Effects of orchidectomy on levels of the mRNAs encoding gonadotropin-releasing hormone and other hypothalamic peptides in the adult male rhesus monkey (Macaca mulatta)

Journal of Neuroendocrinology

Volumn 12, Issue 2, 2000, Pages 167-176

  El Majdoubi, M ^a   Ramaswamy, S ^a   Sahu, A ^a   Plant, Tony M ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

GABA; Galanin; Neuropeptide Y; POMC; TGF

Indexed keywords

GALANIN; GLUTAMATE DECARBOXYLASE; GONADORELIN; LUTEINIZING HORMONE; MESSENGER RNA; NEUROPEPTIDE Y; PROOPIOMELANOCORTIN; TESTOSTERONE; TRANSFORMING GROWTH FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GONADORELIN RELEASE; HYPOTHALAMUS; LUTEINIZING HORMONE RELEASE; MALE; NEGATIVE FEEDBACK; NONHUMAN; ORCHIECTOMY; PRIORITY JOURNAL; RHESUS MONKEY; RIBONUCLEASE PROTECTION ASSAY;

AGE FACTORS; ANIMALS; GALANIN; GAMMA-AMINOBUTYRIC ACID; GLUTAMATE DECARBOXYLASE; GONADOTROPIN-RELEASING HORMONE; HYPOTHALAMUS, MIDDLE; MACACA MULATTA; MALE; NEUROGLIA; NEURONS; NEUROPEPTIDE Y; NEUROPEPTIDES; ORCHIECTOMY; PEPTIDYLPROLYL ISOMERASE; PREOPTIC AREA; PRO-OPIOMELANOCORTIN; RNA, MESSENGER; TRANSFORMING GROWTH FACTOR ALPHA;

EID: 0033969661     PISSN: 09538194     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2826.2000.00433.x     Document Type: Article

References (64)

