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Bretscher MS. Getting membrane flow and the cytoskeleton to cooperate in moving cells. Cell. 87:1996;601-606.
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Bretscher, M.S.1
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Distribution of ferritin receptors and coated pits on giant HeLa cells
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Bretscher MS, Thomson JN. Distribution of ferritin receptors and coated pits on giant HeLa cells. EMBO J. 2:1983;599-603.
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Distribution of receptors for transferrin and low density lipoprotein on the surface of giant HeLa cells
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Bretscher MS. Distribution of receptors for transferrin and low density lipoprotein on the surface of giant HeLa cells. Proc Natl Acad Sci USA. 80:1983;454-458.
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1 or LFA-1. EMBO J. 11:1992;405-410.
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Bretscher, M.S.1
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2+- and calcineurin-dependent recycling of an integrin to the front of migrating neutrophils
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2+- and calcineurin-dependent recycling of an integrin to the front of migrating neutrophils. Nature. 377:1995;75-79.
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Lawson, M.A.1
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Life at the leading edge
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Condeelis J. Life at the leading edge. Annu Rev Cell Biol. 9:1993;411-444.
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Condeelis, J.1
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0031002873
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Protrusion of cell surface coupled with single exocytotic events of secretion of the slime in Physarum plasmodia
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of outstanding interest. The advancing edge of Physarum plasmodia is observed to contain large 3.5 mm vesicles that move to the plasma membrane and fuse with it. When this occurs, a protrusion appears on the cell surface at the fusion point. Electron microscopy shows that, of the many different vesicles in the plasmodium, only these slime-containing vesicles invade the hyaline layer, which contains a dense meshwork of actin filaments. The authors conclude that most of the surface area of the protrusion is supplied by the slime-containing vesicle during exocytosis.
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Sesaki H, Ogihara S. Protrusion of cell surface coupled with single exocytotic events of secretion of the slime in Physarum plasmodia. of outstanding interest J Cell Sci. 110:1997;809-818 The advancing edge of Physarum plasmodia is observed to contain large 3.5 mm vesicles that move to the plasma membrane and fuse with it. When this occurs, a protrusion appears on the cell surface at the fusion point. Electron microscopy shows that, of the many different vesicles in the plasmodium, only these slime-containing vesicles invade the hyaline layer, which contains a dense meshwork of actin filaments. The authors conclude that most of the surface area of the protrusion is supplied by the slime-containing vesicle during exocytosis.
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J Cell Sci
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Sesaki, H.1
Ogihara, S.2
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11
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0030805010
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Secretion of slime, the extracellular matrix of the plasmodium, as visualized with a fluorescent probe and its correlation with locomotion on the substratum
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of special interest. The authors show here that slime vesicles are abundant in the advancing front of a plasmodium, accumulating there in the relaxation phase when pseudopods extend, but are sparse there when the pseudopod is in a contracting phase.
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Sesaki H, Ogihara S. Secretion of slime, the extracellular matrix of the plasmodium, as visualized with a fluorescent probe and its correlation with locomotion on the substratum. of special interest Cell Struct Funct. 22:1997;279-289 The authors show here that slime vesicles are abundant in the advancing front of a plasmodium, accumulating there in the relaxation phase when pseudopods extend, but are sparse there when the pseudopod is in a contracting phase.
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Cell Struct Funct
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Sesaki, H.1
Ogihara, S.2
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84873777564
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Dynamics of surface modification in myxovirus-infected cells
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Marcus PI. Dynamics of surface modification in myxovirus-infected cells. Cold Spring Harb Symp Quant Biol. 27:1962;351-365.
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Cold Spring Harb Symp Quant Biol
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Marcus, P.I.1
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0031455826
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Rapid, microtubule-dependent fluctuations of the cell margin
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of special interest. In this paper, the detailed behaviour of the leading edges of live fibroblasts is watched.
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Dunn GA, Zicha D, Fraylich PE. Rapid, microtubule-dependent fluctuations of the cell margin. of special interest J Cell Sci. 110:1997;3091-3098 In this paper, the detailed behaviour of the leading edges of live fibroblasts is watched.
