Localization of p21-activated kinase 1 (PAK1) to pinocytic vesicles and cortical actin structures in stimulated cells

Journal of Cell Biology

Volumn 138, Issue 6, 1997, Pages 1265-1278

  Dharmawardhane, Suranganie ^a   Sanders, Luraynne C ^a   Martin, Stuart S ^b   Daniels, R Hugh ^a   Bokoch, Gary M ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; CYTOCHALASIN D; ENZYME INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOTRANSFERASE; PROTEIN P21;

ANIMAL CELL; ARTICLE; CELL STRUCTURE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOSKELETON; ENZYME LOCALIZATION; LAMELLIPODIUM; NONHUMAN; PINOCYTOSIS; POLYMERIZATION; PRIORITY JOURNAL; REGULATORY MECHANISM;

3T3 CELLS; ACTINS; ANIMALS; CELL MEMBRANE; CELL TRANSFORMATION, VIRAL; CYTOPLASMIC GRANULES; CYTOSKELETON; GENES, SRC; MICE; MUTATION; PINOCYTOSIS; PLATELET-DERIVED GROWTH FACTOR; PROTEIN-SERINE-THREONINE KINASES; PSEUDOPODIA;

ANIMALIA;

EID: 0030772657     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.138.6.1265     Document Type: Article

References (54)