1. Plant TM. Effects of orchidectomy and testosterone replacement treatment on pulsatile luteinizing hormone secretion in the adult rhesus monkey (Macaca mulatta). Endocrinology 1982; 110: 1905-1913.
2. Plant TM, Dubey AK. Evidence from the rhesus monkey (Macaca mulatta) for the view that negative feedback control of luteinizing hormone secretion by the testis is mediated by a deceleration of hypothalamic gonadotropin-releasing hormone pulse frequency. Endocrinology 1984; 115: 2145-2153.
3. Sagrillo CA, Grattan DR, McCarthy MM, Selmanoff M. Hormonal and neurotransmitter regulation of GnRH gene expression and related reproductive behaviors. Behav Genet 1996; 26: 241-277.
4. Butler JA, Sjöberg M, Coen CW. Evidence for oestrogen receptor α-immunoreactivity in gonadotropin-releasing hormone-expressing neurones. J Neuroendocrinol 1999; 11: 331-335.
5. Huang X, Harlan RE. Absence of androgen receptors in LHRH immunoreactive neurons. Brain Res 1993; 624: 309-311.
6. Herbison AE. Multimodal influence of estrogen upon gonadotropin-releasing hormone neurons. Endo Rev 1998; 19: 302-330.
7. Khachaturian H, Lewis ME, Haber SN, Akil H, Watson SJ. Proopiomelanocortin peptide immunocytochemistry in rhesus monkey brain. Brain Res Bull 1984; 13: 785-800.
8. Morell JI, McGinty JF, Pfaff DW. A subset of β-endorphin-or dynorphin-containing neurons in the medial basal hypothalamus accumulates estradiol. Neuroendocrinology 1985; 41: 417-426.
9. Jirikowski GF, Merchenthaler I, Rieger GE, Stumpf WE. Estradiol target sites immunoreactive for β-endorphin in the arcuate nucleus of rat and mouse hypothalamus. Neurosc Lett 1986; 65: 121-126.
10. Lehman MN, Karsch FJ. Do gonadotropin-releasing-hormone, tyrosine hydroxylase-, and β-endorphin-immunoreactive neurons contain estrogen receptors? A double-label immunocytochemical study in the Suffolk ewe. Endocrinology 1993; 133: 887-895.
11. Eipper BA, Mains RE. Structure and biosynthesis of pro-adrenocorticotropin/endorphin and related peptides. Endo Rev 1980; 1: 1-27
12. Ropert JF, Quigley ME, Yen SSC. Endogenous opiates modulate pulsatile luteinizing hormone release in humans. J Clin Endocrinol Metab 1981; 52: 583-585.
13. Van Vugt DA, Lam NY, Ferin M. Reduced frequency of pulsatile luteinixing hormone secretion in the luteal phase of the rhesus monkey: involvement of endogenous opiates. Endocrinology 1984; 115: 1095-1101.
14. Adams LA, Vician L, Clifton DK, Steiner RA. Testosterone regulates pro-opiomelanocortin gene expression in the primate brain. Endocrinology 1991; 128: 1881-1886.
15. Thind KK, Goldsmith PC. Infundibular gonadotropin-releasing hormone neurons are inhibited by direct opioid and autoregulatory synapses in juvenile monkeys. Neuroendocrinology 1988; 47: 203-216.
16. Decavel C, Van Den Pol ANGABA. A dominant neurotransmitter in the hypothalamus. J Comp Neurol 1990; 302: 1019-1037.
17. Thind KK, Goldsmith PC. Expression of estrogen and progesterone receptors in glutamate and GABA neurons of the pubertal female monkey hypothalamus. Neuroendocrinology 1997; 65: 314-324.
18. Mitsushima D, Hei DL, Terasawa E. γ-Aminobutyric acid is an inhibitory neurotransmitter restricting the release of luteinizing hormone-releasing hormone before the onset of puberty. Proc Natl Acad Sci USA 1994; 91: 395-399.
19. Ferreira SA, Scott CJ, Kuehl DE, Jackson GL. Differential regulation of luteinizing hormone release by γ-aminobutyric acid receptor subtypes in the arcuate-ventromedial region of the castrated ram. Endocrinology 1996; 137: 3453-3460.
20. Leranth C, MacLusky NJ, Sakamoto H, Shanabrough M, Naftolin F. Glutamic acid decarboxylase-containing axons synapse on LHRH neurons in the rat medial preoptic area. Neuroendocrinology 1985; 40: 536-539.
21. Grattan DR, Selmanoff M. Castration-induced decrease in the activity of medial preoptic and tuberoinfundibular GABAergic neurons is prevented by testosterone. Neuroendocrinology 1994; 60: 141-149.
22. Erlander MG, Tillakaratne NJK, Feldblum S, Patel N, Tobin AJ. Two genes encode distinct glutamate decarboxylases. Neuron 1991; 7: 91-100.
23. Martin DL, Rimvall K. Regulation of γ-aminobutyric acid synthesis in the brain. J Neurochem 1993; 60: 395-407.
