Phosphorylation of non-muscle myosin II regulatory light chain by p21-activated kinase (γ-PAK)

Journal of Muscle Research and Cell Motility

Volumn 19, Issue 8, 1998, Pages 839-854

  Chew, Teng Leong ^a   Masaracchia, Ruthann A ^b   Goeckeler, Zoe M ^a   Wysolmerski, Robert B ^a  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; ARGININE; MYOSIN LIGHT CHAIN; MYOSIN LIGHT CHAIN KINASE; PHOSPHOAMINO ACID; PHOSPHOPEPTIDE; PROTEIN P21; SERINE; THREONINE;

ANIMAL CELL; ARTICLE; ENDOTHELIUM CELL; ENZYME KINETICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

ACTINS; ANIMALS; CATTLE; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; GENE EXPRESSION; MUTAGENESIS, SITE-DIRECTED; MYOSIN LIGHT CHAINS; MYOSINS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PULMONARY ARTERY; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY;

ANIMALIA;

EID: 0032438538     PISSN: 01424319     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1005417926585     Document Type: Article

References (65)

1. ADELSTEIN, R. S. & KLEE, C. B. (1981) Purification and characterization of smooth muscle myosin light chain kinase. J. Biol. Chem. 256, 7501-9.
2. AMANO, M., ITO, M., KIMURA, K., FUKATA, Y., CHIHARA, K., NAKANO, T., MATSUURA, Y. & KAIBUCHI, K. (1996) Phosphorylation and activation of myosin by rho-associated kinase (Rho-kinase). J. Biol. Chem. 271, 20246-9.
3. BENNER, G. E., DENNIS, P. B. & MASARACCHIA, R. A. (1995) Activation of an S6/H4 kinase (PAK65) from human placenta by intramolecular and intermolecular autophosphorylation. J. Biol. Chem. 270, 21121-8.
4. BRZESKA, H., KNAUS, U. G., WANG, Z.-Y., BOKOCH, G. M. & KORN, E.D. (1997) p21-activated kinase has substrate specificity similar to acanthamoeba myosin I heavy chain kinase and activates acanthamoeba myosin I. Proc. Natl Acad. Sci. USA 94, 1092-5.
5. BRZESKA, H., SZCZEPANOWSKA, J., HOEY, J. & KORN, E. D. (1996) The catalytic domain of Acanthamoeba myosin I heavy chain kinase. Expression of active catalytic and sequence homology to p21-activated kinase (PAK). J. Biol. Chem. 27, 27056-62.
6. BURRIDGE, K. & CHRZANOWSKA-WODNICKA, M. (1996) Focal adhesions, contractility, and signaling. Ann. Rev. Cell Dev. Biol. 12, 463-519.
7. CERIONE, R. & ZHENG, Y. (1996) The dbl family of oncogenes. Curr. Opin. Cell Biol. 8, 216-22.
8. CHAZANOWSKA-WODNICKA, M. & BURRIDGE, K. (1996) Rho-stimulated contractility drives the formation of stress fibers and focal adhesions. J. Cell Biol. 133, 1403-15.
9. DANIEL, J. L. & SELLERS, J. R. (1992) Purification and characterization of platelet myosin Methods in Enzymol. 215, 78-88.
10. de LANEROLLE, P. & PAUL, R. J. (1991) Myosin phosphorylation/dephosphorylation and regulation of airway smooth muscle contractility. Am. J. Physiol. 261, L1-14.
11. DENNIS, P. B. & MASARACCHIA, R. A. (1993) Activation of an S6 kinase from human placenta by autophosphorylation. J. Biol. Chem. 268, 19833-41.
12. DONAHUE, M. J. & MASARACCHIA, R. A. (1983) Phosphorylation of ribosomal S6 at multiple sites by cyclic AMP-independent protein kinase from lymphoid cells. J. Biol. Chem. 259, 435-40.
