HEPATITIS; CONTROLLED STUDY; HEPATITIS B VIRUS; HEPATITIS VIRUS; IMMUNOHISTOCHEMISTRY; LIVER BIOPSY; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN LOCALIZATION;

EID: 0030695101     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.510260632     Document Type: Article

References (21)

1. Gust ID, Burrell CJ, Coulepis AG, Robinson WS, Zuckerman AJ. Taxonomic classification of human hepatitis B virus. Intervirology 1986;25:14-29.
2. Summers J, Mason WS. Replication of the genome of a hepatitis B-like virus by reverse transcription of an RNA intermediate. Cell 1982;29:403-415.
3. Gerber MA, Thung SN. Biology of Disease: Molecular and cellular pathology of hepatitis B. Lab Invest 1985;52:572-590.
4. Schodel F, Sprengel R, Weimer T, Fernholz D, Scheider R, Will H. Animal hepatitis B viruses. Adv Viral Oncology 1989;8:73-102.
5. Robinson WS. Molecular events in the pathogenesis of hepadnavirus-associated hepatocellular carcinoma. Ann Rev Med 1994;45:297-323.
6. Kaneko S, Miller RH. X-region-specific transcript in mammalian hepatitis B virus-infected liver. J Virol 1988;62:3979-3984.
7. Rossner MT. Hepatitis B virus X-gene product: A promiscuous transcriptional activator. J Med Virol 1992;36:101-117.
8. Zoulim F, Saputelli J, Seeger C. Woodchuck hepatitis virus X protein is required for viral infection in vivo. J Virol 1994;68:2026-2030.
9. Chen HS, Kaneko S, Girones R, Anderson RW, Hornbuckle WE, Tennant BC, Cote PJ, et al. The woodchuck hepatitis virus X gene is important for establishment of virus infection in woodchucks. J Virol 1993;67:1218-1226.
10. Moriarty AM, Alexander H, Lerner RA. Antibodies to peptides detect new hepatitis B antigen: serological correlation with hepatocellular carcinoma. Science 1985;227:429-433.
11. Haruna Y, Hayashi N, Katayama K, Nobukabu Y, Kasahara A, Sasaki Y, Fusamoto H, et al. Expression of X protein and hepatitis B virus replication in chronic hepatitis. HEPATOLOGY 1991;13:417-421.
12. Wang W, London WY, Lega L, Feitelson MA. HBxAg in the liver from carrier patients with chronic hepatitis and cirrhosis. HEPATOLOGY 1991;14:29-37.
13. Zhu M, London WT, Duan L-X, Feitelson MA. The value of hepatitis B x antigen as a prognostic marker in the development of hepatocellular carcinoma. Int J Cancer 1993;55:571-576.
14. Levrero M, Jean-Jean O, Balsano C, Will H, Perricaudet M. Hepatitis B virus (HBV) X gene expression in human cells and anti-HBx antibodies detection in chronic HBV infection. Virology 1990;174:299-304.
15. Levrero M, Stemler M, Pasquinelli C, Alberti A, Jean-Jean O, Franco A, Balsano C, et al. Significance of anti-HBx antibodies in hepatitis B virus infection. HEPATOLOGY 1991;13:143-149.
16. Jung M-C, Stemler M, Weimer T, Spengler U, Dohrmann J, Hoffmann R, Eichenlaub D, et al. Immune response of peripheral blood mononuclear cells to HBx-antigen of hepatitis B virus. HEPATOLOGY 1991;13:637-643,.
17. Kay A, Dupont de Dinechin S, Vitvitski-Trepo L, Mandart E, Shamoon B-M, Galibert F. Recognition of the N-terminal, C-terminal, and interior portions of HBx by sera from patients with hepatitis. Br J Med Virol 1991;33:228-235.
18. Korba BE, Cote PJ, Tennant BC, Gerin JL. Woodchuck virus infection as a model for the development of antiviral therapies against HBV. In: Hollinger FB, Lemon SM, Margolis HS, eds. Viral hepatitis and liver disease. Baltimore: Williams and Wilkins, 1991:663-665.
19. Gerin JL, Cote PJ, Korba BE, Miller RH, Purcell RH, Tennant BC. Hepatitis B virus and liver cancer: the woodchuck as an experimental model of hepadnavirus-induced liver cancer. In: Hollinger FB, Lemon SM, Margolis HS, eds. Viral hepatitis and liver disease. Baltimore: Williams and Wilkins, 1991:556-559.
20. Cohen JI, Miller RH, Rosenblum B, Denniston K, Gerin JL, Purcell RH. Sequence comparison of woodchuck hepatitis virus replicative forms shows conservation of the genome. Virology 1988;162:12-20.
21. Sambrook J, Fritsch EF, Maniatis T. A laboratory manual for molecular cloning. Cold Spring Harbor Laboratory: Cold Spring Harbor Press, 1989.