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J Cell Sci
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Dunn, G.A.1
Zicha, D.2
Fraylich, P.E.3
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0029870635
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Protrusive activity quantitatively determines the rate and direction of cell locomotion
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Keller HU, Bebie H. Protrusive activity quantitatively determines the rate and direction of cell locomotion. Cell Motil Cytoskeleton. 33:1996;241-251.
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Cell Motil Cytoskeleton
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Keller, H.U.1
Bebie, H.2
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0018978165
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Kinetics of membrane internalization and recycling during pinosytosis in Dictyostelium discoideum
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Thilo L, Vogel G. Kinetics of membrane internalization and recycling during pinosytosis in Dictyostelium discoideum. Proc Natl Acad Sci USA. 77:1980;1015-1019.
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Thilo, L.1
Vogel, G.2
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Continuous vesicle cycling in the synaptic terminal of retinal bipolar cells
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Lagnado L, Goomis A, Job C. Continuous vesicle cycling in the synaptic terminal of retinal bipolar cells. Neuron. 17:1996;957-967.
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Neuron
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Lagnado, L.1
Goomis, A.2
Job, C.3
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17
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0032548828
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Sec3p is a spatial landmark for polarized secretion in budding yeast
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of outstanding interest. Sec3p was followed in vivo as a green fluorescent protein conjugate and found at those sites on the cell periphery where exocytosis occurs. The ability of this functional protein to localise was examined in various mutant backgrounds: Sec3p localisation was found to be independent of the secretory pathway, the actin cytoskeleton and polarity establishment proteins.
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Finger FP, Hughs TE, Novick P. Sec3p is a spatial landmark for polarized secretion in budding yeast. of outstanding interest Cell. 92:1998;559-571 Sec3p was followed in vivo as a green fluorescent protein conjugate and found at those sites on the cell periphery where exocytosis occurs. The ability of this functional protein to localise was examined in various mutant backgrounds: Sec3p localisation was found to be independent of the secretory pathway, the actin cytoskeleton and polarity establishment proteins.
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(1998)
Cell
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Finger, F.P.1
Hughs, T.E.2
Novick, P.3
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0031447173
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Subunit structure of the mammalian exocyst complex
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of special interest. Sec6p, a component of the exocyst complex, was localised in rat PC12 cells to the terminals of neuritic processes.
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Kee Y, Yoo J-S, Hazuka CD, Peterson KE, Hsu S-C, Scheller RH. Subunit structure of the mammalian exocyst complex. of special interest Proc Natl Acad Sci USA. 94:1997;14438-14443 Sec6p, a component of the exocyst complex, was localised in rat PC12 cells to the terminals of neuritic processes.
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Proc Natl Acad Sci USA
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Kee, Y.1
Yoo J-S2
Hazuka, C.D.3
Peterson, K.E.4
Hsu S-C5
Scheller, R.H.6
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19
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Membrane recycling and the control of secretory activity in pollen tubes
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Picton JM, Steer MW. Membrane recycling and the control of secretory activity in pollen tubes. J Cell Sci. 63:1983;303-310.
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J Cell Sci
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Picton, J.M.1
Steer, M.W.2
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0029989287
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Plant clathrin heavy chain: Sequence analysis and restricted localisation in growing pollen tubes
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Blackbourn HD, Jackson AP. Plant clathrin heavy chain: sequence analysis and restricted localisation in growing pollen tubes. J Cell Sci. 109:1996;777-787.
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J Cell Sci
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Blackbourn, H.D.1
Jackson, A.P.2
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Localisation of a Rho GTPase implies a role in tip growth and movement on the generative cell in pollen tubes
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Lin Y, Wang Y, Zhu J-K, Yang Z. Localisation of a Rho GTPase implies a role in tip growth and movement on the generative cell in pollen tubes. Plant Cell. 8:1996;293-303.
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Plant Cell
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Lin, Y.1
Wang, Y.2
Zhu J-K3
Yang, Z.4
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22
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0031412148
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Inhibition of pollen tube elongation by microinjected anti-Rop1Ps antibodies suggests a crucial role for Rho-type GTPases in the control of tip growth
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2+-dependent pathway involved in vesicle docking or fusion.