13. ECKOLS, T. K., THOMPSON, R. E. & MASARACCHIA, R.A. (1983) Primary substrate specificity determinants for the H4-specific protease-activated protein phosphotransferase. Eur. J. Biochem. 134, 249-54.
14. ERIKSON, R. L. (1991) Structure, expression and regulation of protein kinases involved in phosphorylation of ribosomal protein S6. J. Biol. Chem. 266, 6007-10.
15. GOECKELER, Z. M. & WYSOLMERSKI, R. B. (1995) Myosin light chain kinase-regulated endothelial cell contraction: the relationship between isometric tension, actin polymerization, and myosin phosphorylation. J. Cell Biol. 130, 613-27.
16. HAEBERLE, J. R., SUTTON, T. A. & TROCKMAN, B. A. (1988) phosphorylation of two sites on smooth muscle myosin. Effects on contraction of glycerinated vascular smooth muscle. J. Biol. Chem. 263, 4424-9.
17. HALL, A. (1994) Small GTP-binding proteins and the regulation of the actin cytoskeleton. Ann. Rev. Cell Biol. 10, 31-54.
18. HAMMER III, J. A., SELLERS, J. S. & KORN, E. D. (1984) Phosphorylation and activation of smooth muscle myosin by acanthamoeba myosin I heavy chain kinase. J. Biol. Chem. 259, 3224-9.
19. HASSELL, T. C., KEMP, B. C. & MASARACCHIA, R. A. (1986) Nonmuscle myosin phosphorylation sites for calcium-dependent and calcium-independent protein kinases. BBRC 134, 240-47.
20. HASSELL, T. C., MAGNINO, P. E. & MASARACCHIA, R. A. (1988) Synthetic peptides derived from the nonmuscle myosin light chains are highly specific substrates for protein kinase C. Biochem. Biophys. Acta 957, 1-10.
21. IKEBE, M., REARDON, S. & FAY, F. S. (1992) Primary structure required for the inhibition of smooth muscle myosin light chain kinase. FEBS Lett. 312, 245-8.
22. IKEBE, M., REARDON, S., SCHWONEK, J. P., SANDERS II, C. R. & IKEBE, R. (1994) Structural requirement of the regulatory light chain of smooth muscle myosin as a substrate for myosin light chain kinase. J. Biol. Chem. 269, 28165-72.
23. JAKOBI, R., CHEN, C.-J., TUAZON, P. T. & TRAUGH, J. A. (1996) Molecular cloning and sequencing of the cytostatic G protein-activated protein kinase PAK I. J. Biol. Chem. 271, 6206-11.
24. KAMISOYAMA, H., ARAKI, Y. & IKEBE, M. (1994) Mutagenesis of the phosphorylation site (Serine 19) of smooth muscle myosin regulatory light chain and its effects on the properties of myosin. Biochemistry 33, 840-47.
25. KEMP, B. E., PEARSON, R. B. & HOUSE, C. (1983) Role of basic residues in the phosphorylation of human platelet myosin heavy and light chains by protein kinase C. Proc. Natl Acad. Sci. USA 80, 7471-5.
26. KEMP, B. E. & PEARSON, R. B. (1985) Spatial requirements for location of basic residues in peptides substrates for smooth muscle myosin light chain kinase. J. Biol. Chem. 260, 3355-9.
27. KENNELLY, P.J., EDELMAN, A. M., BLUMEMTHAL, D. K. & KREBS, E. G. (1987) Rabbit skeletal muscle myosin light chain kinase. The calmodulin binding domain as a potential active site-directed inhibitory domain. J. Biol. Chem. 262, 11958-63.
28. KIMURA, K., ITO, M., AMANO, M., CHIHARA, K., FUKATA, Y., NAKAFUKU, M., YAMAMORI, B., FENG, J., NAKANO, T., OKAWA, K., IWAMATSU, A. & KAIBUCHI, K. (1996) Regulation of myosin phosphatase by rho and rho-associated kinase (Rho-kinase). Science 273, 245-8.