24. Kalra SP. Mandatory neuropeptide-steroid signaling for the preovulatory luteinizing hormone-releasing hormone discharge. Endo Rev 1993; 14: 507-538.
25. Rossmanith WG, Clifton DK, Steiner RA. Galanin gene expression in hypothalamic GnRH-containing neurons of the rat: a model for autocrine regulation. Horm Metab Res 1996; 28: 257-266.
26. Ojeda SR, Urbanski HF, Costa ME, Hill DF, Moholt-Siebert M. Involvement of transforming growth factor α in the release of luteinizing hormone-releasing hormone from the developing female hypothalamus. Proc Natl Acad Sci USA 1990; 87: 9698-9702.
27. Medhamurthy R, Gay VL, Plant TM. The prepubertal hiatus in gonadotropin secretion in the male rhesus monkey (Macaca mulatta) does not appear to involve endogenous opioid peptide restraint of hypothalamic gonadotropin-releasing hormone release. Endocrinology 1990; 126: 1036-1042.
28. Ramaswamy S, Marshall GR, McNeilly AS, Plant TM. Dynamics of the follicle-stimulating hormone (FSH)-inhibin B feedback loop and its role in regulating spermatogenesis in the adult male rhesus monkey (Macaca mulatta) as revealed by unilateral orchidectomy. Endocrinology 2000; submitted.
29. Ma YJ, Costa ME, Ojeda SR. Developmental expression of the genes encoding transforming growth factor alpha and its receptor in the hypothalamus of female rhesus macaques. Neuroendocrinology 1994; 60: 346-359.
30. Mitsushima D, Marzban F, Luchansky LL, Burich AJ, Keen KL, Durning M, Golos TG, Terasawa E. Role of glutamic acid decarboxylase in the prepubertal inhibition of the luteinizing hormone releasing hormone release in female rhesus monkeys. J Neurosc 1996; 16: 2563-2573.
31. Evans HF, Shine J. Human galanin: molecular cloning reveals a unique structure. Endocrinology 1991; 129: 1682-1684.
32. Higuchi H, Yang H-YT, Sabol SL. Rat neuropeptide Y precursor gene expression: mRNA structure, tissue distribution, and regulation by glucocorticoids. cyclic AMP, and phorbol ester. J Biol Chem 1988; 263: 6288-6295.
33. Chen CLC, Dionne FT, Roberts JL. Regulation of the proopiomelanocortin mRNA levels in rat pituitary by dopaminergic compounds. Proc Natl Acad Sci USA 1983; 80: 2211-2215.
34. Danielson PE, Forss-Petter S, Brow MA, Calavetta L, Douglass J, Milner RJ, Sutcliffe JG. p1B15: a cDNA clone of the rat mRNA encoding cyclophilin. DNA 1988; 4: 261-267.
35. El Majdoubi M, Sahu A, Plant TM. Effect of estrogen on hypothalamic transforming growth factor alpha and gonadotropin-releasing hormone gene expression in the female rhesus monkey. Neuroendocrinology 1998; 67: 228-235.
36. Goldsmith PC, Thind KK, Song T, Kim EJ, Boggan JE. Location of the neuroendocrine gonadotropin-releasing hormone neurons in the monkey hypothalamus by retrograde tracing and immunostaining. J Neuroendocrinol 1990; 2: 157-168.
37. Mohr E, Richter D. Dendritic and axonal mRNA trafficking. Regulatory Peptides 1993; 45: 21-24.
38. Roselli CE, Stadelman H, Horton LE, Resko JA. Regulation of androgen metabolism and luteinizing hormone-releasing hormone content in discrete hypothalamic and limbic areas of male rhesus macaques. Endocrinology 1987; 120: 97-106.
39. Roselli CE, Resko JA. Regulation of hypothalamic luteinizing hormone-releasing hormone levels by testosterone and estradiol in male rhesus monkeys. Brain Res 1990; 509: 343-346.
40. Caraty A, Locatelli A. Effect of time after castration on secretion of LHRH and LH in the ram. J Reprod Fert 1988; 82: 263-269.
41. Jackson GL, Kuehl D, Rhim TJ. Testosterone inhibits gonadotropin-releasing hormone pulse frequency in the male sheep. Biol Reprod 1991; 45: 188-194.
42. Hileman SM, Lubbers LS, Petersen SL, Kuehl DE, Scott CJ, Jackson GL. Influence of testosterone on LHRH release. LHRH mRNA and proopiomelanocortin mRNA in male sheep. J Neuroendocrinol 1996; 8: 113-121.
43. Levine JE, Chappell P, Besecke LM, Bauer-Dantoin AC, Wolfe AM, Porkka-Heiskanen T., Urban JH. Amplitude and frequency modulation of pulsatile luteinizing hormone-releasing hormone release. Cell Mol Neurobiol 1995; 15: 117-139.