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2+-dependent pathway involved in vesicle docking or fusion.
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Plant Cell
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Lin, Y.1
Yang, Z.2
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The small GTP-binding protein Rac regulates growth factor-induced membrane ruffling
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Ridley AJ, Paterson HF, Johnston CL, Diekmann D, Hall A. The small GTP-binding protein Rac regulates growth factor-induced membrane ruffling. Cell. 70:1992;401-410.
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Cell
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Ridley, A.J.1
Paterson, H.F.2
Johnston, C.L.3
Diekmann, D.4
Hall, A.5
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24
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0032482379
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EGF induces recycling membrane to form ruffles
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of outstanding interest. Quiescent KB cells from a human carcinoma cell line are found to have a uniform distribution of transferrin receptors on their surfaces. Epidermal growth factor induces ruffles in two minutes: these are greatly enriched in transferrin receptors compared to the rest of the plasma membrane. This shows that exocytosis of membrane (internalised by coated pit endocytosis) occurs into the forming ruffles. Activated Rac therefore seems to act as a switch, redirecting exocytosis from random locations on the cell surface to specific sites where ruffles ruffle.
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Bretscher MS, Aguado-Velasco C. EGF induces recycling membrane to form ruffles. of outstanding interest Curr Biol. 8:1998;721-724 Quiescent KB cells from a human carcinoma cell line are found to have a uniform distribution of transferrin receptors on their surfaces. Epidermal growth factor induces ruffles in two minutes: these are greatly enriched in transferrin receptors compared to the rest of the plasma membrane. This shows that exocytosis of membrane (internalised by coated pit endocytosis) occurs into the forming ruffles. Activated Rac therefore seems to act as a switch, redirecting exocytosis from random locations on the cell surface to specific sites where ruffles ruffle.
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(1998)
Curr Biol
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Bretscher, M.S.1
Aguado-Velasco, C.2
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25
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0025801660
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Molecular genetics of cell migration: Dictyostelium as a model system
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Egelhoff TT, Spudich JA. Molecular genetics of cell migration: Dictyostelium as a model system. Trends Genet. 7:1991;161-166.
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Trends Genet
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Egelhoff, T.T.1
Spudich, J.A.2
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26
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0024436810
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Capping of surface receptors and concomitant cortical tension are generated by conventional myosin
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Pasternak C, Spudich JA, Elson EL. Capping of surface receptors and concomitant cortical tension are generated by conventional myosin. Nature. 341:1989;549-551.
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Nature
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Pasternak, C.1
Spudich, J.A.2
Elson, E.L.3
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27
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0030924544
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Dictyostelium myosin II null mutant can still cap Con A receptors
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of special interest. This paper shows that D. discoideum amoebae lacking the major myosin gene can cap Con A receptors, but do so less efficiently than wild type. When treated with Con A alone, these cells clear the labelled receptors from the front regions of the cell only, whereas wild type clears them all to the tail of the cell. With greater cross-linking, near normal capping occurs. The partial clearance of receptors from the cells' fronts is the first example reported of the partial capping of a protein.
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Aguado-Velasco C, Bretscher MS. Dictyostelium myosin II null mutant can still cap Con A receptors. of special interest Proc Natl Acad Sci USA. 94:1997;9684-9686 This paper shows that D. discoideum amoebae lacking the major myosin gene can cap Con A receptors, but do so less efficiently than wild type. When treated with Con A alone, these cells clear the labelled receptors from the front regions of the cell only, whereas wild type clears them all to the tail of the cell. With greater cross-linking, near normal capping occurs. The partial clearance of receptors from the cells' fronts is the first example reported of the partial capping of a protein.
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(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 9684-9686
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Aguado-Velasco, C.1
Bretscher, M.S.2
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28
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0029740182
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Ligand binding regulates the directed movement of β1 integrins on fibroblasts
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Felsenfeld DP, Choquet D, Sheetz MP. Ligand binding regulates the directed movement of β1 integrins on fibroblasts. Nature. 383:1996;438-440.
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Nature
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Felsenfeld, D.P.1
Choquet, D.2
Sheetz, M.P.3
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