Load-sensitive rat gastric vagal afferents encode volume but not gastric nutrients

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 274, Issue 2 43-2, 1998, Pages

  Mathis, Carole ^a   Moran, Timothy H ^a   Schwartz, Gary J ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Brain gut communication; Food intake; Vagus; Visceral afferents

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; FEEDBACK SYSTEM; FOOD INTAKE; MALE; NERVE TRACT; NEUROTRANSMISSION; NONHUMAN; PRESSURE VOLUME CURVE; PRIORITY JOURNAL; RAT; SATIETY; SENSORY NERVE CONDUCTION; VAGUS NERVE STIMULATION; ANIMAL; EATING; ELECTROPHYSIOLOGY; INNERVATION; OSMOLARITY; PHYSIOLOGY; PRESSURE; SENSORY NERVE; SPRAGUE DAWLEY RAT; STOMACH; VAGUS NERVE;

GLUCOSE; PEPTONE; SODIUM CHLORIDE;

AFFERENT PATHWAYS; ANIMALS; EATING; ELECTROPHYSIOLOGY; GLUCOSE; MALE; OSMOLAR CONCENTRATION; PEPTONES; PRESSURE; RATS; RATS, SPRAGUE-DAWLEY; SALINE SOLUTION, HYPERTONIC; SODIUM CHLORIDE; STOMACH; VAGUS NERVE;

EID: 0031936739     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.1998.274.2.r280     Document Type: Article

References (24)

1. Davis, J. D., and C. S. Campbell. Peripheral control of meal size in the rat: effect of sham feeding on meal size and drinking rate. J. Comp. Physiol. Psychol. 83: 379-387, 1973.
2. Davison, J. S., and G. D. Clarke. Mechanical properties and sensitivity to CCK of vagal gastric slowly adapting mechanoreceptors. Am. J. Physiol. 255 (Gastrointest. Liver Physiol. 18): G55-G61, 1988.
3. Deutsch, J. A. Dietary control and the stomach. Prog. Neurobiol. 20: 313-332, 1983.
4. Deutsch, J. A. The stomach in food satiation and the regulation of appetite. Prog. Neurobiol. 10: 135-153, 1977.
5. Deutsch, J. A., and M. F. Gonzalez. Gastric fat content and satiety. Physiol. Behav. 26: 673-676, 1981.
6. Deutsch, J. A., and M. F. Gonzalez. Gastric nutrient content signals satiety. Behav. Neural Biol. 30: 113-116, 1980.
7. Gonzalez, M. F., and J. A. Deutsch. Vagotomy abolishes cues of satiety produced by gastric distention. Science 2212: 1283-1284, 1981.
8. Jänig, W., and M. Koltzenburg. Receptive properties of sacral primary afferent neurons supplying the colon. J. Neurophysiol. 65: 1067-1077, 1991.
9. Kaplan, J. M., W. Siemers, and H. J. Grill. Ingestion, gastric fill, and gastric emptying before and after withdrawal of gastric contents. Am. J. Physiol. 267 (Regulatory Integrative Comp. Physiol. 36): R1257-R1265, 1994.
10. Mei, N. Intestinal chemosensitivity. In: Advances in the Innervation of the Gastrointestinal Tract, edited by G. E. Holle and J. D. Wood. Amsterdam: Elsevier Science, 1992, p. 273-281.
11. Phillips, R. J., and T. L. Powley. Gastric volume rather than nutrient content inhibits food intake. Am. J. Physiol. 271 (Regulatory Integrative Comp. Physiol. 40): R766-R779, 1996.
12. Schwartz, G. J., P. R. McHugh, and T. H. Moran. Gastric loads and cholecystokinin synergistically stimulate rat gastric vagal afferents. Am. J. Physiol. 265 (Regulatory Integrative Comp. Physiol. 34): R872-R876, 1993.
13. Schwartz, G. J., P. R. McHugh, and T. H. Moran. Integration of vagal afferent responses to gastric loads and cholecystokinin in rats. Am. J. Physiol. 261 (Regulatory Integrative Comp. Physiol. 30): R64-R69, 1991.
14. Schwartz, G. J., P. R. McHugh, and T. H. Moran. Pharmacological dissociation of responses to CCK and gastric loads in rat mechanosensitive vagal afferents. Am. J. Physiol. 267 (Regulatory Integrative Comp. Physiol. 36): R303-R308, 1994.
15. Schwartz, G. J., and T. H. Moran. Sub-diaphragmatic vagal afferent integration of meal-related gastrointestinal signals. Neurosd. Biobehav. Rev. 20: 47-56, 1996.
16. Schwartz, G. J., and T. H. Moran. Duodenal nutrient exposure elicits organized gastrointestinal motility and gut vagal afferent signals in rat. Soc. Neurosci. Abstr. 22: 17, 1996.
17. Schwartz, G. J., T. H. Moran, W. O. White, and E. E. Ladenheim. Relationships between gastric motility and gastric vagal afferent responses to CCK and GRP in rats differ. Am. J. Physiol. 272 (Regulatory Integrative Comp. Physiol. 41): R1726-R1733, 1997.
18. Sengupta, J. N., and G. F. Gebhart. Gastrointestinal afferent fibres and sensation. In: Physiology of the Gastrointestinal Tract (3rd ed.), edited by L. R. Johnson. New York: Raven, 1994, p. 483-519.
19. Smith, G. P., C. Jerome, and R. Norgren. Afferent axons in the abdominal vagus mediate the satiety effect of cholecystokinin in rats. Am. J. Physiol. 249 (Regulatory Integrative Comp. Physiol. 18): R638-R641, 1985.
20. South, E. H., and R. C. Ritter. Capsaicin application to central or peripheral vagal fibers attenuates CCK satiety. Peptides 9: 601-612, 1988.
21. Tamura, C. S., and R. C. Ritter. Intestinal capsaicin transiently attenuates suppression of sham feeding by oleate. Am. J. Physiol. 267 (Regulatory Integrative Comp. Physiol. 36): R561-R568, 1994.
22. Walls, E. K., R. J. Phillips, F. B. Wang, M. C. Holst, and T. L. Powley. Suppression of meal size by intestinal nutrients is eliminated by celiac vagal deafferentation. Am. J. Physiol. 269 (Regulatory Integrative Comp. Physiol. 38): R1410-R1419, 1995.
23. Wirth, J. B., and P. R. McHugh. Gastric distension and short-term satiety in the rhesus monkey. Am. J. Physiol. 245 (Regulatory Integrative Comp. Physiol. 14): R174-R180, 1983.
24. Yox, D. P., and R. C. Ritter. Capsaicin attenuates suppression of sham feeding induced by intestinal nutrients. Am. J. Physiol. 255 (Regulatory Integrative Comp. Physiol. 24): R569-R574, 1988.