Regulation of macropinocytosis by p21-activated kinase-1

Molecular Biology of the Cell

Volumn 11, Issue 10, 2000, Pages 3341-3352

  Dharmawardhane, S ^a   Schurmann, A ^a   Sells, M A ^a   Chernoff, J ^a   Schmid, S L ^a   Bokoch, G M ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHALASIN D; PHOSPHOTRANSFERASE; PLATELET DERIVED GROWTH FACTOR; PROTEIN P21; WORTMANNIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FIBROBLAST; GENE EXPRESSION; MEMBRANE STRUCTURE; MEMBRANE TRANSPORT; NONHUMAN; PINOCYTOSIS; PRIORITY JOURNAL; REGULATORY MECHANISM; TRANSPORT KINETICS;

EID: 0033783040     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.11.10.3341     Document Type: Article

References (50)

1. A role for phosphoinositide 3-kinase in the completion of macropinocytosis and phagocytosis by macrophages
2. Cdc42, and PAK-mediated signaling leads to Jun kinase and p38MAP kinase activation
3. Wortmannin blocks lipid and protein kinase activities associated with PI 3-kinase and inhibits a subset of responses induced by FcRl cross-linking
4. Induction of membrane ruffling and fluid-phase pinocytosis in quiescent fibroblast by ras proteins
5. Getting membrane flow and the cytoskeleton to cooperate in moving cells
6. Membrane traffic during locomotion
7. Influence of epidermal growth factor (EGF) on ruffling activity pinocytosis and proliferation of cultivated human glia cells
8. p21-activated kinase (PAK) has substrate specificity similar to Acanthamoeba myosin I heavy chain kinase and activates Acanthamoeba myosin I
9. A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases
10. Requirement of Cdc42 for Salmonella-induced cytoskeletal and nuclear responses
11. Phosphorylation of non-muscle myosin II regulatory light chain by p21-activated kinase (γ-PAK)
12. Phosphatidylinositol 3-kinase regulation of fluid phase endocytosis
13. Clathrin polymerization is not required for bulk-phase endocytosis in rat fetal fibroblasts
14. Induction of mutant dyamin specifically blocks endocytic coated vesicle formation
15. Membrane targeting of p21-activated kinase 1 (PAK1) induces neurite outgrowth from PC12 cells
16. Localization of p21-activated kinase 1 (PAK1) to pinocytic vesicles and cortical actin structures in stimulated cells
17. Circular ruffle formation and closure lead to macropinocytosis in hepatocyte growth factor/scatter factor-treated cells
18. Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signaling to actin cytoskeletal dynamics
19. PDGF α, and β-receptors activate unique and common signal transduction pathways
20. Ruffles induced by Salmonella and other stimuli direct macropinocytosis of bacteria
21. The coated pit and macropinocytic pathways serve distinct endosome populations
22. Intracellular routing of transferrin and transferrin receptors in epidermal carcinoma A431 cells
23. A role for p21-activated kinase in endothelial cell migration
24. The p21(Rac/Cdc42)-activated kinases (PAKs)
25. Regulation of human leukocyte p21-activated kinases through G protein-coupled receptors
26. A brain serine/threonine protein kinase activated by Cdc42 and Rac1
27. Expression of constitutively active α-PAK reveals effects of the kinase on actin and focal complexes
28. Macrophage colony-stimulating factor (rM-CSF) stimulates pinocytosis in bone marrow-derived macrophages
29. M-CSF-induced macropinocytosis increases solute endocytosis but not receptor-mediated endocytosis in mouse macrophages
30. Labeling of endocytic vesicles using fluorescent probes for fluid-phase endocytosis
31. Myosin phosphorylation by human Cdc42-dependent S6/H4 kinase/γPAK from placenta and lymphoid cells
32. The small GTP-binding protein Rac regulates growth factor-induced membrane ruffling
33. Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: Downregulation by cytokines and bacterial products
34. Inhibition of myosin light chain kinase by p21-activated kinase
35. Selective modulation of the endocytic uptake of ricin and fluid phase markers without alteration in transferrin endocytosis
36. p21-activated kinase 1 (Pak1) regulates cell motility in mammalian fibroblasts
37. Emerging from the Pak: The p21-activated protein kinase family
38. Human p21 activated kinases regulate actin reorganization in mammalian cells
39. A modified tetracycline-regulated system provides autoregulatory inducible gene expression in cultured cells and transgenic mice
40. Fluorescent labeling of endocytic compartments
41. Phorbol esters stimulate macropinocytosis and solute flow through macrophages
42. A contractile activity that closes phagosomes in macrophages
43. Macropinocytosis
44. Kinase deficient Pak1 mutants inhibit Ras transformation of Rat-1 fibroblasts
45. Activation of actin-activated ATPase in smooth muscle by phosphorylation of myosin light chain with protease-activated kinase I
46. Distinct endocytotic pathways in epidermal growth factor-stimulated human carcinoma A431 cells
47. β-Type receptor for platelet derived growth factor mediated a chemotactic response by means of ligand-induced activation of the receptor protein-tyrosine kinase
48. Identification of a central phosphorylation site in p21-activated kinase regulating autoinhibition and kinase activity
49. Rho family GTPases regulate p38 MAP kinase through the downstream mediator PAK1
50. A conserved negative regulatory region in αPAK inhibition of PAK kinases reveals their morphological roles downstream of Cdc42 and Rac1