Muscarinic M3 receptor inactivation reveals a pertussis toxin-sensitive contractile response in the guinea pig colon: Evidence for M2/M3 receptor interactions

Journal of Pharmacology and Experimental Therapeutics

Volumn 289, Issue 1, 1999, Pages 464-476

  Sawyer, Gregory W ^a   Ehlert, Frederick J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MUSCARINIC M2 RECEPTOR; MUSCARINIC M3 RECEPTOR; PERTUSSIS TOXIN; PHOSPHATIDYLINOSITIDE; 1 (2 CHLOROETHYL) 4 DIPHENYLACETOXYPIPERIDINE; BORDETELLA VIRULENCE FACTOR; DIPHENYLACETIC ACID; DRUG DERIVATIVE; MUSCARINIC AGENT; MUSCARINIC RECEPTOR; MUSCARINIC RECEPTOR BLOCKING AGENT; N-(2-CHLOROETHYL)-4-PIPERIDINYL DIPHENYLACETATE; OTENZEPAD; OXOTREMORINE; OXOTREMORINE M; PHOSPHATIDYLINOSITOL; PIPERIDINE DERIVATIVE; PIRENZEPINE;

ANIMAL TISSUE; ARTICLE; COLON; GUINEA PIG; MALE; MUSCLE CONTRACTION; NONHUMAN; PRIORITY JOURNAL; RECEPTOR INTRINSIC ACTIVITY; RECEPTOR SENSITIVITY; SMOOTH MUSCLE CONTRACTION; ANIMAL; BIOLOGICAL MODEL; DRUG EFFECT; HYDROLYSIS; IN VITRO STUDY; METABOLISM; PHYSIOLOGY; SMOOTH MUSCLE;

ANIMALS; COLON; DIPHENYLACETIC ACIDS; GUINEA PIGS; HYDROLYSIS; MALE; MODELS, BIOLOGICAL; MUSCARINIC AGONISTS; MUSCARINIC ANTAGONISTS; MUSCLE CONTRACTION; MUSCLE, SMOOTH; OXOTREMORINE; PERTUSSIS TOXIN; PHOSPHATIDYLINOSITOLS; PIPERIDINES; PIRENZEPINE; RECEPTOR, MUSCARINIC M2; RECEPTOR, MUSCARINIC M3; RECEPTORS, MUSCARINIC; VIRULENCE FACTORS, BORDETELLA;

