Site-directed mutagenesis of squalene-hopene cyclase: Altered substrate specificity and product distribution

Chemistry and Biology

Volumn 7, Issue 8, 2000, Pages 643-649

  Dang, Tongyun ^a   Prestwich, Glenn D ^a  

^a UNIVERSITY OF UTAH   (United States)

Author keywords

Site directed mutagenesis; Triterpene biosynthesis

Indexed keywords

BENZOPHENONE DERIVATIVE; DRUG DERIVATIVE; ENZYME INHIBITOR; MUTASE; RO 48 8071; RO 48-8071; SQUALENE; SQUALENE HOPENE CYCLASE; SQUALENE-HOPENE CYCLASE; TRITERPENE;

AMINO ACID SEQUENCE; ARTICLE; BACILLUS; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; CYCLIZATION; ENZYME SPECIFICITY; ENZYMOLOGY; GENETICS; KINETICS; METABOLISM; PHOTOAFFINITY LABELING; PROTEIN MOTIF; SITE DIRECTED MUTAGENESIS; STEREOISOMERISM; TEMPERATURE;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; BACILLUS; BENZOPHENONES; BINDING SITES; CYCLIZATION; ENZYME INHIBITORS; INTRAMOLECULAR TRANSFERASES; KINETICS; MOLECULAR STRUCTURE; MUTAGENESIS, SITE-DIRECTED; PHOTOAFFINITY LABELS; SQUALENE; STEREOISOMERISM; SUBSTRATE SPECIFICITY; TEMPERATURE; TRITERPENES;

EUKARYOTA;

EID: 0033835264     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-5521(00)00003-X     Document Type: Article

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