Constitutive overactivation of protein kinase C in guinea pig brain increases α-secretory APP processing without decreasing β-amyloid generation

European Journal of Neuroscience

Volumn 12, Issue 9, 2000, Pages 3191-3200

  Roßner, Steffen ^a   Beck, Mike ^a   Stahl, Tobias ^a   Mendla, Klaus ^a,b   Schliebs, Reinhard ^a   Bigl, Volker ^a  

^a Paul Flechsig Inst for Brain Res   (Germany)

^b BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

Author keywords

Amyloid precursor protein; Animal model; Development; Guinea pig; Microencephalopathy

Indexed keywords

ALPHA SECRETASE; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; PROTEIN KINASE C;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN DISEASE; CELL DENSITY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; GUINEA PIG; HIPPOCAMPUS; IMMUNOBLOTTING; NEOCORTEX; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROCESSING; PROTEIN SECRETION; SIGNAL TRANSDUCTION;

AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; CARCINOGENS; ENDOPEPTIDASES; ENZYME ACTIVATION; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GUINEA PIGS; HIPPOCAMPUS; METHYLAZOXYMETHANOL ACETATE; MICROCEPHALY; MODELS, ANIMAL; NEOCORTEX; PEPTIDE FRAGMENTS; PHORBOL ESTERS; PREGNANCY; PROTEIN KINASE C; PROTEIN SYNTHESIS INHIBITORS; RNA, MESSENGER;

EID: 0033802581     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9568.2000.00211.x     Document Type: Article

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