EID: 0032588529     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. 2 muscarinic receptor subtype coupled to both adenylyl cyclase and phosphoinositide turnover. Science (Wash DC) 238:672-675.
2. Benham CD, Bolton TB and Lang RJ (1985) Acetylcholine activates an inward current in single mammalian smooth muscle cells. Nature (Lond) 316:345-347.
3. Berridge MJ, Downes PC and Hanley MR (1982) Lithium amplifies agonist dependent phosphatidylinositol: Responses in brain and salivary glands. Biochem J 206:587-595.
4. Black JW and Leff R (1983.) Operational models of pharmacological agonism. Proc R Soc Lond Ser B 220:141-162.
5. 3 muscarinic receptors. Life Sci 60:1121-1128.
6. Candell LM, Yun SH, Tran LLP and Ehlert FJ (1990) Differential coupling of subtypes of the muscarinic receptor to adenylate cyclase and phosphoinositide hydrolysis in the longitudinal muscle of the rat ileum. Mol Pharmacol 38:689-697.
7. 2 muscarinic acetylcholine receptors couple to G alpha i2 and G alpha i3 in Chinese hamster ovary cells: Activation and desensitization of the phospholipase C signaling pathway. J Biol Chem 268:5676-5685.
8. Eglen RM, Hegde SS and Watson N (1996) Muscarinic receptor subtypes and smooth muscle function. Pharmacol Rev 48:531-565.
9. Ehlert FJ (1987) Coupling of muscarinic receptors to adenylate cyclase in the rabbit myocardium: Effects of receptor inactivation. J Pharmacol Exp Ther 240: 23-30.
10. Ehlert FJ, Thomas EA, Gerstin EH and Griffin MT (1997) Muscarinic receptors and gastrointestinal smooth muscle, in Muscarinic Receptor Subtypes in Smooth Muscle (Eglen RM ed) pp 87-147, CRC Press, Boca Raton.
11. Ehlert FJ and Yamamura HI (1995) Pharmacological analysis of muscarinic receptor-mediated inhibition of adenylate cyclase and stimulation of phosphoinositide hydrolysis, in Molecular Mechanisms of Muscarinic Acetylcholine Receptor Function (Wess J ed) pp 47-69, R. G. Lardes Company, Austin.
12. 3 muscarinic receptors in the rat peripheral lung. Biochem Pharmacol 52:643-658.
13. Furchgott RF (1966) The use of beta haloalkylamines in the differentiation of receptors and in the determination of dissociation constants of receptor-agonist complexes. Adv Drug Res 3:21-55.
14. Giraldo E, Vigano MA, Hammer R and Ladinsky H (1988) Characterization of muscarinic receptors in guinea pig ileum longitudinal smooth muscle. Mol Pharmacol 33:617-625.
15. 2 muscarinic receptors in rat intestinal smooth muscle. J Pharmacol Exp Ther 263:221-225.
16. Inoue R and Isenberg G (1990a) Acetylcholine activates nonselective cation channels in guinea pig ileum through a G protein. Am J Physiol 258:C1173-C1178.
17. Inoue R and Isenberg G (1990b) Intracellular calcium ions modulate acetylcholine-induced inward current in guinea-pig ileum. J Physiol 424:73-92.
18. 2 muscarinic acetylcholine receptors are coupled to multiple signaling pathways via pertussis toxin-sensitive guanine nucleotide regulatory proteins. J Pharmacol Exp Ther 258:938-944.
19. Lee HK, Bayguinov O and Sanders KM (1993) Role of nonselective cation current in muscarinic responses of canine colonic muscle. Am J Physiol 265:C1463-C1471.
20. Maeda A, Kubo T, Mishina M and Numa S (1988) Tissue distribution of mRNAs encoding muscarinic acetylcholine receptor subtypes. FEBS Lett 239:339-342.
21. 3H]4-diphenylacetoxy-N-methylpiperidine methiodide to longitudinal ileal smooth muscle muscarinic receptors. Eur J Pharmacol 176:197-205.
22. 2 muscarinic receptor inhibition of agonist-induced cyclic adenosine monophosphate accumulation and relaxation in the guinea pig ileum. J Pharmacol Exp Ther 280:189-199.
23. Ringdahl B (1985) Structural requirements for muscarinic receptor occupation and receptor activation by oxotremorine analogs in the guinea-pig ileum. J Pharmacol Exp Ther 232:67-73.
24. 3 muscarinic receptors in the guinea pig colon. J Pharmacol Exp Ther 284:269-277.
25. 2 receptor in smooth muscle of guinea pig ileum. Mol Pharmacol 44:102-110.
26. 3-mediated contractions and phosphoinositide hydrolysis. J Pharmacol Exp Ther 271:1042-1050.
27. Thomas EA, Hsu HH, Griffin MT, Hunter AL, Luong T and Ehlert FJ (1992) conversion of N-(2-chloroethyD-4-piperidinyl diphenylacetate (4-DAMP mustard) to an aziridnium ion and its interaction with muscarinic receptors in various tissues. Mol Pharmacol 41:718-726.
28. Wall SJ, Yasadu RP, Li M and Wolfe BB (1991) Development of an antiserum against m3 muscarinic receptors: Distribution of m3 receptors in rat tissues and clonal cell lines. Mol Pharmacol 40:783-789.
29. Zhang L and Buxton ILO (1991) Muscarinic receptors in canine colonic circular smooth muscle. II. Signal transduction pathways. Mol Pharmacol 40:952-959.