Induction of uncoupling protein expression in brown and white adipose tissue by leptin

Endocrinology

Volumn 140, Issue 1, 1999, Pages 292-300

  Commins, Scott P ^b   Watson, Patricia M ^a   Padgett, Mark A ^a   Dudley, Andrew ^a   Argyropoulos, George ^a   Gettys, Thomas W ^a,b  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LEPTIN; MESSENGER RNA; UNCOUPLING PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; BROWN ADIPOSE TISSUE; CALORIC INTAKE; CONTROLLED STUDY; ENERGY EXPENDITURE; MALE; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; THERMOGENESIS; WHITE ADIPOSE TISSUE;

EID: 0032893256     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.140.1.6399     Document Type: Article

References (51)

1. 1. Lin P-Y, Romsos DR, Leveille GA 1977 Food intake, body weight gain, and body composition of the young obese (ob/ob) mouse. J Nutr 107:1715-1723
2. 2. Thurlby PL, Trayhurn P 1978 The development of obesity in preweaning obob mice. Br J Nutr 39:397-402
3. 3. Trayhurn P 1984 The development of obesity in animals: the role of genetic susceptibility. Clin Endocrinol Metab 13:451-474
4. 4. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM 1994 Positional cloning of the mouse obese gene and its human homologue. Nature 372:425-432
5. 5. Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P 1995 Recombinant mouse Ob protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 269:546-549
6. 6. Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D, Lallone RL, Burley SK, Friedman JM 1995 Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269:543-546
7. 7. Pelleymounter MA, Cullen MJ, Baker MB, Hecht R, Winters D, Boone T, Collins F 1995 Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269:540-543
8. 8. Haynes WG, Morgan DA, Walsh SA, Mark AL, Sivitz WI 1997 Receptor-mediated regional sympathetic nerve activation by leptin. J Clin Invest 100:270-278
9. 9. Collins S, Kuhn CM, Petro AE, Swick AG, Chrunyk BA, Surwit RS 1996 Role of leptin in fat regulation. Nature 380:677-677
10. 10. Nicholls D, Locke R 1984 Thermogenic mechanisms in brown fat. Physiol Rev 64:1-64
11. 11. Himms-Hagen J 1985 Brown adipose tissue metabolism and thermogenesis. Annu Rev Nutr 5:69-94
12. 12. Klingenberg M 1990 Mechanism and evolution of the uncoupling protein of brown adipose tissue. Trends Biochem Sci 15:108-112
13. 13. Bouillaud F, Ricquier D, Mory G, Thibault J 1984 Increased level of mRNA for the uncoupling protein in brown adipose tissue of rats during thermogenesis induced by cold exposure or norepinephrine infusion. J Biol Chem 259:11583-11586
14. 14. Himms-Hagen J 1989 Brown adipose tissue thermogenesis and obesity. Prog Lipid Res 28:67-115
15. 3-adrenergic receptor agonist treatment of diet-induced obesity in mice. Endocrinology 138:405-413
16. 3-adrenergic agonist. J Clin Invest 97:2898-2904
17. 17. Fleury C, Neverova M, Collins S, Raimbault S, Champigny O, Levi-Meyrueis C, Bouillaud F, Seldin MF, Surwit RS, Ricquier D, Warden CH 1997 Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia. Nat Genet 15:269-272
18. 18. Gimeno RE, Dembski M, Weng X, Deng N, Shyjan AW, Gimeno CJ, Iris F, Ellis SJ, Woolf EA, Tartaglia LA 1997 Cloning and characterization of an uncoupling protein homolog. A potential molecular mediator of human thermogenesis. Diabetes 46:900-906
19. 19. Vidal-Puig A, Solanes G, Grujic D, Flier JS, Lowell BB 1997 UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue. Biochem Biophys Res Commun 235:79-82
20. 3-adrenergic agonists, and leptin. J Biol Chem 272:24129-24132
21. 21. Hwa JJ, Ghibaudi L, Compton D, Fawzi AB, Strader CD 1996 Intracerebroventricular injection of leptin increases thermogenesis and mobilizes fat metabolism in ob/ob mice. Horm Metab Res 28:659-663
22. 22. Hwa JJ, Fawzi AB, Graziano MP, Ghibaudi L, Williams P, Van Heek M, Davis H, Rudinski M, Sybertz E, Strader CD 1997 Leptin increases energy expenditure and selectively promotes fat metabolism in ob/ob mice. Am J Physiol Regul Integr Comp Physiol 272:R1204-R1209
23. 3-adrenergic receptor expression in white adipocytes from C57BL/6J mice. Endocrinology 138:2697-2704
24. 3-adrenergic receptor messenger ribonucleic acids. Endocrinology 135:1025-1031
25. 25. Jacobsson A, Stadler U, Glotzer MA, Kozak LP 1985 Mitochondrial uncoupling protein from mouse brown fat. Molecular cloning, genetic mapping, and mRNA expression. J Biol Chem 260:16250-16254
26. 26. Bray GA, York DA 1979 Genetically transmitted obesity in rodents. Physiol Rev 51:598-646