1. Bagrodia, S., B. Derijard, R.J. Davis, and R.A. Cerione. 1995a. Cdc42 and PAK-mediated signaling leads to JUN kinase and p38MAP kinase activation. J. Biol. Chem. 270:27995-27998.
2. Cdc42/Rac- activated kinase. J. Biol. Chem. 270: 22731-22737.
3. Bokoch, G.M., Y. Wang, B.P. Bohl, M.A. Sells, L.A. Ouilliam, and U.G. Knaus. 1996. Interaction of the Nck adapter protein with p21-activated kinase (PAK1). J. Biol. Chem. 271:25746-25749.
4. Bretscher, M.S. 1996. Getting membrane flow and the cytoskeleton to cooperate in moving cells. Cell. 87:601-606.
5. Burgess, D.R., W. Jiang, S. Mamajiwalla, and W. Kinsey. 1989. Intestinal crypt stem cells possess high levels of cytoskeletal-associaled phosphotyrosine-containing proteins and tyrosine kinase activity relative to differentiated enterocytes. J. Cell Biol. 109:2139-2144.
6. Chang, J., S. Gill, J. Settleman, and S.J. Parsons. 1995. c-Src regulates the simultaneous rearrangement of the actin cytoskeleton, p190 RhoGAP and p120 RasGAP following epidermal growth factor stimulation. J. Cell Biol. 130: 355-368.
7. Chant, J., and L. Stowers. 1995. GTPase cascades choreographing cellular behavior: movement, morphogenesis, and more. Cell. 81:1-4.
8. Chong, L., A. Traynor-Kaplan, G.M. Bokoch, and M.A. Schwartz. 1994. The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells. Cell. 79:507-513.
9. Conrad, P.A., K.A. Giuliano, G. Fisher, K. Collins, P.T. Matsudaira and D.L. Taylor. 1993. Relative distribution of actin, myosin I and myosin II during the wound healing response of fibroblasts. J. Cell Biol. 120:1381-1391.
10. Cvrckova, F., C. De Virgilio, E. Manser, J.R. Pringle, and K. Nasmyth. 1995. Ste20-like protein kinases are required for normal localization of cell growth and for cytokinesis in budding yeast. Genes Dev. 9:1817-1830.
11. Dharmawardhane, S., M. Demma, F. Yang, and J. Condeelis. 1991. Compartmentalization and actin binding properties of ABP-50: the elongation factor-1-α of Dictyostelium. Cell Motil. Cytoskel. 20:279-288.
12. Dowrick, P., P. Kenworthy, B. McCann, and R. Warn. 1993. Circular ruffle formation and closure lead to macropinocytosis in hepatocyte growth factor/scatter factor treated cells. Eur. J. Cell Biol. 61:44-53.
13. Fechheimer, M., J.I. Daiss, and J.J. Cebra. 1979. Interaction of immunoglobulin with actin. Mol. Immunol. 16:881-888.
14. Galisteo, M., J. Chernoff, Y. Su, E. Y. Skolnik, and J. Schlessinger. 1996. The adaptor protein nck links receptor tyrosine kinases with the serine-threonine kinase Pak1. J. Biol. Chem. 271:20997-21000.
15. Granger, B.L., S.A. Green, C.A. Gabel, C.L. Howe, I. Mellman, and A. Heleniu. 1990. Characterization and cloning of Igp 100, a lysosomal membrane glycoprotein from mouse and rat cells. J. Biol. Chem. 265:12036-12043.
16. Hall, A. 1994. Small GTP-binding proteins and the regulation of the actin cytoskeleton. Annu. Rev. Cell Biol. 10:31-54.
17. Hartwig, J.H., G.M. Bokoch, C. Carpenter, P. Janmey, L. Taylor, and T.P. Stossel. 1995. Thrombin receptor ligation and activated rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets. Cell. 82:643-653.
18. Herskowitz, I. 1995. MAP kinase pathways in yeast: for mating and more. Cell. 80:187-197.
19. Hotchin, N.A., and A. Hall. 1995. The assembly of integrin adhesion complexes requires both extracellular matrix and intracellular rho/rac GTPases. J. Cell Biol. 131:1857-1865.
20. Knaus, U.G., S. Morris, H. Dong, J. Chernoff, and G.M. Bokoch. 1995. Regulation of human leukocyte p21-activated kinases through G protein-coupled receptors. Science (Wash. DC). 269:221-223.
21. Kozma, R., S. Ahmed, A. Best, and L. Lim. 1995. The Ras-related protein CDC42Hs and bradykinin promote the formation of peripheral action microspikes and filopodia in Swiss 3T3 fibroblasts. Mol. Cell. Biol. 15:1942-1952.
22. Krek, W., G. Maridor, and E.A. Nigg. 1992. Casein kinase II is a predominantly nuclear enzyme. J. Cell Biol. 116:43-55.
23. Leeuw, T., A. Forrest-Lieuvin, C. Wu, J. Chenevert, K. Clark, M. Whiteway, D.Y. Thomas, and E. Leberer. 1995. Pheromone response in yeast: association of Bemlp with proteins of lhe MAP kinase cascade and actin. Science (Wash. DC). 270:1210-1213.
24. Luttrell, D.K., L.M. Luttrell, and S.J. Parsons. 1988. Augumented mitogenic responsiveness to epidermal growth factor in murine fibroblasts that overexpress pp60-src. Mol. Cell. Biol. 8:497-501.
25. Maher, P.A. 1996. Nuclear translocation of fibroblast growth factor receptor in response to FGF2. J. Cell Biol. 134:529-536.
26. Manser, E., T. Leung, H. Salihuddin, Z. Zhao, and L. Lim. 1994. A brain serine/threonine protein kinase activated by Cdc42 and Rac1. Nature (Lond.). 367: 40-46.
27. Manser, E., C. Chong, Z. Zhao, T. Leung, G. Michael, C. Hall, and L. Lim. 1995. Molecular cloning of a new member of the p21Cdc42/Rac-activated kinase (PAK) family. J. Biol. Chem. 270:25070-25078.
