Monocytes from Wiskott-Aldrich patients display reduced chemotaxis and lack of cell polarization in response to monocyte chemoattractant protein-1 and formyl-methionyl-leucyl-phenylalanine

Journal of Immunology

Volumn 161, Issue 2, 1998, Pages 1026-1033

  Badolato, Raffaele ^a,c   Sozzani, Silvano ^e   Malacarne, Fabio ^d   Bresciani, Susanna ^a   Fiorini, Maurilia ^a   Borsatti, Alessandro ^e   Albertini, Alberto ^b   Mantovani, Alberto ^b   Ugazio, Alberto G ^a   Notarangelo, Luigi D ^a  

^a UNIVERSITY OF BRESCIA   (Italy)

^b UNIVERSITY OF BRESCIA   (Italy)

^c UNIVERSITY OF UDINE   (Italy)

^d Servizio di Immunologia Clinica   (Italy)

^e MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

FORMYLMETHIONYLLEUCYLPHENYLALANINE; MONOCYTE CHEMOTACTIC PROTEIN;

ARTICLE; BASOPHIL DEGRANULATION; CELL ADHESION; CELL MIGRATION; CELL POLARITY; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOGLOBULIN PRODUCTION; MONOCYTE; NEUTROPHIL CHEMOTAXIS; OPPORTUNISTIC INFECTION; PRIORITY JOURNAL; RESPIRATORY BURST; THROMBOCYTOPENIA; WISKOTT ALDRICH SYNDROME;

CELL MOVEMENT; CELL POLARITY; CELL SIZE; CHEMOKINE CCL2; CHEMOTAXIS, LEUKOCYTE; CHILD, PRESCHOOL; HUMANS; INFANT; MONOCYTES; N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE; PROTEIN BINDING; WISKOTT-ALDRICH SYNDROME;

