Critical involvement of interferon gamma in the pathogenesis of T-cell activation-associated hepatitis and regulatory mechanisms of interleukin-6 for the manifestations of hepatitis

Hepatology

Volumn 23, Issue 6, 1996, Pages 1608-1615

  Mizuhara, Hidekazu ^a   Uno, Maki ^a   Seki, Nobuo ^a   Yamashita, Masakatsu ^a   Yamaoka, Makiko ^a   Ogawa, Toshikazu ^a   Kaneda, Kenji ^b   Fujii, Takashi ^a   Senoh, Hachiro ^a   Fujiwara, Hiromi ^c  

^a ASTELLAS PHARMA INC   (Japan)

^b OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CONCANAVALIN A; GAMMA INTERFERON; MONOCLONAL ANTIBODY; RECOMBINANT INTERLEUKIN 6;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTRON MICROSCOPY; FEMALE; HEPATITIS; LIVER INJURY; LYMPHOCYTIC INFILTRATION; MOUSE; NONHUMAN; PASSIVE IMMUNIZATION; PATHOGENESIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

EID: 15844425587     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1053/jhep.1996.v23.pm0008675184     Document Type: Article

References (14)

1. Wermers GW, Band H, Yunis EJ. Role of the HLA system in antigen recognition and disease. In: Arias IM, Jakoby WB, Popper H, Schachter D, Shafritz DA, eds. The liver: biology and pathobiology. Ed 2. New York: Raven, 1988:885-896.
2. Tiegs G, Hentschel J, Wendel A. A T cell-dependent experimental liver injury in mice inducible by concanavalin A. J Clin Invest 1992;90:196-203.
3. Decker K, Keppler D. Galactosamine hepatitis: key role of the nucleotide deficiency period in the pathogenesis of cell injury and cell death. Rev Physiol Biochem Pharmacol 1974;71:77-106.
4. Galanos C, Freudenberg MA, Reutter W. Galactosamine-induced sensitization to the lethal effects of endotoxin. Proc Natl Acad Sci U S A 1979;76:5939-5943.
5. Lehmann V, Freudenberg MA, Galanos C. Lethal toxicity of lipopolysaccharide and tumor necrosis factor in normal and D-galactosamine-treated mice. J Exp Med 1987;165:657-663.
6. Mizuhara H, O'Neill E, Seki N, Ogawa T, Kusunoki C, Otsuka K, Satoh S, et al. T cell activation-associated hepatic injury: mediation by tumor necrosis factors and protection by interleukin-6. J Exp Med 1994;179:1529-1537.
7. Kobayashi M, Fitz L, Ryan M, Hewick RM, Clark SC, Chan S, Loudon R, et al. Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biological effects on human lymphocytes. J Exp Med 1989;170:827-845.
8. Chan SH, Perussia B, Gupta JW, Kobayashi M, Pospisil M, Young HA, Wolf SF, et al. Induction of interferon-γ production by natural killer cell stimulatory factor: characterization of the responding cells and synergy with other inducers. J Exp Med 1991;173:869-879.
9. Brunda M. Interleukin-12. J Leukoc Biol 1994;55:280-288.
10. Landolfo S, Colano F, Giovarell M, Prat M, Cavallo G, Forni G. Inhibition of interferon-gamma may suppress allograft reactivity by T lymphocytes in vitro and in vivo. Science 1965;229:176-179.
11. Rosenberg AS, Finbloom DS, Maniero TG, Van der Meide PH, Singer A. Specific prolongation of MHC class II disparate skin allografts by in vivo administration of anti-IFN-γ monoclonal antibody. J Immunol 1990;144:4648-4650.
12. Noronha IL, Eberlein-Gonska M, Hartley B, Stephens S, Cameron JS, Waldherr R. In situ expression of tumor necrosis factor-α, interferon-γ and interleukin-2 receptors in renal allograft biopsies. Transplantation 1992;54:1017-1024.
13. Nastala CL, Edington HD, Mckinney TG, Tahara H, Nalesnik MA, Brunda MJ, Gately MK, et al. Recombinant IL-12 administration induces tumor regression in association with IFN-γ production. J Immunol 1994;153:1697-1706.
14. Zou J-P, Yamamoto N, Fujii T, Takenaka H, Kobayashi M, Herrmann SH, Wolf SF, et al. Systemic administration of rIL-12 induces complete tumor regression and protective immunity: response is correlated with a striking reversal of suppressed interferon-γ production by anti-tumor T cells. Int Immunol 1995; 7:1135-1145.