28. Manser, E., H.-Y. Huang, T.-H. Loo, X.-Q. Chen, J.-M. Dong, T. Leung, and L. Lim. 1997. Expression of constititively active α-PAK reveal effects of the kinase on actin and focal complexes. Mol. Cell. Biol. 17:1129-1143.
29. Martin, G.A., G. Bollag, F. McCormick, and A. Abo. 1995. A novel serine kinase activated hy rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20. EMBO (Eur. Mol. Biol. Organ.) J. 14:1970-1978.
30. Martin, S., D.W. Rose, A.R. Saltiel, A. Klippel, L.T. Williams, and J.M. Olelsky. 1996. Phosphatidylinositol 3-kinase is necessary and sufficient for insulin-stimulated stress fiber breakdown. Endocrinology. 137:5045-5053.
31. Mitchison, T.J., and L.P. Cramer. 1996. Actin-bascd cell motility and cell locomotion. Cell. 84:371-379.
32. Niu, M.Y., and V.T. Nachmias. 1994. Two-step mechanism for actin polymerization in human erythroleukemia cells induced by phorbol ester. Cell Motil. Cytoskeleton. 27:327-336.
33. Nobes, C.D., and A. Hall. 1995. Rho, Rac, and CDC42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell. 81:53-62.
34. Nobes, C.D., P. Hawkins, L. Stephens, and A. Hall. 1995. Activation of the small GTP-binding proteins rho and rac by growth factor receptors. J. Cell. Sci. 108:225-233.
35. Nusrat, A., C. Delp, and J.L. Madara. 1992. Intestinal epithelial restitution. Characterization of a cell culture model and mapping of cytoskeletal elements in migrating cells. J. Clin. Invest. 89:1501-1511.
36. + encodes a protein kinase that interacts with Cdc42p and is involved in the control of cell polarity and mating. EMBO (Eur. Mol. Biol. Organ.) J. 14:5908-5919.
37. Peppelenbosch, M.P., R. Qiu, A.M.M. de Vries-Smits, L.G.J. Tertoolen, S.W. de Laat, F. McCormick, A. Hall, M.H. Symons, and J.L. Bos. 1995. Rac mediates growth factor-induced arachidonic acid release. Cell. 81:1-20.
38. Quinn, M.T., T. Evans, L.R. Loetterle, A.J. Jesaitis, and G.M. Bokoch. 1993. Translocation of Rac correlates with NADPH oxidase activation: evidence for equimolar translocation of oxidase components. J. Biol. Chem. 268: 20983-20987.
39. Ridley, A.J. 1995. Growth factor-induced actin reorganization in Swiss 3T3 cells. In Methods In Enzymology. W.E. Balch, C.J. Der, and A. Hall, editors. Academic Press, San Diego, CA. 306-313.
40. Ridley, A.J., H.F. Paterson, C.L. Johnston, D. Diekmann, and A. Hall. 1992. The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell. 70:401-410.
41. Rivero-Lezcan, O.M., A. Marcella, J.H. Sameshima, and K.C. Robbins. 1995. Wiskott-Aldrich syndrome protein physically associates with Nek through Src homology 3 domains. Mol. Cell. Biol. 15:5725-5731.
42. Schneider, C., R.A. Newman, D.R. Sutherland, U. Asser, and M.F. Greaves. 1982. A one-step purification of membrane proteins using a high efficiency immunomatrix. J. Biol. Chem. 257:10766-10769.
43. Schreiber, E., P. Matthias, M.M. Muller, and W. Schaffner. 1989. Rapid detection of octamer binding proteins with "mini-extracts", prepared from a small number of cells. Nucleic Acid Res. 17:6419.
44. Sells, M.A., U.G. Knaus, D. Ambrose, S. Bagrodia, G.M. Bokoch, and J. Chernoff. 1997. Human p21 activated kinases regulate actin reorganization in mammalian cells. Curr. Biol. 7:202-210.
45. Stossel, T.P. 1993. On the crawling of animal cells. Science (Wash. DC). 260: 1086-1096.
46. Symons, M., J.M.J. Derry, B. Karlak, S. Jiang, V. Lemahieu, F. McCormick, U. Francke, and A. Abo. 1996. Wiskett-Aldrich syndrome protein, a novel effector for the GTPase Cdc42Hs, is implicated in actin polymerization. Cell. 84:723-734.
47. Thom, D., A.J. Powell, C.W. Lloyd, and D.A. Rees. 1977. Rapid isolation of plasma membranes in high yield from cultured fibroblasts. Biochem. J. 168: 187-194.
48. Todaro, G., Y. Matsuya, S. Bloom, A. Robbins, and H. Green. 1967. Growth regulating substances for animal cells in culture. V. Defendras and M. Stoker, editors. Wistar Institute Press, Philadelphia, PA.
49. Tsakiridis, T., C. Taha, S. Grinstein, and A. Klip. 1996. Insulin activates a p21-activated kinase in muscle cells via phosphatidylinositol 3-kinase. J. Biol. Chem. 271:19664-19667.
50. Van Aelst, L., T. Joneson, and D. Bar-Sagi. 1996. Identification of a novel Rac1-interacting protein involved in membrane ruffling. EMBO (Eur. Mol. Biol. Organ.) J. 15:3778-3786.
51. Wennström, S., P. Hawkins, F. Cooke, K. Hara, K. Yonezawa, M. Kasuga, T. Jackson, L. Claesson-Welsh, and L. Stephens. 1994. Activation of PI-3 kinase is required for PDGF-stimulated membrane ruffling. Curr. Biol. 4: 385-393.
52. West, M.A., M.S. Bretschez, and C. Watts. 1989. Distinct endocytolic pathways in epidermal growth factor-stimulated human carcinoma A-437 cells. J. Cell Biol. 109:2731-2739.
53. Zarzov, P., C. Mazzoni, and C. Mann. 1996. The SLT2(MPK1 ) MAP kinase is activated during periods of polarized cell growth in yeast. EMBO (Eur. Mol. Biol. Organ.) J. 15:83-91.
54. Zhang, S., J. Han, M.A. Sells, J. Chernoff, U.G. Knaus, R.J. Ulevitch, and G.M. Bokoch. 1995. Rho family GTPases regulate p38 MAP kinase through the downstream mediator Pak1. J. Biol. Chem. 270:23934-23936.