29. KNAUS, U. G., MORRIS, S., DONG, H. J., CHERNOFF, J. & BOKOCH, G. M. (1995) Regulation of human leukocyte p21-activated kinases through G protein-coupled receptors. Science 269, 221-3.
30. KOZMA, R., AHMED, S., BEST, A. & LIM, L. (1995) The ras-related protein cdc42Hs and bradykinin promote formation of peripheral actin microspikes and filopodia in swiss 3T3 fibroblasts. Mol. Cell. Biol. 15, 1942-52.
31. KRUEGER, J. K., PADRE, R. C. & STULL, J. T. (1995) Intrasteric regulation of myosin light chain kinase. J. Biol. Chem. 270, 16848-53.
32. KUMAR, C. C., MOHAN, S. R., ZAVODNY, P. J., NARULA, S. K. & LEIBOWITZ, P. J. (1989) Characterization and differential expression of human vascular smooth muscle myosin light chain 2 isoforms in nonmuscle cells. Biochemistry 28, 4027-35.
33. KUREISHI, Y., KOBAYASHI, S., AMANO, M., KIMURA, K., KANAIDE, H., NAKANO, T., KAIBUCHI, K. & ITO, M. (1997) Rho-associated kinase directly induces smooth muscle contraction through myosin light chain phosphorylation. J. Biol. Chem. 272, 12257-60.
34. PAK and the JNK/SAPK MAP kinase cascade. Cell 87, 519-29.
35. MACHESKY, L. M. & HALL, A. (1996) Rho: a connection between membrane receptor signalling and the cytoskeleton. Trends Cell Biol. 6, 304-10.
36. MANSER, E., HUANG, H.-Y., LOO, T.-H., CHEN, X.-Q., DONG, J.-M., LEUNG, T. & LIM, L. (1997) Expression of constitutively active α-PAK reveals effects of the kinase on actin and focal complexes. Molec. Cell Biol. 17, 1129-40.
37. MANSER, E., CHONG, C., ZHAO, Z.-S., LEUNG, T., MICHAEL, G., HALL, C. & LIM, L. (1995) Molecular cloning of a new member of the p21-Cdc42/Rac-activated kinase (PAK) family. J. Biol. Chem. 270, 25070-9.
38. MANSER, E., LEUNG, T., SALIHUDDIN, H., ZHAO, Z.-S. & LIM, L. (1994) A brain serine/threonine protein kinase activated by Cdc42 and Rac1. Nature 367, 40-46
39. MARTIN, G. A., BOLLAG, G., MCORMICK, F. & ABO, A. (1995) A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20. EMBO J. 14, 1970-78.
40. MASARACCHIA, R. A., MURDOCK, F. E. & HASSELL, T. C. (1990) In Peptides and Protein Phosphorylation (edited by KEMP, B. E.) pp. 189-208. Boco Raton, FL: CRC Press.
41. MURAKAMI, N., MATSUMURA, S. & KUMON, A. (1984) Purification and identification of myosin heavy chain kinase from bovine brain. J. Biochem. 95, 651-60.
42. NAKANISHI, S., YAMADA, K., IWAHASHI, K., KURODA, K. & KASE, H. (1990) KT 5926, a potent and selective inhibitor of myosin light chain kinase. Mol. Pharmol. 37, 482-8.
43. NARUMIYA, S. (1996) The small GTPase Rho: cellular functions and signal transduction. J. Biochem. 120, 215-28.
44. PEARSON, R. B., ITO, M., MORRICE, N. A., SMITH, A. J., CONDRON, R., WETTENHALL, R. E. H., KEMP, B. E. & HARTSHORNE, D. J. (1991) Proteolytic cleavage sites in smooth muscle myosin-light-chain kinase and their relation to structural and regulatory domain. Eur. J. Biochem. 200, 723-30.
45. PERRIE, W. T. & PERRY, S. V. (1970) An electrophoretic study of the low-molecular-weight components of myosin. Biochem. J. 119, 31-8.
46. RIDLEY, A. J. (1995) Growth factors induced actin reorganization in swiss 3T3 cells. Methods Enzymol. 256, 306-13.
