Single Streptomyces lividans K+ channels. Functional asymmetries and sidedness of proton activation

Journal of General Physiology

Volumn 114, Issue 4, 1999, Pages 551-559

  Heginbotham, Lise ^a,b   LeMasurier, Meredith ^a   Kolmakova Partensky, Ludmilla ^a   Miller, Christopher ^a  

^a BRANDEIS UNIVERSITY   (United States)

^b YALE UNIVERSITY   (United States)

Author keywords

Block; Gating; Permeation; Potassium channel

Indexed keywords

CHARYBDOTOXIN; CYSTEINE; POTASSIUM CHANNEL; POTASSIUM ION; PROTON; SODIUM ION; TETRYLAMMONIUM; THIOMESYLIC ACID METHYL ESTER;

AMINO ACID SUBSTITUTION; ARTICLE; CHANNEL GATING; ELECTRIC POTENTIAL; LIPID BILAYER; MEMBRANE ELECTROPHYSIOLOGY; MUTATION; NONHUMAN; PROTON TRANSPORT; STREPTOMYCES LIVIDANS;

BACTERIAL PROTEINS; CHARYBDOTOXIN; ESCHERICHIA COLI; HYDROGEN-ION CONCENTRATION; INDICATORS AND REAGENTS; ION CHANNEL GATING; LIPID BILAYERS; MESYLATES; MODELS, MOLECULAR; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; STREPTOMYCES; TETRAETHYLAMMONIUM;

EID: 0032875483     PISSN: 00221295     EISSN: None     Source Type: Journal    
DOI: 10.1085/jgp.114.4.551     Document Type: Article

References (30)

1. + channels. Effects of channel gating, voltage, and ionic strength. J. Gen. Physiol. 91: 317-333.
2. Bezanilla, F., and C.M. Armstrong. 1972. Negative conductance caused by entry of sodium and cesium ions into the potassium channels of squid axons. J. Gen. Physiol. 60:588-608.
3. Chen, T.Y., and C. Miller. 1996. Nonequilibrium gating and voltage dependence of the CIC-0 Cl channel. J. Gen. Physiol. 108:237-250.
4. Coronado, R., and C. Miller. 1979. Voltage dependent caesium blockade of a cation channel from fragmented sarcoplasmic reticulum. Nature. 280:807-810.
5. + channels (SCK1): oligomeric stoichiometry and stability. Biochemistry. 36:10343-10352.
6. + channel. Biochemistry. 37:3229-3236.
7. + conduction and selectivity. Science. 280:69-76.
8. French, R.J., and J.B. Wells. 1977. Sodium ions as blocking agents and charge carriers in the potassium channel of the squid giant axon. J. Gen. Physiol. 70:707-724.
9. + channel: peptide and channel residues mediating molecular recognition. Neuron. 12:1377-1388.
10. + channel. Biophys. J. 65:1613-1619.
11. + channel. Biochemistry. 36:10335-10342.
12. + channel. J. Gen. Physiol. 111:741-750.
13. Heginbotham, L., and R. MacKinnon. 1992. The aromatic binding site for tetraethylammonium ion on potassium channels. Neuron. 8:483-491.
14. Hille, B. 1991. Ionic Channels of Excitable Membranes. 2nd ed. Sinauer Associates, Inc., Sunderland, MA. 607 pp.
15. Holmgren, M., Y. Liu, Y. Xu, and G. Yellen. 1996. On the use of thiol-modifying agents to determine channel topology. Neuropharmacology. 35:797-804.
16. Kavanaugh, M.P., R.S. Hurst, J. Yakel, M.D. Varnum, J.P. Adelman, and R.A. North. 1992. Multiple subunits of a voltage-dependent potassium channel contribute to the binding site for tetraethylammonium. Neuron. 8:493-497.
17. + channel. Neuron. 19:175-184.
18. MacKinnon, R., S.L. Cohen, A. Kuo, A. Lee, and B. Chait. 1998. Structural conservation in prokaryotic and eukaryotic potassium channels. Science. 280:106-109.
19. + channels. Science. 250:276-279.
20. + channel-blocking peptides. Neuron. 15:5-10.
21. Newland, C.F., J.P. Adelman, B.L. Tempel, and W. Almers. 1992. Repulsion between tetraethylammonium ions in cloned voltage-gated potassium channels. Neuron. 8:975-982.
22. + channel studied by EPR spectroscopy. Nat. Struct. Biol. 5:459-469.
23. +-channel activation gating. Science. 285:73-78.
24. Schrempf, H., O. Schmidt, R. Kummerlin, S. Hinnah, D. Muller, M. Betzler, T. Steinkamp, and R. Wagner. 1995. A prokaryotir potassium ion channel with two predicted transmembrane segments from Streptomyces livilans. EMBO (Eur. Mol. Biol. Organ.) J. 14: 5170-5178.
25. + channel structure from a complete functional map of the molecular surface of charybdotoxin. Biochemistry. 33:443-450.
26. Wonderlin, W.F., A. Finkel, and R.J. French. 1990. Optimizing planar lipid bilayer single-channel recordings for high resolution with rapid voltage steps. Biophys. J. 58:289-297.
27. Woodhull, A. 1973. Ionic blockage of sodium channels in nerve. J. Gen. Physiol. 61:687-708.
28. + channels by external cations. J. Gen. Physiol. 84:187-199.
29. Yellen, G. 1998. The moving parts of voltage-gated ion channels. Q. Rev. Biophys. 31:239-295.
30. + channel. Science. 251:939-942.