EID: 0032528414     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Remold-O'Donnell, E., F. S. Rosen, and D. M. Kenney. 1996. Defects in Wiskott-Aldrich syndrome blood cells. Blood 87:2621.
2. Molina, I. J., D. M. Kenney, F. S. Rosen, and E. Remold-O'Donnell. 1992. T cell lines characterize events in the pathogenesis of the Wiskott-Aldrich syndrome. J. Exp. Med. 176:867.
3. Oppenheim, J. J., R. M. Blaese, and T. A. Waldmann. 1970. Defective lymphocyte transformation and delayed hypersensitivity in Wiskott-Aldrich syndrome. J. Immunol. 104:835.
4. Derry, J. M., H. D. Ochs, and U. Francke. 1994. Isolation of a novel gene mutated in Wiskott-Aldrich syndrome. Cell 78:635.
5. Stewart, D. M., S. Treiber-Held, C. C. Kurman, F. Facchetti, L. D. Notarangelo, and D. L. Nelson. 1996. Studies of the expression of the Wiskott-Aldrich syndrome protein. J. Clin. Invest. 97:2627.
6. Remold-O'Donnell, E., J. Cooley, A. Shcherbina, T. L. Hagemann, S. P. Kwan, D. M. Kenney, and F. S. Rosen. 1997. Variable expression of WASP in B cell lines of Wiskott-Aldrich syndrome patients. J. Immunol. 158:4021.
7. Kenney, D., L. Cairns, E. Remold-O'Donnell, J. Peterson, F. S. Rosen, and R. Parkman. 1986. Morphological abnormalities in the lymphocytes of patients with the Wiskott-Aldrich syndrome. Blood 68:1329.
8. Ochs, H. D., S. J. Slichter, L. A. Harker, W. E. Von Behrens, R. A. Clark, and R. J. Wedgwood. 1980. The Wiskott-Aldrich syndrome: studies of lymphocytes, granulocytes, and platelets. Blood 55:243.
9. Symons, M., J. M. J. Derry, B. Karlak, S. Jiang, V. Lemahieu, F. McCormick, U. Francke, and A. Abo. 1996. Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization. Cell 84:723.
10. Aspenstrom, P., U. Lindberg, and A. Hall. 1996. Two GTPases, Cdc42 and Rac, bind directly to a protein implicated in the immunodeficiency disorder Wiskott-Aldrich syndrome. Curr. Biol. 6:70.
11. Kolluri, R., K. F. Tolias, C. L. Carpenter, F. S. Rosen, and T. Kirchhausen. 1996. Direct interaction of the Wiskott-Aldrich syndrome protein with the GTPase Cdc42. Proc. Natl. Acad. Sci. USA 93:5615.
12. Banin, S., O. Truong, D. R. Katz, M. D. Waterfield, P. M. Brickell, and I. Gout. 1996. Wiskott-Aldrich syndrome protein (WASp) is a binding partner for c-Src family protein-tyrosine kinases. Curr. Biol. 6:981.
13. Rivero-Lezcano, O. M., A. Marcilla, J. H. Sameshima, and K. C. Robbins. 1995. Wiskott-Aldrich syndrome protein physically associates with Nck through Src homology 3 domains. Mol. Cell. Biol. 15:5725.
14. Ridley, A. J. 1996. Rho: theme and variants. Curr. Biol. 6:1256.
15. Finan, P. M., C. J. Soames, L. Wilson, D. L. Nelson, D. M. Stewart, O. Truong, J. J. Hsuan, and S. Kellie. 1996. Identifications of regions of the Wiskott-Aldrich syndrome protein responsible for association with selected Src homology 3 domains. J. Biol. Chem. 271:26291.
16. Rollins, B. J. 1997. Chemokines. Blood 90:904.
17. Baggiolini, M., B. Dewald, and B. Moser. 1994. Interleukin-8 and related chemotactic cytokines: CXC and CC chemokines. Adv. Immunol. 55:97.
18. Badolato, R., and J. J. Oppenheim. 1996. Role of cytokines, acute phase proteins, and chemokines in the progression of rheumatoid arthritis. Semin. Arthritis Rheum. 26:526.
19. Badolato, R., D. L. Sacks, D. Savoia, and T. Musso. 1996. Leishmania major: infection of human monocytes induces expression of IL-8 and MCAF. Exp. Parasitol. 82:21.
20. Sozzani, S., M. Molino, M. Locati, W. Luini, C. Cerletti, A. Vecchi, and A. Mantovani. 1993. Receptor-activated calcium influx in human monocytes exposed to monocyte chemotactic protein-1 and related cytokines. J. Immunol. 150: 1544.
21. Rollins, B. J., A. Walz, and M. Baggiolini. 1991. Recombinant human MCP-1/JE induces chemotaxis, calcium flux, and the respiratory burst in human monocytes. Blood 78:1112.
