The roles of Jaks and Stats in cytokine signaling

Cancer Journal from Scientific American

Volumn 4, Issue SUPPL. 1, 1998, Pages

  Ihle, James N ^a   Stravapodis, Dimitrios ^a   Parganas, Evan ^a   Thierfelder, William ^a   Feng, Jian ^b   Wang, Demin ^a   Teglund, Stephan ^b  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE RECEPTOR; GROWTH HORMONE; PROLACTIN; PROTEIN KINASE;

ARTICLE; HORMONE ACTION; LYMPHOID TISSUE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; SIGNAL TRANSDUCTION;

ANIMALS; CYTOKINES; DNA-BINDING PROTEINS; HUMANS; MODELS, BIOLOGICAL; PROTEIN-TYROSINE KINASES; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS;

EID: 0031844302     PISSN: 10814442     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (49)

1. Bazan JF. Structural design and molecular evolution of a cytokine receptor superfamily. Proc Natl Acad Sci USA 1990;87:6934-6938.
2. De Vos AM, Ultsch M, Kossiakoff AA. Human growth hormone and extracellular domain of its receptor: crystal structure of the complex. Science 1992;255:306-312.
3. Youssoufian H, Longmore G, Neumann D et al. Structure, function, and activation of the erythropoietin receptor. Blood 1993;9: 2223-2236.
4. Ihle JN. Cytokine receptor signalling. Nature 1995;77:591-594.
5. D'Andrea AD, Yoshimura A, Youssoufian H et al. The cytoplasmic region of the erythropoietin receptor contains nonoverlapping positive and negative growth-regulatory domains. Mol Cell Biol 1991;11:1980-1987.
6. Witthuhn B, Quelle FW, Silvennoinen O et al. JAK2 associates with the erythropoietin receptor and is tryosine phosphorylated and activated following EPO stimulation. Cell 1993;74:227-236.
7. Miura Y, Miura O, Ihle JN et al. Activation of the mitogen-activated protein kinase pathway by the erythropoietin receptor. J Biol Chem 1994;269:29962-29969.
8. Ren HY, Komatsu N, Shimizu R et al. Erythropoietin induces tyrosine phosphorylation and activation of phospholipase C-gamma 1 in a human erythropoietin-dependent cell line. J Biol Chem 1994;269:19633-19638.
9. Miura O, Nakamura N, Ihle JN et al. Erythropoietin-dependent association of phosphatidylinositol 3-kinase with tyrosine-phosphorylated erythropoietin receptor. J Biol Chem 1994;269:614-620.
10. Yi T, Zhang J, Miura O et al. Hematopoietic cell phosphatase (HCP) associates with the erythropoietin receptor following Epo induced receptor tyrosine phosphorylation: identification of potential binding sites. Blood 1995;85:87-95.
11. Shultz LD, Schweitzer PA, Rajan TY et al. Mutations at the murine motheaten locus are within the hematopoietic cell protein tyrosine phosphatase (Hcph) gene. Cell 1993;73:1445-1454.
12. Klingmuller U, Lorenz U, Cantley LC et al. Specific recruitment of the hematopoietic protein tyrosine phosphatase SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals. Cell 1995;80: 729-738.
13. Azam M, Erdjument-Bromage H, Kreider B et al. Purification of interleukin-3 stimulated DNA binding factors demonstrates the involvement of multiple isoforms of Stat5 in signaling. EMBO J 1995;14:1402-1411.
14. Copeland NG, Gilbert DJ, Schindler C et al. Distribution of the mammalian Stat gene family in mouse chromosomes. Genomics 1995;19:225-228.
15. Gobert S, Chretien S, Gouilleux F et al. Identification of tyrosine residues within the intracellular domain of the erythropoietin receptor crucial for STAT5 activation. EMBO J 1996;15:2434-2441.
16. Klingmuller U, Bergelson S, Hsiao JG et al. Multiple tyrosine residues in the cytosolic domain of the erythropoietin receptor promote activation of STATS. Proc Natl Acad Sci USA 1996; 93:8324-8328.
17. Quelle FW, Wang D, Nosaka T et al. Erythropoietin induces activation of Stat5 through association with specific tyrosines on the receptor that are not required for a mitogenic response. Mol Cell Biol 1996;16:1622-1631.
18. Damen JE, Wakao H, Miyajima A et al. Tyrosine 343 in the erythropoietin receptor positively regulates erythropoietin-induced cell proliferation and Stat5 activation. EMBO J 1995;14:5557-5568.
19. Mui A-F, Wakao H, Kinoshita T et al. Suppression of interleukin3-induced gene expression by a C-terminal truncated Stat5: role of Stat5 in proliferation. EMBO J 1996;15:2425-2433.