47. RIDLEY, A. J. (1996) Rho; theme and variation. Curr. Biol. 6, 1256-64.
48. RIDLEY, A. J. & HALL, A. (1992) The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell 70, 389-99.
49. RIDLEY, A. J., PATERSON, H. F., JOHNSON, C. I., DIEKMANN, D. & HALL, A. (1992) The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell 70, 401-10.
50. SANGER, F., NICKLEN, S. & COULSON, A. R. (1977) DNA sequencing with chain terminating inhibitors. Proc. Natl Acad. Sci. USA 74, 5463-7.
51. SELLS, M. A., KNAUS, U. G., BAGRODIA, S., AMBROSE, D. M., BOKOCH, G. M. & CHERNOFF, J. (1977) Human p21-activated kinase (PAK1) regulates actin organization in mammalian cells. Current Biol. 7, 202-10.
52. SINGH, T. J., AKATSUKA, A., BLAKE, K. R. & HUNG, K.-P. (1983a) Phosphorylation of troponin and myosin light chain by cAMP-independent casein kinase-2 from rabbit skeletal muscle. Arch. Biochem. Biophys. 220, 615-22.
53. SINGH, T. J., AKATSUKA, A. & HUNG, K.-P. (1983b) Phosphorylation of smooth muscle myosin light chain by five different kinases. FEBS Lett. 159, 217-20.
54. STOWERS, L., YELON, D., BERG, L. & CHANT, J. (1995) Regulation of the polarization of T cells toward antigen-presenting cells by ras-related GTPase cdc42. Proc. Natl. Acad. Sci. USA 92, 5027-31.
55. SWEENEY, H. L., YANG, Z., ZHI, G., STULL, J. T. & TRYBUS, K. M. (1994) Charge replacement near the phosphorylatable serine of the myosin regulatory light chain mimics aspects of phosphorylation. PNAS 91, 1490-94.
56. TAN, J. L., RAVID, S. & SPUDICH, J. A. (1992) Control of nonmuscle myosin by phosphorylation. Ann. Rev. Biochem. 61, 721-59.
57. TASHIRO, Y., MATSUMURA, S., MURAKAMI, N. & KUMON, A. (1984) The phosphorylation site for casein kinase II on 20 000-Da light chain of gizzard myosin. Arch. Biochem. Biophys. 233, 540-46.
58. cdc42/rac1-activated serine/threonine kinase that is rapidly activated by thrombin in platelets. J. Biol. Chem. 270, 26690-97.
59. TUAZON, P. T., STULL, J. T. & TRAUGH, J. A. (1982a) Phosphorylation of myosin light chain by a protease-activated kinase from rabbit skeletal muscle. Eur. J. Biochem. 129, 205-9.
60. TUAZON, P. T., STULL, J. T. & TRAUGH, J. A. (1982b) Phosphorylation of myosin light chain by protease activated kinase I. BBRC 108, 910-17.
61. TUAZON, P. T. & TRAUGH, J. A. (1984) Activation of actin-activated ATPase in smooth muscle by phosphorylation of myosin light chain with protease-activated kinase I. J. Biol. Chem. 259, 541-6.
62. WALSH, M. P., PERSECHINI, A., HINKINS, S. & HARTSHORNE, D. (1981) Is smooth muscle myosin a substrate for the cAMP-dependent protein kinase. FEBS Lett. 126, 107-10.
63. WU, C., LEE, S.-F., FURMANIAK-KAZMIERCZAK, E., CÔTÉ, G. P., THOMAS, D. Y. & LEBERER, E. (1996) Activation of myosin-I by members of the Ste-20p protein kinase family. J. Biol. Chem. 271, 31787-90.
64. WYSOLMERSKI, R. B. & LAGUNOFF, D. (1990) Involvement of myosin light-chain kinase in endothelial cell retraction. Proc. Natl Acad. Sci. USA 87, 16-20.
65. WYSOLMERSKI, R. B. & LAGUNOFF, D. (1991) Regulation of permeabilized endothelial cell retraction by myosin phosphorylation. Am. J. Physiol. 261, C32-40.