44. Spratt DP, Herbison AE. Regulation of preoptic area gonadotropin-releasing hormone (GnRH) mRNA expression by gonadal steroids in the long-term gonadectomized male rat. Mol Brain Res 1997; 47: 125-133.
45. Toranzo D, Dupont E, Simard J, Labrie C, Couet J, Labrie F, Pelletier G. Regulation of pro-gonadotropin-releasing hormone gene expression by sex steroids in the brain of male and female rats. Mol Endocrinol 1989; 3: 1748-1756.
46. Gruenewald DA, Matsumoto AM. Age-related decreases in serum gonadotropin levels and gonadotropin-releasing hormone gene expression in the medial preoptic area of the male rat are dependent upon testicular feedback. Endocrinology 1991; 129: 2442-2450.
47. Selmanoff M, Shu C, Petersen SL, Barraclough CA, Zoeller RT. Single cell levels of hypothalamic messenger ribonucleic acid encoding luteinizing hormone-releasing hormone in intact, castrated, and hyperprolactinemic male rats. Endocrinology 1991; 128: 459-466.
48. Li S, Pelletier G. Role of dopamine in the regulation of gonadotropin-releasing hormone in the male rat brain as studied by in situ hybridization. Endocrinology 1992; 131: 395-399.
49. Rothfeld JM, Hejtmaneik JF, Conn PM, Pfaff DW. LHRH messenger RNA in neurons in the intact and castrate male rat forebrain, studied by in situ hybridization. Exp Brain Res 1987; 67: 113-118.
50. Park Y, Park SD, Cho WK, Kim K. Testosterone stimulates LH-RH-like mRNA level in the rat hypothalamus. Brain Res 1988; 451: 255-260.
51. Wiemann JN, Clifton DK, Steiner RA. Gonadotropin-releasing hormone messenger ribonucleic acid levels are unaltered with changes in the gonadal hormone milieu of the adult male rat. Endocrinology 1990; 127: 523-532.
52. Malik KF, Silverman AJ, Morrell JI, Gonadotropin-releasing hormone mRNA in the rat: distribution and neuronal content over the estrous cycle and after castration of males. Anat Rec 1991; 231: 457-466.
53. Emanuele NV, Jurgens J, La Paglia N, Williams DW, Kelley MR. The effect of castration on steady state levels of luteinizing hormone-releasing hormone (LHRH) mRNA and proLHRH processing: time course study utilizing semi-quantitative reverse transcription/polymerase chain reaction. J Endocrinol 1996; 148: 509-515.
54. Chowen-Breed J, Fraser HM, Vician L, Damassa DA, Clifton DK, Steiner RA. Testosterone regulation of proopiomelanocortin messenger ribonucleic acid in the arcuate nucleus of the male rat. Endocrinology 1989; 124: 1697-1702.
55. Blum M, Roberts JL, Wardlaw SL. Androgen regulation of proopiomelanocortin gene expression and peptide content in the basal hypothalamus. Endocrinology 1989; 124: 2283-2288.
56. Sagrillo CA, Selmanoff M. Castration decreases single cell levels of mRNA encoding glutamic acid decarboxylase in the diagonal band of broca and the sexually dimorphic nucleus of the preoptic area. J Neuroendocrinol 1997; 9: 699-706.
57. 3H] testosterone. J Steroid Biochemistry 1989; 32: 599-608.
58. Morishima A, Grumbach MM, Simpson ER, Fisher C, Qin K. Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens. J Clin Endocrinol Metab 1995; 80: 3689-3698.
59. Smith EP, Boyd J, Frank GR, Takahashi H, Cohen RM, Specker B, Williams TC, Lubahn DB, Korach KS. Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man. N Engl J Med 1994; 331: 1056-1061.
60. Carani C, Qin K, Simoni M, Faustini-Fustini M, Serpente S, Boyd J, Korach KS, Simpson ER. Effect of testosterone and estradiol in man with aromatase deficiency. N Engl J Med 1997; 337: 91-95.
61. Roselli CE, Resko JA. Testosterone regulates aromatase activity in discrete brain areas of male rhesus macaques. Biol Reprod 1989; 40: 929-934.
62. Khorram O, Roselli CE, Ellinwood WE, Spies HG. The measurement of neuropeptide Y in discrete hypothalamic and limbic regions of male rhesus macaques with a human NPY-directed antiserum. Peptides 1987; 8: 159-163.
63. Sahu A, Phelps CP, White JD, Crowley WR, Kalra SP, Kalra PS. Steroidal regulation of hypothalamic neuropeptide Y release and gene expression. Endocrinology 1992; 130: 3331-3336.
64. Urban JH, Bauer-Dantoin AC, Levine JE. Neuropeptide Y gene expression in the arcuate nucleus: sexual dimorphism and modulation by testosterone. Endocrinology 1993; 132: 139-145.