20. Miyazaki T, Kawahara A, Fujii H et al. Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits. Science 1994;266:1045-1047.
21. Russell SM, Johnston JA, Noguchi M et al. Interaction of IL-2 receptor beta and gamma c chains with JAK1 and JAK3: implications for XSCID and XCID. Science 1994;266:1042-1045.
22. Nosaka T, van Deursen JMA, Tripp RA et al. Defective lymphoid development in mice lacking Jak3. Science 1995;270:800-802.
23. Park SY, Saijo K, Takahashi T et al. Developmental defects of lymphoid cells in Jak3 kinase-deficient mice. Immunity 1995;3: 771-782.
24. Thomis DC, Gurniak CB, Tivol E et al. Mice lacking Jak3 have defects in B lymphocyte maturation and T lymphocyte activation. Science 1995;270:794-797.
25. Lagasse E, Weissman IL Enforced expression of Bcl-2 in monocytes rescues macrophages and partially reverses osteopetrosis in op/op mice. Cell 1997;89:1021-1031.
26. -/-mice. Cell 1997;89:1011-1019.
27. Wu H, Liu X, Jaenisch R et al. Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor. Cell 1995;83:59-67.
28. Darnell JE Jr, Kerr IM, Stark GR. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 1994;264:1415-1421.
29. Schindlet C, Darnell JE Jr. Transcriptional responses to polypeptide ligands: the JAK-STAT pathway. Annu Rev Biochem 1995; 64:621-651.
30. Ihle JN. STATs: signal tranducers and activators of transcription. Cell 1996;84:331-334.
31. Durbin JE, Hackenmiller R, Simon MC et al. Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease. Cell 1996;84:443-450.
32. Meraz MA, White JM, Sheehan KCF et al. Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway. Cell 1996;84:431-442.
33. Takeda K, Noguchi K, Shi W et al. Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality. Proc Natl Acad Sci USA 1997;94:3801-3804.
34. Escary JL, Perreau J, Dumenil D et al. Leukaemia inhibitory factor is necessary for maintenance of haematopoietic stem cells and thymocyte stimulation. Nature 1993;63:361-364.
35. Yamamoto K, Quelle FW, Thierfelder WE et al. Stat4: a novel GAS binding protein expressed in early myeloid differentiation. Mol Cell Biol 1994;14:4342-4349.
36. Jacobson NG, Szabo S, Weber-Nordt RM et al. Interleukin 12 activates Stat3 and Stat4 by tyrosine phosphoryladon in T cell. J Exp Med 1995;181:1755-1762.
37. Bacon CM, McVicar DW, Ortaldo JR et al. Interleukin-12 induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus tyrosine kinases by interleukin-2 and interleukin-12. J Exp Med 1995;181:399-404.
38. Kaplan MH, Sun Y-L, Hoey T et al. Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature 1996;382:174-177.
39. Thierfelder WE, van Deursen J, Yamamoto K et al. Stat4 is required for IL-12 mediated responses of NK and T-cells. Nature 1996;382:171-174.
40. Wolf SF, Sieburth D, Sypek J. Interleukin-12: a key modulator of immune function. Stem Cells (Dayt) 1994;12:154-168.
41. Hou J, Schindler U, Henzel WJ et al. Identification and purification of human Stat proteins activated in response to interleukin-2. Immunity 1995;2:321-329.
42. Quelle FW, Shimoda K, Thierfelder W et al. Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis. Mol Cell Biol 1995;15:3336-3343.
43. Shimoda K, van Deursen J, Sangster MY et al. Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene. Nature 1996;380:630-633.
44. Kaplan MH, Schindler U, Smiley ST et al. Stat6 is required for mediating responses to IL-4 and for the development of Th2 cells. Immunity 1996;4:313-319.
45. Kopf M, Le Gros G, Bachmann M et al. Disruption of the murine IL-4 gene blocks Th2 cytokine responses. Nature 1993; 362:245-248.
46. Liu X, Robinson GW, Wagner KU et al. Stat5a is mandatory for adult mammary gland development and lactogenesis. Genes Dev 1997;11:179-186.
47. Udy GB, Snell RG, Wilkins RJ et al. Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression. Proc Nad Acad Sei USA 1997;94:7239-7244.
48. Suzuki H, Kundig TM, Furlonger C et al. Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor β. Science 1995;268:1472-1476.
49. Schorle H, Holtschke T, Hunig T et al. Development and function of T cells in mice rendered interleukin-2 deficient by gene targering. Nature 1991;352:621-624.