Functional evaluation of p53 and PTEN gene mutations in gliomas

Clinical Cancer Research

Volumn 6, Issue 10, 2000, Pages 3937-3943

  Kato, H ^a   Kato, S ^a,a   Kumabe, T ^a   Sonoda, Y ^a   Yoshimoto, T ^a   Han, S ^a   Suzuki, T ^a   Shibata, H ^a   Kanamaru, R ^a   Ishioka, C ^a  

^a TOHOKU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHATASE; PROTEIN P53;

ADOLESCENT; ADULT; AGED; ARTICLE; CHILD; CHROMOSOME 10Q; DNA SEQUENCE; FEMALE; GENE DELETION; GENE MUTATION; GLIOBLASTOMA; GLIOMA; HETEROZYGOSITY LOSS; HUMAN; HUMAN TISSUE; INFANT; MAJOR CLINICAL STUDY; MALE; MISSENSE MUTATION; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

ADOLESCENT; ADULT; AGED; ALLELES; ASTROCYTOMA; BRAIN NEOPLASMS; CHILD; CHILD, PRESCHOOL; CHROMOSOMES, HUMAN, PAIR 10; DNA, COMPLEMENTARY; FEMALE; GENE DELETION; GENES, P53; GLIOBLASTOMA; GLIOMA; HUMANS; IMMUNOBLOTTING; INFANT; INOSITOL PHOSPHATES; LOSS OF HETEROZYGOSITY; MALE; MIDDLE AGED; MUTATION; MUTATION, MISSENSE; PHOSPHORIC MONOESTER HYDROLASES; PTEN PHOSPHOHYDROLASE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUMOR SUPPRESSOR PROTEINS;

EID: 0033760492     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Tumours of central neuroepithelial origin
2. The molecular genetics of central nervous system tumors
3. Molecular pathogenesis of malignant gliomas
4. Pathways leading to glioblastoma multiforme: A molecular analysis of genetic alterations in 65 astrocytic tumors
5. p53 mutation and loss of heterozygosity on chromosomes 17 and 10 during human astrocytoma progression
6. Deletion mapping of chromosome 10 in human glioma
7. Fine mapping of a region of common deletion on chromosome arn 10p in human glioma
8. Structural and functional evidence for the presence of tumor suppressor genes on the short arm of chromosome 10 in human gliomas
9. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
10. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers
11. Disruption of the MMAC1/PTEN gene by deletion or mutation is a frequent event in malignant melanoma
12. Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in primary breast carcinomas
13. Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies
14. PTEN gene mutations are seen in high-grade but not in low-grade gliomas
15. Somatic mutations of PTEN in glioblastoma multiforme
16. PTEN1 is frequently mutated in primary endometrial carcinomas
17. Frequent inactivation of PTEN/MMAC1 in primary prostate cancer
18. PTEN mutations in gliomas and glioneuronal tumors
19. Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome
20. Germline mutations in PTEN are present in Bannayan-Zonana syndrome
21. Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain
22. Suppression of tumorigenicity of glioblastoma cells by adenovirus-mediated MMAC1/PTEN gene transfer
23. 1 growth arrest in glioma cells
24. The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
25. Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN
26. The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway
27. 1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway
28. PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5-trisphosphate and Akt/protein kinase B signaling pathway
29. Histological typing of tumors of the central nervous system
30. Screening patients for heterozygous p53 mutations using a functional assay in yeast
31. Screening the p53 status of human cell lines using a yeast functional assay
32. Influence of p53 mutation on pathological grade, but not prognosis of non-Hodgkin's lymphoma
33. Alterations of the TP53 gene in human gliomas
34. Genetic sub-types of human malignant astrocytoma correlate with survival
35. Mutational analysis of the PTEN gene in gliomas: Molecular and pathological correlations
36. Mutation in the PTEN/MMAC1 gene in archival low grade and high grade gliomas
37. Mutation and cancer: Statistical study of retinoblastoma
38. Somatic deletion mapping on chromosome 10 and sequence analysis of PTEN/MMAC point to the 10q25-26 region as the primary target in low-grade and high-grade gliomas
39. The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region