27. 27. Himms-Hagen J 1984 Brown adipose tissue thermogenesis, energy balance, and obesity. Can J Biochem Cell Biol 62:610-617
28. 28. Ricquier D, Bouillaud F, Toumelin P, Mory G, Bazin R, Arch J, Penicaud L 1986 Expression of uncoupling protein mRNA in thermogenic or weakly thermogenic brown adipose tissue. J Biol Chem 261:13905-13910
29. 29. Ashwell M, Holt S, Jennings G, Stirling DM, Trayhurn P, York DA 1985 Measurement by radioimmunoassay of the mitochondrial uncoupling protein from brown adipose tissue of obese (ob/ob) mice and Zucker (fa/fa) rats at different ages. FEBS Lett 179:233-237
30. 30. Cummings DE, Brandon EP, Planas JV, Motamed K, Idzerda R, McKnight GS 1996 Genetically lean mice result from targeted disruption of the RIIβ subunit of protein kinase A. Nature 382:622-626
31. 31. Lowell BB, Susulic VS, Hamann A, Lawitts JA, Himms-Hagen J, Boyer BB, Kozak LP, Flier JS 1993 Development of obesity in transgenic mice after genetic ablation of brown adipose tissue. Nature 366:740-742
32. 32. Rothwell NJ, Stock MJ 1984 Effects of denervating brown adipose tissue on the responses to cold, hyperphagia and noradrenaline treatments in the rat. J Physiol 355:457-463
33. 33. Hamann A, Flier JS, Lowell BB 1996 Decreased brown fat markedly enhances susceptibility to diet-induced obesity, diabetes, and hyperlipidemia. Endocrinology 137:21-29
34. 34. Enerback S, Jacobsson A, Simpson EM, Guerra C, Yamashita H, Harper ME, Kozak LP 1997 Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese. Nature 387:90-94
35. 35. Thomas SA, Palmiter RD 1997 Thermoregulatory and metabolic phenotypes of mice lacking noradrenaline and adrenaline. Nature 387:94-97
36. 36. Melnyk A, Harper ME, Himms-Hagen J 1997 Raising at thermoneutrality prevents obesity and hyperphagia in BAT-ablated transgenic mice. Am J Physiol Regul Integr Comp Physiol 272:R1088-R1093
37. 37. Kopecky J, Clarke G, Enerback S, Spiegelman B, Kozak LP 1995 Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity. J Clin Invest 96:2914-2923
38. 38. Scarpace PJ, Matheny M, Pollock BH, Türner N 1997 Leptin increases uncoupling protein expression and energy expenditure. Am J Physiol Endocrinol Metab 273:E226-E230
39. 39. Sarmiento U, Benson B, Kaufman S, Ross L, Qi MY, Scully S, DiPalma C 1997 Morphologic and molecular changes induced by recombinant human leptin in the white and brown adipose tissues of C57BL/6 mice. Lab Invest 77:243-256
40. 3-agonist, on energy balance and brown and white adipose tissues in rats. Am J Physiol 35:R1371-R1382 (Abstract)
41. 41. Picó C, Bonet ML, Palou A 1998 Stimulation of uncoupling protein synthesis in white adipose tissue of mice treated with the β3-adrenergic agonist CGP-12177. Cell Mol Life Sci 54:191-195
42. 42. Cousin B, Cinti S, Morroni M, Raimbault S, Ricquier D, Penicaud L, Casteilla L 1992 Occurrence of brown adipocytes in rat white adipose tissue: molecular and morphological characterization. J Cell Sci 103:931-942
43. 43. Loncar D, Afzelius BA, Cannon B 1988 Epididymal white adipose tissue after cold stress in rats. II. Mitochondrial changes. J Ultra Mol Structure Res 101:199-209
44. 3-adrenoceptor agonist. Biochem Pharmacol 54:121-131
45. 45. Silva JE, Rabelo R 1997 Regulation of the uncoupling protein gene expression. Eur J Endocrinol 136:251-264
46. 46. Cannon B, Nedergaard J 1996 Adrenergic regulation of brown adipocyte differentiation. Biochem Soc Trans 24:407-412
47. 47. Harris RBS, Zhou J, Redmann Jr SM, Smagin GN, Smith SR, Rodgers E, Zachwieja JJ 1998 A leptin dose-response study in obese (ob/ob) and lean (+/?) mice. Endocrinology 139:8-19
48. 48. Grujic D, Susulic VS, Harper ME, Himms-Hagen J, Cunningham BA, Corkey BE, Lowell BB 1997 β3-Adrenergic receptors on white and brown adipocytes mediate β 3-selective agonist-induced effects on energy expenditure, insulin secretion, and food intake: a study using transgenic and gene knockout mice. J Biol Chem 272:17686-17693
49. 49. Bouchard C, Pérusse L, Chagnon YC, Warden C, Ricquier D 1997 Linkage between markers in the vicinity of the uncoupling protein 2 gene and resting metabolic rate in humans. Hum Mol Genet 6:1887-1889
50. 50. Zhou YT, Shimabukuro M, Koyama K, Lee Y, Wang MY, Trieu F, Newgard CB, Unger RH 1997 Induction by leptin of uncoupling protein-2 and enzymes of fatty acid oxidation. Proc Natl Acad Sci USA 94:6386-6390
51. 51. Chua Jr SC, Chung WK, Wu-Peng XS, Zhang YY, Liu SM, Tartaglia L, Leibel RL 1996 Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor. Science 271:994-996