22. Badolato, R., J. M. Wang, W. J. Murphy, A. R. Lloyd, D. F. Michiel, L. L. Bausserman, D. J. Kelvin, and J. J. Oppenheim. 1994. Serum amyloid A is a chemoattractant: induction of migration, adhesion, and tissue infiltration of monocytes and polymorphonuclear leukocytes. J. Exp. Med. 180:203.
23. Dejana, E., F. Bussolino, J. M. Wang, and A. Mantovani. 1991. Cytokine regulation of endothelial cells. In Cytokines: A Practical Approach. F. R. Balkwill, ed. Oxford University Press, Oxford, p. 215.
24. Falk, W. R., R. H. Goodwin, Jr., and E. J. Leonard. 1980. A 48-well microchemotaxis assembly for rapid and accurate measurement of leukocyte migration. J. Immunol. Methods 33:239.
25. Haston, W. S., and J. M. Shields. 1985. Neutrophil leucocyte chemotaxis: a simplified assay for measuring polarizing responses to chemotactic factors. J. Immunol Methods 81:237.
26. Pick, E., and D. Mizel. 1981. Rapid microassays for the measurement of superoxide and hydrogen peroxide production by macrophage in culture using an automatic enzyme immunoassay reader. J. Immunol. Methods 46:211.
27. Premack, B. A., and T. J. Schall. 1996. Chemokine receptors: gateway to inflammation and infection. Nat. Med. 2:1174.
28. Xu, L., R. Badolato, W. J. Murphy, D. L. Longo, M. Anver, S. Hale, J. J. Oppenheim, and J. M. Wang. 1995. A novel biologic function of serum amyloid A: induction of T lymphocyte migration and adhesion. J. Immunol. 155: 1184.
29. Tomhave, E. D., R. M. Richardson, J. R. Didsbury, L. Menard, R. Snyderman, and H. Ali. 1994. Cross-desensitization of receptors for peptide chemoattractants: characterization of a new form of leukocyte regulation. J. Immunol. 153:3267.
30. Murphy, P. M. 1994. The molecular biology of leukocyte chemoattractant receptors. Annu. Rev. Immunol. 12:593.
31. Altman, L. C., R. Snyderman, and R. M. Blaese. 1974. Abnormalities of chemotactic lymphokine synthesis and mononuclear leukocyte chemotaxis in Wiskott-Aldrich syndrome. J Clin. Invest. 54:486.
32. Ridley, A. J. 1995. Rac and Bcr regulate phagocytic phoxes. Curr. Biol. 5:710.
33. Laudanna, C., J. J. Campbell, and E. C. Butcher. 1996. Role of Rho in chemoattractant-activated leukocyte adhesion through integrins. Science 271:981.
34. Sica, A., J. M. Wang, F. Colotta, E. Dejana, A. Mantovani, J. J. Oppenheim, C. G. Larsen, C. O. Zachariae, and K. Matsushima. 1990. Monocyte chemotactic and activating factor gene expression induced in endothelial cells by IL-1 and tumor necrosis factor. J. Immunol. 144:3034.
35. Musso, T., R. Badolato, D. L. Longo, G. L. Gusella, and L. Varesio. 1995. Leukemia inhibitory factor induces interleukin-8 and monocyte chemotactic and activating factor in human monocytes: differential regulation by interferon-gamma. Blood 86:1961.
36. Broxmeyer, H. E., B. Sherry, S. Cooper, L. Lu, R. Maze, M. P. Beckmann, A. Cerami, and P. Ralph. 1993. Comparative analysis of the human macrophage inflammatory protein family of cytokines (chemokines) on proliferation 1. of human myeloid progenitor cells: interacting effects involving suppression, synergistic suppression, and blocking of suppression. J. Immunol. 150:3448.
37. Nagasawa, T., S. Hirota, K. Tachibana, N. Takakura, S. Nishikawa, Y. Kitamura. N. Yoshida, H. Kikutani, and T. Kishimoto. 1996. Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/ SDF-1. Nature 382:635.
38. Wengler, G., J. B Gorlin, J. M. Williamson, F. S. Rosen, and D. H. Bing. 1995. Nonrandom inactivation of the X chromosome in early lineage hematopoietic cells in carriers of Wiskott-Aldrich syndrome. Blood 85:2471.
39. Wengler, G. S., L. D. Notarangelo, S. Berardelli, G. Pollonni, P. Mella, A. Fasth, A. G. Ugazio, and O. Parolini. 1995. High prevalence of nonsense, frame shift, and splice-site mutations in 16 patients with full-blown Wiskott-Aldrich syndrome. Blood 86:3648.
40. Zhu, Q., M. Zhang, R. M. Blaese, J. M. Derry, A. Junker, U. Francke, S. H. Chen, and H. D. Ochs. 1995. The Wiskott-Aldrich syndrome and X-linked congenital thrombocytopenia are caused by mutations of the same gene. Blood 86:3797.